<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLK3</accession>
    <name>A0A218NLK3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cas12f1-like TNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLK3"/>
    <dbReference type="KEGG" id="marh:Mia14_0009"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051491">
        <property type="entry name" value="Recombinase/Transposase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172:SF1">
        <property type="entry name" value="RESOLVASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="142" mass="16014" checksum="89CCD3F725B45E74" modified="2017-09-27" version="1">MFCMKTAYEYRAYPSKEQKRTLNRQMYLSKELYNLLLEKLQYKAESAGCVAMKVDPQYTSMTCSKCGNVQSMSISQRIFVCEKCGMSMDRDVNAARNILKRALDYIIPTTEGHSGSQACRDDIRTSAGEAVAYEAGTIWVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLK4</accession>
    <name>A0A218NLK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PMT family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819524.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLK4"/>
    <dbReference type="GeneID" id="33313568"/>
    <dbReference type="KEGG" id="marh:Mia14_0006"/>
    <dbReference type="OrthoDB" id="133778at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="759" mass="84639" checksum="5F9242431B6B435C" modified="2017-09-27" version="1">MSIKLNDIYSKVKSPAGIATFIYFIVTLIIFYPFILHPSTLSAGTGGDAYQNLWDFWHIGYSIANLKSIYYTKMLFYPIGSDLITQTMSPFMGLITLPFQAFGLIFSYTSGLIIGFTFTGLAMFLLADYLVKNKYAAFFAGLVYAFSAFHFAQGLMHIDYVNLGFIPLTLYFLFRLMDKPSYKEGIYLSIAFALLLFTEFIEQVIMVVLAALIILIWYGISKSKRKIIVNKRFFYSIILAVVIFLLITSFFIVPMVQFLTSKSGASTYSLDNIPHNVIWSDNILEFFVPSYYNGLFNRSGSFYSALYYFDPSEHTAYIGYTVIILSLFAIYKYRKNMGLWILIAFLFGWLALGPYIQIGTAVTSSSFPVPGLTTVPGLFLIYHQIPLLKVIREPDRFFAIFSVAIAIMAAFGIKAMSETKFFEGKNSKIVAIAIISILFLIGSVGLPITSNYINVISTHVSPNKFYRSLSNSTKNFSILILPALSNSYSASPAEYPGLATYQSALADKPLIGGYVTRSNTSENETLEVIPLISEAQTLEENGTFDYQSPIVENYTNQTLLTLYNYQTAIVTVNKGAYNLSTLGYLEDYLYKTFGSKSIVYNSNSTIAFYTLPALYQSVYRSYVSYPISKYWEGESIKVDNQTKQVWIPLSKGELVVYAPYINITTVNGSIYGHNTNINSTVSINAESLVNSTVPLQISIEGGNGDVIYKGSLNITAGLNTYNITVPLVSGPYGNYFEITEYGDNGKPTIGISGISIKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN0</accession>
    <name>A0A218NLN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819541.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN0"/>
    <dbReference type="GeneID" id="33313587"/>
    <dbReference type="KEGG" id="marh:Mia14_0025"/>
    <dbReference type="OrthoDB" id="382199at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="185" mass="20995" checksum="FE7FBE778D358F10" modified="2017-09-27" version="1">MSESSGEAFISESPTHSIKLEFYSEGTGMVTMVWEPVEDAILQTLFDLTGGVLDQKLIESDGKSARDFADGFIEANGLEDVRESVYEDVKLDKACPKCGSKDLSRSEATLKKSNIPIIPTYICKHCNAKSYYLTDTYLKDLVENHKDLFDENELKELNNDKAKLLENMQEYISRIFAVKKIYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN2</accession>
    <name>A0A218NLN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN2"/>
    <dbReference type="KEGG" id="marh:Mia14_0040"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="79" mass="9517" checksum="DE06220DC5578EDF" modified="2017-09-27" version="1">MNVDDKLYFINKLLRDNKFHVTGFLLTKDYIFIKSYRFRTNYYFIIPRLAAPSSLDSIDKLMRYNTINDNRVPISFIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP0</accession>
    <name>A0A218NLP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosome complex exonuclease Rrp41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819565.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP0"/>
    <dbReference type="GeneID" id="33313611"/>
    <dbReference type="KEGG" id="marh:Mia14_0051"/>
    <dbReference type="OrthoDB" id="24266at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="247" mass="26779" checksum="650166F4713EF0F9" modified="2017-09-27" version="1">MASSLNKPKLIINGKRIDGRGFNELRPLKIEAGVLKNADGSAYEEWGNNKVLAAVYGPKEAPRYLADPEKAVIRAKYSMASFSGLDGHGRSAPSRREVEISKVTSDVFSNIVEVSQFPNSVIEIDIEILQSDGGTRAAGITAASVALANAGIPMKDLVYAVSGARIEDKMAVDVNMIEDNYSDADIPFAISPRNNEVLLLQFDGGVTPEQMKEAEKLVLEAGKTISQIQKDALKKSYEDVSAKYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP6</accession>
    <name>A0A218NLP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819568.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP6"/>
    <dbReference type="GeneID" id="33313614"/>
    <dbReference type="KEGG" id="marh:Mia14_0054"/>
    <dbReference type="OrthoDB" id="6637at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="124" mass="14625" checksum="8BD5129408AAE301" modified="2017-09-27" version="1">MENKISITYAPIHEIIVHEIVKVELEDLKRERVTPSGTLPLYWCSGIIFSFSSLPMSRKVLDDYLDGRIHWMEVHFSQMKEYSSSIELKDEQHYSGKIEIRVIDTSKSNVHQEFIKWLKKNTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR7</accession>
    <name>A0A218NLR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L32e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819587.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR7"/>
    <dbReference type="GeneID" id="33313634"/>
    <dbReference type="KEGG" id="marh:Mia14_0074"/>
    <dbReference type="OrthoDB" id="372100at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="122" mass="13836" checksum="AFDF9BFEF1BD3150" modified="2017-09-27" version="1">MAQLKKKEHPKFNVPNFNSKNRKRVPERWRKQRGIDSKKRVKKNFAGAEPTIGYKNPDSIRGIRASGKRAELVHNETELKGIVDSKKNVDIILAKPIGRKKKIALTKIAQKSNLKVVNGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS9</accession>
    <name>A0A218NLS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819572.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS9"/>
    <dbReference type="GeneID" id="33313619"/>
    <dbReference type="KEGG" id="marh:Mia14_0059"/>
    <dbReference type="OrthoDB" id="372127at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="210" mass="23514" checksum="DAE743D7D91EAC24" modified="2017-09-27" version="1">MSEQKKDVNKAEKPKAEAPAEPKAEVKAKPQQKPAKQVEPKEKRYDERSARSASIIRLSGKDIPGNLNIENAIMNIRGIGFTMANGLRYIIDKSLNIPPETRLEDLNDEQLSKLEEVIKDPAKFGIPAFLLNRNKDMETGKDLHVVGNDLVFATRQDISRAVTLRTWIGYRHQYNLRVRGQHTRSTGRRGATVGVTKKANKPATSSSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU0</accession>
    <name>A0A218NLU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819582.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU0"/>
    <dbReference type="GeneID" id="33313629"/>
    <dbReference type="KEGG" id="marh:Mia14_0069"/>
    <dbReference type="OrthoDB" id="372073at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="227" mass="24767" checksum="782E33EC1CB5451C" modified="2017-09-27" version="1">MAKKGGTNHIKSLAAPEFFNISRKEETYVARPLPGRHNLYSVAPLEDSIKKLGYSDNYSDAAKVIKSGKIKVNGKTIKEKKFPIGLNDVISIGKANYLVSIDKFGHISFNETKAPEHFIYKVVGKDKFKGNKIRVRLNSGTVIDAGENAGKINPGDSVKIDSNNKIIEVIKMKKGAKCTVVSGVHVATSGSIEDIKPGNIHTGKVVIIKDDKGEIFETLEKNIITMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU1</accession>
    <name>A0A218NLU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU1"/>
    <dbReference type="KEGG" id="marh:Mia14_0086"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="178"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="48341" checksum="75F16138228564E3" modified="2017-09-27" version="1">MAMELTRAYKFRIYPDTKRQSEIDERLILAQQFYNKILEKSIESYKNGEAKASMAQFNRFVKEIIQDDKRYLKLYSQTRCEIEYRLLKAYQNFFRRIKEGNRKAGFPRFKSRDRYKSITYPQYNGSFSIKRGRLRVSRIGTMRIELHRKIEGTIKTLSIKREGKDYYAIFTTANEIKIPQLEDTNPVGIDMGLHSFIAMSSGMKIEKPRFVRKRAKHLARWQRRIAKREKGSKRRENAKNHLQKEWEHVTEQSDDFSHKLSNKLVNSGYTSFAVEDLHIQNMAKNHNLAQAIYNASWNKFIQMLSYKAESAGMKVISVDERNTTQECSNCHCIREGGERLTLEDRVYNCNRCGMQLDRDVNASINILHRATTLGQRGSYAQGDMASAVQQELKSRIAELRTDKTHPLRDAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV0</accession>
    <name>A0A218NLV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819606.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV0"/>
    <dbReference type="GeneID" id="33313655"/>
    <dbReference type="KEGG" id="marh:Mia14_0095"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="277" mass="29922" checksum="044EF187803444DE" modified="2017-09-27" version="1">MNEKSKKVIMLVVSIVIAMTFISSYLNSDFNSTTPTAPSKSAVKLQPVPFFGSANAIIRNYTSSLYVYENTTDVTNASKLTSLNSSLSSALNVIPSYGETSLPNGYYLRLTGSAVSASQTLKKEFGNEIILKSDALVNIIGNYTSSLYVYENVTGASNLTSLNSNLASAFIALGINDEYPIKNGYDIIKVGSVNNITESLRKEFGNKIILKPTITVDAVPMTYSSKYGDIGIYFNATTLYTLDNVSISAVNSTIPVSIIATVTDNDKPYQVVLKPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV3</accession>
    <name>A0A218NLV3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_338025067.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV3"/>
    <dbReference type="GeneID" id="33313672"/>
    <dbReference type="KEGG" id="marh:Mia14_0112"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="110" mass="12038" checksum="2A5547F8CFD00F13" modified="2017-09-27" version="1">MASSDCKGSDRIKRMLGKYGLTDFQKRVLLFVCTIPKGKTMSYKEVAVAIGHPNSYRAVGTALKENPLPILIPCHRVIRADGKLGEYSNGGTDAKRRILKEEGYIGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV6</accession>
    <name>A0A218NLV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819614.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV6"/>
    <dbReference type="GeneID" id="33313663"/>
    <dbReference type="KEGG" id="marh:Mia14_0103"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="234" mass="27193" checksum="EEF1A072076F9DA9" modified="2017-09-27" version="1">MPKKNSDKNSNKKKQMKVAYVKLASLKDFVKSSCDFSRNFLSSISMKEGKRYRLIAEGERINETEILYYYDTDKISNFIIYNPVKDLEPEMSSKKDNTDMYNNYIISIASMLSNPFKESELKQGSVNMVEIESYKALLIAAINRFSDDNSIGKIYLFNYGKKPYIGTFNLMNGSDNSTFFFSKLPEEMLKEDNGFFKYDYNSDSIEINNNFSTDNLIHVRIVNLAEPFKFFKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW2</accession>
    <name>A0A218NLW2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="13">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">thrS</name>
        <name evidence="15" type="ORF">Mia14_0119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819625.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW2"/>
    <dbReference type="GeneID" id="33313678"/>
    <dbReference type="KEGG" id="marh:Mia14_0119"/>
    <dbReference type="OrthoDB" id="372136at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000002">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000001">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="173"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="13">
        <location>
            <begin position="173"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="569" mass="65419" checksum="EC297E1541157272" modified="2017-09-27" version="1">MKVLQLDVDKISYKPVKPEASVYEESDDAVVEESNAVVMLVSIEKGDDEDVGKMAVKESLEFAKKEKEKVLVIYPYAHLSDKLSGLESALNILKAMRAEASKESSIKVVSAPFGWNKKLMLDIKGHPLAEESHSYSNNMEKGNEVKSELVEHELKIDTSIVRKSDWSNMPDTDHRTIGERQDLYSFQEVSPAMVYWHPKGFTIYKELINLMRHIEYQHDYQEISTPELTNIALYQVSGHLQHYKENMFMFNSSIGDVSLKPMNCPSTILIYKTRKWSYKDLPWRTAIFDKLHRSELSGVASGLFRVKGLTQDDGHIFAREDQIKDEISDLLHIVKEVYGGIFKMQYHANLSTMPDDHMGDLDLWDRATKALKDALDENEIKYDIKDKDGAFYGPKIDFDIKDSMGRLWQCATIQLDYQLPRNFKLEYTDNEGKSRTPVIIHRAILGSLERFTAIMVEHYQGKFPLWLSPIQVRVLSLSEGSNEYASNIYKTLKDKDIRSELDISDRTIEYKIRDGKLQQIPYLLIIGKKEMEKNSISIRDRSGIQSNNVKLDDFISGLNEKVSSRSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW4</accession>
    <name>A0A218NLW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819610.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW4"/>
    <dbReference type="GeneID" id="33313659"/>
    <dbReference type="KEGG" id="marh:Mia14_0099"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="19752" checksum="C07008051EFFAE19" modified="2017-09-27" version="1">MVDKKESDADKLLNNRNPTKVKKGQNKLGSPKLKSKNKYNNMTYGIAILVVLIIIIVIAVAAYYNTGVYKGNVTLSIGTSKGIVYSINNSEYSIYLYSTNSKSNTADVYITKSPIFINKPIEVNLPVGTLVHINTSGKYANLIIKMTSVSSDNATLNIYPVSPSLGISPDYSHITYNATFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW5</accession>
    <name>A0A218NLW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0333 family protein with class III signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819624.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW5"/>
    <dbReference type="GeneID" id="33313677"/>
    <dbReference type="KEGG" id="marh:Mia14_0118"/>
    <dbReference type="OrthoDB" id="381855at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="17344" checksum="A442766C43F2C274" modified="2017-09-27" version="1">MMNRLNKSTGALHSKKGQSSLELLITLSFGLIILLPIVILAFLQIASSSSTLSTTEAQSVASKIASVAVSVGSQGYPAKQLVLVSVPPDVDNIYVGGINNTVGHEVIFVVRTDAGDDYVTAYSPVRIEGSPTLSSISPQGEYLINISAVNSCPGMPSKTCVYVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX5</accession>
    <name>A0A218NLX5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2 14">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0126</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2 14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891409.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX5"/>
    <dbReference type="GeneID" id="33313685"/>
    <dbReference type="KEGG" id="marh:Mia14_0126"/>
    <dbReference type="OrthoDB" id="7506at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="15">
        <location>
            <begin position="69"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="NCBIfam" id="TIGR00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="892" mass="102137" checksum="8FBCF1595590C215" modified="2017-09-27" version="1">MLNKNSLREEFSKDYQKYYSTKLFEEKGFVRKKCRECGKYFWTLDKSRELCGDSEHEPYSFFKDSPKKIGYVDFWNKFAEFFKENGHVEIEKYPVVSRWRPDLYFTIASIQDFQRIEGNKMGFEYPSNPLIVPQICLRFNDIPNVGVTGRHLTSFMMAGQHAFNYPSEGYWIDRTIELNYKFLTEVLGVDKKKLTYIEDVWAMGDFSEFGPDLEAFANGLELVNNVFTQFSYSEGKVSELKGKVVDVGWGFERLLWFASGNYTLYDAVFHRELEYLYEKTGFHPNRETYAKVAGISGLIDIGEDKEGQKKELEIIKRNGIDEKEYLEEIKPAQALYAIVDHTRTLLFAIHDGALPSNVSGGYNLRIILRRVFDFMDRYGFKFDLMDLFRMHCEDLEGLYNGLEDSLDVISKIVDIERKRYDQMKSKSERIIKGIIDKNEELDRGRIKVLYESEGITPEFIESYSRRMGHFISVPDNYYESIIKGDFVEKEKKVKKVSIDTDGLPNTIKLFYDFDNMSDSKVLRVSGNYVVLDRTPFYAEGGGQEADHGTMNGIRVVDVQSDLGVIVHRLESPPSFKQGDFVRCVVDMDRRIRLMAHHTATHLISAAARDVLGKHAWQEGAHKGEEKAHIDIAHFEKLDDKEISEIEMKANSYIFHGIKVSLHDMNRGDAESKFGFSIYQGHGVPSSRLRIIEVDDLNGNLIDAEACGGLHLINRESLIGLIKIISTSRIHDGVDRIEFTAGPASLDYVRSIENKIKNVSKMTNIDSDKLETGISSKIAELEAVAKYSKELEGKLILAESEKLAKEKDLVLIKEFTDYRKEMLRAIVLDVTNRSKEKMVVLYNKEYEVIACAGEDSGADALEYLKSYASSNSFDFHGGGSAHIAEGKLFAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY4</accession>
    <name>A0A218NLY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819650.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY4"/>
    <dbReference type="GeneID" id="33313704"/>
    <dbReference type="KEGG" id="marh:Mia14_0145"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="687" mass="74772" checksum="C8D234BA2FDA094E" modified="2017-09-27" version="1">MSYLRILLLAVISLSLIGMSSSYAASVTPVSINASLSSYLSTYIPNSTIKSSTFVSFEFDNGRYIIMNVTPSEHILLNVTDSHYSFILNNTTAKAIITPILIDLYYPNSSVINSMKNDISEYESYSAPAINSCKVSTGLNEYTFTVANGGYSCETVPRCAADYVATGGMGGILSTAIFTFSDQTTALNNSYTNVVQLLDSLNHTNFNTNIDMVRSNISQISELSAKLPQSALFPLPSDIPNSELNLCTLSATAPYYCLSMGLCTSTPQFNFSYLNNINSTLQSLSMLPVSGSNLNSYVSNMTELASSYVEPVVIKEETGRFNSLINSTSGAYNKSVNESELLLSKFSNSSLSSSLSTLKTVYSYVLGHGINQNLTAAGNEINASLNNNTLVYSKVISTYNPVYNKSINTTGLVVSKELNYLDPPPKLVNLALQQEMLDQQFSNRLNESQLIALNASMQSVYNQTRVYGSYFNGPSFVKSLDSFFIVPFESGYSTSLSSKESSAPYYAMLLSFIIGIIVLFIIYYFTYFKLSRSKKIKVNKVVRNTWAAIFIVLFVIVLIYSYATYAVAASANSFLPFYSFSSMLNNTHTAYIALNKSALLESECANSIKSDFVNKTFTLVGLNKGACSIDGVSYTHCLSYLAGTGSPVIVLNSTGNSIVYKGLYGNILYVNGASAQGNKCYAGSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY9</accession>
    <name>A0A218NLY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819655.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY9"/>
    <dbReference type="GeneID" id="33313710"/>
    <dbReference type="KEGG" id="marh:Mia14_0151"/>
    <dbReference type="OrthoDB" id="377903at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="entry name" value="Dinitrogenase iron-molybdenum cofactor biosynthesis domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="Nitrogenase accessory factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dinitrogenase iron-molybdenum cofactor biosynthesis" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="11522" checksum="CAD1711A22EF798B" modified="2017-09-27" version="1">MQNKIVLATIDEDGNLTGVGRAQRVAIIHIKDGKVENSEEIDVKWGEAHEMEQEGVHHASIAKFIIAYKVNEVMAGGAGPGMQMMLEKLGLTVKIESGNYKSFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM07</accession>
    <name>A0A218NM07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_269799410.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM07"/>
    <dbReference type="GeneID" id="33313714"/>
    <dbReference type="KEGG" id="marh:Mia14_0155"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="13">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="545" mass="60957" checksum="1C6CC50BF2F48D12" modified="2017-09-27" version="1">MATVTFYNKDVEKFMDLDVFKSQISELGMSLEDSNDTSTVVDITPNRPELLYFNNFMREVRLHLGTVKPRSYDSAIGDFEGDLYISPEFRSLRPYGIAFAAKNVDLSGNGLEYLINFTEKLTDTYGRKRKKVALGIHNLDKIVFPLFYNLSDDKEFTPLRYGKAARFSEFVKEGDKEGYSSIFESIEGRYPILKDKSKTLSLVPVINSDETSVGTSTRNILIDINGSDETAVQNTARIIASSLIDIGASIHPVKVHMTQNKSSFVSIDLKGRKVALHFKDFNSRIGLDEKSERCLDLISRSGYLVKSSNSSSATIVIPPYRTDVFGKIDIVEDMAIAYGYNNITPKEISGVYGYGSLDTLTEFKNDISGLLVGLGYSEALNFYLTNRQVEFEYMLQDDPGSVSLLSSKTSTFGIVRTKLLPNLMMNLKTSADQPMPQKLFEIGNVYRVEKGKVSEYLNIAIVAEGAKVNFNDVKADLEAFCNYLGLNLELKESKDPAFIEGRTADIYIDGIKKGIMGEINPEVLLNFSLLEPVSALELRIKKLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM35</accession>
    <name>A0A218NM35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecA-superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819687.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM35"/>
    <dbReference type="GeneID" id="33313743"/>
    <dbReference type="KEGG" id="marh:Mia14_0185"/>
    <dbReference type="OrthoDB" id="27015at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="245" mass="27138" checksum="EABB33C3FC51DEFB" modified="2017-09-27" version="1">MKIGVNIDSGVVNRIKTGVKGLDNMVGGGIPEGSQILFLGSPGAGKTLLSLEILYHNAKLEIPSTFITNEERKGALVNNIKNAFYSFDDYEDYISSNMIQISHRPLIDAFKSRENFEKFISDCVSDIQTNKSKLVIFDSISSLRPIMEDDRTFTRAITYMTEALRDIGVTSILTYEVNQNVSNSDPLSIGLYSTSMFDGIMVLSMNRSEGATQYSIEVTKLRNSAHKLSSLPYQITDSGFDVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM48</accession>
    <name>A0A218NM48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="9">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aspS</name>
        <name evidence="11" type="ORF">Mia14_0202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819701.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM48"/>
    <dbReference type="GeneID" id="33313760"/>
    <dbReference type="KEGG" id="marh:Mia14_0202"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="136"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="9">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA discrimination" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="429" mass="48960" checksum="3CAFFFDF33E4EA72" modified="2017-09-27" version="1">MIRSNYVSEITQEMDNQKVTLAGWVHEVRKLKNVTFLLLRDITGIIQVTGKAGTCDKNIIESMDIPKESVISVEGIVKINPEAKIGFEIIPTKITNLNPISKVIPFETTGKVPAELDTRLDYRYIDLRRLQTEAIFKIESTILNSFRNFLYNKGFNEIRTSSIVAEATEGGADLFPLQYFEEKAYLAQSPQLYKQMAVIGGLDKVFMIMPVYRAEKSNDLYHLNEITQMDVEIGFSDYNDAEKLLKDTLEFIISEVVRRNDSDLKVLGIELKVPETKVIEYAEVVKKLKEKGESIEFGDDFSREHEKAIEKYFGESVLVTEFPTKVRAFYSMPNENNKELSHSYDLIYKGMEISSGAQRIHIADMLVDAIKERGMDPNNFKSYVDAFRCGAPPHAGWSIGLERLAMQITGMKNIRECAMFPRDRKRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM67</accession>
    <name>A0A218NM67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">infB</name>
        <name evidence="11" type="ORF">Mia14_0222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819721.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM67"/>
    <dbReference type="GeneID" id="33313780"/>
    <dbReference type="KEGG" id="marh:Mia14_0222"/>
    <dbReference type="OrthoDB" id="30957at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="587" mass="64769" checksum="2EC23939B80530CD" modified="2017-09-27" version="1">MIRQPIITVMGHVDHGKTTLLDKIRSSAIASKEAGRITQHIGASEVPLSVINEICKDIPNFSSSNMKIPGLLFIDTPGHEAFTNLRRRGGSIADMAIVVVDITQGFQPQTIEAINILKEYKTPFVVAANKIDLLTGWMSNKTRSFQVSYGKQSKTVQDLLDNKLYELVGRFGELGFNSELYSRVSNFQNELAIVPVSAKTGEGIAELLMVVSGLSQRFLELKLNIEVNGPAKGSILEKKEIKGLGTTLDVIIYDGTLHINDQIAFADSNNEVNTTKVKALLKPKPMHEIGASASKFYYVDSVSAASGIKISAVGIEDAMPGSPIIAVTGNDDYKNIIKSEMADIFKTDNAGIILKADSIGSLEAISKLMSSENFRISKKGIGNVNKRDIMDAFSMYGTDPLYAVIIAFNVSIDNDAEEEAKTSGVKIISENVIYKLIDSYKEFVNLRTTAKKKEAEDRITFPSKIEVIAGDCFRVSHPAIFGIKVETGRIKPGFIMINDSGIVVGKIKGIQNEKQPLQEAKRGDEIAMSMDEPTYGRQIQDNQILYTRVTKEMQFLLQNEFSYLLNDDDKKTLEEIIRIMNKNSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM87</accession>
    <name>A0A218NM87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216868.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM87"/>
    <dbReference type="GeneID" id="33313816"/>
    <dbReference type="KEGG" id="marh:Mia14_0258"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="113" mass="12532" checksum="1C8745CD3995ED7A" modified="2017-09-27" version="1">MMNGFMIESDIIFAVMISSVAFILFYSYTLDSNNTLYNEAIKSSDTLYVNMEIQHFVHLGDSGNSAFSNLAVPFNASIKPFNPFDCSANCSANSNSINRLVYLKGSIYEISVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA9</accession>
    <name>A0A218NMA9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819767.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA9"/>
    <dbReference type="GeneID" id="33313832"/>
    <dbReference type="KEGG" id="marh:Mia14_0275"/>
    <dbReference type="OrthoDB" id="6924at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009670">
        <property type="entry name" value="PRK13191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="240" mass="27085" checksum="9B77EA4B941C37D6" modified="2017-09-27" version="1">MDDVNFSMPLIGEKFPELDVETTAGKMKLPDSFNGHWFMLFSHPGDFTPVCTTEFFSFSKRNDDFNKLNTQLIGLSVDSVVSHIAWIKWIEENLKIKVPFPIIGDSMGKVAKRLGMIHAESSSSTVRAVFLVDDKGILRLILYYPLEMGRSVDELLRVIKGLQMADKYKAAMPANWPDNEIIGDKVLNPVPHNIEDADKAMADHKGYAWWLTYKELPANEVEEAKNLDKPGKDESSPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB2</accession>
    <name>A0A218NMB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819769.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB2"/>
    <dbReference type="GeneID" id="33313834"/>
    <dbReference type="KEGG" id="marh:Mia14_0277"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01127">
        <property type="entry name" value="TrwB_TraG_TraD_VirD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="5">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="537" mass="61148" checksum="D60E883ED9CD3CBD" modified="2017-09-27" version="1">MLKINIGEGFDLNAQIVMTGRGCVIGQSGSGKSYLVGVISEELCRNNLPFIIIDTEGEYRNLKSRFDAIWVSSDKASDLNFEVNYSGLLRKSIDDSIPIIFDVSDESDSSGLVSKVLNKLYELETEIHKPYLVIVEEADKFAPQVVRSKEMNIIEELSVRGRKRGIGLLIATQRPANVSKNVLSQCSYGFIGRMTIQNDINAIDILLEDEENKKILTRLNVGEFVSFGLGFNGMVRVKEREIRHMGETPPLSVQRKISSFDDIINDIRKSEGLVQKEVESIKADEPKKVQYKKEDEDIIEVQIMDSRYTIDDARKFAESKANSITNLLHKYEIESIKKIYLPAIYSKLHIPTKDNSTVKEGYSLIAFNDYIIKIDKESLEMYKMPKLNYKKSALTPQESSLLYSLRGYKKATPKKISELSGSEEKESKHMLNHLVDEGILDFDGKYYSLPPIENSYFYIPISFNSSFISSNDIAGSIKPSEAYKKIGLIFAGCKIEKSDTVYMPFFKATFRRKNKIKTMLMDPIAFKDRYNEFKNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC2</accession>
    <name>A0A218NMC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA C-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819773.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC2"/>
    <dbReference type="GeneID" id="33313838"/>
    <dbReference type="KEGG" id="marh:Mia14_0281"/>
    <dbReference type="OrthoDB" id="167534at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004720">
        <property type="entry name" value="PRK06064.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF6">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="387" mass="40980" checksum="824D3B85E7925195" modified="2017-09-27" version="1">MRKVAIVGVGLTKFGERYDASLRNLVSEAGIASFQDAGMSNKDIDALYVGNMASGRLTEQEHVGALVADELALSNVPALKVENACASGGTAFRQAYIAVASGMHDRVMALGIEKMTDVSTSEATTGLGGAGDKSWELDDGITFPGLYALMARRHMHDYGTTEEQMASVAVKNHANAYKNKYAHFHKIISIDDVMKSKMIADPLKLYDCSPISDGSASLIMVPADDAKKYTDTPIIISGSAQASDTLRLADRDDITSIKAARIAAEKAYSQARIKPSDVNVAEVHDCFTIAEIMAMEDLGFYKKGEAAKAIFDGETGLNGRISVNTSGGLKGCGHPVGATGIKQAVEIVWQLRGEAEGRQVSNAMIGLTHNVGGSGSTAVVNILKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD1</accession>
    <name>A0A218NMD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819794.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD1"/>
    <dbReference type="GeneID" id="33313859"/>
    <dbReference type="KEGG" id="marh:Mia14_0302"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="288" mass="32562" checksum="470AA7B2D27DFE61" modified="2017-09-27" version="1">MPKNDKIAVLSGYHLNEIMAKVNEGAKEGDISLNLGISKTKFYHVAEKVVFPEYNSSIDLSEIKKLLKKRSLNDCFTVNDDQLIWIYSFSDQYGVLKLYEPKVDYPPTLFINGSYMHAIRVSKPTEEAFEKAKMLKGVSGNVLDTCFGLGYSTIQLRKYQSIKKVVACEISPEAIEIAKVNPWSNDAFMDKSIDLHNEDVSEFAKAAKEKSFDGILHDPPNFNKFEYLYSESFYSELCRILKPNGKLYHFIGTKGTGNLGIYRSAKRKLQAAGFSRVTEGYRGLIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD5</accession>
    <name>A0A218NMD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD5"/>
    <dbReference type="KEGG" id="marh:Mia14_0300"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.50:FF:000001">
        <property type="entry name" value="Kynurenine formamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0823">Tryptophan catabolism</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="204" mass="22771" checksum="CA18B691C4983ACF" modified="2017-09-27" version="1">MKIYDISMVIEEGMLVYPGDPKLHIYKHTGIPKSKTNVSLIHIGSHTGTHVDAERHIKNGGKTADMIPVDTFYGKCKVLNLTKSGNSIGEKELKKFKINKGDIILLKTNNSLKQYDTFRKDFAHLTEDGARYLISKKIKTLGIDYMSIKKFNADDIVHTLTIENMTLFEGIYLKGVPAGTYTFVGLPLKIKCDGGPARAILIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD9</accession>
    <name>A0A218NMD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YedE/YeeE family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780226.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD9"/>
    <dbReference type="GeneID" id="33313862"/>
    <dbReference type="KEGG" id="marh:Mia14_0305"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="500" mass="54505" checksum="EB12BEF1673C5EFF" modified="2017-09-27" version="1">MIEVTSPIWIGIIIGAVIGGLAEAWGISNPEVLLRLGKWQDRLFVGCIAIAIGTGALALYGLAAAGVAFHWGIKPDYIVGVGLGGIIFGIGIAISGYVPGTVWMALGEGRRDAIYAVLGGLLGAASWTLIYQTSFGHWLVTYLNFGQIYFGGQADTNLGIGFMLAIIWAVIMFGIAYTLPRYKKGKSCAYVSTHKDYKLTPEEQNQYIETTNTLREGSSMPLGKDNLPEKVNYHWTVSSKLFGVVMLSVGIIIGLMVVLGMFFHQIFGESTTYSWIVAELWLPATYWKYSSTVVNTVGWEPFSDIGTLFGAFLASVFLTRRFQSFNNVIPPSWRERFGNSQIKRSVGVFFGAYLMLLGARMADGCASGHILSGDLQMAVSSVEFFVFVMISLLLTAFLIYKRHGNKLLGTDGGLMSMEQRRKIEPKIKNEKGLKIFVVSAAIILVLTAALASGSYNGYNPNANAVAITGFVAIVIIVMTAAWLKTKYNNYSFEGNEENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME6</accession>
    <name>A0A218NME6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216871.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME6"/>
    <dbReference type="GeneID" id="33313870"/>
    <dbReference type="KEGG" id="marh:Mia14_0312"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="212" mass="24917" checksum="FC6D9CD7A513EC38" modified="2017-09-27" version="1">MDVDIVDNNRFGSKRMMIPYKAESNKFMTIDDATHKLENLYINSIVMKYGEYRESILSNRNKLNIAFANDNGILEAEDNLRMHADTLEADKFIKRFKDFEEALVRDRLEIIACNREIENAKTNINGLAVYFANAVYYNYTKIMPNEKDDMVIDVVNRLSMGEGIQDDVRREFTESILDEITIRMKENSHLYKTINEIRGQNMHYFMDKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME7</accession>
    <name>A0A218NME7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819809.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME7"/>
    <dbReference type="GeneID" id="33313876"/>
    <dbReference type="KEGG" id="marh:Mia14_0318"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="405" mass="46323" checksum="2B6611D44513E544" modified="2017-09-27" version="1">MAFLNKSDNSYRHTENLSEKVQKKQTDVLARYETADQQINLLGSKNIASILKIKSNDERVYEVLARSKSVNVQSKLFDTIISKSPDLLEKAIPILIEKGRKEIMEKIWEYIKRTDDPSNPKLLKSGKEESIAYLLLAKDTETSKKIAIDMLDWLKDKSVLETYKTEHKVSEFNYFSQKELMNLHGENRNIYKTYLINQIARMGDEEKLTLLKAIDRLKAYDLFWTEDKVKTKTYYDDKSPLRTRYMYEPLYSIIAGTGNRDVLLKFLDIIKKTDIGSTLIQAKLLDGAYHSIFSYSSIEELAPLILIASHWLKIEDEACDTIIGFARESPSILSLKVNKSPELTVETTADLIAIIGGEEMQKKLVKLVKIPGAVESVTKAINKYGTDEAKVELKKSLESVGLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF6</accession>
    <name>A0A218NMF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819807.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF6"/>
    <dbReference type="GeneID" id="33313874"/>
    <dbReference type="KEGG" id="marh:Mia14_0316"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="168" mass="19879" checksum="FC4F1FD9EFDEAEF0" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQSEIDERLILAQQFYNKILEKSIESYKNGKAKASIAQFNRFVKEIIQDDKRYLKLYSQTRCEIEYRLLKAYQNFFRRIKEGNRKAGFPRFRSRDINASINILKRATLGQRESHAQGESVRPQMEAVLEELRTDKTHPLQDAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF7</accession>
    <name>A0A218NMF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819805.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF7"/>
    <dbReference type="GeneID" id="33313872"/>
    <dbReference type="KEGG" id="marh:Mia14_0314"/>
    <dbReference type="OrthoDB" id="46192at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="COPROPORPHYRINIGEN III OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF5">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01065">
        <property type="entry name" value="anaerobic_coproporphyrinogen-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="36"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="434" mass="48742" checksum="5B7CC314A95862D3" modified="2017-09-27" version="1">MKLNEKINDYEFQPEVYAYPTARCYKKLDGFSVAQLKFTDEINVYLHIPFCSQLCTFCGYLKTLNSETLRKEYISALIKEIKMYEEIIGDKKVISVNIGGGTPSLLQPNELGEIIDALKAANEGILNNAKEVSIEATPESVEYEKFKEFKDLGINRVSIGVESFVDKEIGVAGRHNDGQVSSNAVKTLKELRFRNVVCDLMIGIEDQTEKTFSDSLDTMIELDPDTVEVYALGVIPSTMIGKRHPKGLMGNREKYECYEIARKKFLEKGYFQSCHNRYSKLPEGGYLQEDTVFRGASLIGLGAGARSYAQNIHYRNPFEVLDGKGAISRYMNKINSGSFAVETGIFLSGDERMRRYAIGNIESLDLHKFSNLFGAEFSTVFKEVYSEMISTGCAYEAGSKLKLTAKGLLFRDLIARQLFSSRVEALEGPYRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG4</accession>
    <name>A0A218NMG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylglutaryl-CoA reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819820.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG4"/>
    <dbReference type="GeneID" id="33313888"/>
    <dbReference type="KEGG" id="marh:Mia14_0330"/>
    <dbReference type="OrthoDB" id="10981at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="416" mass="44633" checksum="7E459BC39D931688" modified="2017-09-27" version="1">MRDSYKYQELFKKLDNGDVKLYNIEADLGVDSNEATLIRASYLESKFHASLDHIKNPNVDFSKAINSNIENSVGAITLPLGYAGAIKVSGLYASGEYPILIATTEGKLVAGLSRGISTISKSGGVSTRVLSDGMARDVMVSTESVNDAFEIYQFVNSREGIDFLKSKFKEKTAHGDLLSVKCYQIGKILHIRFKAFTGAAMGMNMVTIAAEYSSEQLLSMFEGKGIKAKILSESGNMCTDKKPSAIDFIEGRGVSVTAEAVIKKELLEKARSSARDVERLNRLKSLEGSAMAGSSGFNAQVANILAGMYAAYGQDIAQIVEGSQSIVEAEESNGDLYISILLPSLEVGTYGGGTRLDAQKEALKLLGLYGEGDLTGSSRLAFAEIVASVALAGELNLLIIESSHELSKSHGELNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH8</accession>
    <name>A0A218NMH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LOSE family ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819831.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH8"/>
    <dbReference type="GeneID" id="33313900"/>
    <dbReference type="KEGG" id="marh:Mia14_0343"/>
    <dbReference type="OrthoDB" id="11469at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050250">
        <property type="entry name" value="Macrolide_Exporter_MacB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572:SF4">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE YTRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572">
        <property type="entry name" value="MEMBRANE COMPONENT OF TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MacB-like periplasmic core" evidence="9">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="8">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="455" mass="46499" checksum="11E2B99DC0940FD4" modified="2017-09-27" version="1">MKQQDILGIVINYMRQKKVRTTLTVFGIMLGPAAIVALLGLVGGFGAYITSELGSTGVTTIYATPLPNFTLNNNVVHTISGMEGVKVALPYYTASGTLTQGTQNTSVSIYAVNISAVPEIIPNLKLQNGSIPSNGFYTAAVVGYDIAHPNITGARNISLNQVITVNGNSGFAGFGGASASPKSYSFLVHGIYAHFGQALFLSPDSSIFIPLSGGILLTNDTGKYSGILISATNASSVSLVSSELTAEYGNNIKVITVSSILSEIESIESSISLILLAVASISLLVAFVSIVTTMYSSVTERTTEIGIMKALGFTSNKIMLVFLYESLIIGLIGGVFGVALGTAGSYGASAVMSHLSVGSSSAGPPAASSSFGGSSSFGSSKGAGFSGRSGFSGGSGFSGSGSSTISSSSINITPVISLQLILEVILLTITIGVLAGIFPAWKASRLVPAEALRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI1</accession>
    <name>A0A218NMI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819830.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI1"/>
    <dbReference type="GeneID" id="33313899"/>
    <dbReference type="KEGG" id="marh:Mia14_0342"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902:SF3">
        <property type="entry name" value="NPCBM-ASSOCIATED, NEW3 DOMAIN OF ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902">
        <property type="entry name" value="S-LAYER DOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="582" mass="61815" checksum="D1374CDC3B80106E" modified="2017-09-27" version="1">MSKFIVYLSVMIFATALLGVASAQGSDSFTLINAYFGSNGTVINPVPGQNSVPLTLVIESNQDKLLSNTSLELYNFNSGFKPINGQGSITEELPDVKPDQTFSITYYIDIPSYAREGTYYLDLEIEPNNTVSEEYTMLVPFIYGGVPSIKYTSDAPHLIPGEINNLTININDTGSGSVTSLQPYFSSEQPINGQNSSIPSIKVLSSPAKIGYLGVNQTVQENLSVYVPESAAGSIANIEITSKYLNYYGQQGMQNYTLSIPVEAPSNLVINETDSSAYLGKSTALAFKIENIGGSAVKSVVATLSTEVSGISITGNSTSYFTSIPAGSNVTYSPTIAVGPSVSEGGYAGTLDISYENQLGQQEQISYPIGFTAVGLTSLVTETPSVSAISEVGNVPIATVSGSLVDEGSGNAYYVTVYAYLKSNGKVIGSNSSYVGEIQLNSPMPFSVTVIPNTTNSNSFAAGFAGKGGFANKTGAFANRTTANKSAANSTDAAEPNYQNLTIEVYEKYQNSFSQNMVSTPETFAVPKPVAYNASAFAKYKVKTNNYTGYYVIAAVIIVIILAFAYRSKKSKSKKHRTGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ4</accession>
    <name>A0A218NMJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A-type ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="5" type="ORF">Mia14_0361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819848.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ4"/>
    <dbReference type="GeneID" id="33313918"/>
    <dbReference type="KEGG" id="marh:Mia14_0361"/>
    <dbReference type="OrthoDB" id="117390at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="208" mass="23713" checksum="A378B9EA11BCB38A" modified="2017-09-27" version="1">MSNINIKITRIELIKTKSSIKVARKGLNLLKMKRSSLVMAFLDLARQIEAMKEDMRNSIDRAMNSNRMADISLGSIVFDRIAYEQANRTAVVSSRNIMGVKIPNIELGSTKMTTSEEYLPLYAVDVIHAYNNLLNMLIEVAAKESALKEILYEIEKLNRRSNAIEHVSIPALVYKAKYIQARLEDMERDQTVSLKFIKGKLDEYKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ9</accession>
    <name>A0A218NMJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">A-type ATP synthase subunit A</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpA</name>
        <name evidence="14" type="ORF">Mia14_0359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The A chain is the catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819846.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ9"/>
    <dbReference type="GeneID" id="33313916"/>
    <dbReference type="KEGG" id="marh:Mia14_0359"/>
    <dbReference type="OrthoDB" id="115235at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000675">
        <property type="entry name" value="V-type ATP synthase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="230"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="584" mass="64253" checksum="1CA916EB0F685660" modified="2017-09-27" version="1">MDGYIYRISGPVVTARGLEGAKMNDVVKVGKSNLVGEIIKLNGDDAIVQVYEDTSGIRPGEPVEDTGRQLSVTLAPGLMGGIYDGIQRPLDKIMAASGDFISRGVEIPSIDYEKKWHFTPTAKEGDAVDSLSIIGTVEETSMITNKIMIPYGISGKIKEIKEGDFTVQETVAIIETEEGEKEISMMQEWPVRYPRPVKDKLPPDVPLITGQRVIDSLFPVAKGGTAAVPGPFGSGKTVIQQQLSKWSDSKIVVYVGCGERGNEMTEILTTFPELKDPKTGKPLMDRTILIANTSNMPVAAREASIYTGITIAEYYRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLGRKIAEFYERAGRVHSLNGNLGSVTAIGAVSPPGGDLSDPVVQNTLRVTRVFWALDASLANARHFPSINWLNSYSLYIDDLKGWFSSNASELWSGLYSESMNILQKEADINEIVQLVGYDALPESDKAVLDIARMIREDYLQQNAFDDVDTYTSMHKQFLMLKSIIDIGEKEKAAVARGVMTSQMSRIDAKAKIARMKFTPEDQIDAYYKDLQSSIADIDKIVKVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK0</accession>
    <name>A0A218NMK0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl11</name>
        <name evidence="10" type="ORF">Mia14_0372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819859.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK0"/>
    <dbReference type="GeneID" id="33313929"/>
    <dbReference type="KEGG" id="marh:Mia14_0372"/>
    <dbReference type="OrthoDB" id="8842at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002232">
        <property type="entry name" value="PRK01143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="155" mass="16255" checksum="145282FC34CE2246" modified="2017-09-27" version="1">MAEVKISGLIEGGKATAGPPFGPALGPLGVNIGAIIAEINKQTSAYAGIKVPITVIVDNVTKDYRIEVGSPPTSAIILKELKLTSGAKTKDETVGDITIAQLKKIAKSKDAVLYGKSEKEKLKQVIGTCKSMGVKVEGQDPREVIKKIDSGEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML1</accession>
    <name>A0A218NML1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819878.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML1"/>
    <dbReference type="GeneID" id="33313948"/>
    <dbReference type="KEGG" id="marh:Mia14_0392"/>
    <dbReference type="OrthoDB" id="52538at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050245">
        <property type="entry name" value="PrsA_foldase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245:SF1">
        <property type="entry name" value="FOLDASE PROTEIN PRSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PpiC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="91" mass="10231" checksum="5CA964F3F300D4F8" modified="2017-09-27" version="1">MPDKIRCSHILVDKESTAKEVLEKLKGGEDFSKLASEYSLDGSRRRGGDLGYFGRGMMVKEFENAAFNLKKGEVSGIIKTQFGYHIIKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR4</accession>
    <name>A0A218NMR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR4"/>
    <dbReference type="KEGG" id="marh:Mia14_0419"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="333" mass="38191" checksum="7EB9DC32D2B9DF0E" modified="2017-09-27" version="1">MVILSKKHENNASCQRNARNGGLLRNTDNKANADQLLFENFKDSRAEIHKISQRLESGQGINKVMDKLGDENFVYSMLNDIGKLVLHDLNYMMKTVAGPDWVDIKPTEFGIELYKPEGLNSEYITGEYSKEKKRCSINLDLFKKIFLKSEVGQSITISEKSILEFLEAVYSTMMHEGFHAVQDNRFGYIDQIKNLDNPNDNIIFMEGSARFVEFFADSLITIGRYTRLDCSNAIEKSFLWHFAVEPVSSLAYERPDLIRNGIKEFIPYNIGMFIFVTRYVANGSFIETLGEIRKMAENGNISNDKLYDMLDNEIKNGSISKLKQKISLDYIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU0</accession>
    <name>A0A218NMU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU0"/>
    <dbReference type="KEGG" id="marh:Mia14_0454"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="127" mass="14846" checksum="52C40EF751B83BEB" modified="2017-09-27" version="1">MTDGVWHYIEGTGFDIHNVKKCNWIKIGEEIDNIPLEVIKSLGRGKKKYMIQAEEEETKILSEYLWSKNNGENLSKYNLELKGMDISKLISTWDYEDIIGIYLQKKCGYYIIPSTRGPNTPKYEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV1</accession>
    <name>A0A218NMV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fic/DOC family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819992.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV1"/>
    <dbReference type="GeneID" id="33314020"/>
    <dbReference type="KEGG" id="marh:Mia14_0464"/>
    <dbReference type="OrthoDB" id="350952at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="137"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="393" mass="45310" checksum="D89EE13411F775A3" modified="2017-09-27" version="1">MDIEEFKNPSGKLLPDSANQYYTFVPDNLPVKIDYDNELLRLLSEASTWLGRLDGAGIELNKVLHNNVNLFIRPQLENEAVESSRIEGTLSNLDDMFKEQAGQKILDEEKRNDILEVRNYIKAQEIGINLMNEQIPIDLQLITKLHSILLQHVRGEKAKPGSIREVQNYISHYQNAIGIEYATYIPPPPERVKELLANMLDYMDSSNDPILVKIALMHYQFEAIHPFLDGNGRIGRLLLILYLIKNKALKLPLLYMSDYFEKNRSAYYSLLRDISKNSTYSEWLKFFLIGAISQSKIVLDKISKLSQYYNEKGKDIEEKYSKSTYVLFQQLFASYIISANTTSHILNVTYPTAKRAIDNLIKEGVIQPLETGKARNQLFVAKGIREIYKEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX7</accession>
    <name>A0A218NMX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820042.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX7"/>
    <dbReference type="GeneID" id="33314048"/>
    <dbReference type="KEGG" id="marh:Mia14_0490"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="24236" checksum="AC34095FA84FD697" modified="2017-09-27" version="1">MQKKEAFEKPSIIWGTIIIIVLAVIVIALFSNILRTQPIEFGVSEGVSYMGFGRIIFTGQTPLNATSTPVEVAFVNYGEASFIFILISIVIAFIALFTKKASIIAAISSFVSFALGIASLYMFSNLISISGEPVAAVAIPGAGIYLMLFAGIILVWAYYLFSAYDINALKKSAKEAAKPAEVEAASENGPNKAEDIKKQISEEVSKEMTSKKETETENKITLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX9</accession>
    <name>A0A218NMX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820057.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX9"/>
    <dbReference type="GeneID" id="33314057"/>
    <dbReference type="KEGG" id="marh:Mia14_0499"/>
    <dbReference type="OrthoDB" id="382860at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="109" mass="12532" checksum="FFA5996028E20F6C" modified="2017-09-27" version="1">MNYKKRGFSLYEIEEYLKGAGAEKINEDAVFTFEKEIEKMTDELMGFASMFANYAGRKSLIKGSDIAFAIGNINSKSIIYLPETSHKIRKVHKRKLAKHRISKVKIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY7</accession>
    <name>A0A218NMY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosylmethionine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820089.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY7"/>
    <dbReference type="GeneID" id="33314079"/>
    <dbReference type="KEGG" id="marh:Mia14_0522"/>
    <dbReference type="OrthoDB" id="204488at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="entry name" value="S-adenosylmethionine synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.340">
        <property type="entry name" value="S-adenosylmethionine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042543">
        <property type="entry name" value="AdoMet_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003366">
        <property type="entry name" value="PRK04439.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697:SF1">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="399" mass="43790" checksum="08E7CDCC7079964B" modified="2017-09-27" version="1">MGNIRVSESQSMPLYNQPVEYVERKGIGHPDSLIDGIMDSISMALSNAYLDEFGEVLHHNVDKGLIIGGSSNATFGSAEITRPIEIIMTGRATQEYNGTTIPVDQIAIDTAKDYLRKHTRFLDVDNEVNYVSKIIKGSSDLNNIFKRGIDMPLANDTSFGVGFAPFTTVERLVLETEHLLNSDEYKAKKPAVGEDVKVMGVRDGNEITLTVAIAFVSQFISSLSEYTAYKEEVTKDIIENASRITDKKINVVVNNGDDTKGSVVYLTKSGLSCESGDDGSVGRGNRVNGLITPFRMMSLEAAAGKNPVNHIGKIYNILANELANDIVRDFPQVTECNISIVSQIGRPINDPKHLNVSIATKKKEDFAKINKKVNELAQEELDNIVYLTKGIIAGEHKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN06</accession>
    <name>A0A218NN06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN06"/>
    <dbReference type="KEGG" id="marh:Mia14_0540"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="422" mass="48187" checksum="D689CA8B94BF7C34" modified="2017-09-27" version="1">MDKLIGVPMPTKAVDLDKDKKVDYLKEDKADRALEKEPKVRFNEKDIEQFKSFIKDLYKADLDGFAGIINSYYKDFRPPELYFDFDSSYKTGFKLIDESKINSVVLAAYDRGLNKIIIKRELLDLYKKGEDNVDSIDHALAHELGHSIAMQSDITKNGVYNSKKSIYGTVTDELLANLFAAELMIVKQGLPISNESVARQLIKDNVDIEFFSKDIDAAKIYLKELDNYSTNVVPSIKRISDTVHAKIIDFSNRGLKSLNYETVVKINNVYFDEVKKQLNDYLINALANYSIHVYSAPLLGASRALLSKRMSVGQLINAVSDDISSVKEIRRYLKGSFASVNLKMLSAIESDLIEITSEQPVIEAVNDQDKISNYAEVFLKVADRVEDEFKNMNRHLEMEIESEKRLLKDFSKFKRKFDRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN24</accession>
    <name>A0A218NN24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820142.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN24"/>
    <dbReference type="GeneID" id="33314114"/>
    <dbReference type="KEGG" id="marh:Mia14_0557"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="369" mass="42260" checksum="2E45D3295ED0C252" modified="2017-09-27" version="1">MTKIAFVSDVAYPWVKGGMESIQYLEMKNLSEKNDVYCFCLQFEKMKKEFDKEGIHYITVAKASVKDLYTSKGSRSIKLAMKFARALPRAIKDYNFDFIYANTFPYLHLKYVKSYCRSHNCILALDVAEVWDLKRWKGYLGTLKGTAAYRYAKNAIHGADYYVANSSVTASQLNSVGIKPNKIKILSPVLDLKIRVKKSKRDTSVVYSGRLIKEKRLDLWIDAVAKAHSLNPNIKGIIIGSGPEETHIRDLASSYDFIKMRKPYATKLWLYNELRRSMCFLNMSEREGLSITTIESAFLETPPLLPDYTPIPDEVKEISIVKSLNSIPEAIVDIASGKINYKLDKDKLKKFDITTINPLFERLIRKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN43</accession>
    <name>A0A218NN43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV prepilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820154.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN43"/>
    <dbReference type="GeneID" id="33314126"/>
    <dbReference type="KEGG" id="marh:Mia14_0570"/>
    <dbReference type="OrthoDB" id="385786at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="289" mass="32399" checksum="D4AE7649749DF1E0" modified="2017-09-27" version="1">MILYDLRIASILVISFAYMLFDLFNKRNVPDLFVYATTAYAIALTIIYFNYTTIAVSLLIAAVIFGAGYLLYKYGQLGAADVFELAAISLMLPYQPSVILNFPQYNFPFIFSILINAGIMALVIMPIYYLPKYSSRFGSILKAKTSKSDIFKASMFLIVYVLFYGFLVLHFGFHIITLAIILVLAVFSFLLLMFEKQIMRAMIRDVNISDLEEGDMIATNLMSDEDLDRLSKLKSFGRLVTGKSISELKESGFNEKLPVYKDAFPFALPIFLGVAIALLAGNLILALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN44</accession>
    <name>A0A218NN44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Thymidine kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="11" type="ORF">Mia14_0580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780206.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN44"/>
    <dbReference type="GeneID" id="33314135"/>
    <dbReference type="KEGG" id="marh:Mia14_0580"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22128" checksum="A51E263C86A42E12" modified="2017-09-27" version="1">MGNKIGKVITITGPMFSGKTSRLIELLERHMRAGRKVALFKPNIDFRYSENEVTSHNGIKMNAIRSPIGLDSRDSIKGKIKGINIIGFDEVQFWKESSHIDDFIEDLAFSGKTIYCSALNRDHFGKPFAITKKILGISDEIYSLTAVCSKCGEDATFTQRINDGKPYFGAIIKIGGKGLYEPRCRNCYVKPTRIIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN48</accession>
    <name>A0A218NN48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amt family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820164.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN48"/>
    <dbReference type="GeneID" id="33314138"/>
    <dbReference type="KEGG" id="marh:Mia14_0583"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF89">
        <property type="entry name" value="AMMONIUM TRANSPORTER SLL0108-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="6">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="438" mass="46697" checksum="1E954EBF67CEA435" modified="2017-09-27" version="1">MVLEIVPNLVNNLWVVVAALLVFIMTIAVGFLEIGELGKHYSRALVKTIIITVSAIFIMAIIGFNTAFAPTVYGVIGNPFYGPGLLLGEFSSNAQGLLTGVWWSMGPKYFNTGLATGSYFLFEAAFASVTFALVSVIVLKKVKMKALALFSIAYFILIWNLPAAWIWNPTGWLYLMGMRDFAGGLVVHAAAGAAGLAIVLEIWLEEKKRGFKQSPKVGIKLNKSWLALGILLLWMGWFGFNPGSVLAFNSSALTVVLTTFLAASSAAVSTMGFKWLKDRAKPDIAYGVNGILMGLIIITPLAGFVSPGSAIVLGLIGGPLFLAAERYFSKAKGFTDPVGLFPGHLVGGIFGVLMIAFFTQHSFAAASGNGILPNGLLFGGGLSALHQLGIEAFGIIVVFAAVFLLSFAFIWLIAKCIGGITDSAYYKEIKSAKAGHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN65</accession>
    <name>A0A218NN65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820180.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN65"/>
    <dbReference type="GeneID" id="33314158"/>
    <dbReference type="KEGG" id="marh:Mia14_0604"/>
    <dbReference type="OrthoDB" id="39416at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="91" mass="10402" checksum="7E7F64956EA7008B" modified="2017-09-27" version="1">MGWIAFGNAERTVYSEALKLEEGESVILSSFKKDRTIRITKGKEGFAIEEDGFENSKFSISDEELKKKIKKLLAFEFPRSHKIMLSIRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN68</accession>
    <name>A0A218NN68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820169.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN68"/>
    <dbReference type="GeneID" id="33314144"/>
    <dbReference type="KEGG" id="marh:Mia14_0590"/>
    <dbReference type="OrthoDB" id="371821at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="385" mass="44005" checksum="F18C675384DDC98A" modified="2017-09-27" version="1">MPDNYKDYTDEEKKQIVEFDKKMSADNEKLIGLFGAKKLKDMSLPAFYTFKNGLMYSHRDFDVFMERLNKHEKSAIVSGFNPSASIHIGHIGVFDTNLFFQKEYGMDIFVPLSDDESYVSGKIKDQKDGLVNSLKLIRSLIAYGYDKNKTHFIIDQIYTNIYNLAIKLSRGITMSEVKDVYGYTNDQNTGLHFYPAIQSAHVIFPQTLGIRNILVPIGPDEDAHIRVSRDLAPKFGYEKVAVLHSRFMPGFDGDSKMSKSKGNAVFLLDDEKAIKKIVLNAFSGGRASVDEHRKLGGIPEIDISYLYLKYLFLDKDEAEKLYDDYRHGRVLSGEMKKLLLEKVLERTEKFKENYSKVTAKDIKKSIMVNEEIDLDSVIEKLGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN73</accession>
    <name>A0A218NN73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820190.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN73"/>
    <dbReference type="GeneID" id="33314168"/>
    <dbReference type="KEGG" id="marh:Mia14_0614"/>
    <dbReference type="OrthoDB" id="33505at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="181"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="415" mass="48736" checksum="58B8998CA1CF92E5" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQNEIDERLILAQQFYNRILEKSIASYQNGKRKVSMAQFNRFIKEIIQEDKKYLKLYSQTRCEIEYRLLKAYQNFFRRIKEGNRKAGFPRFRSRDRYKSITYPQYNGSFSIKRGRLRVSRIGTMRIELHRKIEGTIKTLAIKREGRNYYAVLTTLNEIKTPQVEDTNPIGIDMGLNSFVAMSDGTKIEKPKFMQQERKRIARWQRIVARRNKGSKRRGKAKIHLQNTYEYSTNQSDDYLHKLSDKLVNSGYTSFAVEKLNIQNMVKNHRLAGSIQNVSWNRFIQMLSYKAESAGMKVIKVDSRDTTQECSNCHHIKEGSERLTLGDRLYRCNVCGLEIDRDINASINILHRATTLGQRESHARGESVRPQREAVLAELRTDKTHPLRDVVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN96</accession>
    <name>A0A218NN96_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Mia14_0647</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891446.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN96"/>
    <dbReference type="GeneID" id="33314200"/>
    <dbReference type="KEGG" id="marh:Mia14_0647"/>
    <dbReference type="OrthoDB" id="372162at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="274" mass="30688" checksum="DFBE0C5D42FD21EF" modified="2017-09-27" version="1">MREPVFNGSFYPKYKDETEKFIDSALEKAKIKGDFSKAKCYVAPHAGYIYSGYTAAYTYKAIASNSRLKDVDTIVLIGPNHTGIGTPLSISFEDWRTPLGTAKNDLEFSKELVNYSGSIYHDESAHEDEHSLEVQLPFLQRLVGEKRYVFVCMGDQEVENSELLAKAVTSTAEKLGREIIVLASSDFDHYEKDSIARKKDMELAGYLKNMDYIGFNKAVKSLNDSICGFGPITAALLCSKHYGAKKGEMLDFSNSGNVTKDYDKVVDYMSWAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA5</accession>
    <name>A0A218NNA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820221.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA5"/>
    <dbReference type="GeneID" id="33314207"/>
    <dbReference type="KEGG" id="marh:Mia14_0654"/>
    <dbReference type="OrthoDB" id="56361at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="320" mass="35966" checksum="E7067E0A052BA211" modified="2017-09-27" version="1">MHDIILFNFIIFAIFLSAFLIEVGLALLLLIDFKDKEKIMRYLVPVWEIDGTFGVFYLVDTEATFPTALVPIGFLYIIPIMLAGIIFVFRNSFFGYSEFISNKVNEKKYLRVYAISIIFVAFLAMSVLNSTVSGIGVNLSSYSLNVLQSIFNGFNITLFIGEALLALFADMLIFRFSKRIIYPIAIVVLSLLFIISSLYVGNLNYLISNMYSEYYLLAIPIILIAISLSTYAYKERYTKFAVPITLFISILSFELLEYPGLFNDKLAFASLLVTPSTQPLVLAFGIVGGLIIAFFLVILLRLGLSESKGSPEAVDKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC3</accession>
    <name>A0A218NNC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein with a function in translation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216892.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC3"/>
    <dbReference type="GeneID" id="38419838"/>
    <dbReference type="KEGG" id="marh:Mia14_0641"/>
    <dbReference type="OrthoDB" id="35104at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011481">
        <property type="entry name" value="PRK14890.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733:SF1">
        <property type="entry name" value="SMALL ZINC FINGER PROTEIN HVO-2753-LIKE ZINC-BINDING POCKET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="ZINC-RIBBON RNA-BINDING PROTEIN INVOLVED IN TRANSLATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small zinc finger protein HVO-2753-like zinc-binding pocket" evidence="1">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="56" mass="6303" checksum="258FD0E851C0D0C9" modified="2017-09-27" version="1">MSEILPGKICSSCGRLTHKYSEFKCPKCGKATIIRCDHCREISNTYKCAECEFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC5</accession>
    <name>A0A218NNC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecJ-like exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC5"/>
    <dbReference type="KEGG" id="marh:Mia14_0668"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="473" mass="53356" checksum="A8AEDA3D9A9DCBC0" modified="2017-09-27" version="1">MNKKADKQILSDLMSNEEVIITSIKSNPRYDDCYYTAINSHSIFMFKAKSGYKLYDKLNYDPEDGSIDTIGAATKEYYEEVLSALSGQIHGMNPDDKNIKKMEKPLKEASNMVVRSLLSGAPMAVRFHMDGDGASGAIALYKAFGAIGNIFGIKRPNVIWSPNKGVGYSPWIYNIDRSYVQSFESIEKPIILLTDFGTTPESEPAIKEFTENVIWLEHHPIYEGFPIENIKLYINPWMYGMDSNVTAGFLTAEFASMIAGERYNNLEGASLISDHSNFADLNDKASNDLATVLDALTVNEFYDNYNRISPAYMIGIIEDKAGFEYVLNKAISELNESLDIGVKRSRKHVLKDGTIVYTMDYKFIDERNYDYMKHGRYTTKLHDRLEELNHGGNVTMVYFSKYISIRVSDSLVERVQLLKVIKELEDEDLICNGGGHNEAASIKVKPEEGSLEKTIEMIISKLDDLPNEGGKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND0</accession>
    <name>A0A218NND0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216894.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND0"/>
    <dbReference type="GeneID" id="33314239"/>
    <dbReference type="KEGG" id="marh:Mia14_0686"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="507" mass="54121" checksum="08435A33F15C5A49" modified="2017-09-27" version="1">MIIGAITLIVPLLALFISFMFAKLDGLKSAFVGFIVELAMIVLFYPSARIVDASIWGTFETYSIFGVIWTGMIFGIMYRETGLLRRLLDVLHSVIHSGWGLVASLVGVIQGILGAFNGFAVYPIAIPGIKELGYEPWRSATGYLVLASWTIPLVSLWIAGSLASAASHIPVPTMAPFVGMITIPLIFIAVFGGMKILNIKFNRENLTVSALYIISGIIGIVIFSILIPSAYLLTLIASGFLTLILFVLYSKHLKQDSTGLPKINLSGTLKPFGPIIVGIVLILLWTYPLAGLVAKANYVLKLWTYAPVSINLLTTPAFFIFVVALSTYMFKIKPDENIDSNKPVTKPLGVWSSLVKGSRMSGTALLTTLLGASFAGMAIISGQITTITTLMVKAGSLFYPLLLNVFAWGTGVVFATGTIAAFLISAPQVAVATALTLPVGLLLGIVVVMTMGPADPLKPSEIVYAATLAGAPSKDQSKIFNTALGWMAIELVVTLIVTLALAVLVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND7</accession>
    <name>A0A218NND7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND7"/>
    <dbReference type="KEGG" id="marh:Mia14_0677"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="383" mass="43689" checksum="B024F3CF83720F3D" modified="2017-09-27" version="1">MTSMAYRIASIGDGHWFSRLYPSLQKKQGIELYKISGLSRYEKKKEFLSSLGIDESRYYSVTPNAPLPDDFFEGADVVYVSDPNEFHAAHIIDALSHGKKVAVEKAIATNAEDYQHVIEYIKSNNLEGKFYLHLHYAYKILTLNLSLLLEKYTTKYGKVISSRSVFFENENEEDSRRAAWLFGLGNGGIFLDWIHPFEIYLKGALADKISLDSCTSYAVNQGYHESLPTGLHEVVSMGGRFFSEGFKADVYIAKGVKSALAHKFVDFIFNNGYTLRLDYVNSDVEFTSMYKGVWTLYDDKMMVLESGNPVGKNTAEIFADKLYDLCQGNRMDFSLEDANFIFSPYWAYLEKFSDSPIVKDNKEITHFLEYPLATYLEPMHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF7</accession>
    <name>A0A218NNF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780208.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF7"/>
    <dbReference type="GeneID" id="38419839"/>
    <dbReference type="KEGG" id="marh:Mia14_0696"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="129" mass="13561" checksum="D76DC3FA5F11AF6C" modified="2017-09-27" version="1">MGSIHNIGIIKRVIGLLKVLTIPFILLTVLISTYSSASTLNSSTIGIVSQLGYVRGLLSQIGPLLSAVLFILAGIFYAVGQLMTPEKKASFHTTAINLIIGAIIVAVLSFTSTTLATASTHFLSNSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-03-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF9</accession>
    <name>A0A218NNF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S26e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF9"/>
    <dbReference type="KEGG" id="marh:Mia14_0710"/>
    <dbReference type="OrthoDB" id="51292at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="80" mass="9436" checksum="4BA234DB1D88FCC6" modified="2017-09-27" version="1">MARRGRETLVTCESCGRKVPRSKAVDVEKFTVFSTDMKTNKDIRFTERNKVFYCISCAKHRGIFEMKKRQAMSRANRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH0</accession>
    <name>A0A218NNH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH0"/>
    <dbReference type="KEGG" id="marh:Mia14_0730"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="449" mass="47790" checksum="EA8E2C55CFE58FDE" modified="2017-09-27" version="1">MVPVKRLYLISLVLAFMLLLSYSGAAPTSSTGSRCIVTGTSIPLGQCVLSSFPIALLGIGISLLIIAIAFMVNAIFNLKGLKAWYVGELWEVTKSMIVIIVVFTAILLLSSIAILSVPSTSTCVNSYAPTSSISNNLGGLYGLSDCYLGEEFNDVNTSFYGLFGLSMGLGSVKSLQVVTFIPIPLPVVFQMGSMANLYVSNIIDHTSLALFSFIKDLMEFLVLPLYIILRIIQYGSGESLFMLGLAIFLPIGIILRAFPTLRGIGGELIGIGIGIGLVLPILLLFINQPITSYIAPITTFPSITGTLSSEFSLSTSSAGSLLGSLSGDIIAAAVNVFALQELTLTAPVTVSLGLSSSTSYITTCLSVSGCTSTFDPAYAFIYGFYIGIVNLATPSVYPIWNFLMDISLPILLFYLLLILDLILTIIISDSIARFLGGRVRLGIGKFKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH8</accession>
    <name>A0A218NNH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820300.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH8"/>
    <dbReference type="GeneID" id="33314292"/>
    <dbReference type="KEGG" id="marh:Mia14_0740"/>
    <dbReference type="OrthoDB" id="385045at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="133" mass="15205" checksum="9DB0E8415448EA15" modified="2017-09-27" version="1">MSKSSISNNRCIICGQQKPGLHVKDDFVLDSIRWIKRNITKNEKGYKLVVCKEDYKKYLKERNKYIRRQIFYIAIGIVFAALLIIMSGGSIGAILFGLAIILLLYLLSLLSYIPAVDLPEKFVSKDLKGKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ1</accession>
    <name>A0A218NNJ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0724</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820284.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ1"/>
    <dbReference type="GeneID" id="33314276"/>
    <dbReference type="KEGG" id="marh:Mia14_0724"/>
    <dbReference type="OrthoDB" id="372102at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002447">
        <property type="entry name" value="PRK01611.3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="516"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="631" mass="71409" checksum="26AB1E0AF639E218" modified="2017-09-27" version="1">MSDSPFSQVKGIIAARLKEFSNSIKLDYSLEDIESTIDLSKKFGDLSSSMLMKISKVNGISMDSLVSSIKPYLSNIDYFKEAKVESGFINFYLDKAKFSKLVLELVDSKGEDFMASDSGKGIKVIVESPSVNPVHPWHVGQVRSALLGDTISNMMESCGYEVEREDYIDDLGLQSAEALWGLINKDKLNINLDPEEKYDHYIGKIYVATNTYMQSNNIEEEIKSLSKEMEIDGTYESNLLHDSVSNYITAEYETAFKLNIYHDNLIWESDIVRNNLLEKAMDLLLKKGIVEKSNDKKYEGCIVINYNKMENLPPEIKGLKEQVKVLIRSNGTPDYLAKDIAFHMWKLGIINGVFKFSEFMEKQPNGKPLYTTSISGEDKPFGNAKITVNTIDSRQSYEQSLVKLSIGLVGGEKLAEGFNHLAYGMVNLEGQKLAGRKGTWIGYTADDLINEAYTRAISLIGSRFNLTDSEKDFVARNISVSAIRYEFLKISNEKELIFSWDNALNFEGNSGPYCEYTHARAVRILENFKGKLNPREADFSKLSTDYESEIIKLLSISQDILERASREMKPNLIVDYLSKLSTSFSKFYEACPVIKNDDQELRYARLLLVSAFEKVSSKSMRILGINPIDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ8</accession>
    <name>A0A218NNJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820291.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ8"/>
    <dbReference type="GeneID" id="33314283"/>
    <dbReference type="KEGG" id="marh:Mia14_0731"/>
    <dbReference type="OrthoDB" id="385287at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="385" mass="41169" checksum="06A3C3EBFA1EF22F" modified="2017-09-27" version="1">MSVAVNSCQLFGGSSYVTGWLGMIYLVMGVSIFIIVVVYIVSKLLTSSLNAKLTAVVKSEIMQVFLVAIIILILMSFLETSCSLTTGVSKSLTGMDLTPFQFSSYYLGNLAFGRGIDILEQVYTYAITYAIDSRIWGIIGTLTSLTSPDIPLGSLVKVSFPIGGDLGGMYSIISDGYIAILAPILVISIGMLQLQWLALPVIEYTAFTVILPVALVLRIFSFSGGGLRRASNDFLALAIAMYLIYPLMISFDAYAISFIFSPANPVYSCTNCLNTPFTVNTTSSAGFFSSIYNSTSTASSTGFSVTSPSINTLLSTTILSSYASSLFPPEAIVEFNSIISEMGQYIFTALFMFGIDIVVTVAFAMGLSRGLNSGIEGAASFWSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK0</accession>
    <name>A0A218NNK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK0"/>
    <dbReference type="KEGG" id="marh:Mia14_0735"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="394" mass="43423" checksum="41CF9A6388D4EF62" modified="2017-09-27" version="1">MNRFFKFTIPALFLILVVLLSYGLIYNQFNNTLKSNYGYEILNFGGAGGSSSSQCGLVPSSISKTISSNEPWYCPINEEIFNDWQTYLPIAVIVLLIGLFVDIIIFGIGVALKNDRVRNIGVGELYETFASAIIIFLFLYICAVTFGLIPGVYVGNINPYATAFHLMLTTSNSVEKLYTGLFHTYAMDKFITSIEIKFYGSNLGDLDLNTYGQYIYGVAYTPLEIGFIEPASFIMSMLIDGTAILYSEYYLLVFFSVSAIPVFIIPGVIFRIIPPTRGLGGMMIALGIAFYLVFPTLFAAVYYFSSSSFLTQISVATLQAEQINSQGIASAKGFSSTSPAAENLSSIQSSMSSFWLLVLFYPALIIAVSYAFVQTIAQFISGSTYSSRRIRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM6</accession>
    <name>A0A218NNM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM6"/>
    <dbReference type="KEGG" id="marh:Mia14_0775"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="43" mass="5274" checksum="5A240A82FC01D865" modified="2017-09-27" version="1">MVNMQKTIPESNRKIGKSYYRSKKRAKLRKESRKRMKKVKAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM8</accession>
    <name>A0A218NNM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0147 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820325.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM8"/>
    <dbReference type="GeneID" id="33314321"/>
    <dbReference type="KEGG" id="marh:Mia14_0769"/>
    <dbReference type="OrthoDB" id="65304at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003319">
        <property type="entry name" value="PRK04330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158436">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="90" mass="10029" checksum="1CFC6C121BDD8749" modified="2017-09-27" version="1">MADNKDLEEKIKQINGQMDMLINDTSVPKNVRGAISEAKEKLNSDGEYTIRVSSAIYNLDSVSNDINLPPQARTMIWGVLSLLESIKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN4</accession>
    <name>A0A218NNN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820340.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN4"/>
    <dbReference type="GeneID" id="33314336"/>
    <dbReference type="KEGG" id="marh:Mia14_0785"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="191" mass="22604" checksum="99017DC48544B06E" modified="2017-09-27" version="1">MKKSYGTVNIAFVGPFASGKTYMSKLLVQELKRRNIKAHKLSIADEIKRLARDLFGMKKKNRRLLQVLGAKMRDIDKMVWINYAVNKIKRRNLEPFIIDDLRFLHEYSEIKRNFPNTITVKIRSSKDARDNIYKRLYGRKPTTTESNDSTETELNKIKCDYEIINDYKRESAERSINIMIDKFFTKTAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP1</accession>
    <name>A0A218NNP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820352.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP1"/>
    <dbReference type="GeneID" id="33314347"/>
    <dbReference type="KEGG" id="marh:Mia14_0798"/>
    <dbReference type="OrthoDB" id="24854at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010589">
        <property type="entry name" value="PRK13983.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF32">
        <property type="entry name" value="ARGE_DAPE-RELATED DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="199"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="404" mass="44691" checksum="47411D47A271AF19" modified="2017-09-27" version="1">MDDVSYIDSINNKINSYKDEMISSLSELVGMPAISPEIGGKGELERAGWITEFLKGIGVTEIKRYDYTDTTGATRPNIVSKVGTNKRTIWILCHMDTVAAGDLSLWKQDPFKAYVEDGKIYGRGTNDNGQSLIATLYAAKAIIELKVNLQYNFGMVFVADEEIGSHYGAERLAKEGIFGSDDMMLVPDWGVPTGDKIEIAEKSILWIKVTASGKQVHASTPEDGVNAYKLAVKFLNDLDDQLHSKYNVKDERFDYPVSSFEMTKHDKNVDSINIIPGKDVSYIDCRVLPNYKLDEVIADMKALAEKHSKKGKINIEVFNREDAAKPTDANSEIVQLLSKRINQIRKISVSTVGIGGGTVAKYFRDNGVPVAVWSTEDDVAHQPNEYSVIDALVSDSKVFASLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR7</accession>
    <name>A0A218NNR7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820355.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR7"/>
    <dbReference type="GeneID" id="33314349"/>
    <dbReference type="KEGG" id="marh:Mia14_0800"/>
    <dbReference type="OrthoDB" id="383831at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14475" checksum="E9E02C0B24F75270" modified="2017-09-27" version="1">MDISIKKFSKDNSFELDFDNGLEIVKRGDKKLVWLGTEPISRIRKILGIEKNNAISLKPEEAIYFTEEQAKKMEGCVLLCYNGTTSAFLNNYFKKKFGVNTYLLDGGLKGHEDNYKLFDDSHLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT1</accession>
    <name>A0A218NNT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820403.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT1"/>
    <dbReference type="GeneID" id="33314385"/>
    <dbReference type="KEGG" id="marh:Mia14_0837"/>
    <dbReference type="OrthoDB" id="379229at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="180" mass="19982" checksum="754692E355D7EF52" modified="2017-09-27" version="1">MAKSEVDKVTDETIEKGGMLIKLYFDMQSEDASKLQPLMIDLVSNRLLKEKGVIYCYGAIEEPIKVDDVYSTVAEITTLFEKPSYAFKIAFNYAPAGVEILRPASEIRLTGAELQTILMDLSETSVNYSKYILEKVMKPDELKGIKTAIENRAVVGSKVINGEDKSDKKDAPDATENQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT4</accession>
    <name>A0A218NNT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arylmalonate decarboxylase non-catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820360.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT4"/>
    <dbReference type="GeneID" id="33314352"/>
    <dbReference type="KEGG" id="marh:Mia14_0803"/>
    <dbReference type="OrthoDB" id="41425at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267:SF1">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="221" mass="24968" checksum="E157F462089C9795" modified="2017-09-27" version="1">MPRSKGRIGLIVPANNAAIEYDFWKMVPEGVTVHSTRMPSVKGDEPYNAQEISKFKSDLQSAISLIDKVSDLIVYGRTYGSRYHSGIINLSNKKIILPEEEVIKKLKSNNAKSIYMISPYNKRRTIDTIRFFEYRSIRVSKYVYMDKKSGVEISDTKTADLYGLVKGALESSDNFDAVYIASTALSTYGMKRYIDSSESKLILTENITAFESALRLLDNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT6</accession>
    <name>A0A218NNT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Digeranylgeranylglycerophospholipid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820413.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT6"/>
    <dbReference type="GeneID" id="33314391"/>
    <dbReference type="KEGG" id="marh:Mia14_0843"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054715">
        <property type="entry name" value="GGR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF18">
        <property type="entry name" value="DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22578">
        <property type="entry name" value="GGR_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Digeranylgeranylglycerophospholipid reductase catalytic" evidence="8">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="481" mass="53731" checksum="DB608442699D0D62" modified="2017-09-27" version="1">MEANDKYDLIVAGAGMAGNLAAGIAAKKGLNVLLLDRNSQIEVGKKTNWGWTCGDAVAKSHLDFVTERTGLHFSEPELDYQVEGVYALSPDLESKYKFDGIGYTLDRPEFETKLLKFAVDNGAHYVPNFEVEGPLMENNFVVGIFGKDKDKQPKKFSSKLVIDGLGVSTVLRRRLPENPYVDRFVDIDDIESTGRYIYEFELDHEDPRYYDPKNALIHLNPLLAPGGYGWVFPKSGNKINIGIGVQKSSLDLRNQKLNKKDSLQTLIDEYVKWVPVFKDLKLFNKNNNGKGIWSVAVRRQMESLVFNGYMGVGDSMVMPNPLSAGGIGPALISGILAGENAVKSLEGGDVSLKGLWNYNTEYNQEYGKKTAGLEAFRIYLQSLNVDTLNYGIKTFLTSDEATDLTNGKVPELSMKSKFKFALKGASNIQAFSNLLYIVGKMKKLDSIYEEYPSSPENFEKWRESVKKEIEGVKEKFKPNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT9</accession>
    <name>A0A218NNT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonyl-and alanyl-tRNA synthetase second additional domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820414.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT9"/>
    <dbReference type="GeneID" id="33314392"/>
    <dbReference type="KEGG" id="marh:Mia14_0844"/>
    <dbReference type="OrthoDB" id="11392at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000010">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="241" mass="27072" checksum="C1104F73028D829D" modified="2017-09-27" version="1">MTEKLYLTDSYLKEFEAKVISLNESEGLVELDKTAFYPTGGGQPSDTGVIEFNGKSYSVSDVSKSGDRVFHKVSDTSGLSEGATVKGRIDWDKRYQHMKYHTALHIIDGVVFKEGNGSMTGGQIYDDRARADFDILGLDKDKVLKILEESQQVIDNALPVEVKFLTKEEAEKVPELARTEPGKELMKKLDTFRIIDIKGFDFQLDGGTHVKNTSELGRIELSKYENKGSHNKRIEITLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW3</accession>
    <name>A0A218NNW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW3"/>
    <dbReference type="KEGG" id="marh:Mia14_0859"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="69" mass="7901" checksum="EC75CFE30F1A5BED" modified="2017-09-27" version="1">MNPYRYHIILVTIVSFVVLIINIMAYLAKDETNYLYLFDMAYVVGNSAHFIALSISSNGINIEDEKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW6</accession>
    <name>A0A218NNW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent endonuclease of the OLD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW6"/>
    <dbReference type="KEGG" id="marh:Mia14_0874"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01026">
        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051396">
        <property type="entry name" value="Bact_Antivir_Def_Nuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581">
        <property type="entry name" value="ATP/GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43581:SF4">
        <property type="entry name" value="ATP_GTP PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20469">
        <property type="entry name" value="OLD-like_TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OLD protein-like TOPRIM" evidence="2">
        <location>
            <begin position="369"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="502" mass="56168" checksum="0D0E8CA9BA491D14" modified="2017-09-27" version="1">MYYGDRVVNVDRMHIENFRSVKNLDVKLDKINALIGPNNAGKSNVMKALSIVLGESWPSSKIVDDNDYFDRDRRKPIKIQVMFDQHFVDSRYGMKVYGFGFECQNDDVNFLALDSSGDPLKYSKGTPVRVSQEMKDEVSLVFVDIDRQSTQQIRATQWTLYGKILKFLGSKIPENNKAQFLKAVISAFNSEIFNISPGSDLRYLEEQLKNSVKDHTGFDLTLELSILDPVEAIKNVRPYFKEGTNPSKYDPEEMGAGTQSALSVSIARAYSEIVKKSVILAIEEPELHFHPQACRNFYNRLRLLSESGLQVIYSTHSPYFVDVSKFESLHVVRKKNSTTTIESGLTLLSTGSQQNRIITKFNEGVNQALFADSAVLVEGPDDEIACKAMFEKQGFDLYKNNVSVVSCGGLPNIPTIARVLNALKIDTIALVDEDPGNSNTASIIEKLKGILGDDMVYLQSPNLEGIFGMSSKFNQASALTFFQNYQNGVPQVYSDLTTRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX3</accession>
    <name>A0A218NNX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX3"/>
    <dbReference type="KEGG" id="marh:Mia14_0884"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="6">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="245" mass="25493" checksum="7BD0BB3543512B7F" modified="2017-09-27" version="1">MRIMERIDTGKAKSDRGFASVTTIVSVIIIAVLVFAAISAAAFVMYGSGIGGFGSGGPGGGANSIFIVNNTSFNRMNSVPAGVAVNNSSNTINVTSKSVTLIVEAAPTWYPGQGDFWLIYGLANPNIVIREGTTVHFVFINMDNITHMPAITTNSPPYSYMPMQGNMMGSGTDSGSGMMGYQGGGNGSWLAIGPMLPGTSANANDQAYAASNLTVTFSSSGNYYYICLIPGHAQMGMYGEISVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX9</accession>
    <name>A0A218NNX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780213.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX9"/>
    <dbReference type="GeneID" id="69179826"/>
    <dbReference type="KEGG" id="marh:Mia14_0860"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="213" mass="22918" checksum="936005A0DE13664E" modified="2017-09-27" version="1">MTCSNCFDANGRKITRISVPHKEEYTEGKLKITEGVTIVHYKEGPGTILNWKQIIEGNTSSIADITYIIQYNGKNITNKFKTKYIDTINGKKLVHVDGTGLGSNGKVNVTNKDIALSNVKSDPNAIECLICHALGTVLCTLLAEGVSEDLACEEASGIVCLEFIEDPIVYVVCFGVVASICDVVLQTVIDIGVHVACDLGADYICEKAIGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY4</accession>
    <name>A0A218NNY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY4"/>
    <dbReference type="KEGG" id="marh:Mia14_0916"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="263" mass="30321" checksum="B7A5CB2D8CCF10D0" modified="2017-09-27" version="1">MNGEKEVADTKKKTEAVVDSSEELSKGKSVKAEKAESSSEKAVDGKGQQQEEQDSSKPDQPKIKSINDIIEESKNPEALAIKEKIDAVKKDKFNLMLEVKGLRRRLNYKLAEGEAISKFVNDENNQIDPKKFAYLKKLKNRLEFKLSTEARISLYEEKDIIRKINVISTQLNDLYKFQRLKRKSGYIVKDIEELKTKINEDNNKIADLNNSLDDLYDQVRRILKINRRNAERRPGESQAPKRKFIPQATQEINLEDIAVIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY6</accession>
    <name>A0A218NNY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family chromosome partitioning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY6"/>
    <dbReference type="KEGG" id="marh:Mia14_0894"/>
    <dbReference type="OrthoDB" id="36110at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02042">
        <property type="entry name" value="ParAB_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000285">
        <property type="entry name" value="Sporulation initiation inhibitor Soj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050678">
        <property type="entry name" value="DNA_Partitioning_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696:SF99">
        <property type="entry name" value="COBYRINIC ACID AC-DIAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009320">
        <property type="entry name" value="Nuc_binding_HP_1000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="250" mass="27674" checksum="9D18A507BB5EE70E" modified="2017-09-27" version="1">MIISIANQKGGCGKTTTAANLGALLSEKHRVLLVDIDPQGNLTTHFGINKADQKHTIYDVMLNGRIEDAIIRKDGIDIVPSTIDLAGAEVELTGKIGREYILDNELKRIARKYDFVIIDTPPSLGIFTINSLVASDYVLIPVQAEFFALEGLTQLMRVVELVNSRLSRNLKLLGMVITMFNARTRSSNEVLEDVRKHYSKNLFKTVIPRNVTVTDSTMAGSPAVRYNKNASASRAYVKLASELEKKLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP03</accession>
    <name>A0A218NP03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromate reductase, Class I, flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820488.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP03"/>
    <dbReference type="GeneID" id="33314457"/>
    <dbReference type="KEGG" id="marh:Mia14_0920"/>
    <dbReference type="OrthoDB" id="9059at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="196" mass="21671" checksum="13C1E9B746D94ED1" modified="2017-09-27" version="1">MENSDIVILGICGSLRKDSYNRVILNAAAESGVEGVKFKFADIGDLPLYNQDLDNNLPEPVKRLKHDIESADALLIVTPEYNRSVPGPLKNAIDWASRPYGKNSFDEKPVAVLGATVGRFVGTALVQYHLRGILAFMNAHLMENPQMFITEVGEKVKDGKLVDEETKEGIKKVVDSLKKWAIRIAIEEDDASEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP06</accession>
    <name>A0A218NP06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L18ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820505.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP06"/>
    <dbReference type="GeneID" id="33314474"/>
    <dbReference type="KEGG" id="marh:Mia14_0937"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="63" mass="6931" checksum="F6EFEFA0537DDDE0" modified="2017-09-27" version="1">MMYNVKGRIRKGKDSVGFDINVEGKSEKHAKDVAMVSLCSKQGLHKGQIVIDAAKPMKDAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP15</accession>
    <name>A0A218NP15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP15"/>
    <dbReference type="KEGG" id="marh:Mia14_0897"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="222" mass="25141" checksum="356C0CFD2690332A" modified="2017-09-27" version="1">MSLNNYPRQNIRNCEEILDSLQNKVSMVKQLLAGLRNGPVPLKTTNFTNLLIWSRILINETENLKSCDRKKFEGWYAQYRRELFGDGSHGPDPLLDYFIQARNQLEHQGIIKVGWSINIHHLNIPGDLLKYGPAPPGARGFFLGDQLGGIGWLVDLPNGSQAKYYVNLPKEFVESSLLPHNPPSIHLMNKIQNASVESLAEYYVGYIESMVLSAVKEFRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP16</accession>
    <name>A0A218NP16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Signal recognition particle receptor FtsY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891474.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP16"/>
    <dbReference type="GeneID" id="33314476"/>
    <dbReference type="KEGG" id="marh:Mia14_0939"/>
    <dbReference type="OrthoDB" id="372188at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="12">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="174"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="11">
        <location>
            <begin position="175"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="369" mass="40731" checksum="E42D3B31D7681675" modified="2017-09-27" version="1">MFDSLKKRLSETIKAFSTKEKDEYDKGEVPSENESVVVDEGIINEEITYSDPKIKDNTNLKEKKETEENKNKVKLSGITKAKSLLSKKVKLRDSDISSFTEQVRMILLQSDVSFYTTEDIVSKLEGELREKEFGKNNLDQQLMGSLRNAVSDIIGKEKFDMIDYISAKVESGVKPFTVMFLGFNGTGKTTTIAKIAYNLKLKGRSVVLSASDTFRAAAIEQLDYHAKMVGVPIIKGRYGADPASIAFDAIAYARAHSTDCVLVDTSGRQETNKNLISELEKIARISKPNLTLFVAESVAGSDLADRIKEFNNHIKIDGLVLTKLDCDAKGGNAISVSRETGIPIMMFGVGEGYTDIASYDPNIILDSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP21</accession>
    <name>A0A218NP21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820481.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP21"/>
    <dbReference type="GeneID" id="33314449"/>
    <dbReference type="KEGG" id="marh:Mia14_0911"/>
    <dbReference type="OrthoDB" id="57234at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050189">
        <property type="entry name" value="MFS_Efflux_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124:SF3">
        <property type="entry name" value="CHLORAMPHENICOL EFFLUX PUMP RV0191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43124">
        <property type="entry name" value="PURINE EFFLUX PUMP PBUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="407" mass="42925" checksum="46CA456D67AF52C5" modified="2017-09-27" version="1">MSWIVKSLPYAILLFTIGFGWFGLAPLVPYLMHALSATEAEVLIILSSAYGGAFIVVGLISGWLSAKVSLKGTIILAAVLSFIGLVIRVVSPDYIIFLVASVIAALAYPLAMAPIGAVAVSIDKTKTQSITGMSLGGFFLGMAGGSLLNPLIYESVALRGTLAVTAILSLLALIYIIVGGKDYPSKYQQRSLRGVFKMGMVNNWYSGFIVPATTVMFGGIATGILLLHKLGAMAAVYGGLFGSLAFIGSALGTIILPAVFEKANKEKVGYISMSFLAFVFVLVMAYSLSYTVDIALIAAAFFFFGLFADTLWSMELEGVTKYVEDPAKAGFATSLMQVAGNFGVFIIPALLGPLFSVPSSVSIAIGVVAVLFFILFVASFFLRTDKVSPSGQQKPADSKPKAAKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP22</accession>
    <name>A0A218NP22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820517.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP22"/>
    <dbReference type="GeneID" id="33314486"/>
    <dbReference type="KEGG" id="marh:Mia14_0950"/>
    <dbReference type="OrthoDB" id="46008at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF21">
        <property type="entry name" value="DEHYDROGENASE (FLAVOPROTEIN)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="368" mass="40218" checksum="7E6B9ABAE631DF23" modified="2017-09-27" version="1">MGSYDNVAIIGGGMAGLRLAEKLAGSDIYVTLYEGKRDVSYLADRASGVLSVSGVNRLGIDYSGALKNVLDGAVIYSSRQQMKVVSEKPQAYVLDRKLLIKEAYANAKRAGANIVLGKRLDEAELNSLDDGKTVIVGADGPASSVAKAFGFTPIKEFLLTYKAVYENVNYPESSIVRLFFDNAISKGLFGWLIPYSNDRIELGLGVSEKTKGNSKQAFEKFVKNSNIHAIVDSRKASSEYASVIPIGARRVTVKGNVLLVGDAAGQTKATTGGGLIFGLSCADVALQSIVNAFKNGRPLSDYERSWRKLYGLDLNMHRRLQSYYSNLDNRSIDRALYLLKKLGFDSFLSKHGDMDSIKTMMKRAFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP31</accession>
    <name>A0A218NP31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4325 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820491.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP31"/>
    <dbReference type="GeneID" id="33314460"/>
    <dbReference type="KEGG" id="marh:Mia14_0923"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025474">
        <property type="entry name" value="DUF4325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14213">
        <property type="entry name" value="DUF4325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4325" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="102" mass="11955" checksum="52331326084771B6" modified="2017-09-27" version="1">MKTIKLYEFVSTYPSYRLSADKLFDFIKNNSDDKIIVDFSNVEGVTHSFASQYRIDKKYCSKDVKEINMGDNVKKMFKSLNNKKTDGQGYVEIQDFNPRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP46</accession>
    <name>A0A218NP46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP46"/>
    <dbReference type="KEGG" id="marh:Mia14_0983"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049142">
        <property type="entry name" value="MS_channel_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21088">
        <property type="entry name" value="MS_channel_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel transmembrane helices 2/3" evidence="10">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="9">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="309" mass="34166" checksum="1A477E8329988B8D" modified="2017-09-27" version="1">MGIYRRLLMVGLLVIVLAFIVSYLLGVYSKFFVNAHVDLIWIHALIVGIAGIIIIEMVGRTIKDRVKSRNNETKVVGDLFEVVAYTILLIVILNELQVNVMGLLVGAGFLGIVLGLAAQSTIGNLIAGFELMASKPFSIGEKVTISTWQYGLIAPTYQHDVMVPGFTGTVSKIGIMYTEMVADNGTPIVVPNSIMNQAVIFNKKRVGKIRVFSHVEVDIKIDYSRFRDYFNEGVSKSTVKNVSIEIKNITQLAFGVDIYADGNLDDEPKIKDQLSEYALKAISRIMKEDNEAKDKENADSKDKAAEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP60</accession>
    <name>A0A218NP60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP60"/>
    <dbReference type="KEGG" id="marh:Mia14_0992"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="170" mass="18777" checksum="CC059AB8A0C91A11" modified="2017-09-27" version="1">MSQMPKSQKTASNQSIWIAVIVIIIIIAVLALVGLSYEIPLNKTQGTANIIVYIKTPDTFFYSLDLNLSGEGITRSVGINHPFNSSNESYKVNSTTSNSTTIIQMTQEFEGLKPFSEYKITLQGAMGPRCYPGVPCIYEKPNILEIINETRTVETGADRTTTYVTILNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP64</accession>
    <name>A0A218NP64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative adenosine-specific kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820557.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP64"/>
    <dbReference type="GeneID" id="33314531"/>
    <dbReference type="KEGG" id="marh:Mia14_0995"/>
    <dbReference type="OrthoDB" id="371841at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="entry name" value="Ta1353-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="BLL5354 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155:SF1">
        <property type="entry name" value="BLL5354 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="Ta1353-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="161" mass="17802" checksum="D03B73E149023C6C" modified="2017-09-27" version="1">MVEFEVVDIKKDEEIEFILGQAGFIKTVEDLYEAIISSTPEVLFGLAFCEASGKQLVRSEGNDDELKHLAEENALNVGAGHCFLIFFKKAFPINVVNNIKAVPEVSGIYCATANPVQVIIAKTHQGRGIMGIVDGMPSKGIETDEDKESRYNMLRKFGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP72</accession>
    <name>A0A218NP72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891477.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP72"/>
    <dbReference type="GeneID" id="33314546"/>
    <dbReference type="KEGG" id="marh:Mia14_1011"/>
    <dbReference type="OrthoDB" id="275427at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19072">
        <property type="entry name" value="AKR_AKR3F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="307" mass="34645" checksum="0B4C7492374639E6" modified="2017-09-27" version="1">MKLKKLGNSITSFSEIGLGTWKLIPDSVEVPKVAAYLFEKGVNFIDTAEMYQNESELGSMLKTIKHEPFIATKVSPNHLHYSDVIKSCNESLSRLGVSQITLYQIHWPNHHINLKETIRAMEYLVEQGKIKYIGVSNFDQKELEEAMSYTKNSKIVSDQLEYNIAFTEVEDSGLLDFCKSNNVSVIAYSPLARGQIKNYTELYGVLSSIGEKYNSNAFQVALKYIISDEDVIAIPKISSMPHAEEIIGCEEFEISQKDISRIKEAARDIRKPLAGSSLKKILKANGSWAKLMEKHERSRINRGGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP75</accession>
    <name>A0A218NP75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19p</name>
        <name evidence="6" type="ORF">Mia14_0964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820531.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP75"/>
    <dbReference type="GeneID" id="33314500"/>
    <dbReference type="KEGG" id="marh:Mia14_0964"/>
    <dbReference type="OrthoDB" id="30559at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="128" mass="14883" checksum="1A8A9BE556884C56" modified="2017-09-27" version="1">MVERVAYRGLLSEQAKSLTDEQYLEMLNSRERRFIKRNSMQFKEIMEQVKKHRKNGKPIRTHLREAVILPSWVGLTFSVYTGKDFQNLEITANMLGHRLGEFAYTTKRVVHSAPGVRATRGSKFLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP76</accession>
    <name>A0A218NP76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosomal protein L14e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820582.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP76"/>
    <dbReference type="GeneID" id="33314558"/>
    <dbReference type="KEGG" id="marh:Mia14_1023"/>
    <dbReference type="OrthoDB" id="63594at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="76" mass="8614" checksum="E77CB3E8208058B7" modified="2017-09-27" version="1">MLVEVGRVCVKKFGRDAGSAAVITSIEKDGFVKIVTSKRPKERRCNIRHLEFINTKIDVENKDLLNRTLGISNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP83</accession>
    <name>A0A218NP83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor aIF2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216926.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP83"/>
    <dbReference type="GeneID" id="33314511"/>
    <dbReference type="KEGG" id="marh:Mia14_0975"/>
    <dbReference type="OrthoDB" id="84794at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="264" mass="30133" checksum="B70B9B2E73BDD064" modified="2017-09-27" version="1">MEEHTPKFGDLVIGEISKISPFGAYCKLLEYNNLETFLPLREISSGWIKNIHEFLHINQRVVCKVIYIDKSKGTIDVSLKKVTPRDAKIKINKYTLEKRSEVIIQQALKMTNLEGRKVEIINSILQEFPNYTSFLSKLSDSGEPIKGSSVPVALQEEILRLIQSSRKKKEYKVSYILTLSTYDPKSSIDSIKQSLSDAESKTGCGIYYISSPRYHISAEADNYLNAEEKIKKALSIIKTELKGFDIEMEKEKVKKDKEDIISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP90</accession>
    <name>A0A218NP90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_1031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0104 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820590.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP90"/>
    <dbReference type="GeneID" id="33314566"/>
    <dbReference type="KEGG" id="marh:Mia14_1031"/>
    <dbReference type="OrthoDB" id="107034at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00374">
        <property type="entry name" value="flippase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39087">
        <property type="entry name" value="UPF0104 MEMBRANE PROTEIN MJ1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39087:SF2">
        <property type="entry name" value="UPF0104 MEMBRANE PROTEIN MJ1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="371" mass="41963" checksum="D11D52E20D046661" modified="2017-09-27" version="1">MEDSESKNKKDKKSIWYTILHIQNLNEDDYLHLVKRLMYFVGAGFVASFLIFFVIAYIGGIGRVSNIILSSNVGLYILAFAAVLSGYLIRFIKWDYYLKVVGIEVPKKKSMAIYLSLYSMDLTPGKLGRVLAAYTINRVTKKRVTKIVPIVTMDIFTDFIGVGILAIFTALYFNKFVVEVLAIDILLLLPYLFILNSRFYRFIKRIVKNERFLKFFNIYGDEYFASQSILNTPKTYILSVLVSVPAAFLNALALYFSLLAIHLKVSIPVIETVFIATSSALFGMITGIPGNLGVTDGSLVALISALFSLNLNISSAVTIMFRFATLWFGVIIGGIFLVYTFRYWTNKDVIKEGLTESINNAKNHIEKKFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA3</accession>
    <name>A0A218NPA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_1034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA3"/>
    <dbReference type="KEGG" id="marh:Mia14_1034"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="23774" checksum="DF014DD83C8AAAC7" modified="2017-09-27" version="1">MLGFYNIQGIVMDLSLLLIEPYKININVWAFEFMKDISSPPLNTFMALLAKSFLIVIPLLVLYLYFSKKDMNVYTFIVAGIVFYLVSDAIKLIVREPRPCNVSELNWINVVSCQSTFSFPSNHASVLTGLSFFLSKYKYIRVLYIIWLFLVLFGRVYLGLHYFTDILAGMALSIVLYYIVIHFKDKINNFFNGIVKKIFPKLALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA6</accession>
    <name>A0A218NPA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_1029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA6"/>
    <dbReference type="KEGG" id="marh:Mia14_1029"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46549" checksum="FEBA1D846FFE89DE" modified="2017-09-27" version="1">MFCMKTAYKYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYKETGKTLTEFRMNVWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKKQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKIGRINFVNHRNIEGGIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPKIGIDLGIMQYVALSDNTILQNAKITKHQRKHSRVLQQNISRKEKGSSNRRKAVTRFARYSEHISRIRLDCINKISNELVNSYSFIAYEDLEINNMVKNHRYAKSISESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSMSISQRAFVCEKCGMSMDRDVNAAQNILKRALDSISPTTEGHSGSQACRDDIRPSARGAVAYEAGTTLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL0</accession>
    <name>A0A218NLL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N6-threonylcarbamoyl-adenosine(37)-tRNA synthase allosteric regulator Cgi121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL0"/>
    <dbReference type="KEGG" id="marh:Mia14_0007"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="162" mass="18662" checksum="E9A92EFA047F8198" modified="2017-09-27" version="1">MHMEDVDFINSLLKHSFAFRLYKRKSSFEIIFDQADRFNKQNAKKYEFVLLLKPYLSDDYPELVFAYINACLSFKNKTNRSSSIPLEMLIYLSGAKSITEAISKLGADKKGEFLIFSNSLDTLDTMEREGLIECREELKNRNINAEDLPALSNIAKNKLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL6</accession>
    <name>A0A218NLL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AEF-2-diphthine synthase (DPH5)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819520.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL6"/>
    <dbReference type="GeneID" id="33313564"/>
    <dbReference type="KEGG" id="marh:Mia14_0002"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="253" mass="28498" checksum="F130E603F0CD8D73" modified="2017-09-27" version="1">MLYLIGVGLSNYDVTMEGLEACRRCKQLYAEAYTSNLTEEKLKDLSKILEKEIDQLGRTDLEENAKILINQAAKEDIGLLINGDPLIATTHKTLLMEASASGVGTKVIHSTSILSVSMGESGLDFYRIGPVCTIANWSEHYHPISFYETIKGNMDHNLHSIMLLDYDYERQSTMPIEKVAFILSEAEEHYKKKIISEDTKFLVLNNIGTENGKIKLYTFAKLKTAKIKGMNTIILLAKLSNLEEEWISKIEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL7</accession>
    <name>A0A218NLL7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo3</name>
        <name evidence="4" type="synonym">rpoD</name>
        <name evidence="6" type="ORF">Mia14_0013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819530.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL7"/>
    <dbReference type="GeneID" id="33313575"/>
    <dbReference type="KEGG" id="marh:Mia14_0013"/>
    <dbReference type="OrthoDB" id="84933at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="188" mass="21066" checksum="618FB48201DEA12F" modified="2017-09-27" version="1">MDIDISQNNNKVFEFTLAGVSNAFANAIRRVAMNGVKSFAIDKVTFYENSSAMFDEYIAHRIGLVPITTPSGYKDTDEVMFTLEAEGPLTVYSNDLKTTEPDVKVAIENIPIMKLAEKQRLRIDGKAVLGSAVKHAKFQPGLVTYEQMNDNSFKFYIESFGQMLPKDIIIRALDILEDEIKSISKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM5</accession>
    <name>A0A218NLM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819540.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM5"/>
    <dbReference type="GeneID" id="33313586"/>
    <dbReference type="KEGG" id="marh:Mia14_0024"/>
    <dbReference type="OrthoDB" id="85079at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.240">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38137">
        <property type="entry name" value="PRC-BARREL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38137:SF1">
        <property type="entry name" value="PRC-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC-barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="80" mass="8880" checksum="B216556D6144019A" modified="2017-09-27" version="1">MLTSDLYGKEIITNTGHKLGYVEDIILDMESGSVNSLMLVKLEDLASGKSKGEEFKKNTVNYERVKNISESVIVGTEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN6</accession>
    <name>A0A218NLN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex RNA-binding protein Rrp42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN6"/>
    <dbReference type="KEGG" id="marh:Mia14_0052"/>
    <dbReference type="OrthoDB" id="30932at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="4">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="259" mass="28548" checksum="7256A72B1B8D5E99" modified="2017-09-27" version="1">MDAMSKMKSNYVKKLSEEGKREDSRDAFSFREIKITKGIIEHAEGSAQVDIGDTRVIAGVKMVVESPHDDTPNEGNLIVSVTILPMAATEYESGPPSPEEIELSRVTDRGIRSAVSIDPASLFIEEGKVWSVYVDVYVLNYSGNMLDAASIAAMAALTNARVPEYKDGSANYEKRDKKLSIKNVVTSTTFAKIGDSLFLDANENEESAMNARLTIQVDDTQIRAMQKGLSGSFTMEEINKLIDISFDKHKELKGLIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN7</accession>
    <name>A0A218NLN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor 1A</fullName>
            <shortName evidence="2">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eif1a</name>
        <name evidence="6" type="ORF">Mia14_0044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819558.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN7"/>
    <dbReference type="GeneID" id="33313604"/>
    <dbReference type="KEGG" id="marh:Mia14_0044"/>
    <dbReference type="OrthoDB" id="2586at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003084">
        <property type="entry name" value="PRK04012.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="100" mass="11506" checksum="C09623150A57FDF4" modified="2017-09-27" version="1">MMYNRKSNPNSPPPQLRIPKGNETAGKVAKVVGASKFIVNCADGKERLCDIPGRFRRRFWIKEGDTVLIQPWSVQSDKRGDIIWKYSIMDVDKLHSKNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP7</accession>
    <name>A0A218NLP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor aIF2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819557.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP7"/>
    <dbReference type="GeneID" id="33313603"/>
    <dbReference type="KEGG" id="marh:Mia14_0043"/>
    <dbReference type="OrthoDB" id="38099at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003067">
        <property type="entry name" value="PRK03988.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="4">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="138" mass="16252" checksum="BAF5A80A4D08882E" modified="2017-09-27" version="1">MEDKEYTELLHNAFSKLPNLEEEHQDFVIPKVDSMIQGNKTIIKNINAIADRARRKREEISRYFEKELGVPTSLEDQRLVITGKFREEDLNKKLERYFNVYVICRECHKPDTHLENAGNGMYYLVCEACGARYSLKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ0</accession>
    <name>A0A218NLQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819542.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ0"/>
    <dbReference type="GeneID" id="33313588"/>
    <dbReference type="KEGG" id="marh:Mia14_0026"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="75" mass="8566" checksum="FF5F276FA6DB7FFF" modified="2017-09-27" version="1">MPISKRTIKNYVKEKYKVRISDDAIESIIKFLDSQAGKIAKEAVNNAKIKKHAMITHDDIEQAIIKNSVKVKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR5</accession>
    <name>A0A218NLR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo12</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpo12</name>
        <name evidence="8" type="synonym">rpoP</name>
        <name evidence="9" type="ORF">Mia14_0055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819569.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR5"/>
    <dbReference type="GeneID" id="33313615"/>
    <dbReference type="KEGG" id="marh:Mia14_0055"/>
    <dbReference type="OrthoDB" id="129238at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00615">
        <property type="entry name" value="RNApol_arch_Rpo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023464">
        <property type="entry name" value="Rpo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="43" mass="4961" checksum="A7F16CE509F372F7" modified="2017-09-27" version="1">MDYICANCGRDVDYNENFIACSYCNSRIVIKKRPSIPREVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS1</accession>
    <name>A0A218NLS1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS1"/>
    <dbReference type="KEGG" id="marh:Mia14_0066"/>
    <dbReference type="OrthoDB" id="10698at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="NCBIfam" id="TIGR03630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="99" mass="11086" checksum="77FB1C4B1C80D8A4" modified="2017-09-27" version="1">MINLECNDPKCPIHGNLKTRGAEFEGIVVSTKAAKTAIIKREYTIFLHKYERSLRKTSKIHAYSPECMNIKTGDKVLIAGCRKVSKTKAFVVMKKVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS4</accession>
    <name>A0A218NLS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819581.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS4"/>
    <dbReference type="GeneID" id="33313628"/>
    <dbReference type="KEGG" id="marh:Mia14_0068"/>
    <dbReference type="OrthoDB" id="10899at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="179" mass="20114" checksum="681B6645F7DA9552" modified="2017-09-27" version="1">MGMLKSSQPRKQIKFRHEAPMHLKQHFVHANLNKSAREKYKLNKRAVQICKGDTVKIMTGSHKGTTGKVTVVNTKRQFIYLDSLKRKNAKGKEMNIPVTASNVSIIELNLSDKYRASKLKLKQVIAPKAEPVKKELPSSSETANNEKSESKESHSTEVQNKEPESEESESSAIADKNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS7</accession>
    <name>A0A218NLS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS7"/>
    <dbReference type="KEGG" id="marh:Mia14_0073"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="176" mass="20213" checksum="0529E02CCD67535E" modified="2017-09-27" version="1">MVIMYTIDIPEGIKVEESGNTLKITGKLGSNERQFNESLMNVKLEKNQIVIEKTNFKKLDKKASIAIKTFMSEIRNDIKGVNEYYETKMEAVFAHFPMTLEISGKKLIIKNMLGERTARESRIIGDSKVEIKDKTLKIYGTKLDDVMQTAANFRTTTKVKNKDERVFQDGIYFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU7</accession>
    <name>A0A218NLU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819613.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU7"/>
    <dbReference type="GeneID" id="33313662"/>
    <dbReference type="KEGG" id="marh:Mia14_0102"/>
    <dbReference type="OrthoDB" id="384311at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="286" mass="31025" checksum="F27396EC7B4C2035" modified="2017-09-27" version="1">MKKLIVLMFALLVMSGLGYISAQSAQNSSLQPSYVRMIEPYSSILYANSSVYLGKVAPGQTFYVTISSTSLNKNNKSINLGWNHFVAYGLPKGWVVENSSYNINEPSVKIKAASNASYGIYNFTLEAVNSGDIAGIGEPKIHAEINVSKDVIKLYLPYTSIKINPLQASIVYVIINNTGVSDNPFIIGSTGVPGWNFTQSVISKHGSSNEFAYPVKVDAPGIYTMSLYVRSATSPEVYESENISVTARSTLFTDYNSIGSGSVLFPIIYAPVDAVMYLIGVLVKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW8</accession>
    <name>A0A218NLW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecB family exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW8"/>
    <dbReference type="KEGG" id="marh:Mia14_0127"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="293" mass="34254" checksum="2892E5F89A61EE56" modified="2017-09-27" version="1">MIELNALERLHKSSVTATDIASQYWCEKQMELYKLSRAKKATAEIKKGKAIHEMMENEVNVPIELNPKSYGDSLFKTLYTTYKSLESLGKTDRAREIQIYGSLNGFRLVGKIDEIRILKGQAVIIEDKTRSSDRVPGEAELITHKVQVMTYKKMFDDISNGSYTFDDFKNTYGIGRLRLTDDFVKQLSDIGLDDEQKSFDYVSNKVFELYRKVNTGSSLYLRYINQFTKEEIKVLKFQYSSSEISKMLEFSLRYWKGERDALPVPYEEKWKCNHCMFFGNDCKVWWPQRKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW9</accession>
    <name>A0A218NLW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW9"/>
    <dbReference type="KEGG" id="marh:Mia14_0131"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="330" mass="37676" checksum="DA71073D1F01AB7F" modified="2017-09-27" version="1">MWEDVTQNLLIYKRTLSKGGMVMVSKDKKVYKNKVTELEYKGNSLIYPNGSSIMGNQFKNEFDYVKFIAGKGPKLVLVGGGERKVETPLKLAGYLNPSDDIDIAAKESDVNYILNNHKSGTFRMIDNTKTVCEGLSSYKEVIYYSLFSVIKDTEVPDRDKYIDIFTRNIGPIPVYENMFNDAINAKISYESSSGKESIKVKLQPPEYSIATSLNPLVYKDKRAIPEIVSLYMLFSKDFIDFDSVLQGAMKLLKASEKLVADKISVYSNNYNPPEDIDMARYTNYSDNINKISSKLGNNRNKVRRILRKGDVEMEKFDEFYETLSNAFKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ0</accession>
    <name>A0A218NLZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819657.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ0"/>
    <dbReference type="GeneID" id="33313712"/>
    <dbReference type="KEGG" id="marh:Mia14_0153"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="GDGT/MA_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056488">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045702">
        <property type="entry name" value="rSAM_GDGT_ether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306:SF1">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23545">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="162"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="625" mass="71089" checksum="D4FE974EA7779C0D" modified="2017-09-27" version="1">MVDKMSDNIKIMSAKLDEASLQVQKTEPEGFSQNIVSNINNVRPTVNAGEEAQEMVDPVLAPYHRSMEEIEKMPVIEKTKTVCPECKLIIDGIIYKDGDNVMIRKYCPEHGWTMEKYWEDYDMYMKMRRYNYFGRGFDNPNTITDTKGVNCPFDCGMCERHKSHTGLANVVVTNRCHLSCWYCFFYAKEGESIYEPSLAEINKIFLNLRSQKPIPANAIQITGGEPTMHPHIIEIIELAKKAGFDQIQLNTTGINIGANPELAVKIRHAGVSTLYMSYDGVTKRANPKNHWETPMALDACRKAGIGVVLVPTVIRTINEKELGLMINFALNNSDVVRAVNFQPVSLVGRMPSRLREKQRITIPGAIKLIEEQTNGVVAKEDWFSVPYIGGINKFIESLTGEYKYDMSIHFACGAGTYIFLDSDNKIIPITRFVDAAGLVEHLEKGIAEMEGKSKTQRRIIAMKTVLGMNKFIDKSKQPKSINFAKLLMSVILKHDFSTLGKLQMKSIFLGMMHFQDEYTYDIHRVEKCDIHYAMPDGEVLPFCTFNVFPEVYRDKIQKQYSVPSKEWEVSHPGWNYAKDKYMRNIKELEASPAYRKAYGEMTDYFALPVNGGKHVQGFANEALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ1</accession>
    <name>A0A218NLZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819651.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ1"/>
    <dbReference type="GeneID" id="33313705"/>
    <dbReference type="KEGG" id="marh:Mia14_0146"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="108" mass="12511" checksum="C5CCBF1C3CE5B371" modified="2017-09-27" version="1">MIGEDFKEEGSLSLNEVYDILSKRKEESELSYEQKMTFEYAEKFQIPSAKFKKIKSDLEAMELNNNLINKLLELNPKSPEVIKYAAASNRVTLDEEQINKILSEFKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM03</accession>
    <name>A0A218NM03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819661.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM03"/>
    <dbReference type="GeneID" id="33313716"/>
    <dbReference type="KEGG" id="marh:Mia14_0157"/>
    <dbReference type="OrthoDB" id="381840at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="258" mass="28809" checksum="C7501A95504ABC47" modified="2017-09-27" version="1">MYKHLTIFIAAVIFALLLAGNANAGYSVVHLNTTVILNTSNTAQVNEVLTVYVSNYSVKQYETDRDALNLSLSTWQGLIGPELTQHILNSHSGVYGFKFLPGPLVPTDYGGGYANLYMTYYVKGVQLSDRVAPRVIRYTFNDSVFNFGHSLSGEYLYPNTTLTIIPPSGAKIVSIYPLPDSPSTGFSDNYKNVTEFSWYDQEPLSKFTFQYDLDTSLGFEINEFLYNTYNSKSLPIYLAIVIIVVVVLGVLLALRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM23</accession>
    <name>A0A218NM23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819681.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM23"/>
    <dbReference type="GeneID" id="33313737"/>
    <dbReference type="KEGG" id="marh:Mia14_0179"/>
    <dbReference type="OrthoDB" id="136394at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="145" mass="16973" checksum="00C36EF36D63D638" modified="2017-09-27" version="1">MKFIIIKSVDKPYSDDPDSFISWFCKSFGLESEIENSDSIEKDLLKQFINAALAGKGISSSDLTENFKIARTTIIYHLNRLIEAGWIVKRGRMYYLRGKELSDVIEEIEYDINREMMKMLDIAKQFDRLSKSRSENKKFKKVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM28</accession>
    <name>A0A218NM28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819685.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM28"/>
    <dbReference type="GeneID" id="33313741"/>
    <dbReference type="KEGG" id="marh:Mia14_0183"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF18">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="1">
        <location>
            <begin position="270"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="446" mass="51934" checksum="06D83C12CBC18068" modified="2017-09-27" version="1">MKQQLNDNLLSAYNPWWSSKYRNAKKTKYLAYYSKLYKLPELKNGQKLIITNTDYNESIIKQILYGYVNRRRSKRNMVYVPFENLGDSDVISIFREIKKSPSKLDVFVSGIDPYLKFSLDKGKLLFSTINNSKSIKKLFISTRFLPSSTSNRHITKLSTGAKHYTISPITFRDYILKFGKHDIKGYLASLPIIAKSNPKYMEKIYLQACAIRDSGNESFFKDLFSSYSRSGGFISSIVDYKNKEDLYDAVYNYRKSLMQEFESLKVPAYDLEKLLFAITNSCGSIYTFDSMESDTKLPKRLVMYYYKLLLDLGIIKPVLKFDIKNNSPTKLVRKTYLSDPITYIAFSDFYNNYNRTEILMQGPLIENIVGVELMRRFGQVYTLKEGVEVDFFLPSMDLGIEVKSGSAKYNSYHMDFPRNRVVFNSNRLKKENGLFEIPYYLFLALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM37</accession>
    <name>A0A218NM37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase DnaG</fullName>
            <ecNumber evidence="9">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaG</name>
        <name evidence="12" type="ORF">Mia14_0195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819695.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM37"/>
    <dbReference type="GeneID" id="33313753"/>
    <dbReference type="KEGG" id="marh:Mia14_0195"/>
    <dbReference type="OrthoDB" id="8643at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050219">
        <property type="entry name" value="DnaG_primase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003108">
        <property type="entry name" value="PRK04031.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313:SF2">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="501" mass="55569" checksum="4C6BCAD054C38827" modified="2017-09-27" version="1">MAKSYIDIVKYVIEAKFDIDGTVEKPDIIGAIFGQTEGLLGEDLDLRDLQKNGKIGRIEIESSSNSGKTSGTLVLPSSLDRVETCILGAAIESVDRVGPYETNFKVLKIEDTRNEKRAHVINRAKDLLKSLMENVIPDSKEISDMVESEVKSSTVINYGPENLPAGPDIDKSSSIIIVEGRADVVNLLRSDIANAIAVGGATTDIPKSLIKLATEKEVTVFTDGDHGGTMIVKNIASVADIDYVARAPDGKEVEELTRKEIIKALRSKMPMEQAAVVYKISLPESNHNSESRGNNKESANNNYNKDRPRFKNNHNYPQYSKPAEPQEQKKQLRGPEPPVDAEEDKIHVETSREPKVENKEPEAVPAKKEVEENQRPAPERQQSIKKQAAKEELKEKPAELVEKVKLKPEESMIASLSELKNTLRGRIYGSDKKLIAEVPIRELIQSIQDIDNIESIVFDGIITQRLVDLANKKSVKSIYGVRSSQIARKYGSMLLYTSDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM51</accession>
    <name>A0A218NM51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DrugE1 family ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819698.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM51"/>
    <dbReference type="GeneID" id="33313756"/>
    <dbReference type="KEGG" id="marh:Mia14_0198"/>
    <dbReference type="OrthoDB" id="203821at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF2">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="132"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="374" mass="40162" checksum="1666365AADBDD82A" modified="2017-09-27" version="1">MSIVSDSLIIYKREMLIFKSKLRTNLIRSLIFPLVLILMLGNLGANSDIITNIGVVNYASNPSAYNFVQSLQSNNDLNVEMLTTQQAALSALKAGQITDVVVISPSFPSLNTQNPGIYIYYANNFADLGNSVNIIESLAEQYESNIGKPIEYSSTSSPDQVVSDPAYAADASYRTFLVGGVIVMVAVFGSMFGGGMSIITDRQLGNLKSFLITPINKLSIILGKIMSGTTQALIYGVIAILIGLLDGATVAMGIAGVAIILVLIALTAVAFSAITIILASRISKIEVYSIIANAITLPLWFISGAFFPTSSLPSWLYPLSVIDPLTYSASGIRYIMMYGYYPINSAILDFSVLIAFSVVVLLLSFKLFSTTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM53</accession>
    <name>A0A218NM53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM53"/>
    <dbReference type="KEGG" id="marh:Mia14_0215"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050664">
        <property type="entry name" value="Octanoyltrans_LipM/LipL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43679:SF2">
        <property type="entry name" value="OCTANOYL-[GCVH]:PROTEIN N-OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43679">
        <property type="entry name" value="OCTANOYLTRANSFERASE LIPM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="41"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="282" mass="32428" checksum="24D42DB50273C675" modified="2017-09-27" version="1">MTSRLSAKPKIKSDIYYLGYQKNSIFDNMAIDEVLMELADKENKFFFRLYDFNKDSIILAFSDSMENVKAVDGNVELTRRLSAGKPIYIDDNVLSYSFIGPMKDNGTLKNGESIHDFFGTIIMDSIKSISNDPERPNIKLGKAYSIKVGEKPIVGNGQHISLSHSFMYHGIIAVGKWNAEKVNAYLNLVRKDYEALKDLPSIESINRVKGQSIEYYKSELIKQIIKNINNRFNSVKEISKEESNEINKMKLEKVPKYKDIGWIDRKDILLKKDSRFCLLWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM56</accession>
    <name>A0A218NM56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819725.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM56"/>
    <dbReference type="GeneID" id="33313784"/>
    <dbReference type="KEGG" id="marh:Mia14_0226"/>
    <dbReference type="OrthoDB" id="371709at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052339">
        <property type="entry name" value="Fe-S_Maturation_MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831:SF1">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="96" mass="10886" checksum="0C4807B30FB59C76" modified="2017-09-27" version="1">MVTKKEVLEALSQCRDPEIDADIVNLGLIYGIQIDENDINLKLTMTSPMCPVTSLILADVQMRLENIPGIGHANIELVWDPIWTPEMMSDELKYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM58</accession>
    <name>A0A218NM58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819713.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM58"/>
    <dbReference type="GeneID" id="33313772"/>
    <dbReference type="KEGG" id="marh:Mia14_0214"/>
    <dbReference type="OrthoDB" id="4631at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="228"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="434" mass="48499" checksum="8393E8490109DFBC" modified="2017-09-27" version="1">MTLFEELGIEKTLVDKLNAIGIVDATEVQKVSIPIILAGKDVVVRSKTGSGKTYAFVLPILNKLSGMDYRNPVAIVLAPTRELAMQTYKAIENLGDRRFKPVVVYGGVSINPQINGIKNGCNIVIGTPGRLLDIMDRGVLKLDNIKYAVIDEADDMLNMGFIEDVNRILSATKKERQTMLFSATIPRELNSTIHNHTTEPEFISIGGTDGITVKTIDHSFYLTRKNKKFQTLLTYLKENNPGKTIVFSRTKSGADLVCEALKEAGVNSMLIHGGLTQDRRERVLNNFKVNGEVLVTTDVLARGIDIKDIQTIINYDLPEDTDVYVHRVGRSARMGKSGKAFNIVSDSEEELIQEIENKNKIKMNEIVLHIDKYANLASESIEKAMAKSKRKTGFRSARGSSERPDRYRRNDSRSKPYTNNNKRHGKSGRYVYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM62</accession>
    <name>A0A218NM62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819720.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM62"/>
    <dbReference type="GeneID" id="33313779"/>
    <dbReference type="KEGG" id="marh:Mia14_0221"/>
    <dbReference type="OrthoDB" id="6874at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="186" mass="20885" checksum="B982971C5306E3E7" modified="2017-09-27" version="1">MIERTLVLIKPDGVQRQMVGKLLNIFEESGLKVVGLKLVKPKKENVEKHYAADEKWMVSVGTKTKASYAEKGVKLDKTELEIGQEVRNKLLSYLVGKPTVAIALEGNEAIYAVRKIIGSTEPKKADPGSIRGRFGTDSYAKADSEDRAVRNLVHASEDKENADREIYIWFDKDELLDYTVANEPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM75</accession>
    <name>A0A218NM75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C39-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819742.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM75"/>
    <dbReference type="GeneID" id="33313805"/>
    <dbReference type="KEGG" id="marh:Mia14_0247"/>
    <dbReference type="OrthoDB" id="378762at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021770">
        <property type="entry name" value="DUF3335"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11814">
        <property type="entry name" value="DUF3335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="232" mass="26303" checksum="C594175504EF650F" modified="2017-09-27" version="1">MKKTVPTAEKKIVKKSKLFEIPIYSQSEDFTSSAASVMMVLKYLNKDYKMLKEDEFSIWNETVYGSVWHGSRYGIAYALAKRGAKPYIVSSNIKDLGYERKIAVYEGINLDALQSAFDEIKTKIKDYEVKEVKGNVTINTIKRYMSDNQIPIVLVNANVLNSTVSPNGSPQWVVIKGYDEDTFYINDSYSGITLIMEPEMLTKSLGYEGEYYMILVKAKKISSKPTKASKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM83</accession>
    <name>A0A218NM83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VIC family potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819740.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM83"/>
    <dbReference type="GeneID" id="33313802"/>
    <dbReference type="KEGG" id="marh:Mia14_0244"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050721">
        <property type="entry name" value="Trk_Ktr_HKT_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43833">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43833:SF9">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN YUGO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="253" mass="27900" checksum="147FFCE0EC9F9DF4" modified="2017-09-27" version="1">MASFSLKLIVYIILILVTIVVGSLATYTVGNYYQVFNLKKLSYLDAVYFTVTTLSTVGSNIVPDTNLGMIFETLLIISGLGVFLGALSLIAGEVMEDRMDKLTGSIVGIQKRFFKNHIVLIGTDSVNLVLAENLKKLNKNFIILSSDSNEVDKLKNLGYKAFMVDVTSEAELKKFTLEKAFEIIIDMSNSSMLLYTFLVVNSISKESDKIIIIHSQEAEKRLADLNLPANCTIINPSSLVAVNIINSLTNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA1</accession>
    <name>A0A218NMA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system ATPase GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819746.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA1"/>
    <dbReference type="GeneID" id="33313810"/>
    <dbReference type="KEGG" id="marh:Mia14_0252"/>
    <dbReference type="OrthoDB" id="33500at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050921">
        <property type="entry name" value="T4SS_GSP_E_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486">
        <property type="entry name" value="TWITCHING MOTILITY PROTEIN PILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486:SF6">
        <property type="entry name" value="TYPE IV PILUS RETRACTATION ATPASE PILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="2">
        <location>
            <begin position="126"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="493" mass="56553" checksum="82E41163A924C3C1" modified="2017-09-27" version="1">MSWPLMSKLKRSLNEQGSYETNLSPIQLNFSVSNLPFDKQVEKLGRFKVIGKKKNIYLYLLNPENYKLDDYKASQLKRYAVEYLVNSDINLEYSSESIEYISRFLMERYSSDPFLSYIIAHDTVGYGPISILLENSKDIEEILVNGPKSNISIYHAKYGYCETNLKFNGEDEFRFTMNKILSETLNELNEDSPVVDAQLKDGSRIHVQIKPYSENGATASIRLNGSKSIGIRKLLESGTIVKEDIVYLWMGLEVGCNIIISGSPSSGKTTLLTAISALMPRYERIITIEEDVNELKFYSNFINAVNLKSRSKQGLTLKDQVINSLHLRPDRLIIGEIRGPEAHDIFFGANTGIPFITTMHSEADENSLLARLESRPMSVESHLIQSLDIAIFMEHRYDNTRKLSRLVEYNWLSKAETIGDKELPMVKLNAMVNNTIFDMHLLNESKVIKRYATLHGMSNDEAVNEFMRRSKFLEAIPRDTEFSSYIERYWEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA2</accession>
    <name>A0A218NMA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819757.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA2"/>
    <dbReference type="GeneID" id="33313822"/>
    <dbReference type="KEGG" id="marh:Mia14_0265"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="331" mass="39470" checksum="BB0D754605A211F7" modified="2017-09-27" version="1">MVVKDLNYGVGKDFERITFLDMTRFNDNQKHIELTIQCKNGNQANELINSLEHSKHANIRKVSFLNLHLNPDNTTSLYQSAKFSYILEYLENDKPKEYVFSGPANKLRSLDYLSKFYNQFETFAYWLDKDYNKVRIEFDYKSEVNKDLEKVKMNALSTFEHNSKSYYVWLYPDNSTTSYILKESTKFKVQRKSFLYLLNNLASKQEKGSHYILSYYYLGIKREIEIIPPNDISKGLLDFLSENADNLNSELIRDAYKRDIEINFTKRVNYIDFEMSNQNGRDYSGYAFGNRLDRAIYKLEDKIDGEGDHKLRDKYIRLYNHLWEMKKFIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA4</accession>
    <name>A0A218NMA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819764.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA4"/>
    <dbReference type="GeneID" id="33313829"/>
    <dbReference type="KEGG" id="marh:Mia14_0272"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="168" mass="20122" checksum="D474072A2CEA5CB6" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQNEIDERLILAQQFYNRILEKSIASYQNGKRKVSMAQFNRFVKEVIQDDKRYMKLYSQTRCEIEYRLLKAYQNFFRRIKERNKKAGFPRFRSRDINASINILKRATLGQRESHARGESVRPQMEAVLEELRTDKTHPLQDAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB6</accession>
    <name>A0A218NMB6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB6"/>
    <dbReference type="KEGG" id="marh:Mia14_0279"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="9">
        <location>
            <begin position="125"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="8">
        <location>
            <begin position="403"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="822" mass="93987" checksum="C9AA0FC723F36BF9" modified="2017-09-27" version="1">MIKLEDNEKPYGNYVDGALLDIDYVIPEENKAWIRFSVKGTDGKNYLFYDKKFVPYFYFIPDTKIGVEEIKKLKAQAGGQIKVPSRVEKETKALFGKPTAVFKVVTDIPTDVSAFADSFKKFGRCYEYDIPFGRRYLIDNNIIPLINYRFYLKDDDLVKVEPLEDKKSEVKLNYLCFDIETYNPHGMSRPEVDPVIMISYSYHSNDSDGNGVITTKKVNLPYVTYVEKEEQLFSEFENLLDKLDIDIVTGYNSATFDVRYMLDRAKALKIKFNMARYKDRETRIERYGLAEKVRIAGRVHVDTYLVVKFIAVVGAAEYILKLDNFKLKTVYDAVSGDTKHNVEKLDIWKLWDNGGEDLLELTKYNLSDSESLRKVYETFIPIMIELTRTTGNVLSDIAVSTTGQMVEFMLMRYAQEFGELIPNKPSSEDIRKRAMEPVVGAYVVTPEPGIYSNIAIFDFRGLYPSIIISHNIDPSSICDGSNENYCKDVYESPTGTKFSKTRKSIMPTILLILINQRAEVKKLYKLDKDNILLGSRSQALKIVSNSFYGYMGYIRSRWYSRECAGSVTAYGREYIHKLKDLAESKGFKVIYGDTDSIMFLLGNKTKDDAMKFLSDYNATLPEGMNLELEDFYTRGVFVGKKIQKGTTGAKKKYAMLSESGKIKIRGFELVRRDWSKVARDTQLKVLNEILKEGDAKKAVDIVRDVIAKIREGNMPIKEFAIITQLRKSIKNYTSKSPELVAAKKAIDQGLKTEDDLKDSVITYVITKDGASISDKASLLEFAKSYDPEYYINHQILPATLKILKELGYDEDYIKNLGTQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB8</accession>
    <name>A0A218NMB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819774.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB8"/>
    <dbReference type="GeneID" id="33313839"/>
    <dbReference type="KEGG" id="marh:Mia14_0282"/>
    <dbReference type="OrthoDB" id="5812at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34069">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34069:SF2">
        <property type="entry name" value="BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="4">
        <location>
            <begin position="224"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="346" mass="36651" checksum="D86933BD8077320F" modified="2017-09-27" version="1">MASIVSYGTYIPKSKIRITDIAASWNASGSEMEKSTGMIEKAFASEDEDLLTMSFESANAAIDSFHDKGNGDIDGILIGFDSDVEKGMEISPALISALNLDNGILASDIGPSHKSATTSIILMDGLIDSGLVKSGLVVAAGNLIGKEGEASGYRGSSASNSFILSKSDEGIADILGFYSFNSDVKDEWSIKSGEKMLSFSSGRFGSQLGYANHISKAVSGLFGKLGLKASDFKQVIFSQANTGQMLNTAKQLGFTSEQLEANSILKNTGDSGSTAEMVALANALESSDSGDLILLSSYSQGFGSDAIAIKVNKKSNPKNSVRSMLDGGRYLNYFDYLKSRKARIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD0</accession>
    <name>A0A218NMD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819780.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD0"/>
    <dbReference type="GeneID" id="33313845"/>
    <dbReference type="KEGG" id="marh:Mia14_0288"/>
    <dbReference type="OrthoDB" id="377794at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="202" mass="23650" checksum="BECD9BC1E34CB9CA" modified="2017-09-27" version="1">MALYPKLNFTYSYIYDSTFAQLESKEYISIKDSRLAGYIDSIEKELSYFDKKVFDNFQKFSGLKWQKPYIDVYISKYAPYSLSVPLTIKIYKDAKVATAILVHELAHNIVFQNQKQVLYKKLFADFDKYSAETKYHIIEGSILYLLNKDLFHDGLGGFFRYDNWISPKAGIAYRDAISIVLREGSENIIKRYIKKIDSCLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF9</accession>
    <name>A0A218NMF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819808.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF9"/>
    <dbReference type="GeneID" id="33313875"/>
    <dbReference type="KEGG" id="marh:Mia14_0317"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="83" mass="9639" checksum="3B7689EB05A8D889" modified="2017-09-27" version="1">MASKTKSAEGKYKLVVYDTFEGEFYSQKEYKTKEEALKSAKDKLKELERLQPSSHSGGQDYIGIQDRVFIQYPDGRMIRIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG0</accession>
    <name>A0A218NMG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tic20 superfamily protein translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819824.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG0"/>
    <dbReference type="GeneID" id="33313892"/>
    <dbReference type="KEGG" id="marh:Mia14_0334"/>
    <dbReference type="OrthoDB" id="329551at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="107" mass="12012" checksum="99B6148C895DEEAF" modified="2017-09-27" version="1">MSAKSKKSVSGDSTDNLTFLITYLLEWLTGVIVYFTVGQKDKRARFHAIQAIVLGIVSIVLSFILDFVFLPLSGIVVLLIWLYGMYIGYEAYKGVDIKVPILSDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG9</accession>
    <name>A0A218NMG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819821.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33313889"/>
    <dbReference type="KEGG" id="marh:Mia14_0331"/>
    <dbReference type="OrthoDB" id="387626at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="636"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="785"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="855"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="926"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1577" mass="170077" checksum="7DAE766F024BC7B6" modified="2017-09-27" version="1">MGNKRSIKTKSSKTKHSHKKNAQSALEYLVTYGWAILIIAVVISLLYFFVAVPSNVVPNSCSFVTGANCEDMELGSNSISHTSTISLLITNSKDYAIKDPSITVEYNKVNVTHSCYPSYVLPGGSIICVANMSTYLPTNTYTYGNLYLNSEDCGSSNSSSCANAPKQIYAGKFNTHVALVVKPSLTISLNASSGHNGRWPADNYPDELTANVIFLGYPLAGSTVNFTEVPDEETLFPTYASTSSQGIAHSFVYGTTIGNIKVNATFGNYTSHYVYINFSPVTQYHLIFNVPYGKVTITTPINSTTFTKNATGTTICNSELNYSTPSQVTLVSNEAYENFTYAESNGVKYYNSTGSIPIYCNSTTVSFNYTTYYKLNENVNPSYSSGVVSSSPLSSNGYYKKDSSLQLSAKSSNPKEWVFANWTCAASTSIGSTCYSGNSQSPTIIMSNPVNETANFDPMLSLRVIPGGDGTITASSPSGASTSSSTFTSYPEPYGSKITLGESPANSTFRFYKYVGLGTGNYTGNSTSPTITFDNPINETAEYDVYLNELASPSSADASLSPGSGWYFPNSTITLSEVNNTGYRFAGWTGYENNASSSFTMTVPNTDFTEQANYDVYLTELSSPSAAAKTLLPGTNWYIPGSTINLSETNNTGYKFMNWTGQFSSTRNPMSITVPSTPFTETAEYAVALKLSVYEHGDGKATVSPGGSTNSSSIFWETPGASLYFTETNTTGYKFAKWVGYDSGNSSNFTMTAPNSQFNETAEYDVYLTELSYPSNAASSLLPGSGWYLPNSSITLSEKNNTGYKFVNWTGYEKSTSSSFTMTVPNTDFTEQANYDVYLSEPSYPSGGAKTLSSGSGWYFPGTSITLSETNNTGYRFIDWTGYEGSNSSSFGMTVPTEPFTEQANYDVYLTELSYPSNAAYSLSPGSGWYLPNSSITLSEKNNTGYRFVNWEGYENSTSSSFTMTVPTVPFTEQANYDVYLTELSYPSSGASSLKPGDGWYFPGTSITLSETNNTGYKFKDWTGNEGSASSSFTMTVPTEPFTEQANYDVYLTELSYPSSAPSSISPGTGWYFPGSSITVSTSANTGYQFENWEGYENSTSSSFTMTVPTEPFTEQANFKVGLYISIDPSNGGSSNPTAGKWAYYYPNTTTIIKLSANVTSDAEWSFTGFSCSYNGNDRCPSNVNPSVAFIGDSPLYVTAYFESVDLYYIAGFDTSAGYHTNHVYYAPINYSNGQMGEWYETESIFGPNGPNNKGVNSESSVSNQGCAVESPNNTYSFPSVWCAGGNNATVGEYYQVESASLTPSGIQDNTWYVQSPPGNDTLNHATTEASAVISGDYMYYIGGEKLDGCSFLGVAQDCVYNHVDEAELFPGESSSWSTVGNYPIKDYIIYEAAVSYDGYIYIVGGATSGESSETNAVYSAKVNSDGTIGSLTAQNDYPYSVAQLSCTASAGYIYCVGGYVENGCTVDGISASCTYNQVWSAPISNGYVGTWTRQASYPRGAYGESCASYYDGINSNSVIYCVGGENSSIPGYEGVHYAYADDGTISGWYDGTTYPYNVTRGVAVLAVTGGPNVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH2</accession>
    <name>A0A218NMH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA modification enzyme AMMECR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819834.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH2"/>
    <dbReference type="GeneID" id="33313903"/>
    <dbReference type="KEGG" id="marh:Mia14_0346"/>
    <dbReference type="OrthoDB" id="25187at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="208" mass="23379" checksum="AD698150E787A869" modified="2017-09-27" version="1">MNYLNFDDGVKLVWAARESITEYLNRSDFDRNEIESKLKGSGFDKRYGIFVTLYNYKNSNLRGCVGFPRAVGKLRDSVIDAALSAAFEDYRFGSLGKGELGNVVLEVSVLSPMERIEGNPDYLMENVNIGEDGLLIEYQGYSGLLLPIVAVEEKFDSKTFLEEVCMKAGLKGNEWKDGSAKLYKFQTQIFKEKSPAGEVYEVDLSNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI7</accession>
    <name>A0A218NMI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819841.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI7"/>
    <dbReference type="GeneID" id="33313911"/>
    <dbReference type="KEGG" id="marh:Mia14_0354"/>
    <dbReference type="OrthoDB" id="52651at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="143" mass="15978" checksum="2DD098A8A1C47100" modified="2017-09-27" version="1">MISICTDGASRGNPGDSASGFQIYDESGKVIAKKEIYNGIKTNNYAEYNAIINALQWCVDNTKPNDTEITLYSDSKLVVSQINGIYKVKSPEMAELNLKAKDIIKKFKSVKLVNKPREFECIAKVDHAINLFLDKVEQDKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ8</accession>
    <name>A0A218NMJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819860.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ8"/>
    <dbReference type="GeneID" id="33313930"/>
    <dbReference type="KEGG" id="marh:Mia14_0373"/>
    <dbReference type="OrthoDB" id="135517at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="116" mass="13374" checksum="05AF46938483BC98" modified="2017-09-27" version="1">MSMMDYFVPPKELVDLTPEEVKERIKGDSYMLVDVRTDWEYRNGHIKGAVLYPHGSEKRFVEKFGVPDNVILVCKTGHRSRASANELVRLGVKKIYHLEGGMDNWRKNGFEEESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML0</accession>
    <name>A0A218NML0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819856.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML0"/>
    <dbReference type="GeneID" id="33313926"/>
    <dbReference type="KEGG" id="marh:Mia14_0369"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="155" mass="17995" checksum="8B1341B1FC0D52A3" modified="2017-09-27" version="1">MIGNTMTKDYNNRDNETLTSKDSYINLRTTVRKAYEERNKVELNKQLAERTKVYLKAKSIAEDLGKTDYIGSLPKGLFLRGTKYKSYRTDDFEIKLDTSTYEITIKDSRSKIVFEGKGLSAMETDFYKPSVKLNKFLSKAMESANLIRLKKQLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML9</accession>
    <name>A0A218NML9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA modification enzyme NFACT subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819866.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML9"/>
    <dbReference type="GeneID" id="33313936"/>
    <dbReference type="KEGG" id="marh:Mia14_0379"/>
    <dbReference type="OrthoDB" id="10943at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="376" mass="42932" checksum="A2235076B9BBE854" modified="2017-09-27" version="1">MRQLSTLEITAVIEELKNVEGMFVDKFYLVSEDEFRLKLSRTGEKVNISCKLCYSFNKTKYLKSADNHKSTFESAVRKRLNGTHVEEISQINDDRIIKIGFAKGETKKYMIIEMFAKGNMIVADDQSKIELAYKQHEFKDRKIRVNEIYKPPEKAKITITDAIESRMPQMLNEILSNADGSQKLIKFLNSNVNIGLPYIEDSILECGADPNSKLSEINESMLSSILDKIHLKTNLIQTPQPIIYFDAADGILDFAICPLIKYKDKKSQTKSSISEMLDDVNYGEGAEQAIPKVNEKAEEAASSVRKQMEIIESMKERVEYDRRAGKKIFENMAVLNEVLEFALSQRHITLEDLKSKFPYLNITGIDLKDKTITVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN6</accession>
    <name>A0A218NMN6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TraB family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819892.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN6"/>
    <dbReference type="GeneID" id="33313960"/>
    <dbReference type="KEGG" id="marh:Mia14_0405"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22637" checksum="CE90F3B0BAAB5C87" modified="2017-09-27" version="1">MAFKNIAKNDNKVVIIGERHNSEIDKKAEVELIETYKPGLILMEGYNSNDRNKEKNPYFDNDKLIFDVAEKYNIKIENPDLKVDELPGSSSIAKRHEELVSKYNSFLSAEENSELRNSKDEIIAEMRELGEKLKKVQMEEKPIREEHMKNVIVSNLNLNETEKSILVIVGDTHVKNLKTLLRKEGVESETYRSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN7</accession>
    <name>A0A218NMN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819884.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN7"/>
    <dbReference type="GeneID" id="33313955"/>
    <dbReference type="KEGG" id="marh:Mia14_0399"/>
    <dbReference type="OrthoDB" id="8389at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="384" mass="42784" checksum="820B259716DCA30F" modified="2017-09-27" version="1">MESPSNSTENKLSLIKRSPTEEILTEERLVEYLNAGTKLNHYIGFEISGMVHLGTGLVGMQKVTDLQEAGVNTSLFLADYHTSINNKLGGDLDNIRKIALGYFKEALQQSIKCVGGDPDKTKVVLASDFYEKEGIEYLENVLKVAKGMSLGRAKRSVTVLGRKSGDDISLAQLVYVPMQVADIYGQKVNLAHAGMDQRKAHVVALDTSKNFSYTPVALHHHLLMGINITEEQRKLVIEARANKDREQFENSIVDIKMSKSKPYSAIFVHDSEEEIRAKISKALCPPKETDVNPIIDMIKYIIAPTFLRKGENMRIENAKTGSAVEFGSMKELEEAYVKGGIHPLDLKNMVAESLISILEPARRHFSSGEGLRHLNELKELMITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP0</accession>
    <name>A0A218NMP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819903.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP0"/>
    <dbReference type="GeneID" id="33313967"/>
    <dbReference type="KEGG" id="marh:Mia14_0413"/>
    <dbReference type="OrthoDB" id="120490at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="177"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="408" mass="47571" checksum="31559B99A4ACF821" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQNEIDERLILAQQFYNRILEKSIESYKNGEAKASMAQFNRFVKEVIQDDKRYLKLYSQTRCEIEYRLLKAYQNFFRRIKEGNKEAGFPRFKSITYPQDNGSFSIKRGRLRVSRIGTMRIELHRKIEGTIKTLSIKREGKDYYAIFTTANEIKIPQLDDTNPVGIDMGLHSFIAMSSGMKMEKPRFVRKRAKHLARWQRRIAKREKGSKRRENAKNHLQKEWEHVTEQSDDFSHKLSNKLVNSGYTSFAVEDLHIQKMAKNHNLAQAIYNASWNKFIQMLSYKAESAGMKVIKVDSRDTTQECSNCHHIKEGSERLTLGDRLYRCNVCGLTIDRDINASINILKRATLGQRGSHAQGESVRPQREAVLEELRTDKTHPLQDAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP6</accession>
    <name>A0A218NMP6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0412</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819901.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP6"/>
    <dbReference type="GeneID" id="33313966"/>
    <dbReference type="KEGG" id="marh:Mia14_0412"/>
    <dbReference type="OrthoDB" id="39992at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="349" mass="38581" checksum="791087A8508A60BA" modified="2017-09-27" version="1">MSASILKIDEKDLHKSLDTAANIIKNGGTVVFPTETVYGLGANAYDPEACLKIFKAKNRPADNPLIVTVSNFDMVNEVAYIDADLLKIMKKVWPGPLTLLLKKKDSIPSIVASGMDTVCVRFPDNQIALSLIEKSGVPIAAPSANLSTKPSIVDSNDAIEDLKDRVDAIIDAGRVRYGVESTILDATKKPYELLRPGAFSVEDLNKLFGKISINEAAKGYKESKVALTPGMKYRHYAPSKRLFLIENEEQFKKFISSERSKPFTALCSEENAKYAKYEKIILGSDIYEVAHNLFYAFRELDKGNNKFGVIQSFPENSIGFGVMNRVRKASYLIIKENGDLNGIIDANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR6</accession>
    <name>A0A218NMR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819957.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR6"/>
    <dbReference type="GeneID" id="33313999"/>
    <dbReference type="KEGG" id="marh:Mia14_0444"/>
    <dbReference type="OrthoDB" id="23530at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="180"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="285" mass="32189" checksum="EB3E6C520AA8107D" modified="2017-09-27" version="1">MEKVIEKVIPGKSTHDGAGVKLFRVFSNIPDLTDPFLLLDNFGSSDIKDYIEGFPWHPHRGIETVTYVIKGKVDHRDSEDNQGTIYPGDLQWMSAGSGIFHEEMPKYIEEKNKIYPDMVGFQLWINLPANRKMSTPVYRSIKGKDVPSIRLGSSEIKLIAGRFGNDYGAYDGGTQDVTYMHVKLNDDRIAFSIKELYRAIIYVFEGYAKVGNSVYSKGQAIIFSEAGNSISVSGKGELMFMSGRPLKEPVAWYGPIVMNNYDQIKQALLELQHNAFVKDRKPLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS7</accession>
    <name>A0A218NMS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819945.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS7"/>
    <dbReference type="GeneID" id="33313991"/>
    <dbReference type="KEGG" id="marh:Mia14_0436"/>
    <dbReference type="OrthoDB" id="386646at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="358" mass="41323" checksum="EADD7A53E0206669" modified="2017-09-27" version="1">MDNPIIIEAKKRVFTEAVMDACDALHLPVPEINFSGDDDNNPNELAHSHPDLYKICISERQLKLQDSAGLKETANHEMTHLIGMIEHGKEFEKVKNQLILKGWKPPKSSGIQFIDGYTINEQSNQIRNDPEEYAKVNEDSDLVKFLEGKASDKQTTKERTPTKELETDDSRIEDTDYQETKKAYNKTNHSKIDEAGIGESRIKTGLNMENGTANSFDDIIICQRNGCNKKAVAKCKYCNEAFCEEHKDPVLVMSTQEVWSLNQIRKSDPEKYEKYTKDWKRTDGHPCPAYTIIWNKKHEAELKNRYNDFINFNYEKYFTNTNGKYINKVSKPLSLSKNIMWVLIIIIVIIVILLYKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT7</accession>
    <name>A0A218NMT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type III restriction-modification enzyme subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216878.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT7"/>
    <dbReference type="REBASE" id="210409">
        <property type="entry name" value="M.Mar14ORF449P"/>
    </dbReference>
    <dbReference type="GeneID" id="38419836"/>
    <dbReference type="KEGG" id="marh:Mia14_0449"/>
    <dbReference type="OrthoDB" id="57527at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF24">
        <property type="entry name" value="TYPE III RESTRICTION-MODIFICATION ENZYME STYLTI MOD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="5">
        <location>
            <begin position="92"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="680" mass="79056" checksum="EFB45C6646DA0367" modified="2017-09-27" version="1">MEKDEKYVELLWHDKYKKMEISHMTPIDYPNLPFQVVETVNKPRSKGGVNASLFPEDKWPENYPKDWRNKLIWGDNKLVMSSLLKQGWAGKINLIYIDPPFYTGSNFSFKTKVDDSEIEKEPSIIEKRAYNDTWSGGIASYLKYMYNRLSLMKELLVENGTIWIHLDEHIGHYVKVMMDEIFGYDNYINQIVWRKTNSPKAQSIGFGNQYDMIFIYGKNKQLININPVYKTPNEDYLRSFVYDDGDGKGPYQTTALIAGGTQRTVGRKVFEFRGITAPWLYSQENLEMFWNEGKIYKTKNGGYRLKVYLKDTHGQIVSDIWVDKEVNPLQGQSQEFLQFDTQKPESLLKRIILSSSSPGDLVADFFCGSGTTLAVAEKLGRRWIGSDLSKYAIQVTRKRLLDIHNSKDLMDEKKDKYGKPARPFELWNIGNYELAYWKENPQDYLSFMIKLYEANPLNGFRYIHASKGPRAVHIGSSNSPVSMDEIRNFITECINNNFKEADVLGWEWNYEVNDLAKKLAEKEGLDLRLIQIPNVNELKSVLADSDFDLKLLKIPDQVIKKNLIPSVKFNELAYLGISKVISDKELTLKIEDFNLNPSPDVLEALKNLKDSRQLIDYWAVDWDFKGDTFHNQWQSYRTKKDLKVEYEANHKYEEKGEYQVMVKVVDVFGNDTNKIIKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW4</accession>
    <name>A0A218NMW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820066.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW4"/>
    <dbReference type="GeneID" id="33314064"/>
    <dbReference type="KEGG" id="marh:Mia14_0506"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="301" mass="34169" checksum="5EFF5E31A1794D20" modified="2017-09-27" version="1">MDGSEGIRVFYGIEWLLDDLLPVPTEAEMGYMYGEKGADRGAYLQIAEIMRNKTRKIVPDIFNNSDKDVTIETGNQFIAASPPRPYEEWVYDCAKSDMVVIGPKEMEVRVIQRLKHEESTALEEKRKIWEYLPQFEKELQELHDSGLINGILGRGSYFAANGFPIKDDNIDFVLLREGNWSDEEKEGIINILKKLPAAWIYVIGAGKNGNKIDIWNGKEGVYFTLVDSRSIEFALGLRYERYILQNSIGIEIAGMGKDESESVAKRLCTMLPAHNRVSEFGLPRLQKPGRRSDAGPSPNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX5</accession>
    <name>A0A218NMX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820053.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX5"/>
    <dbReference type="GeneID" id="33314055"/>
    <dbReference type="KEGG" id="marh:Mia14_0497"/>
    <dbReference type="OrthoDB" id="6762at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="142" mass="15771" checksum="DEBEB02C3306CD34" modified="2017-09-27" version="1">MDGIDDSIISLIDSGTINYSTIAKKLGMPLSTVHFRVRKLEKEKIIEGYKGEVNWKNAGMSVLAFIFVNVDVDLLKKLHKTQQQLLNELTGISYVKEGYIVTGEADIFLKVIAKDTEELGKVLLNSIDAKEGVVKTKTMVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY8</accession>
    <name>A0A218NMY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding beta-propeller fold protein YncE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY8"/>
    <dbReference type="KEGG" id="marh:Mia14_0514"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="528" mass="56385" checksum="230CBBFBE81AD0B5" modified="2017-09-27" version="1">MSKFNRISLGIILILVGIIFISVISNSTTLSIANPKISYGTWTVISANSTNPANVTEIAVNGKVVSESLIHGIPDYYTFYGFGSGVCNQTISAGNYNIVSFTVSPNQSAKICSNLPSSAVGENASTLNVLKAKTNLNLYVNKTYNASVGESFLFNSSSKLNILPLVISINGRSVNTTYINAPLKVITPSSGFTINNKTYDINGTLNLALSSNGKDLYAVNYYNTVSEVNLSSGKVVGILTGFYGPSSMAIINNSYAYVTNAYGNNVSLVNLVSGSIVKNITGFDYPEDVVIAPGNRYAYVTNLMNNTISKISISSNKVVGGISGIFNGPYDIAFSSQGYMFVTNYYIGIVQVVNTTSGKSITNFPTNFKLPEGIAIAPDGLIYVANANLSESNVESYSVQSIPNYLSIMYEPDPQGIVIPSNGTVMYVSNRNSTISVFNIGNYSYNALLKPGNYTIELSSPGNANYTSAKVFSNFTVTGKLVNVTNTTAPTRPPSKPLPLEDLYIVVAIIVIIIIIAIIAVAAKKRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ1</accession>
    <name>A0A218NMZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mevalonate pyrophosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820118.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ1"/>
    <dbReference type="GeneID" id="33314094"/>
    <dbReference type="KEGG" id="marh:Mia14_0537"/>
    <dbReference type="OrthoDB" id="375869at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="328" mass="36432" checksum="C6A727219D797A96" modified="2017-09-27" version="1">MAKDEKIISEVKAEANPTIPIIFVSSVRDNRLPLHNSMGLSVTDNEGKTKVVTHISRTDSGELESFILNGKALQLERVQSMSEVLRAFQKESGKNYGIKAESDNYNVFAGSSDAGAAAFVVALDKMFGTNYETEKIAFLANKISESAIRAVYGGLNTLVVEGPGAPYAKQLASEEDLKDIHIFAMTFDYDSRLSAAEIFQLTRSSPFYDYRLKMVPQWEAKIKLGLLHKDWNMVFSNAEDNCSNAHYLIESSGGRARKKEMMNAVIDVEEIRQSGLPVYWTAGGGNVINAFTWDPYASDVLKELRSRGQKPVEYKVAPSARVTEVKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN05</accession>
    <name>A0A218NN05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820072.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN05"/>
    <dbReference type="GeneID" id="33314068"/>
    <dbReference type="KEGG" id="marh:Mia14_0511"/>
    <dbReference type="OrthoDB" id="378173at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050664">
        <property type="entry name" value="Octanoyltrans_LipM/LipL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43679:SF2">
        <property type="entry name" value="OCTANOYL-[GCVH]:PROTEIN N-OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43679">
        <property type="entry name" value="OCTANOYLTRANSFERASE LIPM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="308" mass="34941" checksum="C8020EA2A9B341F9" modified="2017-09-27" version="1">MFDYEYWGNNILPIDDNMAIEEYLLDESAKKNVATVRFWNVNKDSVVIGYGESTSNIKRVDSSFDFTRRITGGSHVQFDKNCLAYTFTAPRDGSFRHFDDMRKYYAEKIVDALSDLGIDDIVADNKASTINVDGKVIASHAMFWGVDSALIHGLMLIDHYDVDKLYERMILKDRKIGKNVYREYDALKSAPAAKDLLFTDKTDVPKDRKVDYVKEKIVDRILEKVTDGRYVKRGIDGSVIGASRRLVSSTHIGTPWVSKRAPPYTSDIVEAIPGEELAGKLKKDLGYCMYIEVPDKDFSKMVEPADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN15</accession>
    <name>A0A218NN15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820088.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN15"/>
    <dbReference type="GeneID" id="33314078"/>
    <dbReference type="KEGG" id="marh:Mia14_0521"/>
    <dbReference type="OrthoDB" id="42004at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="139" mass="16441" checksum="BC1861DC14C725F6" modified="2017-09-27" version="1">MYMFKDKVMVYDTDYQGIAHYASYYRFFTDAIEGYKRDVLELQTNTINDSIWFVVVESKAQYHKSLHINDEIYIELYPKLSKSKKALTYELKIKLVNTGELCTEGYLTMVSINHKLWKAVEIPSELLKRIMKSDDKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN25</accession>
    <name>A0A218NN25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780204.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN25"/>
    <dbReference type="GeneID" id="33314088"/>
    <dbReference type="KEGG" id="marh:Mia14_0531"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="345" mass="39565" checksum="69CD73F9ED29F7F3" modified="2017-09-27" version="1">MEPKISVIISSYNRKEFIRAAVQSVMDQTLRKDLYEIIVVKNFIDGEIDSFLQQNNVKNLYYSPDIARGAGTKAVKGIKASKGDVICFLDDDDVFSNDKLEEVYKLFADGRIGFYHNGHKIYYSGKAIDGTWADSGNYYLTGKEAFTDEDIKFLAKHQFWFNSSSISMRKGIIDLELLGKVNFTIDYYLAFMGINSNMDAVFDYMPLTLYGVHNSNGSKSSTEDFKKFCDSHNAYNSSRIDDHIALFDYFKGKKVGLLLGKYFFKKKLGYLLFSSRGNAAKIDYIKTSFDLLKSDIKLKMYGDIAEAIGGCTLFLISPNSLRRRLYKMYLKNEEERERLLERRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN31</accession>
    <name>A0A218NN31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAT family APC superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820163.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN31"/>
    <dbReference type="GeneID" id="33314137"/>
    <dbReference type="KEGG" id="marh:Mia14_0582"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="14"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="464" mass="49491" checksum="BD7F22A53447E83E" modified="2017-09-27" version="1">MEYTLNKVLGLRDAVIINLGAIIGAGIFVIIGLAIGRSGPAIILSILLSAFIAILTGLSFSEIARHTSKEGGVYEYGKEAFTPAAGFVGGLMWTFSNMIAISAVALSLGQYVDSFLSIKTPAMFFAIPAIVIFALLNIFGIKNSAKTLTALVALNIIILVLFIMFGLTHFAISNFTNFAPNGFNGILAGSALIFFAFTGFSRVTTIGDEVKDSEKTIPKAIVASILISAVIYIAIAVVAVGLLPYQDIASSAAPLSAAIAVLHNPIIDLIIAFGGITATAGVVLTGILGTSRVLFAMGRDNELPGQIAKIDRYSTPQVAIVLSAIIAIVFIYFVSFSTIVEASNAAVLIAYAIINVSALVLWNRLRKEEIKTNKLIRRSYFFIIPILSVITIAVTIAYLGYIALESSFVIFVAFSLIYLVKYGISKSGHGVSANEHVPYVSMVRLFGKSRSEFSKLVNSGRYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN38</accession>
    <name>A0A218NN38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0573</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820156.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN38"/>
    <dbReference type="GeneID" id="33314128"/>
    <dbReference type="KEGG" id="marh:Mia14_0573"/>
    <dbReference type="OrthoDB" id="5866at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049333">
        <property type="entry name" value="Topo_VI_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20768">
        <property type="entry name" value="Topo_VI_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Type II DNA topoisomerase VI subunit A all-beta" evidence="14">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="15">
        <location>
            <begin position="195"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="370" mass="42557" checksum="5E0D06283D52F0A1" modified="2017-09-27" version="1">MPDESPKTRITEDVLREFGNMLIRDIFSDKNPSFQTSVRSRTNVVFDKSKGFLTLGDSKEEHSFINVSQSKGFMQTIAIAAKCYSFIKQNQHATIRDLFYQLKYSLGDDLDENIFNEQSESNPLIEDLEVALDLRREQLNLNANRKGVLVGNMRIIDKFGDETVEIDGAKTGRSGWAIPSDVDNDIQFVDIDADYVLVVEKDALWYRLNEDKFWKKENAIIISPMGQAARGTRRLIRKLSDKGLPIYVFNDCDAWGWYIYWTIKTGSINLAYISDDLATPKAKFIGVTMSDLEAYPFLKGLTMKANDMDIKKAQEMLNYPWISRYPEWVNELNLVLKMKKKLEQNSLEGPKLSFVDEYINDKIKKGNFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN52</accession>
    <name>A0A218NN52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase 3'-5' exonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820168.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN52"/>
    <dbReference type="GeneID" id="33314143"/>
    <dbReference type="KEGG" id="marh:Mia14_0589"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="239" mass="27378" checksum="22BFA01C09FEEB39" modified="2017-09-27" version="1">MALAIIDCETTGLKWYKNGIVSLGAVDITSDDKFYEECRVEDDIEVDETSLLVNGFKDADVKDPSKKSESEVLKSFINWCKYHSVNMISGFNVEFDISFLYGIAKRGNVDFAAFPKYYFDIKSIFERNVLMDISKRPMVNEVCAKYGIDVGTPPYVHVSMDKTLKFYNIDEDEPKPHLAINGAVFATELYFLMKYKTHYISRFSNSEIPDYLNALKFDFGPPLKVENLIRSIELKLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN62</accession>
    <name>A0A218NN62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820181.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN62"/>
    <dbReference type="GeneID" id="33314159"/>
    <dbReference type="KEGG" id="marh:Mia14_0605"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="509" mass="57315" checksum="4A9AEAC29D30AC97" modified="2017-09-27" version="1">MFNHNKKAKNYNGLVFEAEKTPYPLYAAATLSAVLAVLFLSYFIIMNNALMILASLILFIALSFVIIAEDEYMNITLGLAIAFIYASSAVYFNVPELVLVFLISVYTLIVIFAGSKIRLSAKIILFIAFVVPMLMSALGFNADENLTINVGIIGYYLLISLAIAVSIRFIFSKGKSRFPNKLSSYYKSLSGTPFYILAAIICLILLVLPIYPMQPSFNPSLLPYSTLTLNSSSKANFIYLYLNLSKFKHFEVYNASSIGFYTLSGKPIDANIAKSITNLSAVPAMLNISPSNTTIKVMFFVPKNESHTVQDLESTNRTTNAVSRISNASRFSYRNKTISYSIYQKVNYTKYEGIEKFQKYYTYDSICQSDYQNSYAFKVNGSHAFSLFQFSNSSSFDNALIKSKSDTYNGYNQSFRNYSTKQFYNVANATLPVSNCTDFAILTNSTLDVGTTVYYYRYDAAMENISTEFPSYWYVNKSFVSGRYSFLPASLNYLYNVYKTDTMNSTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN64</accession>
    <name>A0A218NN64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216891.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN64"/>
    <dbReference type="GeneID" id="33314167"/>
    <dbReference type="KEGG" id="marh:Mia14_0613"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd21109">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="136" mass="15414" checksum="F6EE8FC94098FB7C" modified="2017-09-27" version="1">MPEYPKILSSYNINKWDLSLLLPKEGLENYKSLTDGIENGLDEKTLNNILEKAKEYGITTSLGDTKPQSTGHQIFECGAGLHFMSIQADLTAYPCPLLPYTRFKNLYGFSIHKLEEARDIWESNQFNKVSGKSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN80</accession>
    <name>A0A218NN80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820192.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN80"/>
    <dbReference type="GeneID" id="33314170"/>
    <dbReference type="KEGG" id="marh:Mia14_0616"/>
    <dbReference type="OrthoDB" id="26307at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37524">
        <property type="entry name" value="RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37524:SF2">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE FTSJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="202"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="411" mass="46627" checksum="7355A78F4E45FB09" modified="2017-09-27" version="1">MNKVKIANHTMIENTEDKSYLIFVDHRFSKMAEKAIKFVLPQCQLKPYELNNNSDFNTVFFKLEIKNTSDDIPKMIKKSASSFVDFVMPVDSIIDIGNSIKYEKIEDVIRKIIDNCGYASFKIEVKKVDHKLDETAKSIEVHLGGDLEKLGYKADLKTPKVMMYAILLNTSVVIGHVDTSMQKDYILDLFRQSSKEKIEKLNRAEFKIEEAAKFFDIDLSKCHIGLDIGAAPGGWTHYLSQKGVRMVAVDKALLNYKKMGDKKVLILADEIDTPKIKEIIKTENLANTISVESIVNESIDFKNYDIIHIKANMEPNDRLELLKKFGKFDLLAIDTNTSPLESTTIVNSLAGLLNPEASLVMTAKLVTRNFNKHVSTVEAELSKNYKSIKLKKLPHNRREFTVHGVYKGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB8</accession>
    <name>A0A218NNB8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Mia14_0662</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820229.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB8"/>
    <dbReference type="GeneID" id="33314215"/>
    <dbReference type="KEGG" id="marh:Mia14_0662"/>
    <dbReference type="OrthoDB" id="372134at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="131"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="427" mass="47322" checksum="E6107C8D96579AD0" modified="2017-09-27" version="1">MKVYVKTYGCTLNQADSDIIKTLLKDSNITVSDDEADSDAVIVNTCTVKTATEQRIINKLERLQKSGKRTIVTGCMASANPDLISKYVPSVSIITAPNISSLPAALGKVAEGERVVYDRYGAVDRMSYFKPGSGIISRIPIGDGCLSNCAFCETKRARGPLNSFSSDLIAKAISYSVRKGAKEIELTSQDVGAYGADRKSSIAELLDKIKTLDIGDDYYIRIGMLNPEHALKHIEAFTDALNSGHFYKFIHLPVQSGSDSVLKDMNRDYDISQFYEVVDRLRSNVKDLMLETDIIVGYPTEKEKDFEETLEMVKDVKPDVSNLSKFARRPHARASKLEQLSENEIKRRSVEATRIIRRVQNSINKKLIGTSQDVMLTERTGISINGRNPSYKQVIIAGESDGLELGDRCKVKIYSSTSNALYGKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC0</accession>
    <name>A0A218NNC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-oxoacid dehydrogenase multienzyme complex, dihydrolipoyl acyltransferase (E2) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820241.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC0"/>
    <dbReference type="GeneID" id="33314227"/>
    <dbReference type="KEGG" id="marh:Mia14_0674"/>
    <dbReference type="OrthoDB" id="56234at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="443" mass="47426" checksum="0B0531A6353B0556" modified="2017-09-27" version="1">MEIIKFVDIGEGITEGNVVKLNHADGDNVKEDETIMEIETDKAVVNIPTPLEGMIKYAVANGAQVKPGDALAVVGAKDEVSSYKFGASVQNEGPRADAESKNKPSATPASQMPAAPNTATAASPSTPQNTDDQKKSIMATPAVKRLALDMNVDIYKVKGTGPNGKILEADVKAYASGSKSAAPKQESNAVGNAQQAQANQIQHAESADNYGPTKKVPLSFLRKVIAKNMEASSSIPVASHMDLIDSGNLVDIVERTKEGFTKDFGIKLTYLPFMIKAATVALKDNPYFNASYDPENKEVTLKQYYNIGLGAKTDEGLKIIVIKDADKKSILQIAKDLTDLREKLYSKTIQLNDMKGTSFTITNIGSLGGGYMGMPIINPPDVAILSFGIIKDTPVVKNGAVVPGKVMEFTLTFDHRVVDGAAAADFGNELKRLLENPYMLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC7</accession>
    <name>A0A218NNC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820233.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC7"/>
    <dbReference type="GeneID" id="33314219"/>
    <dbReference type="KEGG" id="marh:Mia14_0666"/>
    <dbReference type="OrthoDB" id="386898at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="200" mass="20812" checksum="12AD768063202051" modified="2017-09-27" version="1">MEKNFKAQSAMEYLMTYGWAILIVAIVLAALYVLGVFNGSTFVGTSCSPAYGALCTSPIAAPYNFSVSLTNIGQTDWAATTLAFVPSSSIMPATENMLSYPDGSVIGNVISLNGGNFDGAQGATAMKSGFPTKVFFNDDPSSDDCIEGNALSSCPKVGSIPGGIGSTTSGEIWAIYTLQATNNTAPYYAVEVAKVTMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND6</accession>
    <name>A0A218NND6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820244.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND6"/>
    <dbReference type="GeneID" id="33314231"/>
    <dbReference type="KEGG" id="marh:Mia14_0678"/>
    <dbReference type="OrthoDB" id="23890at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007161">
        <property type="entry name" value="PRK09599.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="303" mass="33562" checksum="A56241947A62E21A" modified="2017-09-27" version="1">MSDKEIVFLGLGKMGKNAVLNMLSKGYKVYAYNRSEEPRKEVEAKGAVVSDDPIKLLNMVKGNRIVWLMLPAGEITNEFSRKILPELHEGDIVVDGSNAFYKNSMELYNMFKSKGVEYVDAGCSGGPSGARNGMSIMVGGEKNTFDKLAGLFKDVSVPDGYKYIGPAGSGHFVKMVHNAIEYGMMESIAEGIDLISSGPYKDSVNLKDISEVWTHGSVIRGYLMDLTLNMLSKDEKLKEISPFVEDTGEGRWAVQTAAEFSVPFNAITNALYERYESRQDYRMGKRVLAGLRNEFGQHGFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF6</accession>
    <name>A0A218NNF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF6"/>
    <dbReference type="KEGG" id="marh:Mia14_0701"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="227" mass="26603" checksum="36ADACB3C18B4DC5" modified="2017-09-27" version="1">MIYMDTRLLLIIFFLLLATLVLTMHYLTYLHISYLIAGLLVLVGSVILSNLGNDVNSYKYDIFYRDKRTFRLTDQFLERVGIYRDQRPMRLQDISDILERNAELPLEDGFSRKFELKSMFFRRGFLIYGDLVFGNYGQVRKKLIAKMVYDRSIYEHFLSFSDMDRTVALNKVFDNLELDKTAATDSKFIFVLNPDELEKFNCLLNLPYANNSLLALRMAFGDVEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG6</accession>
    <name>A0A218NNG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNHL superfamily nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891453.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG6"/>
    <dbReference type="GeneID" id="33314273"/>
    <dbReference type="KEGG" id="marh:Mia14_0721"/>
    <dbReference type="OrthoDB" id="15228at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707:SF1">
        <property type="entry name" value="DUF460 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="POSSIBLE NUCLEASE OF RNASE H FOLD, RUVC/YQGF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="159" mass="17920" checksum="A7B5F4926A50E979" modified="2017-09-27" version="1">MMYIIVGVDTGKTSAIACLSLSGKYIFSSHKRDAGSNWIVSEIQKVGTPIVIANDKHNGKSDIIRKITASFNASLFLPNEDLSMKNKKLEARIMKIKNPHERDAYTSALNAYNKYANKLKQAERIAKEKDYKDINLLKAKVIKKYSINEIMEGKKANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH5</accession>
    <name>A0A218NNH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820292.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH5"/>
    <dbReference type="GeneID" id="33314284"/>
    <dbReference type="KEGG" id="marh:Mia14_0732"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="474" mass="50559" checksum="3F04B8DFEF3F269C" modified="2017-09-27" version="1">MIDTMLAITSFSNTRTNLIPLIALAIGLDASFVSIWYILGSLLNNNSLKQSAINEIYQLFGNIIIVILIVFLLLAFSSIFYNSLQGTKMMNSTTIYSMCQNINSSSSLSILNPSDSGSGSSLLYSGKSGSFPGLCEMVKNPTTTTEKIDYPVATSAVILANLTNQTFTNLNYLFGVEAYIGFLSKLTPTDAICTGEIAPPDIIPISCVVPFSSLPILLFIRSQYTPLSGYSAIYSGLATLGGLITTAMESFTAQLLIIVSFIYVWPILLFLGLALRSVFFTRRIGGLFIALAVAFILFYPSVMALEYLSLNRVVAPTDVLTVNSTVVGSNVIAPVYNYTDTSSNKLGSLDFFVEPSIKSVAQSTSCWAGTGSGLILTESGMILETDSVSNLVDLYKVFDGGFDGDVGAYSLGLATCNEQGAISTLFASFDIYGIMGITAYLLPIFNIIIVISGVVGLSGMLGGDTNLAGLSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH9</accession>
    <name>A0A218NNH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH9"/>
    <dbReference type="KEGG" id="marh:Mia14_0709"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="407" mass="45254" checksum="CE0D499D5E2B1767" modified="2017-09-27" version="1">MAMADLNQDDLLIFKVRKKRESGSVNASPQPQSQGNPNSNINAGTNPNINFSKSTVQNKSASSNPVTNDNNKIPTNKPVQRPEINPVSKPESRPGSQPKFEQPKAYGSTYGAVQPETQTRPNTQSYESYQNQPQAGNYPTYQQPNAPQAPAFVASQMSDQQFNQALGSVMMDQSYMANEKHKETKAQLESRRMAANLMCVWHPWRPAYAICNYCHRPFCYEDLVSHNGNYYCLEDIDKVSTGYGQAGSKIFDSNSSEYLMLGSVLMILPIIIIAILASSQVSYLLEFIKTYGISALKLSANFSYLLLSVSLIFVLLQFFGGLFSFIDPKTGPKFGIFANILVIALFVYLSATYLQLYEILIAIFSFFSLMLVAYSIMVREPTGKSAANYHSNTDESIESTFANVGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK5</accession>
    <name>A0A218NNK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acidic ribosomal protein P0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820313.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK5"/>
    <dbReference type="GeneID" id="33314305"/>
    <dbReference type="KEGG" id="marh:Mia14_0753"/>
    <dbReference type="OrthoDB" id="30930at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="4">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="277" mass="30266" checksum="25AD3CEFA91DD973" modified="2017-09-27" version="1">MLTKQDKEKFVKEGVEKIKKYKVVGVLPLNSIPDSLLQSSRNKLRSDINFIIGKKSLLTMILESSEETKKLESELKGTSAIILSNENPFELYKRFSANSMKLAAKPNQKAIDDINIAEGETSLQPGQGVTELKSAGIDVKIDKGKVVISKSKVLVKKGDTISNLVAKALHTLDMKPFTATLVPSAIMYEHLKFGREALSITSDSLKIDIAHAFSAAYNLSLDAGFINLYTIKPMISKAYTEAMALGINAKIYDTGITEKLLEIAAAEAKSLNEKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK8</accession>
    <name>A0A218NNK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820294.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK8"/>
    <dbReference type="GeneID" id="33314286"/>
    <dbReference type="KEGG" id="marh:Mia14_0734"/>
    <dbReference type="OrthoDB" id="386591at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="392" mass="41592" checksum="F5C0CE15032FC0A0" modified="2017-09-27" version="1">MFGKNKNHGKFAIALLLALALIGSAYLFAVQTPIAFAGPAGYGASPNNANLVAANSGVEGYGLASRLNVQELSLVSPTGFASKWLALAFIFAISIIMVAVFVYEISNISNSTNGKMWARTQIYEAVLSIIMLLIFIGIGSILMVNPKAAYNSVGLLPFQCNTASINTIYNLSACDMGTFNSNVDSLIYIIYGFTFSSGLEPGFSVSVTPLGIEGQQKLWSVSGGISSFMPSSSLDIYSYVIVALITLLILNYVQMILLTGSLFFLAVFVSLGLVLRALGFSRSFGGSLIALGVGLGIIYPLLVSISYGFVVASQSAIVLPSFSAISSSDPLAIVSNFISYMFGGYLDSIGYVLVGLTFLPFLNFIILDSFMIDFSSAIGERIGFMSLMTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM0</accession>
    <name>A0A218NNM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820321.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM0"/>
    <dbReference type="GeneID" id="33314316"/>
    <dbReference type="KEGG" id="marh:Mia14_0764"/>
    <dbReference type="OrthoDB" id="206224at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049874">
        <property type="entry name" value="ROK_cs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964:SF149">
        <property type="entry name" value="BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="ROK (REPRESSOR, ORF, KINASE) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="307" mass="33886" checksum="0D14B311F858604E" modified="2017-09-27" version="1">MYYDINIVENESVLGFEVGASKTIALVGDLSGNVFSKIIADTRNEKDDKEVLFRQLKELQKKVSKKYDFNYVSMTFPGAINRKGIVAYTPNLPGWKGYNLMKGLKERFDSEVFVENDANAQAVAEKIYGYGRKYSNFIYLTVGTGIGGGIFIDDKLYSGHNGWAGEFGHMVIGEGPKCGCGRYGCLETLASGSAIKRMAFEAGKNMSGKEVFEAWFDGDKAAKAIVEKAASSFTIGIANIVNIFDPEAIIIGGGITKNNERYLGYIRKKLPKELGNYRRRIKIIRASENLIEKAPLALAAYRLNIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP5</accession>
    <name>A0A218NNP5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">Mia14_0795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 5">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820350.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP5"/>
    <dbReference type="GeneID" id="33314345"/>
    <dbReference type="KEGG" id="marh:Mia14_0795"/>
    <dbReference type="OrthoDB" id="134160at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002317">
        <property type="entry name" value="PRK01250.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="168" mass="19234" checksum="1DB3BFDDA2A2F36C" modified="2017-09-27" version="1">MNFSKQTDDFPETFYSFIEIPMGSGIKYEYKPELDNVVVDRFLFTSMVYPTNYGFALGTKAKDGDPLDILVISQQPIGSGNIIKCRPIGIAIMSDEEGSDNKVIAVPVDKVDPSFSSIKDIEDFPQYMKDKIKHFFEHYKELEKGKFMKFEKFDSKEVAIENLKESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ4</accession>
    <name>A0A218NNQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820344.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ4"/>
    <dbReference type="GeneID" id="33314340"/>
    <dbReference type="KEGG" id="marh:Mia14_0789"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="24324" checksum="A4277AD655CFD7B2" modified="2017-09-27" version="1">MLFKNEFISAVNSVINPKINSKHKSFSQIMSTYYKASIIPLIIAVVIGFAAGYLFGPFSFILRHRSAIAAGFIGGALNSAYAIIAILVIIPLSLIIYAAIYYIFADLALKIWKGSYEEVLVSFMYGNLLIVIFFFLVFIPIVSIAASIALSIWGIAVVSIVMGRQMKMDPWRAFGGMVVTGIVIIAIAMMLMMLLFGFAYLASSVGSGLSLSHLSKPPIAAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ5</accession>
    <name>A0A218NNQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820379.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ5"/>
    <dbReference type="GeneID" id="33314368"/>
    <dbReference type="KEGG" id="marh:Mia14_0819"/>
    <dbReference type="OrthoDB" id="300624at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="172"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="422" mass="47134" checksum="78DE8FF6C2E3D9BC" modified="2017-09-27" version="1">MDNNINNYQSLREDAISMQKSGRASQNYLRDILYKKYNFKIQLLPPNGNAIAASSDYAKYESILGIKFNVRITGGLDVVNDMPNEVEVYTPGSFNIQRKKLFDNSDLYAAFVHAFSEKIIYIRPKAGKPVNIILDYSHNLYPIQLIIDSSSKELSTINEIILSGKSDDLPPAVIMHEVSANKDSSLEFNIMHLGGDSGVVSMLRANADEYSKLDINEIYAGNSFTKEESRIVSAAESAEVNIRKTVAGSMNQKFDLMSDLVNAERNTKCDSSLNVIASGSSVCYAKDFAEVREGAEKSVSHISQRGIIRDSTASLNMMPDMSINESYTKASHYSYSSPIDKDELFYLESRGMSEEQAEHLISLGFFSTNVGKIRDREVRNSAISILDYVLSKRDYHIPKGLKPIEWDFYGGMGIIEGIKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ7</accession>
    <name>A0A218NNQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_269799405.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ7"/>
    <dbReference type="GeneID" id="33314369"/>
    <dbReference type="KEGG" id="marh:Mia14_0820"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD N-terminal" evidence="3">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="208"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="471" mass="52614" checksum="B456697540678102" modified="2017-09-27" version="1">MSDLANSVLQEEKEYAEKYGFSDKLAYDEMKVGISEDVVIHISKLKNEPEWMLKKRLLGYKIFKDKPVPNWGPDLSQINYDSIYYYKKPKSSQNSDNWDKVPEEIKRTFDKLGVPEAERKFFAGGAAQYDSEVVYHHLKDDLEKRGVIFTDMDTAVKEHPDLVKKYFGSVIPPTDNKYAALNTATWSGGSFIYVPKGVKLSLPLQAYFRINAESSGQFERTLIIADEDADVTYIEGCTAPIYINSSLHAAVVELVAKKGAHIRYVTVQNWSKNVYNLVTQRAFAAENARVEWIDANIGSGANMKYPSVYLQGEGAKGEILSIAVAGDSQRQDTGGKVYHLASNTTSKIISKSISKGTGITTYRGLVHIDSRARNARSTVKCDALLLDENSKTNTYPYNEIYADDAFVSHEATVGRLGEDELFYLMSRGLSEDDAIATAVLGFIQPLVEVLPMEYSLELKRLIKMDTSNSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR9</accession>
    <name>A0A218NNR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L41e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR9"/>
    <dbReference type="KEGG" id="marh:Mia14_0833"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="37" mass="4777" checksum="8311B3C4013F283C" modified="2017-09-27" version="1">MGSIPRKWKKKGRMRWKWKKKRRKRLKRAQKRRVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS3</accession>
    <name>A0A218NNS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS3"/>
    <dbReference type="KEGG" id="marh:Mia14_0831"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="164" mass="17896" checksum="330F71B09F91ED93" modified="2017-09-27" version="1">MKVIAINFKSKRLRILKDIFSKPLYLAILVVAGFLYYFLLYTIIKMSSFHGIIILTAPLYMFYLLVATSAVLITISIYGIRKRIAIKDATAGGVVSVVMPSVGGLVAGCGCSAPLLSSLLIPVLGSIGAESFISYLSAYNIYIFGVLVLINLIIIYYQLNLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS6</accession>
    <name>A0A218NNS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820428.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS6"/>
    <dbReference type="GeneID" id="33314402"/>
    <dbReference type="KEGG" id="marh:Mia14_0856"/>
    <dbReference type="OrthoDB" id="55547at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="291" mass="32382" checksum="734597256B4EC9CF" modified="2017-09-27" version="1">MGSRKNELIMSGAVIVSKDGNVLKTKINNYKTPIKVSPKIPTPNVIANSGLKNMSLIFSDKTQGYHMAFREMNYDITEKQVVQSGKAYSLYFEITDDEDTTYLEGNIIPLESNKGVLFLSVNVSPKNPENVDLFSLPIVIRYKGSFLSIIKDLSSIISNLKKDASTKRNRIYGKMVSLLEAFPDIYANNRNRLDIINNLELSFKVTLMDFNFTCCLENALSLTDCVLSVPDIEEICAECLVLPDCLAACFDFLTLPACLVCFSLDVLACAYCVYKAGECTEDAIKVIDCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS8</accession>
    <name>A0A218NNS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS8"/>
    <dbReference type="KEGG" id="marh:Mia14_0852"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="123" mass="13144" checksum="CBB35F6651D2E670" modified="2017-09-27" version="1">MCPPLACTPSTGPHASPPIKIHPVLLTQSTPLLIYGSHSFSERAPPLLRSSGVVSCARRSWCMCGATHHRFAWCSTPPTADAYTTRSCFAGLPARFGHIILSCGVQYRGGGLRGCLTAQCRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU1</accession>
    <name>A0A218NNU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820438.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU1"/>
    <dbReference type="GeneID" id="33314410"/>
    <dbReference type="KEGG" id="marh:Mia14_0864"/>
    <dbReference type="OrthoDB" id="55537at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="60" mass="6763" checksum="59F86213D5A5EA43" modified="2017-09-27" version="1">MEKADVDITKVKSTFASKFPEHPLTKILISEPDYLTAEEFLAKVQTWLAFFNGDGEDGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV1</accession>
    <name>A0A218NNV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216907.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV1"/>
    <dbReference type="GeneID" id="33314376"/>
    <dbReference type="KEGG" id="marh:Mia14_0827"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="929" mass="104880" checksum="B6040C3D75C44A7E" modified="2017-09-27" version="1">MGGKRSVPKGTYNIFSLGDMGGAQAYMSERNLIGMSRYLRGLDNSNLPNVLILGGGVMPYFPTKGSTANNNYLDTIVPKLNSILDSAIYMKPHLNRMLSLLPKETKIIYTLGDEDRKNILEIQRSLGLAYKNDMEYLEKLISDENLTVNSRVEILKGIDTSKAKFREMLAKDKNEQSKYDRDMKELQNIKVKEGINREEKKEAEERRDLLKALYTLKVQESDPSDGKFDKYLSQKKEEMSKILEEMKNVTDSDKLAELSAKSKAISNSIRVMGNKMKEKSSTNEQYKSDMRNKSVDNYTGNSLTDHRSHEIINKLSESYYLSYLKDAFGRKRKLTLQNEKVDGMIIDAGRGKFNLITAYSLNVILGARSIGSNNKIVGKLDILANNGLNAEKINPKLDNILVTSKNNNSSFTIEPYRDRSDLLTFALAQGPFTDPGKVTSKWNEWVNTKYTQSVQKGIVSNGFTILRVSDPGLPVKYETKTSDMLFELYVDEMKEQYKVLNKRWSIVKDQDIQFPLNGVSNADLEYYVAMNKLPSELKDWELKKYYPLIKAKIEDDLKASMNAERNPEARRELEMLFSQSSADVKSNNENNKLVIALINDIHISNNLLYELLEKSIEDLIKKEPDILVLGGDILDGFYKNHGAEPHINNSSYHVEKVKDILRKDSADTLNEFYKMKSEQLYFNIDEQVIFLLDKLEDLVYKIAEKGGTVITISGNHYNKTEGQGHRDESTVIANSLRQRLQGYLDGIRKAGGNAELEKNLEKAIYGITAIVGGEFGAGEKNINGLKVYLSHEMGTSSESSLVKYIMDKRPDRPGAFISGHDHIAEAGFVGPNLFVKGPSMQESDSSFMNFLPIPVGDYPKGAINGYTLIELDLDRDSRILDSSIEYVLARNLIRSDSPSAIISKANKKADNISVNYHNQGDKEKSKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV7</accession>
    <name>A0A218NNV7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="13">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysS</name>
        <name evidence="16" type="ORF">Mia14_0836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891462.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV7"/>
    <dbReference type="GeneID" id="33314384"/>
    <dbReference type="KEGG" id="marh:Mia14_0836"/>
    <dbReference type="OrthoDB" id="9445at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="14">
        <location>
            <begin position="14"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="15">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="13">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="484" mass="56621" checksum="45DDC1756F794548" modified="2017-09-27" version="1">MKVYNTLTRSEEEFVPLNDKTVNMFVCGQTPYDDAHLGHARNYIIFDVVARWLRHEGYKVNYVQNITDIDDKIINRAKEQGITAEQLERRYEKRFLEDMEVIGVKKDITKYARSHDYIEAIRQQIQLLLDKGYAYYLDGDIYYDVDKFKDYTKLSGMKLEELKNHRVEPKEGKKNVYDFALWKAAKPGEPKWDIKLNINGKEMELQGRPGWHIEDTAITYTLFGPQYDLHGGASELIFPHHTNEIAQAEAAFGKKPFVRYWLHVGVLNINNVKMSKSLKNFITIRDALAKYDPEALRLLMVSANYRKEINYTEKMMEDSQGKLNYMYNSFSILYNYHKIISSKGSDESNLINEFKKFEKEFTELMNDDFNTSVALMKLIAILTTVRAYLESHDGITQSSKDSLIKGILEYANIFGILENTYYKESIPEGLEDLMKERDRLRKSKNYAEADKIREDIKQRYGVLLEDTEYGTVWYKKRAQESTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW0</accession>
    <name>A0A218NNW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820463.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW0"/>
    <dbReference type="GeneID" id="33314429"/>
    <dbReference type="KEGG" id="marh:Mia14_0886"/>
    <dbReference type="OrthoDB" id="385331at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="159" mass="17819" checksum="890E7E2226896C75" modified="2017-09-27" version="1">MNYDATRRNRMGTPSRLGVNLILLEFFLLIIQFVIGMWMNLFAVFPSFGQSFFMYGMMQVMFSVPELMVHMMLGIFIGLVSLMIFFVFAMAGDYRLSALSAVASISILTAGIGGLEFMFSGFTNNIFSFLMSLGFIFTIVAYASILYMISSSDRRTGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY7</accession>
    <name>A0A218NNY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ACPSF2 family 5'-3' exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820493.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY7"/>
    <dbReference type="GeneID" id="33314462"/>
    <dbReference type="KEGG" id="marh:Mia14_0925"/>
    <dbReference type="OrthoDB" id="40950at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF52">
        <property type="entry name" value="MRNA 3-END PROCESSING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="229"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="419" mass="46502" checksum="31989D1F708D9361" modified="2017-09-27" version="1">MNIRILGAGQEVGRSAIMIEGEKKLMLDYGVKLENNVPELPVAMPNVDGIVLSHAHLDHSGAVPTYYRNKRVPTYGTSSTLSLIDLLLEDTIKIAKKEHTMPIFSKKDLGKMSNNYVNLPYHRKIDINPWKLKFYDAGHISGSAISEIERPKAKSYNKIVYTGDFKLQPQLLHYGAEMVKSDVLIIESTYANRDHPDREELISKFIAEVKETIESGGTALVPAFAVGRGQELLTMLYKNGLADVTYVDGMIRKATHLVTEGEERIKDAALLDKAIAKSSWIEEAKDRNEALSTPSVILTTAGMLTGGPVLNYIQHLNKKSKIFLTGYQVEGTNGRMLIDQKKIILDGELKDISTPVSVYDFSAHSGKTDLYNYVRESAPNVVVCVHGSEENTKLFAETLRGEGFEAYAPKVGDKIELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP24</accession>
    <name>A0A218NP24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820523.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP24"/>
    <dbReference type="GeneID" id="33314492"/>
    <dbReference type="KEGG" id="marh:Mia14_0956"/>
    <dbReference type="OrthoDB" id="31129at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="81"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR02236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="316" mass="34314" checksum="FA67B552B6829B9F" modified="2017-09-27" version="1">MVKDKVVREIDDLPGIGEATAEKLRNAGIDSLDKIAVYAPHDLADLIGISPEAAKKAIAAAQEATTINYSTGNEVDSFRRELGKISTSSKNLDELIGGGIETKAITEIYGKFASGKTQIGFQLSVNAQLPKEQGGIEGNVLFIDTEGTFRPERIESMATSKGMDPEKALENIMVVRATTTDQQILTVERADKLIVEKNIKLIIVDSVTALFRAEFIGRGALGERQQKLNSHIHKLQLLADKYNAAIYITNQVMDNPGILFGDPTTPIGGNVIAHAATTRLYIRKSKEDKRIVRLVDSPDMPDGECIIRVTPGGITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP30</accession>
    <name>A0A218NP30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820479.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP30"/>
    <dbReference type="GeneID" id="33314447"/>
    <dbReference type="KEGG" id="marh:Mia14_0909"/>
    <dbReference type="OrthoDB" id="87545at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="147" mass="17409" checksum="9A236DA63F707FD3" modified="2017-09-27" version="1">MRIVRVKENRIKDVKALSQKYEFEVNRDWDNLLNGKETEIYILVDKGRTIGFTGLIHNDWNETLQILDIFIDPEIRNRGYGRQAISFLLGNAKRMHRYRCIIAEAPAKDNIDKFYAKLGFRKCGYNDRYYTNDDNGDIAIFMSYDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP32</accession>
    <name>A0A218NP32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Mia14_0961</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.</text>
            <dbReference type="EC" id="2.4.99.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820528.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP32"/>
    <dbReference type="GeneID" id="33314497"/>
    <dbReference type="KEGG" id="marh:Mia14_0961"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ASI14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122331" checksum="91C1A84DB9C5BE28" modified="2017-09-27" version="1">MSAVLAIIVAFITLFVPGELLALALLRKTKLNLVDISIIGFVFGLVATPTMTWVEAYLIPYMHFFTFSLGLFEANALVLTIIGIILCFWQGVFSFSKLREFTKPKVSDKSLYQLSIEDIRSKLDSYDEGKKMVENHKTDESESLRHYEDSLEKLEGEEKINFEKEFRERNSTMMLDHKQEEMSLLEKLSAPKQANNGSNQTNLADKIKTHWVYEVLILLIIASFVIGMESEVIAPVFFQFDPYYYMIGTEALLTYGYQPQYTYFAWPTISKGVITRAQPLLPYLEAYWYSLANYLGPHYTVLNNALMSYTSSFYPPIVGAILVFVIFMMLYKEYGKYIALIGASLAATMPVLVTEFTAGQQLTEPWGIFSLFFFFMAYLLAVKDKNSVRLAIFAGVAFAFTFLGAHYYTVDMGVLAVYIIFEGIIDLAARKGIPKGFYKMNIIVLITIAVFLAAYTPYHATFSVNVPKILGIPLTVSGPALALLLVAVLDYGPKLLNKYNILFKKIDRTAYIEWIIAIAVIALIAMAFTPLGKPIIKVLDISKKFTSPSSALFMTVAEYEPSGLLYNFGAAGFGLVGSSIFGVPIMVWLVSAISVLLILVSIAYRRSETGVFYLAVALPLMYVGFIEVEYLPHFGIAFILLFCIMLGEILYLIASKFKLKQEINISNLSDIFKENKTYVYSVLIIGLFFVSTILAIIALLILIFKYSYKNKAMYSLLGLFLIIVIAGSLLKGSLLQGESSSFTSAIVSQAYYSAGNTTAACNNEMGADFFCNTVPTYWISFGKWLSANVGPNAPRVLSWWDYGDWINFFGHSNAVIRGDNANATEDEAVAASYVLGPKYGFNTSEMANMMNTNQTAYAVFDQGLIDKWGALDFLGCVYVNGTSEAYAKAAAAGTGQPYVLGTSPCEIEHDPEYVLVPYVVLDPYYSSGPSLSDYCSFSTSSNQFARIYTITNQSINSQYECMSEVPNSNGAVQLYTSNDTPTNSYINLQDNIGIQYLNISGVETPFEEYMAIYTPNGPNGTITDAPTQFYTSNFYKGFFLNELPGFHQVYSYINDSKGTNLVNYTDPLKAFELNNFTGKLPPQVPKPSYVHNNYTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP41</accession>
    <name>A0A218NP41_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ORF">Mia14_0979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820542.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP41"/>
    <dbReference type="GeneID" id="33314515"/>
    <dbReference type="KEGG" id="marh:Mia14_0979"/>
    <dbReference type="OrthoDB" id="68499at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="48"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="331" mass="37668" checksum="762E7F5270696AFC" modified="2017-09-27" version="1">MSEMPQIIKEKMTHQGYHFVGKHSAVKICEYTANGIEGKTLCYKYTFYGIHSWQCIQATPAIGCDLGCKFCWRLIPEEIGVNWNELNAVDHWDDPDSIVDGMIKEQLRIVSGYKSGADTNLKKKRWEESRYPRHVALSLTGEPTFYPKMSGLLKAFHKKGISTFLVTNGTLPEAIAKMDPLPTQLYISVEAPDKETYVKVTRPKIPDAWDRYMKTLSMLKTLKTRTVFRMTLVKGLNMDNIEGYASLVKFAMPNYVEVKGFSFIGGARNEARGLNLSSMPSHEEIKEYAHKLSELTGYKEVSEHKPSRIMLLCRDEESAKSRIIDFSKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP44</accession>
    <name>A0A218NP44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820541.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP44"/>
    <dbReference type="GeneID" id="33314512"/>
    <dbReference type="KEGG" id="marh:Mia14_0976"/>
    <dbReference type="OrthoDB" id="31247at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="MJ1210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00162">
        <property type="entry name" value="proteasome assembly chaperone family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="255" mass="27975" checksum="A4F2F34A69FAA39A" modified="2017-09-27" version="1">MKNTFIKYKKGVKLKSPILIVGLPGIGAVGKLVATQMIKEFKGKRIATLYSSHLPPRVIMLKNGKVRLVSNRFYLLKTKTKNDIVILTGEDQAVTPEGQYTVNNEIVRFFKSELKGKEIITVGGYNISGNYTDSPRVLGNASSDKVIKEFKKAGVVFGESRGTIFGAAGLIVAFSKMQKLDSICIMGESSLIDMDPNAAKAVLKVLSKKFSLNIDMKKIDSMIEATAKMIKELESQMSSNAALPPESKENSSYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP48</accession>
    <name>A0A218NP48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl39e</name>
        <name evidence="5" type="ORF">Mia14_0933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820501.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP48"/>
    <dbReference type="GeneID" id="33314470"/>
    <dbReference type="KEGG" id="marh:Mia14_0933"/>
    <dbReference type="OrthoDB" id="65887at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="57" mass="6934" checksum="CBCB8170F0247AC4" modified="2017-09-27" version="1">MSKKDITKKRRLGKFLKQKRRIPVLATIRTKRRLESNKFARDWRHTKIRSKVDLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP49</accession>
    <name>A0A218NP49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF981 superfamily multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820552.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP49"/>
    <dbReference type="GeneID" id="33314526"/>
    <dbReference type="KEGG" id="marh:Mia14_0990"/>
    <dbReference type="OrthoDB" id="57193at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009324">
        <property type="entry name" value="DUF981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06168">
        <property type="entry name" value="DUF981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="187" mass="20096" checksum="9863B5BD7EBCCA74" modified="2017-09-27" version="1">MAFVDSLAVMLLAVAMSAAFIAYYLVGIAKGKKMDSLAGPIFMLGIFDFLSGFYMSFFWPLPGAYNMLFGDPMLMLGIIMIAGGFAIYKNTDGRPISLIGFFLGIYLFAESYGMVAYHLEAGAELLSALGFYLVSGLSGFLSPLVYLKSKNNNKKAYYLLAALLVLVVLAAMFIGTAAIIGHLSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP68</accession>
    <name>A0A218NP68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820549.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP68"/>
    <dbReference type="GeneID" id="33314522"/>
    <dbReference type="KEGG" id="marh:Mia14_0986"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121:SF6">
        <property type="entry name" value="SLR6007 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="580" mass="66227" checksum="1FBC858966146997" modified="2017-09-27" version="1">MIYKKFRRIFGFGLCRKRSAKSENIFALDFGKKLGTLHRYEKVAFSFYGKSSLIYEYGWKNADGSLILDMEKQKNLNILISGASGSGKSTLLKDLLIQMKDKVPILLLDPNGEHKELVELLNGTYRDSDYSGINPFGLDGISVNDRISELFYLFSTVLNLGSHQSYRLNSILRYVYRNKGVVNFDLPELPSTPNMYDLLKEINTFIDNSRSKPDSYSLENMKNKFELINRRSLNDSSFDVKSLLKGTNGINLAKLNNKNLRFIYLHELFSRIYQHMHSLESKGGTKLYIVIDEADTLLDEDIYMKVLSKFFEEGRKYGFGIIAVTHESSSLNKQIIANSNLTLSFQSKEPTELNYLSNIFSGSINEKNNVIKAALSSLNTNEFIIHDPVSKGLFKVKGKSYNEISKSIFNSDFAGYANLLYRYAKYPVELNSLLTHLPLESISYGLKNGIISKYLYKGKLYIMANKSNLSIEHEISVNEIMNYLDLVRVRNFKGTGRGKPDIVAYYNGFRIAVEYETGKKNFGSSKRMIEERIKHYSAVIVVVHEKSYQYYRDYLKLNDVHVVPSSNLQAIESIIKSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP70</accession>
    <name>A0A218NP70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820572.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP70"/>
    <dbReference type="GeneID" id="33314548"/>
    <dbReference type="KEGG" id="marh:Mia14_1013"/>
    <dbReference type="OrthoDB" id="42691at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="262" mass="29604" checksum="19770A5096B43D88" modified="2017-09-27" version="1">MALDSFNAFLSRTNGIGTLDLVKKGNLYDITDSEANSFYDEIVVPKLNQLKGLIYYSDIIRSIISGRYEAMAGNFRSAEENNRFIIERGCLSEFVEGTNKKYDEALKDMDWHNMVDRGYIISSFAEAMRRIRTLDPRVKELDSKSIFLAGKAVCKEHLEFPFYSITIKAFGGLKKVRCRCGNEADYLTLAMPKVSALIELASFITNANPNSLYSVYSNLSRVVHPYGFTDFPKGKSYALWLRDLNLILSSILNLHGVSKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP82</accession>
    <name>A0A218NP82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_1004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820565.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP82"/>
    <dbReference type="GeneID" id="33314540"/>
    <dbReference type="KEGG" id="marh:Mia14_1004"/>
    <dbReference type="OrthoDB" id="10460at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040865">
        <property type="entry name" value="PriX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033412">
        <property type="entry name" value="primase_PriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18689">
        <property type="entry name" value="PriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Primase X" evidence="2">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="332" mass="38304" checksum="D255EF133CA82F89" modified="2017-09-27" version="1">MYSSEDLNFAYRYPFTDIAKQIISSLNLTSIDFKYLELGKERAISDIKGDLPYYDILIDSIKLDEIISYAYAKMMVMALKRPDYVEKFSVSESKRALQAMEKDSEQDIFKLSSSLGITLHKDQNDNFLIKFNVYLHNIPNDPFFALSNQQLHNGLVIISFNKLKRLLERASYNTIKESFNYEEKVKLPKEVMDYSKGIRDETKVVIKGKNNTAWIEKLLETPITDVRHRTVNLILAPYLVNIKGLSVDDAFKVITDYIEKCKTVNPDTKINETYIRYQIEYAKSKGTKPLKFSNAKELLSGLIDFDVRAESESKDSDKDKTKKGKNKQGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP89</accession>
    <name>A0A218NP89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_1017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820576.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP89"/>
    <dbReference type="GeneID" id="33314552"/>
    <dbReference type="KEGG" id="marh:Mia14_1017"/>
    <dbReference type="OrthoDB" id="9194at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22015" checksum="7D506B908DE6B446" modified="2017-09-27" version="1">MKDIEGKKVYETPDEIMDKSHTALIVWDVQNMLVNSIFNKEEFLKNVNALISRAREAKMPIIYTRITPLSKKFQPKPSLASNRSFDGMPKDALELAVTPSEDEVVIHKNTASLFIGTNAEMLLRNAGVESLIFTGIATEYGVESSAREAVNRGFYVVVANDAVSSQDKESHERSLLNMQRLIKELPTSEILKAIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP92</accession>
    <name>A0A218NP92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl34e</name>
        <name evidence="5" type="ORF">Mia14_1024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820583.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP92"/>
    <dbReference type="GeneID" id="33314559"/>
    <dbReference type="KEGG" id="marh:Mia14_1024"/>
    <dbReference type="OrthoDB" id="43096at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_eL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047868">
        <property type="entry name" value="Ribosomal_L34e_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="107" mass="12017" checksum="C1E8ADE33E8ADA61" modified="2017-09-27" version="1">MPKPMHRSHSFRKLKRVTSTGKVVVHYERKKNSLPHCGLCGVELNGIDQDLKGGRSRRTNSRLFGGVLCANCTAKIVTMRSRIEQGDMKLDDIGIKEKAFVLQLVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA9</accession>
    <name>A0A218NPA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820558.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA9"/>
    <dbReference type="SMR" id="A0A218NPA9"/>
    <dbReference type="GeneID" id="33314532"/>
    <dbReference type="KEGG" id="marh:Mia14_0996"/>
    <dbReference type="OrthoDB" id="27149at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="182" mass="20101" checksum="506D70817C791E37" modified="2017-09-27" version="1">MIDFGKFRIECCNGVYCPSDDSFLLGDIVEEYSFGKVLDLGTGSGYLGIIAALKGDDVTFADIDTNALECARQNVALNHLEGKFVETDLFSGIKGKFNTIIFNPPYLLSDKLVDKALDGGFDGRQVIDKFLSSVGNHLLTENQVLLLESSLNSYEKDAKELSAEVFEKNLFYEKLAVLKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPB0</accession>
    <name>A0A218NPB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNHCP family predicted zinc binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820594.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPB0"/>
    <dbReference type="GeneID" id="33314571"/>
    <dbReference type="KEGG" id="marh:Mia14_1036"/>
    <dbReference type="OrthoDB" id="102288at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024439">
        <property type="entry name" value="RNHCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12647">
        <property type="entry name" value="RNHCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNHCP" evidence="1">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="106" mass="12230" checksum="1980E9AF0D1BA46D" modified="2017-09-27" version="1">MDGLEIKRFQRVVEDFHCEHCGTYVKGNGYTDHCPNCLWSRHVDNNPGDRACKCKGMMKPVSVIYYRSGRFKLNYVCTKCKAKKSVYSASGDNQESLERLINRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLI8</accession>
    <name>A0A218NLI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the Lhr helicase family. Lhr-Core subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819519.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLI8"/>
    <dbReference type="GeneID" id="33313563"/>
    <dbReference type="KEGG" id="marh:Mia14_0001"/>
    <dbReference type="OrthoDB" id="372104at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17922">
        <property type="entry name" value="DEXHc_LHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="Lhr-like_DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF5">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="WHD_Lhr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="237"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="915" mass="102891" checksum="0608AB661F0B0E6B" modified="2017-09-27" version="1">MSIYENFISKYQKFTPIQEKAIPIIAGGSNCLVIAPTGSGKTEAAVLPIIDRASKINGEGIKILYITPLRALNRDMLGRLRWMADLAGLTIGVRHGDTSNSERSKQVRSAPDIIVTTPESLQSMLPTKGMGVKLANVKFVIIDEIHEFYFNKRGAQLSLGLERLEEKAPNFQRVGLSATVKNPDLVKGYLAGLRECKIAQISEGKNFSISIKMPEKPKGNMSQIIDKFGLDEPSAARLECIADEIEESSSTLIFANTRQIVEALGSKLLYLDKIHPFGGIGVHHGSLEKDERIEIENSFRDNKIKSIIATSSLELGIDIGSINKVIQYGSPRQSLRLAQRIGRSGHSISKTSDGTIISTGIVDTLESVAVIDNLKAKELESFEVQKNALDVLANQVCGIILDKNSCSIDEIYTIVRRSYNYLTMEKPALENNLRFMDSLKLIGFDGKTAVATSRTRMYYYDHLSVIPDSHRYRVRNIANNKIISTLDEEFVSNNIDENSIFITKGLPWRVISIDKDTIVVEPSSNLDAAIPDWSGEDIPVSYSVASRMRDIIGRNELGNYIDKSLYGKAEKFIEDQAEHWKPSSDKVMVEMYDNYTILYTWLGTLANDALSRLIAKYLTMNAGHSINIKSSPYLIFFDVSDEIAIKSMLLGIDPVSVYQKLKESITETDFFRYKFTRVAKIFGIIDRDAVMSKSLTKHIISTLIGSPVYEETLREIIENYFDIKNLIGFFKRVHSRNAEVVFKNIKKQSPLTKAILKSAYYNKELIMPLMPNDELVNSFSKYTLDKKANLICTYCGFEFKRNLSEIIDEGRILCPTCQSPMVTINTNGYINVIKKIKEKKELTETDKRVRMSMMADADLVYSYGGRAVAALSTYGVGHRTAARALLMQRTSKEKFFVDLIEAQKQFIKNKKYWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN3</accession>
    <name>A0A218NLN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819538.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN3"/>
    <dbReference type="GeneID" id="33313584"/>
    <dbReference type="KEGG" id="marh:Mia14_0022"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="65" mass="6995" checksum="236B93E48E898C92" modified="2017-09-27" version="1">MTETKKKKSKVTKKAAKKVAKIVVKKATSMAKPKKAASKPKAKKAQKPASKTVAKKAKSSKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP1</accession>
    <name>A0A218NLP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease P protein subunit aPop5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819561.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP1"/>
    <dbReference type="GeneID" id="33313607"/>
    <dbReference type="KEGG" id="marh:Mia14_0047"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="114" mass="12864" checksum="4D1FC3275F155B90" modified="2017-09-27" version="1">MREKHRYVLVKSSETIKALLGSEYTKDPGKAFSKLMNRYLLFELGDVHYSDANPQVAAILDDKTFILKVLLNGFRDSVIGLAFINKVNNIPVSFTTLKSSGTIKSIKTYYKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP2</accession>
    <name>A0A218NLP2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP2"/>
    <dbReference type="KEGG" id="marh:Mia14_0034"/>
    <dbReference type="OrthoDB" id="25810at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_eL8_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR03677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="140" mass="15087" checksum="3B655C8ECBED40B6" modified="2017-09-27" version="1">MAEVSKEILDNTYEALQSVKQSGKIKKGVNETTKSIERGMAMFVAYASDVQPAEIIAHLPKLCEDKKVPFIEVPSKLDLGKAIGLNVQCSAVSVENAGSAESSLKSIISKITGKSSEKKESQAKEAKKEEAKESASEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ6</accession>
    <name>A0A218NLQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819577.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ6"/>
    <dbReference type="GeneID" id="33313624"/>
    <dbReference type="KEGG" id="marh:Mia14_0064"/>
    <dbReference type="OrthoDB" id="31282at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815:SF1">
        <property type="entry name" value="DUF373 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF373 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="45587" checksum="43FAB578E9B7EB19" modified="2017-09-27" version="1">MSDRLLVLAVDIDNDLFQKTGINGPVVGREKVLDAAAKLTLADPLDSDGNTLFEAVKKYDELKEKDYEVYVAEITGAVTENFLADEEISRQIDQLMNELKVDACVLVTDGASDNRVLPILKTRLKVNSVDYVRIKQAEGFENTYFTIMEKLKEPHYARIVFGIPAILILLFSISYYFHLGIAFPFVLIGLYLIIKGIGADTILIDSFTSLGMSIKRISFIFYIASILFAISSLIVGYSSYISSITSGNSVPVSYAYSIEGILLLFPISIVLYIIGRIIDLNNLHMYYRVINQGVYIGYSVITLSLVYVFSAWIIGQIYFSQLIGYAILAFIIGYAVTELTFSFKRHVVKGLKLKNKVVINELGTYIGKVYNINIRKSKMSVKTDYNLTLTFDIDRIVGISDRVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ7</accession>
    <name>A0A218NLQ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819567.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ7"/>
    <dbReference type="GeneID" id="77386053"/>
    <dbReference type="KEGG" id="marh:Mia14_0053"/>
    <dbReference type="OrthoDB" id="372011at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="91" mass="9989" checksum="037C4CDB8DF0A5BC" modified="2017-09-27" version="1">MSSGNIRYGATIRKRKRAVTQQKIALYKCESCGKNSVERISTAIWRCRHCGKIYAGGAYTFTTAMGAISKHSLDSVGKSQRTAVQDSSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR9</accession>
    <name>A0A218NLR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein L5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819583.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR9"/>
    <dbReference type="GeneID" id="33313630"/>
    <dbReference type="KEGG" id="marh:Mia14_0070"/>
    <dbReference type="OrthoDB" id="372044at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="172" mass="19283" checksum="1E04CDC23779DEFA" modified="2017-09-27" version="1">MSDKNSMKDIEIDKVVINIGSGSDSKLQDNAKRLLEKITHMKPADSLSKRRNPTFKISKGTKIGAFVTLRGKNASTLLPKLFEAADNKLKPKAITTNTINFGIREYIDINGIKYDPSIGMLGMNVNVALKRPGFRVADKKIKRGKIREHHKKISNEEITEFVKNKFKVSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT6</accession>
    <name>A0A218NLT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820597.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT6"/>
    <dbReference type="GeneID" id="33313650"/>
    <dbReference type="KEGG" id="marh:Mia14_0090"/>
    <dbReference type="OrthoDB" id="42776at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="140" mass="15732" checksum="6F1E20E16F3300C2" modified="2017-09-27" version="1">MEFGSDDERERFILGNFKVIAVVGCSREEGKPSHDIPKYMQEAGYKIVPVNPNADEILGEKSYPSLLDIPFKVDVVDVFRPGSEALEIAKEAHSIGAKALWLQEGIFNESAEKYAEDNGILFVMNRCMMKEHVRLIEGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT7</accession>
    <name>A0A218NLT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo7</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo7</name>
        <name evidence="4" type="synonym">rpoE</name>
        <name evidence="7" type="ORF">Mia14_0092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819603.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT7"/>
    <dbReference type="GeneID" id="33313652"/>
    <dbReference type="KEGG" id="marh:Mia14_0092"/>
    <dbReference type="OrthoDB" id="7927at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04460">
        <property type="entry name" value="S1_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00865">
        <property type="entry name" value="RNApol_arch_Rpo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046399">
        <property type="entry name" value="RNApol_Rpo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006333">
        <property type="entry name" value="PRK08563.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="199" mass="21810" checksum="B7119869FB9A986E" modified="2017-09-27" version="1">MYKVFSVTDNFKLPPSEFGNDINKVATHILQEKYEGLLDPDVGIVLAIYGIKDISDGIIYPGDASTHHKVNFSILTYKPEVDEVDIGIVTELVDFGAFVRMGPIDGLVHVSQITDDFISLDKKVNSFVSKNSGKSLKKDDIVYTKISTISMKKSIKDSRIALTMKPYGLGKVEWILAGSKKKESPKGGKPAVAAKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU3</accession>
    <name>A0A218NLU3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819605.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU3"/>
    <dbReference type="GeneID" id="33313654"/>
    <dbReference type="KEGG" id="marh:Mia14_0094"/>
    <dbReference type="OrthoDB" id="8615at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054016">
        <property type="entry name" value="FKBP26_IF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048261">
        <property type="entry name" value="SlpA/SlyD-like_ins_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861:SF3">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22199">
        <property type="entry name" value="FKBP26_IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="244" mass="27413" checksum="724707FDFF5A69F5" modified="2017-09-27" version="1">MSFKEKDFVEINYTAYDAEKGNVLSTTYKDKAKEADIYDEHVNYGPTLIILGSHAVVPGLEKELMNMNEGESKTFTLEPKDAFGERRKDLIGVMPISQFRENKIDPQPGMQINLDNSVATVVSVGSGRVVVDRNHPDAGKSIKYEVEVVRQLKDEKEKIEGLAKTYSVQPSRVEKEGDKFVLYYDPKFKKNADYFIGKANALSAIFAYVDGITKMNVVEEYENSAESNASEENSDTEHNEEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU6</accession>
    <name>A0A218NLU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the Lhr helicase family. Lhr-Core subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819592.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU6"/>
    <dbReference type="GeneID" id="33313639"/>
    <dbReference type="KEGG" id="marh:Mia14_0079"/>
    <dbReference type="OrthoDB" id="372104at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17922">
        <property type="entry name" value="DEXHc_LHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18796">
        <property type="entry name" value="SF2_C_LHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="Lhr-like_DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010338">
        <property type="entry name" value="PRK13767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF6">
        <property type="entry name" value="LARGE HELICASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="WHD_Lhr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="41"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="281"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="895" mass="102298" checksum="99A03ED73198AF87" modified="2017-09-27" version="1">MIEFVEKPFSDEESLSVLNKYVREWFTSNFSELTPPQKFSFKLISEHKNVLITAPTGSGKTMSAFVSILNDMFNRSLSNRLDNKIYCLYISPLKALNNDVLRNLTKPLEGIYETIKKDKGLEIIKENIKSVTIGVRTGDTDAKERRQQLVHPPNILVTTPESLAILLNSEKFLHNLDSLEYVVIDEIHELANNKRGAHLSLSIERLVNQLGKDVNRIGLSATLYPLDEAAKFLVGLKGGVPRQCYVVDASWSKKLEVKSISPVKDLLYTPPEEVETAIYDEINSIIKKSKTTLIFTNTRSGTERVVFNLKRRFKYTDADIGAHHSSLSKESRINIEESLKKGNLKCAVSSTSLELGVDIGDIDNVVQLGSPKSVTRAIQRIGRSGHSFREIAKGEIIVVNRDDLVECSIMLYAALKHHLDSFSIPMNPLDVLAQHIVGMAINKVWKVDEAYEVVRQAYPYSTLEKEDFISLINYLAGNYVGLESRRIYGKIWYEEEKQEFGKRGMYIKPIYMLNIGTIPDSVAISVYLKGTKEWIGNLEEGFLVRLKPGDIFTLGGKLYQFEYSKGMSCYVSKADSKTPTIPPWFSETLPLSYELAVEIGEFRRRFTEMIKPYTKYSKAKLQKIIKGKTLPKDADEVLSKLPINSYAKYAILEYFMEELLFIGEIPNDRLLLIESTSDELEGENYLIFHSLYGRRINDTLSRLSAMILGEMMNEDIGTMVTDNGFILLTGSRAVSEKLLDELMRNMVDADPYKVLSENIENTELMKRKFRQIAARSFMILRNYKGNKMSVLRQQINSNLILQALKEIDPNFPIIKETYREIFNDMMDLPRTKALLQRIKKGSIKYRMVETPSPSPFAHMMLTHAHSDVVMMKDRRDYLLHLHKLVMSRLYERKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX4</accession>
    <name>A0A218NLX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819640.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX4"/>
    <dbReference type="GeneID" id="33313693"/>
    <dbReference type="KEGG" id="marh:Mia14_0134"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="183" mass="21627" checksum="641657D42890BA89" modified="2017-09-27" version="1">MATYFEKRSAKKRKSELEKEYVKKDKEFDYMTQNKDELTKRAIGVIESENDDKPLSEEKIKVVSKAVQSTMDYITSNRDRYINHFKDIIKYYDDVKEDDPERIEKLRNFTAPLRDSVISIIEDSLTAEENAMLTDDDKKLIYVVIQVGFIKPYTRHRLAAQKYGDMMRAEDQIINSKKNDVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY8</accession>
    <name>A0A218NLY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TATA-box binding protein (TBP), component of TFIID and TFIIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819654.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY8"/>
    <dbReference type="GeneID" id="33313708"/>
    <dbReference type="KEGG" id="marh:Mia14_0149"/>
    <dbReference type="OrthoDB" id="166719at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="116" mass="13093" checksum="D740A74E3175DE76" modified="2017-09-27" version="1">MPKKIESTDLILPDLPHKKNVELKPTYKVVNIVASADLNTDLDLYGLAKLSYDIDYEPEQFPGAILKIRDPKSALLLFKNGKVICTGARTEDEVRRSIMQAVDLVKKYLKQYGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ9</accession>
    <name>A0A218NLZ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2 13">6.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2 13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819662.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ9"/>
    <dbReference type="GeneID" id="33313717"/>
    <dbReference type="KEGG" id="marh:Mia14_0158"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000192">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009687">
        <property type="entry name" value="PRK13208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="10"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="605"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="NCBIfam" id="TIGR00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="809" mass="93720" checksum="4238094BC4D4B5C9" modified="2017-09-27" version="1">MYDPESEKKWNTYWKENEMFLFDETDRKKPIFIIDTPPPNTTGELHMGQVYWISYIDSIARYKRFKGYNVLYPQGWDTQGFPVELQVEKDHKGLSKEEFYNKCVEYATKNLNKMKEQMLEMGASFDDRYEYVTMSDDYHRKIQLSLIEMQEKGLIYLADHPVEWCPHCKSSISREESDDVEKNTTLNYIEFKFDSKEEKSIIIATTRPELLHACVAIMVNPSDERYNKLIGKEAIVPIFGQKVKVFSDESIDKDFGTGAEMVCTFGDKHDAELYYKYNLRLIKSIDDDGRLINAGKYEGLSIKEARSAIIDELRTLNLLSKQDNLKHSVKIHDRCSSEIEIISSLQWFVKTKEFSGKLKEYAKQIKWTPANTIQKLFDWADYIEWDWNISRNRVFGTPIPFWYCSDCHYILAADKEKLPINTSSIKPPIDACPKCGSHNLVGEEKVCDVWVDSSITPMIIAGWPDNKELFKRAFPVSVRIQGVDIIRTWAFYTTLRTMLLTDNKPFENLLLNGMILGKDGREMHKSFGNGVNPRDAIKQYSIDSIRLWVAISGDIGSDKKYSDSLLNYSKSFILKVYNSAMFIKNLIDKSMPPEEPPPKGFELLDIWIINRFNEVVKEADKYYSEFNLYGAAMALVNFYWYEFCDYYIEDVKYRVYSDGESISKKAALYTLNYIMSNSLVMLAPIIPHAAEEINSLFSDSSVFNKKFPEYKELAPEETYTINGYIFKSSIVNIDYINAGKFVNQIITDVRKEKAQRKLALNAPVKSIKLEVPETYYEIAKVSEKDLKGILNADKITLTKSNEYSLSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM08</accession>
    <name>A0A218NM08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819676.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM08"/>
    <dbReference type="GeneID" id="33313732"/>
    <dbReference type="KEGG" id="marh:Mia14_0174"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="598" mass="65160" checksum="F285C1DA15E16367" modified="2017-09-27" version="1">MGLNRFNGKNKKGILLTLLMIIVLILMMAELITYVTLNISYDDLSSSAVSTGSSSAMVKTISPAISSFLKLSLKNSVSVLVNYESDPKLRGNNFVINTKSDIIDLMDNQSLYGIDYRNAIGMDISDYLNLLESKASADGVDLEIENGTLNVYQSNSTDLEAEYTAVAILNNSGLLSYYPIVAVANVSLEGMPDLHSVQNANFNNLVIPLNFTLYTLGNSSYALSGFTYMSPTLPGTLYYFTKPTCQSIPSSIQNGNYILLANNASGINGSVCGMAGLVANVTNTTGISKPYLVYPNSTINLLSKYSNSGSTKVILGPNPALYNYTALKNYIADGYYFKSNDSEDYLQEGEYNPDTTSNYGLVSFNSYSRQVAEFDGVNSDANISSFGPELVSNITISAWINNNGKGNYSQNIADVNGKIINEPNGLFYIGVKGKDGKAIVGWSNIANIFKYNSSGGVIAPNNWYFITGVWNKVTGNLSLYVNGKLVNTTQIAFPPPLTPSISINEINIAGKMIVGSDQLVMNNFNGSIANVQIYNKSLSPASVEYLYYQGLDGRPLNDYGLIAWYPLNGNAFNYYNYSYNLTQSNMAYTNYISYTESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM14</accession>
    <name>A0A218NM14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819658.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM14"/>
    <dbReference type="GeneID" id="33313713"/>
    <dbReference type="KEGG" id="marh:Mia14_0154"/>
    <dbReference type="OrthoDB" id="381915at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="24748" checksum="A38E377F19DE7602" modified="2017-09-27" version="1">MDRHSKIVLTNEYQEDLKKNKDVTQGDLDKQYIIEEGNKFRVPYRMVRMVTFKNVVKEGEFRDQPHAARLQYRLMEKDSILKARVNFIKNTITIMYNPKNADNLKDKISLEEIVDFLKTQNVNVNAENAEDVDFDYVKDFYSYAFNPPSIREHPPYGYTVDEWKELKATYQKKLEEGKEKSWNKFLEFQKNYEALHPEINWEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM17</accession>
    <name>A0A218NM17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system membrane protein GspF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM17"/>
    <dbReference type="KEGG" id="marh:Mia14_0172"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="entry name" value="Type II secretion system (T2SS), domain F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056569">
        <property type="entry name" value="ArlJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35402">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Type II secretion system protein GspF" evidence="8">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="340" mass="37241" checksum="5ABC874253DB304C" modified="2017-09-27" version="1">MILYYKDNNKGNAQNNDPNTNATQMPNPTQSNSYQVPAGGIGGTPEDESRRRVRRDTASFQRPSRIDLYLQGVAAKHKGLEQSLKEQGINESVTSFLKRMLFASVIVAVSIGVVGFILFLHLGLVIAFAALVGIVVGVAAFQFSFKAFINYPSKKKVSNGKDIERNILFASRDLIISLRSGMPLFNAMVSISSGYGAASREFAHVVEKVQFGESLEQAIDDTASESKSASFRKLMIQASVSIKAGSNIVDSLQEIVDDLSRERVIQLHAYGQKLNAIAMFYMLFGVILPSMGIAVVTILTTFIALIVVTPELLYGVLVGIIFLQVVFLQMIRSSRPIFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM32</accession>
    <name>A0A218NM32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819690.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM32"/>
    <dbReference type="GeneID" id="33313747"/>
    <dbReference type="KEGG" id="marh:Mia14_0189"/>
    <dbReference type="OrthoDB" id="34330at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040854">
        <property type="entry name" value="Hol_resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
        <property type="entry name" value="HOLLIDAY JUNCTION RESOLVASE HJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651:SF1">
        <property type="entry name" value="HOLLIDAY JUNCTION RESOLVASE HJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="127" mass="14871" checksum="7DE59313E2ED3066" modified="2017-09-27" version="1">MHRYVKGARSERELINFFYKLNYSVIRSAGSGVNSLSPDIIVIKNKKGFAFECKAWDRSSLSIDKDRYKSLMDWESNTGMNTFIAWRMNIKGWYFIKPEEMNETDKHYTITMTNALKIGRNLNSIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM43</accession>
    <name>A0A218NM43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">albA</name>
        <name evidence="8" type="ORF">Mia14_0201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Acetylation at Lys-31 decreases DNA-binding affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM43"/>
    <dbReference type="KEGG" id="marh:Mia14_0201"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00285">
        <property type="entry name" value="DNA-binding protein Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003088">
        <property type="entry name" value="PRK04015.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="110" mass="12203" checksum="68C3257A6BE7293B" modified="2017-09-27" version="1">MADEMNVANDETRTEEEGRKTNETNIVYIGKKPTMNYVLAVVTQFNNGMNEVSIKARGNSISKAVDVKEIVINKFLTDVKQKDISTASEELTNEDGSKSKVSSINITLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM46</accession>
    <name>A0A218NM46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM46"/>
    <dbReference type="KEGG" id="marh:Mia14_0213"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="94" mass="10653" checksum="A3935BF16399C31D" modified="2017-09-27" version="1">MVGVMMNGINKENMKTASCALCGKKLNKTDTKFVLASSNFNVNTMPLDRRVLCVDCYIKTINKTRSNTYSKGSVEVKSHMRHRLARTMLYNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM71</accession>
    <name>A0A218NM71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819727.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM71"/>
    <dbReference type="GeneID" id="33313786"/>
    <dbReference type="KEGG" id="marh:Mia14_0228"/>
    <dbReference type="OrthoDB" id="7928at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000029">
        <property type="entry name" value="Replication factor C small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="323" mass="36655" checksum="46E98002FA69D869" modified="2017-09-27" version="1">MDNLDLPWTEKYRPKSLNDVIGQNEIVKRLRSFVKTGNFPNMIFAGPAGIGKTTCAIAIANDLYKDRIEGAFKELNASDARGIDVIRGEVKEFARTLSLADVPIKIIFLDEADALTTDAQHALRRTMEKFSSETRFILSANYASKIIDPIQSRCVVFRFKPLNEKDMKEYIERIIKGENLDISDSAIEALIYISEGDLRKLTNTLQSAAMRSNKIDESDIYEIAARARPKEIVNMLKFALNGEFEKSTEELDKLMIQYGLSAEDILLQCYKEIPNMNIKEKDKLRLMVDIASYNFRIVEGANERIQLQAMLAHIAMIGIQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM82</accession>
    <name>A0A218NM82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780225.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM82"/>
    <dbReference type="GeneID" id="33313799"/>
    <dbReference type="KEGG" id="marh:Mia14_0241"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="82" mass="9045" checksum="67136328DBF08E1F" modified="2017-09-27" version="1">MMNANVNFTQERPFDLLNKSIGKQVLVRLKNNLSIRGKITSFDAHMNIVMDGAEELDSSGELKAKLGIILLRGGNIIFVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM98</accession>
    <name>A0A218NM98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819761.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM98"/>
    <dbReference type="GeneID" id="33313826"/>
    <dbReference type="KEGG" id="marh:Mia14_0269"/>
    <dbReference type="OrthoDB" id="57108at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="116" mass="13614" checksum="001C05822769449E" modified="2017-09-27" version="1">MNKKYIEEIMNLRGNNRPVRYIAKKMGVNKEVIEEIITSNIISSEPLIDGLVKGKQFQESPDYITTKQLIEKLDINVVFKNNTVLSYIAKNRSNHHDRLMDYIRYQLLSLKKDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA6</accession>
    <name>A0A218NMA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819758.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA6"/>
    <dbReference type="GeneID" id="33313823"/>
    <dbReference type="KEGG" id="marh:Mia14_0266"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="153" mass="17947" checksum="356D35678330E200" modified="2017-09-27" version="1">MDNAHSNTVLINNKATSKKTDMVDAIIKDENRLIRLNRFKFLRNEEYRLSEKKKLYADIKLDLESLNEKGALDYLRDSIYMLRENKQKNLYGVNISDIYQKLDKRVLNDANNEINNNSNFTNYTVIILDTKNNRKLASNFISRIISSKAFSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME0</accession>
    <name>A0A218NME0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819783.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME0"/>
    <dbReference type="GeneID" id="33313848"/>
    <dbReference type="KEGG" id="marh:Mia14_0291"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="149" mass="16348" checksum="C0E107AE705CCEBF" modified="2017-09-27" version="1">MGILGDLKSKIEGPAITATPDEVFDFLTNDGYQSMQMNNASSGAAGRLVGMLADSIRDIKLESSDGNSKTITYSYKAGPEVFSNKLVIKILSANDHQASWMKFEAAGGYNPNTYQSPSQKFESQIRNMVGQRFGTTQMLHTDKDNNRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME4</accession>
    <name>A0A218NME4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME4"/>
    <dbReference type="KEGG" id="marh:Mia14_0310"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46542" checksum="4BCCD1D969687E98" modified="2017-09-27" version="1">MFCMKTAYKYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYKETGKTLTEFRMNGWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKKQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKIGRINFVNHRNIEGGIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPKIGIDLGIMQYVALSDNTILQNAKITKHQRKHSRVLQQNISRKEKGSSNRRKAVARFARYSEHISRIRLDCIHKISNELVNSYSFIAYEDLEINNMVKNHRYAKSISESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSMSISQRIFVCEKCGMSMDRDVNAAQNILKRALDSISPTTEGHSGSQACRDDIRPSAGEAVAYEAGTIQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF2</accession>
    <name>A0A218NMF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819813.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF2"/>
    <dbReference type="GeneID" id="33313880"/>
    <dbReference type="KEGG" id="marh:Mia14_0322"/>
    <dbReference type="OrthoDB" id="376856at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="158" mass="17318" checksum="B43B9E1D2ABFE40F" modified="2017-09-27" version="1">MVESAASGSEKILGDLSSKLTPTEREILLNEGMTQAKVSEILNLPVKVEVIAQHEISGVIMRQVRIYTEKANGMRATVYFAESVIPIGGNSDQFIAIMREKGMGIGQAINALHIAQKRQIIDVYADESVISRNYSIEGEGLFVLITEVFPRNVLKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF4</accession>
    <name>A0A218NMF4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819810.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF4"/>
    <dbReference type="GeneID" id="33313877"/>
    <dbReference type="KEGG" id="marh:Mia14_0319"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="154"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="453" mass="52125" checksum="8B2558A13F183056" modified="2017-09-27" version="1">MKDEKSLKSVHLSSLLEKGLEHSEKYATSVSDLRKKIGEEVFLRGWVYRHRRTGNMAFVVLRDGTGIVQCSVNKDNVKPDEWESANDLYIDSVVNLIGEVREDDRAPDGIEVQVREFGVAFKGEPFPITKDQSTEFLLDMRHLWIRSPKMIDILKLKASVINDIRGFLDEKGFLEVQPPLITGSAAEGGATLFEVNYFDRKAYLSQSGQLYLEAVINGYPLVYGFAPSFRAEPSRTPRHLAEFWQLEAEMAFYNQDMNMKLQEQILEHVAHSEAKNHPDILKRFGRDPQDLLDIQTPFERMKYEKALDILKEKGLDVKWSDGLGMDEEKALMQDRKQPVFLTNQPKEIRAFYMRINPDDPRTVLDADLLAPEGIGEIFGGSERVSDYDELMGRIKEQNLKEEDYQWYIDLRKYGSIPHSGFGIGSERVVRWILKLDSIRDAIPFPRTMNRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG5</accession>
    <name>A0A218NMG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819817.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG5"/>
    <dbReference type="GeneID" id="33313885"/>
    <dbReference type="KEGG" id="marh:Mia14_0327"/>
    <dbReference type="OrthoDB" id="8612at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097506">
        <property type="term" value="F:deaminated base DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10030">
        <property type="entry name" value="UDG-F4_TTUDGA_SPO1dp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051536">
        <property type="entry name" value="UDG_Type-4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693:SF1">
        <property type="entry name" value="TYPE-4 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693">
        <property type="entry name" value="TYPE-5 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22584" checksum="977B51B379FF7998" modified="2017-09-27" version="1">MKIDKTLESLASQVNSMKKFGDAVVFERVSDLFMEKGEKLSLLIIGEAPGYEEVRIGKPFVGRSGKLLDKWLQVLQVKDYVITNVVKSHPVDAKTQYNRKPTEEEIAYWRPILEKEIKALKPKAILCLGDVAYKTLTNSGRTITSTIKEGIRFEYNGIPVIIYFHPSYLLRNKDYDWKPDMVKIKEVLDSLKSQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ2</accession>
    <name>A0A218NMJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819853.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ2"/>
    <dbReference type="GeneID" id="33313923"/>
    <dbReference type="KEGG" id="marh:Mia14_0366"/>
    <dbReference type="OrthoDB" id="7186at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11593">
        <property type="entry name" value="Agmatinase-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="294" mass="33045" checksum="C0065E9555FFC49F" modified="2017-09-27" version="1">MDILNSMPPYNLFGLEGSDYDKAKVVAIPIPYDSTTSYRSGSREGPHAVIEASRNIELYSEILEKDISRMGIYTTEEILPDVSSPENMVKRIESEVSHFLDDEKIPLVIGGEHTVMVGSLRAVSNKYGKDGFSVLHFDAHSDSRDSFMGSKYSHACVMARARELCDSCYSVGVRSIDEEDYRKYKDILYMKDINSMDDDSIADMIIRSTKKKLYFTFDLDVMDPSEMPSVGTPEPDGMRYKQISNILSKVFPEKEVIGMDFTELCPIPGFTAPNYIAAKLIYTALGYAFVANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ7</accession>
    <name>A0A218NMJ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>sn-glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ7"/>
    <dbReference type="KEGG" id="marh:Mia14_0378"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003198">
        <property type="entry name" value="PRK04169.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF22">
        <property type="entry name" value="GERANYLGERANYLGLYCERYL PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="275" mass="29665" checksum="27328ADFFE4647B2" modified="2017-09-27" version="1">MIITVLLMQFKTKIGKVEKYIYEKLDTQGSLLLSVIDPLDYKSEKDAINSAVSISQGGADLIVVGGSTGVQGEILDDLALKVKEKVDTPIVLFPGNIATITKYADAIYFMSLLNARNPYWITQAQMLAAPLIRQMNIEALPIGYIVVSPGGTVGWVGDANLVPREKPNIAAALALAGQYLGDRFIITDTGSNPRMQHSGPVPEEMVRAVKSVINVPYIVAGGIISDSDISKILKAGADMVQIGTAFEKSVNVKKTIELFSRTVKEEGKKKLKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK1</accession>
    <name>A0A218NMK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819863.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK1"/>
    <dbReference type="GeneID" id="33313933"/>
    <dbReference type="KEGG" id="marh:Mia14_0376"/>
    <dbReference type="OrthoDB" id="384708at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="303" mass="34785" checksum="8E9E7FB6F138BDD8" modified="2017-09-27" version="1">MADDKSLLEKLVYKLIKKHIAGVTAASAIRVAKQINKNGLRASLTFLNDSRYNSASPNFHYNYTSYLQLTKELFRLGINSDISLRLSQIGYPDKQGIDEMIPDMLNYLSSKNVLWIEYEDCYDIDSVINFASAIKDNKIGVEVPLDKFESKKLLKSIPLVKNIKIIPYESRKPADIMDTKPKKKTDLFTEYGNAVSKLKGLKVNIYIYMQDEKMVQKFINANRAIKRNLTFEIPLGYSNKKISMLLKNNINLCIYTAYGKDWIPYAINKLTSGRIKEIAVNLLDKKDKKVDYDDIKDLPIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML3</accession>
    <name>A0A218NML3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML3"/>
    <dbReference type="KEGG" id="marh:Mia14_0383"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861:SF3">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="153" mass="16835" checksum="29F362B1FEB6F382" modified="2017-09-27" version="1">MIFMKEQNSNTDQKPTTVEEGDEVEVYYTGKLQSGEVFDSNEKSEPLKFKVGSGEIIKGFDDAVRGMKEGESKDVEIEPKDAYGEYSNDLSIKVPLSTFGDSKPVKGMGVETEEGQQGIITDVNDTEATVDFNPPLAGKVLKFNIKVSQVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML8</accession>
    <name>A0A218NML8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML8"/>
    <dbReference type="KEGG" id="marh:Mia14_0374"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359">
        <property type="entry name" value="A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359:SF19">
        <property type="entry name" value="DNA REPAIR GLYCOSYLASE MJ1434-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="240" mass="27596" checksum="5400F6864C2E53DD" modified="2017-09-27" version="1">MEEYFIVSKGDFILSKDMKTIYRLLKKRFGFLNWWPGDSDFEILVGAILTQQTSWKNVEKAVANLKDAHMLDISKISECDIDYLQQLVHPAGFYRQKAIRLKEICSAIIKDYDGFENFLSLDAKNLRESLLSMKGIGRETADSIILYASGKPVFVVDAYTRRILGRVYRQEEAYRNIGYDELQKEIESGIKKDLGLYKDFHAQMVQLGKDYCLKKPLCTNCPLNGICLYSIHNNGVHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN8</accession>
    <name>A0A218NMN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UMF10 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819908.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN8"/>
    <dbReference type="GeneID" id="33313970"/>
    <dbReference type="KEGG" id="marh:Mia14_0416"/>
    <dbReference type="OrthoDB" id="57531at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518">
        <property type="entry name" value="C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="392" mass="41301" checksum="09EA032F971C64F0" modified="2017-09-27" version="1">MRKWLTKDVLLISLSAFFADAGYQALIAGFPIFLVLYLKAPVYYLGIAMALAYGIGSVFAYYGGKLSDRHSKKKIAILGNLLIPILSFTGFALFAAEATTIFSAGWWARNFRTPARRAMIGDISSRLDKARVYGFLNALDVGGGVVAVAYLSIGIYLGIALKLIFLATAIPILISSLCLFLVSYKGSPSKGKSKRAISSIKAATKAAKAKAGAYKGVILATGIYGLSFYSLSFPVLTIAQESTDFYGVLSYAVFLLVSAIVGYIVGVFAKRVVRNLAVFGYFLAGIGSLIIGLSYHFGLGIVVSYIGIFVIGIAVGTIETLEPTIVSLAKSKINSGSGMGALTSSRSIGLFVANLALGFLYVIGPLYAYGFAAAMAILAGSVLLALGSNSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ0</accession>
    <name>A0A218NMQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819894.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ0"/>
    <dbReference type="GeneID" id="33313961"/>
    <dbReference type="KEGG" id="marh:Mia14_0406"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="249" mass="28886" checksum="825E0A4ECCF553E0" modified="2017-09-27" version="1">MVFKNKVDKIVFNKNEDLDICNKAMHIYAKKESFKEIQHMLDNADMNILQVEGGMIDILFISYKNEKVALVEYSIEDKGRAELTVYKDNGWREKLDDIYKEAGLIGKHTASEINKDPHSSLAIDYKKIVKYRTEEAEKKLYNGSLNDLLDKSINVYDASSKFDEIKEALYKKRISINLISNRRNDVYIDISHNGKLVAKISKYGERKAVDNKLFASIYDGGWQKDLYEIYSRSKELEGEDNQKSELKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ9</accession>
    <name>A0A218NMQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819928.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ9"/>
    <dbReference type="GeneID" id="33313980"/>
    <dbReference type="KEGG" id="marh:Mia14_0425"/>
    <dbReference type="OrthoDB" id="38613at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="147" mass="16920" checksum="2E770CFDC6097D3D" modified="2017-09-27" version="1">MENADNVTLKEATDSDEKGLTRLYRKLYEGDEDQDFFKSKAIPSYFKSGSKVFIARSGNDTIGFVWAIYYEHIKSKGIGIIEELYVDDGYRGRGIGKELVSKAIDYLKKKKVLVVIVTTDPQMEDAQKFYKAVGFKVSREWFYYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS4</accession>
    <name>A0A218NMS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS4"/>
    <dbReference type="KEGG" id="marh:Mia14_0455"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058966">
        <property type="entry name" value="MJECL33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25924">
        <property type="entry name" value="MJECL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="377" mass="44103" checksum="3D17CD32056AAEF7" modified="2017-09-27" version="1">MVLVNFGLSKVETLKEMKEEMQNYLVKYTDEIENYDNKSQKTNDKKIKTYIIESNNPKPEDVIWPENINLIPTKDRNLKLIKTKISNNQGISYLDCSDPRFWYLHTNIDSNNTKKIINDLVNHNKSKLDFCWYSSNFLEKKVGFGKSEGFNIKFRNEFLTKKEKNEENSVKEFSMLLFGGGAKEVLDSLRQKGNPLISNVTLTQIKQTFNSDSGFVKESIGYKGSFTLNKGDSIINHFNTLDSVKNKYFNIINRLENEYRIKFSGNESGIKIDGMYSLIEFNKEIEDLNLFIDRIFSTKKPFRLWGIPQYLEKDFVRVLAVDLHTFDKFTLEITPNYMRIFLSENSCGNVIVRLFTNLQLFFDSQIKLKGYDDEQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW1</accession>
    <name>A0A218NMW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891436.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW1"/>
    <dbReference type="GeneID" id="33314030"/>
    <dbReference type="KEGG" id="marh:Mia14_0475"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051011">
        <property type="entry name" value="Metal_resp_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033788">
        <property type="entry name" value="HTH_metalloreg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132">
        <property type="entry name" value="ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132:SF6">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REPRESSOR CZRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="124" mass="14167" checksum="2423A769E419AC96" modified="2017-09-27" version="1">MSYNKLDDQSISLFFGAIANPKRFRILVTLNERGPMCVSQLEELLGIEQSDLSHNLQCLLNCRFVNREQRGKEKVYSLNEDMKVLVDSINSHIEAYDRYIKSCEIVNDKNLVKGVDNGKLSNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW8</accession>
    <name>A0A218NMW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820019.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW8"/>
    <dbReference type="GeneID" id="33314035"/>
    <dbReference type="KEGG" id="marh:Mia14_0480"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="189" mass="21669" checksum="4B7D03F7232077F7" modified="2017-09-27" version="1">MYFEPTSFKLKDGREAEITDIKPEYREDMINNYFSYFDEVEKGESAYGSDIGILLSYTKESYEDEVEWFNKKLKKVESDEQIARVAIVDGHPVGLIDIRKGGLGRKHIGELGIAIRKDYRGLGVGKALMEDALRLAKGWVKIATLALFEGNKSAYTLYKKLGFEEYGRLEDAMELRNKSLTEILMFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX0</accession>
    <name>A0A218NMX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820078.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX0"/>
    <dbReference type="GeneID" id="33314072"/>
    <dbReference type="KEGG" id="marh:Mia14_0515"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="118" mass="13394" checksum="371E6D59322A854A" modified="2017-09-27" version="1">MAALLIYGISLLAIALLIIIGEILAISRMINLLKSRINRINTENNLRDSGNPYRYANAILIFYTLVFLGSFLYIAIKLIENLKESILIVIIFDIVLIIFGVPIYLSYAILKKTYSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ0</accession>
    <name>A0A218NMZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820071.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ0"/>
    <dbReference type="GeneID" id="33314067"/>
    <dbReference type="KEGG" id="marh:Mia14_0509"/>
    <dbReference type="OrthoDB" id="46178at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="74" mass="8382" checksum="BF8D17E831A49569" modified="2017-09-27" version="1">MNRESIIMPEWRRNLLERLSIVLILFELVLSVIFILLGYSESSMYLRGVGVGLTIAWVTSSIAYMFGIKAANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN00</accession>
    <name>A0A218NN00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wybutosine (YW) biosynthesis enzyme, Trm5 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN00"/>
    <dbReference type="KEGG" id="marh:Mia14_0528"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5a/b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="357" mass="40799" checksum="36BAC1DAE5A290CE" modified="2017-09-27" version="1">MEKTTFVKAKKNIAENVRRQLLKLSLLDNSFTILSDSSYIYFPLKDQNGIQSLMGDFGGELKTVKKLGVRINRRADDYRYGLGSILTQKELKDFSSGYDAFGNIAVISLPDSLAEKENDIAKIILNSNKNLTTILKKAGPVKGVYRVRPVKYLLGKRTYIADYKENGCRFVFDVRRVFFSTRLAYERNRISNLVSHGETVMVPFAGIGPFAIEIAKKRPDADVVALELNKYGVYYMKKNIKINKANNVEAVLGDFHEASKGYRLMFDRIIMPLPKSSTVFLDDAIAVAKSTAVIHLYAFYEKDRINELKDEIIEHGKANKYKVTFLFERVVRTYSKSMIEVVLDYRIEKQNTVWAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN11</accession>
    <name>A0A218NN11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820102.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN11"/>
    <dbReference type="GeneID" id="33314086"/>
    <dbReference type="KEGG" id="marh:Mia14_0529"/>
    <dbReference type="OrthoDB" id="33505at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="6">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="7">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="415" mass="48182" checksum="4938C9C6D1BA115D" modified="2017-09-27" version="1">MEIISAYKFRIYPDAKRQKEIDLQLLLSKEFYNLLLEKSIKSYKGGNKKLSMSTLNKFAKEIEKDKRFLQIYSQVRCEIKYRVLKAYKNFFRRINEKKQGKKVKAGFPRFKSKDRYYSITYPQDNGSFSIKKKGKKHMLRVSKLSGRIEIELHRPIEGKIKTLTIKKKAEEYFAIFTTITETEPPKIEDTNPVGIDMGLHSFVTTSDGMKTEKPKFVRKHVKHIARWQRKIARREKGSERREKAKQHLQNEWEHVAEQSNDFAHKLSSKLVNSGYTSFAVEGLHIQNMVKNHNLAQSIYNASWNRFIQMLSYKAESAGMKVIKVDAKDTTQECSNCHHIKEGNERLTLGDRIYHCNVCGLTIDRDINASINILKRATLGQRGSHAQREGVRPQMEAVLEELRTAKTHPLQDAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN34</accession>
    <name>A0A218NN34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820140.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN34"/>
    <dbReference type="GeneID" id="33314112"/>
    <dbReference type="KEGG" id="marh:Mia14_0555"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="382" mass="45180" checksum="DD4C69A165448170" modified="2017-09-27" version="1">MNKKKLNVVQLHSVIFKGDAVSNIMLAIDKINKENNWSSSLIADLFSEYKGIPVWASADYNKSSYISGIPYLISRFIRLDNKTKWLKEYLNAKKEYKPNVARNLIEKADIRIWHYGAFYTLFRYFHERDILFYHGITYPYLGYNSEFNIYSKTMLQSILDMNPFVIVQSQFIKQSIADLGFKSNNIYILPLFHKYKLPYQERYTKPIHLISWGRYALNKGIPELVRACNQYKIPIRIFGDNYQTREFKDEYREALRFNVNNYATLSSKIDDFENELNPATIYISNSHHEGFGMPLIEAEAHSLPVLVRKGTAMDELVKDGYNGYLFKDINEIPELINKIKKNYKQISYNAWKHSQGFSYENFKKQYLKIINKYLEYKKTNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN35</accession>
    <name>A0A218NN35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proton-efflux P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820165.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN35"/>
    <dbReference type="GeneID" id="33314139"/>
    <dbReference type="KEGG" id="marh:Mia14_0584"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000211">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="804" mass="89049" checksum="9179AE5801A2FFBB" modified="2017-09-27" version="1">MVADLKDLTSDELVKKLESDYEKGLSEDEEKKRLEQYGYNQFTEEKQNFVLLFLKKFYGPVQLLLWLIIVISFLLNHMHTFYIVIALLVFNAVVGFFEEYRADKSVDALKSRLSPTARVKRSGSWVMVPTNLIVPGDIVRIRLGDIVPADAKVIEGNSLEIDESILNGESLPKDKAKDDTLYEGSIVKRGEGTAIVFGTGYNTFYGRTAKLVQHAKPKSHLETAIMGIVKYLIAGDIAIILVMFGYGVFVLHTAITVLLPFLLVMFIASVPVALSAAFTVSMALGTQRLASKSILVTKLEAIEETSNMDVLCMDKTGTLTMNKITVKDTYPYKCGVGDILRYAYDSSREEDNDPIDNAVIDYCKSNKIKPDKQENFLPFDPSLKRTEAIIDENGKKYKVAKGAAHVIIAMSGNLSADDLDSYKKKLLEFANNGFRTIAVATNEDLESKDSSNWSFKGFVALYDPPRPDSKELIKELHSLGVGTKMITGDNIAVATQISNQLGIGNNIIDLTASEKEGNKKALEEMIEKANGFADVYPEDKYQIVKSLQNYKHIVGMTGDGVNDAPALKQAEVGIAVSNATDVAKSAAALVLTKNGIEVITNAIKESRRIFRRMVTYSMVKISKVFQIIGFIAIIYIALHYIAISPFLLVLLIFTNDIVNIAISTDNENYSSSPNAWNVRSIMSVSMIIGFLLIAQSLLLLPVEFDLLHLTVLQFETATFIMFDISDNFMVYNIRSKRPFWKSRPSNTLLLSSVFGIGLGLALALSGTFMAAIPLEMAGFIIAFAVIFLFVIDAAKYRLFKHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN49</accession>
    <name>A0A218NN49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820148.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN49"/>
    <dbReference type="GeneID" id="33314120"/>
    <dbReference type="KEGG" id="marh:Mia14_0563"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="226" mass="26051" checksum="7CBE07515A675B44" modified="2017-09-27" version="1">MRGLAEKYDTFIFDWDGTIITTTELRKLDSKLDFRLLFKRRESMKHLGNVKNEVKNSGSLLYKIYFRDSRKMRKVERDIKNKVYALAINIVLSFTRPRLHNGVREMLQEMNDKGKTVAVFTNGNVDRIMKEAEMLKIGDYFTAMLSAQSVNRLKPNPLGLEVLIKGISADKKRTLYIGDMVDDIVTAKRAGVASCAIADGLDRKEDLKESDPTYIFRSMEEFKKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN53</accession>
    <name>A0A218NN53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDC48 family ATPase of the AAA+ class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_269799403.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN53"/>
    <dbReference type="GeneID" id="33314151"/>
    <dbReference type="KEGG" id="marh:Mia14_0597"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="215"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="487"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="718" mass="79320" checksum="70A17A523DC6D68E" modified="2017-09-27" version="1">MVDGIELTAVGALVTDDGRGIARMDSKARKLLNVVSGDIVEIKGKRRSTAAIVWQAPQQDEGLNFIRVDGWIRENIGVGIGDKVFVSKANVSEATKIVIAPPKNQTTPVPPDFEDYAKSKLENKPLMKGDIIPIPMFRYAFKFVVAQVIPHGVVKVTPNTEIVVRSESVSESAVKIGDVHYEDIGGLKTEIQKIREMVELPIRYPELFERLGIEPPKGVLLYGAPGTGKTLLAKAVANESDANFIDISGPELVSKFVGESEERLRGIFEEAKEKAPTIIFMDEIDAIAPKREEATNEVERRMVSQLLTLMDGMSSRGQVIVVGATNRPDAIDAALRRPGRFDREIEIGVPDRNARKEIIQIHTRNMPLDKGVDIDNIANITHGYTGADLAALAREAAMSTLRRILPEVLDKNEVSNELLMNLKVSNQDFLEAFNSIQPSALREVFVERPNVHWSDIGGLEKVKAEIKEAVELPIKDPEAFEKIGIRPVKGALLIGPPGTGKTMLAKAVATEREANFISIKGPEILNKYVGESEKAVREIFRKARMAAPCIIFIDEIDSIGYLRGGDSESSRVSELVVDTLLTEMDGLKDMKNVIVIAATNRPDVLDPALLRPGRFDKIIDIPMPDEPTRLAILKVHTSKMPLAKEVDLEEVAKITDGYTGAEIENLVREAGMNAIRNKESKVTKDDFDKALVEVKPTVPRELAERIQKFKSEPDLMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN76</accession>
    <name>A0A218NN76_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820185.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN76"/>
    <dbReference type="GeneID" id="33314163"/>
    <dbReference type="KEGG" id="marh:Mia14_0609"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="130"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="435" mass="50726" checksum="4D45FB9AE557ED85" modified="2017-09-27" version="1">MEYQHASEMKDYEGKEVSVRGWIYRKRESGGIIFIILRDSSGTIQISIKKDSVSPETWSDAEKSTIESSIEAFGTLKKDSRSPTGYEITGKSMKLVSLSEPFPITEYQSTELLLDNRHLWLRSRKMTEIMKVRSHIFRYTREMLDKQGFYEITPPIITASGGETGADMFELDYYGKKAYLTESSQLYSESMIYSLEKVYSFVPSFRAEKSRTIKHLAEYWHLEPEMAYYDLGMNMELQENLVSYIAQHVVDNDEESLKELGIDKEVLKIVKPPFKRVTYEKALEILNDKGKDLKWGDDFGVEEERLLTEDEDKPIFITYWPKELKPFYMPVNPKDERTVLCADMQAPHGNGEIIGASQRIYKYDELMERFGQVEKAKGVKFNMDNYKWYIDLARYGSVPHAGFGMGMERVIKWMMGLDHIRDAIPYPRMMNRNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN82</accession>
    <name>A0A218NN82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820201.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN82"/>
    <dbReference type="GeneID" id="33314187"/>
    <dbReference type="KEGG" id="marh:Mia14_0633"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="295" mass="32395" checksum="28224A2E813373C7" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILVIAVVLAALYSLGIFNPSTFAPKASAGSCEVVRPFGPTTTTDIHLEGTCTNMLPKYVAQFNGKGSTGITLNTYNFNTTPFTISFWEYYLGYTTCYTSSNGGNCGENVTMYINPNKCSSTPNYLCVIDFDLRTTSLHWFTWDRDIFYPVQTGKWLFITWTYNPANKNNISAYLNGKFVGGNTGSNVVLDGQIELGEGGSMGSIDGYVSNFQIYNSSLSANQISALYDEGIGGDPIDLTNLVGWWPLNGNANDYSGNDYNGKGVDVGYSPTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN85</accession>
    <name>A0A218NN85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="4" type="ORF">Mia14_0601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + H2O + H(+) = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820177.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN85"/>
    <dbReference type="GeneID" id="33314155"/>
    <dbReference type="KEGG" id="marh:Mia14_0601"/>
    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="180" mass="20333" checksum="7B562A4140C677EB" modified="2017-09-27" version="1">MILSDFDIKSMVSQKRLTIEPLTDDSIRENGIDFRLADEVARHKAFDESFVLDPTDENMIKGSYKLDKTLKEIVINPHEQVLLSTYESISMPDDVAGFVELRSTWARHGLSMPPTIIDAGFNGTITLEVVNNAPYKILLRPGQRFAHIILEKLNNKTGKVYNGNYNMQKGIKLPQVLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN97</accession>
    <name>A0A218NN97_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820209.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN97"/>
    <dbReference type="GeneID" id="33314195"/>
    <dbReference type="KEGG" id="marh:Mia14_0642"/>
    <dbReference type="OrthoDB" id="84643at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="83" mass="9019" checksum="26CA97D95607023D" modified="2017-09-27" version="1">MAKVGVVYKVYPKQDVDADTLMGKIKSELSPVSISAEDIAFGIKVIKAFFTYDDSEQGSSTMEEKLNGIDGVAQVEVDEESLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA1</accession>
    <name>A0A218NNA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lon-A peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820208.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA1"/>
    <dbReference type="GeneID" id="33314194"/>
    <dbReference type="KEGG" id="marh:Mia14_0640"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="4">
        <location>
            <begin position="41"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="617" mass="67426" checksum="CFC226BCFF6CE214" modified="2017-09-27" version="1">MKFKYYCLSFLIMIMLAGTMHAQVVGTASIHAPALIAYNNTGIITTINLTVTRGDGYVNITGPISVGSSTLNSSKDAVNYAAKYLGINKDDYNFTYVINDRNASVSGPSAGMAMTLLAISSLTHKPLLHNFTLTGEILPNGSIGEIGGVYDKVSAAKREGLKFVLVPAVPSTSFENEIYYIIELRFNIPVIPVANISDAMGYAMEGKPISGNEVKYSFYTNYHLNKIPNASLSCIGPCYNNYFKGLTNFTLNMTSSELQTLESNPLLYNATSQFSGLLNQSKELSGKGYYYAAADIAFLDYANIYTFVNSNQSIPEGLNTVNAVESECNSIQAPKMTNNNFLYRIGGELRQLWGEYTSQSTSEEYNATTDDSDGVIRNMYDAGVSNAWCGAASYMYNASSAIGGLNYTTNSSLSGIAYKVVENASNYPGIYTTTAISAYKSGNYPLAIYDGAYAYAIDGNSSSNMTESEMLNSSKSISYNSTYGIWATQFANEAMFYYYEAKITDNASQSELYAVQSYHTALLANELSNYSKVIYDNLKVAPVTVTTSSVSYSGILLVDIALFMVLALAVIIAILLVLIVKIVRIESRISELSDSHNRSRPSPNRKARNTKRFKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB2</accession>
    <name>A0A218NNB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SelB-II domain-containing translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB2"/>
    <dbReference type="KEGG" id="marh:Mia14_0658"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTu-like" evidence="1">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="319" mass="34745" checksum="8855120572B495D2" modified="2017-09-27" version="1">MTNHNHPGSPHHLQVGGCHLISIPINNGVADFIGKKGAEDSLVYYNRIYNDDTIVAISPANLDDKFYGLAESITLSHIIVIDAKSIDKQLGEVLIATALAGKPTIIIEHDTIDQSQLEGMLKQLNLPNYTTCKMEDILGKIASYKLDSNDASGQCRVDIDRSFNVKGAGTVVLGIVRKGSVKVHDKLLGKDSKEVIVRSIQSQDRDIQEAGVSTRVGLALKGADSDEFKKGDTLSNYKIDPKKSITATINVSSINKEDVKEKSSYIFVSGFSYTSATVSSFDGKSISLVFDKPLCIESSDSFMLIRKQEPRIFAFGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC2</accession>
    <name>A0A218NNC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820216.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC2"/>
    <dbReference type="GeneID" id="33314202"/>
    <dbReference type="KEGG" id="marh:Mia14_0649"/>
    <dbReference type="OrthoDB" id="27340at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="314" mass="34014" checksum="C9653D865381AAB6" modified="2017-09-27" version="1">MVEDVIVIGGGPAGLSASLYLAREDFHPMVIAGLEAGGQLLLTTTVENYPGFPEGIQGPELVDKFRKQSSRFGTRFVDENAVSIDLKSRPFTVKTASDEYKANCIIVATGASPRLLGLESEKKFIGKGVSTCATCDAPFFKNKKVIVVGGGDTAMEDSDFLTKFAESVTIVHRRDEFRASKIMQERVKSNKKINIIWNSEVVEILGDAKVTGARIKNVVNGEESTIETDGVFMAIGYSPNTKFLEGVLPMENGYIVTKDDVNTDIPGVYVAGDDADFKYRQAATAVGSGVKAALEARAYIQQLKYDESKGQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC4</accession>
    <name>A0A218NNC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin-NADP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820240.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC4"/>
    <dbReference type="GeneID" id="33314226"/>
    <dbReference type="KEGG" id="marh:Mia14_0673"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050415">
        <property type="entry name" value="MRET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354">
        <property type="entry name" value="NADH OXIDOREDUCTASE HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354:SF5">
        <property type="entry name" value="PROTEIN RFBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="241" mass="27388" checksum="BDEF72AFBEF78F02" modified="2017-09-27" version="1">MKQYKIERKTYELVENFSGTPEVQIIRLKPVDGEPMMFDAGMFVMIYGTDSEGKQYIGRAFSIASDPHSEIMEFFIVKEHGGHRSHFLDSKIGDKFTISGPSGQFRFIPEEDKKVLFIAGGTGFAPFLSMMRDIKKNNYDTDAILVYSVKYPSEIILKDELYSLSEELKIKKFITVTRPAEGDNWDGEKGHIDSNRIKSYAPDVTERTVYICGPLNFVKAMKESLAELNVDPKKVKADVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND1</accession>
    <name>A0A218NND1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820251.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND1"/>
    <dbReference type="GeneID" id="33314240"/>
    <dbReference type="KEGG" id="marh:Mia14_0687"/>
    <dbReference type="OrthoDB" id="386320at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="226" mass="24930" checksum="7B2AECCF99787820" modified="2017-09-27" version="1">MSKTMETKDKILKSLKVKKRTITELSEELGLSKSTVSQHLYELIDSGLIEEEPNDHFKKLKYFRLRSKEGVNETAGMRIRLIGAAVLIVAVVSIFAIVLSGGSQNNANDTIVKPSLACPMLPYYSTANYSDVGNIVLNNAEGNQCFLTYVNTKSDVIDVGNGVHYSSYDGTLSVPSVNYTYKMGPKQVLNIENAADEGNCWAYKTIEMFNITYSGNATNCKSEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND5</accession>
    <name>A0A218NND5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820248.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND5"/>
    <dbReference type="GeneID" id="33314237"/>
    <dbReference type="KEGG" id="marh:Mia14_0684"/>
    <dbReference type="OrthoDB" id="8480at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="3">
        <location>
            <begin position="98"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="460" mass="50342" checksum="81E6114FBEE0AC18" modified="2017-09-27" version="1">MVPDLRESLSILDNKKEVLHVDQKIDINDVGKVLMKAYHDPKQPVIVMNNVGDSKMPVVANLFTSREKAAIYFGTTEDKLFDKLNHGLANPIKPKVIENPECQEEVITTNIDLEKLPIPKYSPDDGGRYITPGITISKDPETGAYDMGHYRYELLGGNKLSFLAQSFHRFGINIQKAKAKGLKCEAAIILGYEPALGFAAQAKSSNPDDYEVAGGLYGEPLQLAKAKTIDLLVPARAEMVLELEIDYNTLVNEGPLGEYTGYYTPASQKPVAIVKAITQRKNPMMQALLTGKPSPITENHVLKQIPFEAVMLGDLKSKFPTVTDLTIPPFGGVQAAVIFSMKPQFAGQAKEAILHVLGSFVAPKYAIAVDPDINVHDMDDVMWALSFRVKADRDIFTIPDTQRVPLDPSSHEGRSEAQTDTKTAVGVDATIPVGIKYPEVADVPGWKDFDVPGLDVGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF0</accession>
    <name>A0A218NNF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-serine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820245.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF0"/>
    <dbReference type="GeneID" id="33314232"/>
    <dbReference type="KEGG" id="marh:Mia14_0679"/>
    <dbReference type="OrthoDB" id="120213at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="192" mass="21889" checksum="9C2776535800419B" modified="2017-09-27" version="1">MILESAGKHITMKPLEYKDAIDISVLGSDLEIARVTAEPGKFPYPYTIPNAVSFIAYSINMMQSKSELNFGIHDSKGALMGVFGIFNLNYFTRKCEIGFWLGKKFWRKGFGSEGVMMLIKFSFENLGMNKVYAKAFSDNLKGSGLLEKLGFGLEGELKDEIRYGKKYKNVLIYSILRKDYLKIYKNYEMNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF4</accession>
    <name>A0A218NNF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF4"/>
    <dbReference type="KEGG" id="marh:Mia14_0700"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="212" mass="24746" checksum="670E53F069C22B85" modified="2017-09-27" version="1">MIYMQFSSSFMAKGKLLTDFHSLSEDISYLHLFKINSYGTSLDYSIDMKGEKLSLVFSTNMISYSFYYDTLSDNYYLLNFSRFIRLINYLKRHYRIDFESVYPYLSNSISIKLDEAKLGYFKSEQKVKGNILEYLDNLSESNFNLSEKLIQINRYNKDILSELSIYKKFSQTVASNLRKANFENDSLEEAASRSFGIDIKLAHAVLKSLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG1</accession>
    <name>A0A218NNG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820267.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG1"/>
    <dbReference type="GeneID" id="33314257"/>
    <dbReference type="KEGG" id="marh:Mia14_0705"/>
    <dbReference type="OrthoDB" id="6609at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Archaeal Nre N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Archaeal Nre C-terminal" evidence="3">
        <location>
            <begin position="307"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="47762" checksum="9196D24EE3ABCD5A" modified="2017-09-27" version="1">MEDLNKLINSLSFNNPVVKVRRSMEVYRNMKNPSIISSYYRNQYSSILDKDYVSGSSPTEIFIGRFGYPKVFIGPMISPFMKDSSMLANPSLWKGLPIEKIIQMRLQLVRGMHISNIHDVENGRVEEEVRDLALSDKPADSDINFIGKPLVRPKLDADLSPFGPTVKIKDMMVSNSRSNRDIERLYSDYDANAGTAVKELYKNKVDVYRIQKGVSAGLFGLKSNRKFVPTRWSITMVDDLISKSLREEVKGNEKIDNIKLFYNVALDNRWLIVFMPSNWEYESIEAFYPKTTWNVNSNEISIYSSYEGYRGRKKYAEIGGCYYAARLEVGEKLKTMKKQASVLILREVHEGYTLPVGVWNVREHVKQTLETKPVELDSYSEMFRYINEKLDINVSEWVKNSKILTDLLKQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG5</accession>
    <name>A0A218NNG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820257.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG5"/>
    <dbReference type="GeneID" id="33314247"/>
    <dbReference type="KEGG" id="marh:Mia14_0694"/>
    <dbReference type="OrthoDB" id="103472at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04179">
        <property type="entry name" value="DPM_DPG-synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050256">
        <property type="entry name" value="Glycosyltransferase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090:SF7">
        <property type="entry name" value="RFBJ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="296" mass="33797" checksum="99C9AD660003FE24" modified="2017-09-27" version="1">MSDISIIIPTKDELNVKNILKDIEKNFKKNEIEIIIVDKSKPEIKRKIKDLGFPVIDQISNGYENALVEGFKRAKSPILATIDADGTYLVKDLKSVILELDKGDYDFISGDRSSGLRKMTFYISFGNKFLTKWFNFLYHRKMHDVLSGVFAMKREVFDKIKYDDAFRAGTLFFEIEAVRRGYRIKDIPISYADRVNTKSRITKSKPIYGFFIAFYSIKYARDYRPLVLFGAIGILLIIAGIIVGALVVQNYFATGVLIEVGRALISFMLIVLGFLSIITGLILDMLLEIEKILLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG9</accession>
    <name>A0A218NNG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG9"/>
    <dbReference type="KEGG" id="marh:Mia14_0703"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="95" mass="10857" checksum="F9806CBF66291A3F" modified="2017-09-27" version="1">MNITNGIYHHKKEKNLVDSLLLAVSLVLLLLPIPVIASILLRLNLTLLALIWLIAIYVVSYGYVRVERLYIQRKYWIAVVAMQSLAAIILVMAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH3</accession>
    <name>A0A218NNH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820266.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH3"/>
    <dbReference type="GeneID" id="33314256"/>
    <dbReference type="KEGG" id="marh:Mia14_0704"/>
    <dbReference type="OrthoDB" id="385330at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="766" mass="86091" checksum="17F7621124A3501C" modified="2017-09-27" version="1">MVNARFSVDSVPDNGIDASLFFDAVKGIPFAMVFDFNETKTYIELLSDEPDLYVKGICYRIPGLELSKAATGPSKGNFRIGSFLKVNLDSREVLKTSHGIFEDCFNLGIEKGTFGILFLPAKDQEIEYSSKEIENSLTSIETKETSSINSRIAGYNSSYSTQHDVFYNSDDKIVLGYILNSINKALLKGSAVYKTLFFTDVENPYINNYLHSKFLILESGLVYNYGISDIAEYLSKSKQIILGSNELGYLLDFEGIHRVNHIIETGNFPSKGDIGIGTIMKHAVLDSNRGLYLDRSILNLGVLISGLPGTGKTHESMAIVEQVIKLGIPTVVISSTKEWDNFAYDNNLYCVRLLNDKSPINFFSCPDKSNRDKFWRDLAMLLASASDAGPYRRPLEKCLIDAFRRIYKSTGSPSPADVIEETIKSIIDMHGKRTNTGVKYTKHGENIKAALENLIDLLSNAEYSSEFGIKFEDMLGKGAVFDASEAGSNMKKLVYSLILNQFYSIISSTDESGDNSLRMLLVVEEAELVFKDDDSPAVEDMRTRIQDFRKKGIGLIFITHGALEIDSDLRRLLQIKLYFRQSSDMAIYAVKDLLSDIDNDRLVSKIKHMPSGVFGLSSISKDGYHRYPMDLLFLKSLFYNYAGKRDRDLIKGYLKSNSIPIPEEIYENLVFSGYPELNTADSQSEKNYKILQRISKLVLKYMGNKVYEVPFDKLEYGFNLIKDRVYDLELSTENDVCLLHLAIKPSGIGMKIGFTLRHGKLGIVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ5</accession>
    <name>A0A218NNJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820288.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ5"/>
    <dbReference type="GeneID" id="33314280"/>
    <dbReference type="KEGG" id="marh:Mia14_0728"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="127" mass="13000" checksum="D81496DDDF00507B" modified="2017-09-27" version="1">MGHNVISFVSAQQDKIRLLALLGAVIFGFASMTAGATSYSNVTNTICGVYTEIKTIVFILGLVLVILGAIMYAVGHVLPATSRGSIQGYGTGMIMAGIIAVIIAVLAPYILSTIGGNAYANAIASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ7</accession>
    <name>A0A218NNJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2666 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820306.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ7"/>
    <dbReference type="GeneID" id="33314298"/>
    <dbReference type="KEGG" id="marh:Mia14_0747"/>
    <dbReference type="OrthoDB" id="86044at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022620">
        <property type="entry name" value="DUF2666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10869">
        <property type="entry name" value="DUF2666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2666" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="153" mass="17149" checksum="643F60A0145A006D" modified="2017-09-27" version="1">MDGKPDNYIDFSVKYNDWVAIKRLSIDDKVTPEEVVYNLASIESSIDSKVYKFLGIDINSIDSLAKNLAKQSGSGYKGLPKLASLIDTKQVKDSLSKACKTQVVVPFAKSYLLDKSLKYMKLSADIELPTMLKAFPDLKARYKYKAPKSKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK4</accession>
    <name>A0A218NNK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820301.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK4"/>
    <dbReference type="GeneID" id="33314293"/>
    <dbReference type="KEGG" id="marh:Mia14_0741"/>
    <dbReference type="OrthoDB" id="379590at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="243" mass="28056" checksum="F24FB92810E5A1CC" modified="2017-09-27" version="1">MPESMGIIKPKVKEFYLNSRLVGSFDDMLGRFSDVKTFISKKQQDNSLVLVSIESRDMQKNPFLFIVLVFKPDSITVQYSIPLDSSEKMRKIYVIRAVLELLALVTDLYIVDQSALYTYINSSIDDILGSLSQSYSSLFNSYDSLFSEFREIRRLNLELQNSNKTLTAKAVQMEDENKRLNEQLDQLHKYSDQALMVMVEDWIDEHNNTIDLDAFSNTHHIPISRVEQILNKMVTEGYISIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL0</accession>
    <name>A0A218NNL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YnfM family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820323.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL0"/>
    <dbReference type="GeneID" id="33314318"/>
    <dbReference type="KEGG" id="marh:Mia14_0766"/>
    <dbReference type="OrthoDB" id="29061at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129:SF1">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="44762" checksum="28B366AC6084C075" modified="2017-09-27" version="1">MEESSLPKGSFSHKEKLMSLAFTSFGHFSNDFTILLFSLLIVYYSQDYGISLAVLGAVAIIYNVLSGLLSTPIGSYADRTGQYRTLIAIGIAIIGIAVILFALSFQFSHYVLPLMLISAVVIGTGQAFYHPLGASVLRVTYEAKTSSALGINGAFGSVGRSVLPVLLVPMIILYGEFHALLFIAGYLFIVALIIFLGLDFIKPQNGSIERKSEKSSDDKLGQGGIERYERAIFILVLIVFIRAMFLTGTTTYISEYLVSRVHSDIIMSYIMAISFITAVAGQPIFGRITEIKGGKFSIIVTTVLSTIFFILFMLSGSNAILDTITYASFVFMGFTGFPVLLGYVSQIVPKKVATKSNGLVWGLGNTVGGGVGLAIMSIVLFLKITLVDTMWIMVIFGIVSCILLPLLPRKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL3</accession>
    <name>A0A218NNL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S8e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820338.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL3"/>
    <dbReference type="GeneID" id="33314334"/>
    <dbReference type="KEGG" id="marh:Mia14_0783"/>
    <dbReference type="OrthoDB" id="372305at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="132" mass="14894" checksum="06D2FB130CFC2951" modified="2017-09-27" version="1">MSLLSKQMHSKSKTIRTGSGKRKVKFRDKKRYEIGNYFISTKMSEEDVRVNYRGRGGKITSKLKKAATANVLTKEGYKKAKIKVVVESKDNRNFARLNTITKGTIINTDVGKAVVLNRPGREGFINAKLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL7</accession>
    <name>A0A218NNL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL7"/>
    <dbReference type="KEGG" id="marh:Mia14_0774"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="196" mass="22832" checksum="8AECC05E5CAFD774" modified="2017-09-27" version="1">MSESMNDEDLDYLSRVNKLYSFIIKKYQDYIEKSETRSIADMPRLITPESERVSDIASFIKSKFPSYLYENDFYGASIQALEYLKSNIKEVAMPVQFWLKPDDVINVGLGEDIDKNVLLCSLLVALGNYSSKVLVVSNDNRKEVFVYYEFNYRFFLIDIKGKIELFDSNKDLFSYAGIDDNSEAYEFNNLSYFKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN6</accession>
    <name>A0A218NNN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820361.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN6"/>
    <dbReference type="GeneID" id="33314353"/>
    <dbReference type="KEGG" id="marh:Mia14_0804"/>
    <dbReference type="OrthoDB" id="372183at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="242" mass="27480" checksum="1E7F97A220BD31E6" modified="2017-09-27" version="1">MHNEVSDVIKDEILSFLQYRSKGDEEAIARKLENVQTINGKLYIRNVRFDINISDSKAVVGAALANIPLIFIGAKHEAELPSEKLSKIYGAAERLISLKDSTLNDIATLEIYLLMEMGLRELYSMQVSGEAIVSYKGKSIALKDMDYRKLKLYVKMKHMSLYDIKVNGRAFPYSQGSLLSWAEGYMESDYVEAFKISLNVRNLLAHGELEWNLNPSIESLYTASYMVNSLFDNLEKRSNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP4</accession>
    <name>A0A218NNP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820333.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP4"/>
    <dbReference type="GeneID" id="33314329"/>
    <dbReference type="KEGG" id="marh:Mia14_0778"/>
    <dbReference type="OrthoDB" id="11138at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="158" mass="17875" checksum="ABD1B9478FE09EE4" modified="2017-09-27" version="1">MEECELCGKPISDIVYTIEVEGVSLRVCSKCAAGKKIIGKEQLDIPKSPKPSYFASDYKREQPAEDDIELVDNYGEKIRQALEREKLPLKVLAEMISEQESYLKRVIEDKTTPPQELVGKLEKTLGIKLTMSKRAKIEKVALPKSKASTLEDYIKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR3</accession>
    <name>A0A218NNR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TatD family deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820390.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR3"/>
    <dbReference type="GeneID" id="33314378"/>
    <dbReference type="KEGG" id="marh:Mia14_0829"/>
    <dbReference type="OrthoDB" id="26412at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46124">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46124:SF2">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="275" mass="31143" checksum="5D23967283CF84EB" modified="2017-09-27" version="1">MVQSLQIQSQTRQKKEQITGEIRVFNIIDAHCHLDQLKQEDINDSLMYIAGMVTNGVDMPSNIRNLELADNKHIFACLGIHPEFAASLKKYEVDYVIDFIKRHSKSIKGIGEIGLDYKFASQIKGSKPKQRSLFLRMLTLANKLDLPVTVHSREAMDEVLYMLHKKKVKKAHIHFFEGTVEQAMKAVEYGYMISIPPLPSSKRNAVIKAVPMKNLMAETDSPTAGSLPKDVIYSIELIAKAKGMGLEETAKELTINTRRFFNIGEEHNSLLRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS5</accession>
    <name>A0A218NNS5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Mia14_0840</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820408.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS5"/>
    <dbReference type="GeneID" id="33314388"/>
    <dbReference type="KEGG" id="marh:Mia14_0840"/>
    <dbReference type="OrthoDB" id="12044at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39188">
        <property type="entry name" value="MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39188:SF3">
        <property type="entry name" value="STAGE IV SPORULATION PROTEIN FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="17">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="17">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ASI14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="361" mass="40637" checksum="71E6E623D441BDF5" modified="2017-09-27" version="1">MSMWSPIIGKFKGIPIQLHWTFVLLMIFALVISVPLFFVLVILFACVLLHEMSHTLTAYRNNVPVEKIILYPLGGGSLIDSDVLDPELEFRISLAGPIASFIMGFAFGIVAVIMPGGEIESFIQIFFLLNILLAVFNIIPWFPLDGGRVLRGYFRKKYSFINATKKTVMVSNAITILFIIGTLVYAAVSNYTIVYKEFIIFIDIFMAMFIYSGAKSEMELAYIRENTKNLSISSLVSKNYILFRKPASLKEIYDAVIKYHTNIILFKSKAGYQVISKLPAPNINALNLNISNKQSSSYYKLSLPVVDYNKKVYDVFNKMQNTNLPIIGVTKGKTLVGVISRQHLDSFISLHMSNISSVQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT2</accession>
    <name>A0A218NNT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT2"/>
    <dbReference type="KEGG" id="marh:Mia14_0841"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323:SF1">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="257" mass="28993" checksum="1257A091DC670CC6" modified="2017-09-27" version="1">MLHLNNIKFVYGKPALIAKSYGHRCMAIGDLHIGYENRLLKKGIHIYNNMDIMASSILKMSEDYGIHRLILLGDVKDSIMRPGRYELESLKRFFDLLSPLDLSVVNGNHDSFLSEITGIDTVDELLSGDFAFLHGNRFPSLKAMGKKVIITAHNHIAVEINEGHKNFYKEKAWLISSINRNNAKKFYDEFSASKLIVMPAFNPFIIGSAVNFESGKDKKNINPLFSNGIFDYNKSYVYSLNGIKLGTVSQLIAKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT5</accession>
    <name>A0A218NNT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT5"/>
    <dbReference type="KEGG" id="marh:Mia14_0866"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="134" mass="15146" checksum="6848D190F10D7C92" modified="2017-09-27" version="1">MDEDTLILTFLVSAPAFFITSLLWPGLFQHLISMATSGNIFYEIIGIAGIAYAVIGAVIIIIFAFTLLIYILVFGVIFFFPAYLIYTMLGLEYSLILVAVLCTIAILYFLETHTVSVEHYTIVVNPHRRYIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU6</accession>
    <name>A0A218NNU6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">Mia14_0848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891465.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU6"/>
    <dbReference type="GeneID" id="33314397"/>
    <dbReference type="KEGG" id="marh:Mia14_0848"/>
    <dbReference type="OrthoDB" id="7375at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI14135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="486" mass="56305" checksum="084978D4E53A5110" modified="2017-09-27" version="1">MSDENEKEQVKALTAKKKDNFSEWYTQILINSEFIDYSAVSGVIVFRPSSYYVWDKIREATDVLFKEAGIKDAYFPLFIPERFLNKEKEHIAGFNPEVAWVTGAGNSTFDERLAVRPTSETIMYDSYSRWIKSWRDLPLRLNQWNNVVRWEFKHPTPFIRSREFLWNEGHTAFATEKEALEEREQVLGIYSKVLKEVLALEGVPGKKTNKEKFAGAIASYSIEMLMPDGWAIQGPDFHNDGQNFSKSFDIKFTDKNGNYQYVHQNTFAISTRMIGIMVAMHSDDKGLVIPPKLAEIQVVIIPIYNDSNKEKILKYAEELKSKMKDLRVYVDSSDAYSPGWKFNEYELKGIPIRLEIGQKEYEGRFATAKRRDTGEKFTFNVDESESKIKGTLDKIHENLYNKTKEFLESHIHKVYDYEKFKDLIGKDSGFVQAPWCGSTECEDKIAEETKAKATNMPFDAQHDLDGKKCIYCGKEAKYFVNFARSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU7</accession>
    <name>A0A218NNU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820456.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU7"/>
    <dbReference type="GeneID" id="33314422"/>
    <dbReference type="KEGG" id="marh:Mia14_0879"/>
    <dbReference type="OrthoDB" id="33200at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013603">
        <property type="entry name" value="TRASH_TR_C_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08394">
        <property type="entry name" value="Arc_trans_TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="179" mass="20786" checksum="0C05A12D47E4E1B3" modified="2017-09-27" version="1">MRRNISELEQRLILLLKRNSRMSIVDIARELGTSRLTAKKALDSIVSSGRIKKFTISLADEEIDMVLVYTDNLENIPENIILERFCLIDGSYMIILYYEDLIKIKKANIKRVEIATSREVNENMTRAEGIHCDYCRKEIKDNPISLEIRGKTYYVCCPNCERDLKKRGEVILEENSGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU8</accession>
    <name>A0A218NNU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216912.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU8"/>
    <dbReference type="GeneID" id="33314411"/>
    <dbReference type="KEGG" id="marh:Mia14_0865"/>
    <dbReference type="OrthoDB" id="55704at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="112" mass="13492" checksum="94AFAEFBC0AED32B" modified="2017-09-27" version="1">MERTERIVLRGEEEPQVIRYVMADPQKKGTLERLQETVIEKTVNQYELEDRRQIDSVMRFMERNPDISYVEYESNPVFRIDRTITKLGLIFRREEATISATITPNRRFRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU9</accession>
    <name>A0A218NNU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820383.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU9"/>
    <dbReference type="GeneID" id="33314372"/>
    <dbReference type="KEGG" id="marh:Mia14_0824"/>
    <dbReference type="OrthoDB" id="33505at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="415" mass="48292" checksum="6927B5D071221AFC" modified="2017-09-27" version="1">MEMIRAYKFRIYPDAKRQKEIDLQLLLSKEFYNLLLEKSIKSYKGGNKKLSMSTLNKFAKEIEKDKRFLQIYSQVRCEIKYRVLKAYKNFFRRINEKKQGKKVKAGFPRFKSKDRYYSITYPQDNGSFSIKKKGKKHMLRVSKLSGRIEIESHRPIEGKIKTLTIKKKAEEYFAIFTTITETEPPKIEDTDPVGIDMGLHSFVTTSDGMKTEKPKFVRKPVKHIARWQRKIARREKGSERREKAKQHLQNEWEHVAEQSNDFARKLSSKLVNSGYTSFAVEGLHIQNMVKNHNLAQSIYNASWNRFIQMLSYKAESAGMKVIKVDAKDTTQECSNCHHIKEGNERLTLGDRIYHCNVCGLTIDRDINASINILKRATLGQRGSHAQREGVRPQREAVLEELRTDKTHPLQDAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV8</accession>
    <name>A0A218NNV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820433.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV8"/>
    <dbReference type="GeneID" id="33314407"/>
    <dbReference type="KEGG" id="marh:Mia14_0861"/>
    <dbReference type="OrthoDB" id="55589at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="175" mass="19993" checksum="AB2209F143863917" modified="2017-09-27" version="1">MRYRLIYLSIGIAIMVIDILLALKYPKILIYSLWGSFLGFFIPFGIGFSTLLYGAFKAKDYGINPVIGTIGSGGFTRVIRQNRIQGTRTWKTDHDILSELPGALKSPDGKTVEYSSLFIRKPYGSTKYTKRLNEAANKYIAGEIDEEGFYNYVGKRGPKEEQMLEFIKKFKNDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY0</accession>
    <name>A0A218NNY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820485.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY0"/>
    <dbReference type="GeneID" id="33314454"/>
    <dbReference type="KEGG" id="marh:Mia14_0917"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="390" mass="44044" checksum="71B3E108C7054C5D" modified="2017-09-27" version="1">MSESLKIVFYTDSFLPAVDGVVTSILAFKKELENRGNQVHIVAVGNSETRKLVKHNKDITIVRGVKFNKYPQYIFSLTPFTASFKVRKFNPDILHLQTPFTVGLYGLMSSRINNYPAIGSFHTLFNKKEIIEEYLTSNEQMKKFLIKYSWKYLKYFYNKCDATVVPSESIKKYLANRKVKNINVIPNGIDVERFNPSKFSKPLRKTLLGKQNDNASIVLYLGRLSREKNVDVLINAASQLKAEKIKFVIGGTGPLLNKYKEMVANKGLGEKFKFVGFVNEKDLPSYYATADAVCLPSTFETQGIVSLEALASGTPVVGADYLALKNLIVNGKNGELFKPMSAKDCAIKIKKVINNKSSYKEPERTAKEYSIEKMTDKLLNLYVSTLNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY5</accession>
    <name>A0A218NNY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY5"/>
    <dbReference type="KEGG" id="marh:Mia14_0892"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="48" mass="5233" checksum="FC8EA262FA25D6A0" modified="2017-09-27" version="1">MAKPITNSTPAFTSPLKMTNRIMNTINAPPIDVSIVELVTAIWVAHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ6</accession>
    <name>A0A218NNZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820478.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ6"/>
    <dbReference type="GeneID" id="33314445"/>
    <dbReference type="KEGG" id="marh:Mia14_0907"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="100"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="522" mass="60482" checksum="88735DC3F3330120" modified="2017-09-27" version="1">MGYSYYRNRRFSVRLFTVILFVILAFSGVGFSIYLFYVAKSLYVYVIAIGFLLLSVISGGFNLYASMFYYKSYFYKDFLRQINYKLNKKIPEKDLPTVAVAVPVYNENPKILKSTMENLSKMKYPKKKANFYLLDDSTDKRKAEIFKEFSKLYGFRYIHRKNRKAFKAGALNNLLGKMKEEYLAVFDYDEKLVNRNFLLDIIPYFNDKNVSYVQTKKDYVKTGELFPDSCTLFDSFFFDFIEPSRAMDNTAIFAGSCGIIRKSTLKLVGGFPEYIVEDTFFSFESNIRKFKGLYIPKIYALGESMKTFTDLAKQQWRYNYGDTQFLSYFLHRTKNVKTLKERADYFTHGFGLNYISVLVVLFTLISIFIVFSNVPFTALNFYKVLFAGGVVSSYLYLEIFGMVALVGSFLGPAIMTKIYFGSFKRGVMFYLLNFALAIIRTKAALSAVLHTNTKINWSRGNGSITNNLFYSIINTKVELGFAFFIFMLSYIASITNHVSGGVWLLMYGMLYLTTTIFTYKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ9</accession>
    <name>A0A218NNZ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">50S ribosomal protein L31e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820502.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ9"/>
    <dbReference type="GeneID" id="33314471"/>
    <dbReference type="KEGG" id="marh:Mia14_0934"/>
    <dbReference type="OrthoDB" id="10127at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="140" mass="15946" checksum="029172A7A1F04965" modified="2017-09-27" version="1">MANRLLTVNIRNYINRQPRGKRRNRAVRYIRERIAHYTGTEIENVKIDKKLNEAIFKVYSKTALPVKMKLDIDGSGIVTASPFTATITDSSKPAEEGKKKENADKKPSAEKVNEKKAEKPKEKEPKESSKDSKKESKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP14</accession>
    <name>A0A218NP14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP14"/>
    <dbReference type="KEGG" id="marh:Mia14_0945"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="164" mass="17189" checksum="C3DC681B4A0C5D84" modified="2017-09-27" version="1">MEFNTVAPLTVSASGSGSVSPSGTNDYQDGSSPGISESAGYGYYFAGWSCSNINGSGCYSGYNNPAYPTINGNIRETAHFNPNPESDYIYVNKGTGSVSPSGTIGENYGSNVKISATPGGRCGFLDLYAWHFSGWTGSYSSSSNPYTFTQPDYGISEGANFVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP17</accession>
    <name>A0A218NP17_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prefoldin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891473.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP17"/>
    <dbReference type="GeneID" id="33314475"/>
    <dbReference type="KEGG" id="marh:Mia14_0938"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="NCBIfam" id="TIGR00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="139" mass="15773" checksum="488BC604C65CFFB3" modified="2017-09-27" version="1">MASESVGNYDYETINYLRQAYQSRYEELSKAIDLELSRLEKLGQVLESLNKTEKLAKNKVLYPMGEGFYFEAEAGDMGSILVHVGGGYYVEKGLDDAKSFLSMSAKKEQGIISQIMKAKDEVEENIVRLEYQSASQNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP23</accession>
    <name>A0A218NP23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TATA-box binding protein (TBP), component of TFIID and TFIIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820516.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP23"/>
    <dbReference type="GeneID" id="33314485"/>
    <dbReference type="KEGG" id="marh:Mia14_0949"/>
    <dbReference type="OrthoDB" id="350539at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="119" mass="13152" checksum="359F74F9AABEF3F6" modified="2017-09-27" version="1">MVKAKNPKKVSKSKPVAKESVKERGNSSLDNPKINIQNIVVSADLHATIDLYSLSKDVKAVDYEPEQFPGAIFRVPESKAIILFKNGKMICTGSKTEKEVKEVLDYVSKVVSKFVVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP29</accession>
    <name>A0A218NP29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820510.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP29"/>
    <dbReference type="GeneID" id="33314479"/>
    <dbReference type="KEGG" id="marh:Mia14_0942"/>
    <dbReference type="OrthoDB" id="85079at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.240">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38137">
        <property type="entry name" value="PRC-BARREL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38137:SF2">
        <property type="entry name" value="PRC-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC-barrel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="84" mass="9262" checksum="B85C24E6BA8F4443" modified="2017-09-27" version="1">MVKFIIGRQLVGKKVITTDGFDLGEFVDADFSPVTGKINAILVEPDPESSVATKMDTDDDGKIKVPYAAVHSVNDYIMVDRREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP42</accession>
    <name>A0A218NP42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="7" type="ORF">Mia14_0971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820537.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP42"/>
    <dbReference type="GeneID" id="33314507"/>
    <dbReference type="KEGG" id="marh:Mia14_0971"/>
    <dbReference type="OrthoDB" id="5935at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="256" mass="29631" checksum="92DF066740F5009A" modified="2017-09-27" version="1">MSNNIKVPGNAGNRKKVNQVSKKKDILKNKVLNKGKEVKVIQKSNKLPLVKDPYKRLDKKEAKKSKPADAKMIESIYGTTDMQKKIREVIQDLASNEVVTTYLSQRVSKNSIDIVRELVKPKTDDEIAEDLDMKINSVRRIVNILHTYGLTNYRREKNKEGWESFYWYINIRKIPDFLNYVVSVSSTKLNIDEKCNDYFVCSYCYNENRMIFNFDSAFEADFKCVNCGGPMIRISKLQAIDLAKNKLKIEGLKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP50</accession>
    <name>A0A218NP50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ORF">Mia14_0931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820499.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP50"/>
    <dbReference type="GeneID" id="33314468"/>
    <dbReference type="KEGG" id="marh:Mia14_0931"/>
    <dbReference type="OrthoDB" id="371836at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_eS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_eS19_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006811">
        <property type="entry name" value="PRK09333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="135" mass="15018" checksum="26B69602F34768F4" modified="2017-09-27" version="1">MTNLYDVKPGELVKVASAKLKDKISKPDYINFVKSGAGRERPPSDPDFWYIRAASILRQVYINGPIGVSRLRTKYGNAKSHTVHRKHSVRASGSIIRDLLQELEKAKLVKNTPAGRVITPEGASFMDKLSGEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP54</accession>
    <name>A0A218NP54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820551.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP54"/>
    <dbReference type="GeneID" id="33314525"/>
    <dbReference type="KEGG" id="marh:Mia14_0989"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="115" mass="12336" checksum="90F2FAC7B577B36A" modified="2017-09-27" version="1">MDGQIKDSSTGMQASKIGMISGLSFVVMIIFGAIVGDIVFYTFLNSILFYFVGPSSIFLTLVIGIVIVIISASFISQSNEPSGLLYAAIFLGCMGVPLFGGVEIYRVAKKHNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP55</accession>
    <name>A0A218NP55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ORF">Mia14_0984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820547.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP55"/>
    <dbReference type="GeneID" id="33314520"/>
    <dbReference type="KEGG" id="marh:Mia14_0984"/>
    <dbReference type="OrthoDB" id="14749at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="271" mass="30291" checksum="42B73450312F7BEA" modified="2017-09-27" version="1">MFEIKIDDAKYWKNCTDSIVSLVDEGSFYISKEGINLKAMDPSGISMVSFQAPNKIFSKFDVSAKAEAKAKSADSDGEKESKDKEEKSSGYYIGLNLSNFSKLLNSARSGEQLSMKDKDNKMILEFLSSNGHRSYILPMIDVKKSTDSEPKIEFDSSISIKSDYFKGILKDAAQLSTYVGFKLEEDTLIVSAKGDAGELEEEFKSDNEQIHKIDTKKPSSATFNLDYLSRMISACPSSETITLEMKSDQPIRLNYNIGDAKVSYYLAPYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP66</accession>
    <name>A0A218NP66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820561.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP66"/>
    <dbReference type="GeneID" id="33314535"/>
    <dbReference type="KEGG" id="marh:Mia14_0999"/>
    <dbReference type="OrthoDB" id="26738at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF85">
        <property type="entry name" value="SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="346" mass="39616" checksum="794B4CCF79A37505" modified="2017-09-27" version="1">MDANDAKSFKDFISLYKDKVYGLIDGYLPNGEPSAYFESVRCYTDRKGQYRRPSYVLLWSLLYGGDIEEAMLPAASQQVSEDWLLMIDDWMDDNNLRRGGPSAHLIYGDRYAINAASNLQSINWKIVYDACKKLGPEREKRYFDKFYDMINVTHQGQYRDIHLTSDIKDITKFTREDYYTSIHAKSAYYSVYGPMQQGAIVANADEKVIGEIKEYGTPAGLAFQIKDDILDCTSTTDQLGKSIGTDVRDGVKTIILWHAVQDASQDVLNKLAEIYKKKPVDKSKEEIGFVLNQFNELHSIDKSKEDMQKLVDESVEKFNKYTSDIPESHIKELARESIGYAANRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP73</accession>
    <name>A0A218NP73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820575.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP73"/>
    <dbReference type="GeneID" id="33314551"/>
    <dbReference type="KEGG" id="marh:Mia14_1016"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="189" mass="21854" checksum="A77D5AEC68A203C3" modified="2017-09-27" version="1">MDENENMPAWIMAQDLLTKLKYEFANREISLLYDEIKAGRVDFKGALVTDPDKSNENEKYTFMISHLIEERSKIHEMYDSYLKDADNINDPNLLSRVEGLKKFILAVDSIAVLEDYKKEMDDWILDASLSITDSNPSDIIYNTLLNSPKRQEIAEFSITNPYFKNEVLSKDEYALIKNAYDKAKSTDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP77</accession>
    <name>A0A218NP77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820567.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP77"/>
    <dbReference type="GeneID" id="33314543"/>
    <dbReference type="KEGG" id="marh:Mia14_1007"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="89" mass="10038" checksum="450AADDBD72B06C6" modified="2017-09-27" version="1">MDIEKLKTLGKHILVAFCGIVIFTVVSYGLQVVNSYFAGVQNYFNGQSFENTFYTVSVIFIVLMAIDSIFIWLEPFGSDSLIDFIMIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP81</accession>
    <name>A0A218NP81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820580.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP81"/>
    <dbReference type="GeneID" id="33314556"/>
    <dbReference type="KEGG" id="marh:Mia14_1021"/>
    <dbReference type="OrthoDB" id="382658at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="128" mass="14466" checksum="C2D00D7101966FC6" modified="2017-09-27" version="1">MEDNEFEKLTLDYQKVEEQLQNLKIQLEQYKLQSNDLSQAKSEVEKSTGKVYSSIGGVIIEATKDSALSEIKDKEESINLRSSLLSKQISELEKKEATLKSRADELLKEARENEKKQGMGGVSVNMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP94</accession>
    <name>A0A218NP94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_1032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539376.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP94"/>
    <dbReference type="GeneID" id="33314567"/>
    <dbReference type="KEGG" id="marh:Mia14_1032"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="383" mass="44528" checksum="69B89573084BFC24" modified="2017-09-27" version="1">MKICVLNPFFYPYKGGTEKVLFEVYRRLAKKNDITVVTSAPKNYRTDFEDRISGIKVIRLKSDFIYIPKAPMPFVFMHNLDEVLKKVDADLYHINNRFQYFYSTLKTIKDMDKKIAITIHNSSPKNIDATTDNFGYLYDYSWGKKLIHNSDIITGVSMDAIKMTVPKEDVRRSKVIYNGVDFKRFKPRGKNNKIVKKIKSEYYETGINVLNNGRLVTQKGQIYLMKAVSNLLKENYDIKLTLIGNGPLYNKFIRFAKMHGMYENFRIISGIPEEFLPYYYNAADVFVFPSLYEPAGMALLEAMSSEIPSMATRIGGIPEMMGSCGLYFPSENSQGIYSRLKKIIDNGFDKELLIKGRERMVKYHDWNKIAKEYEELFESNLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA5</accession>
    <name>A0A218NPA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820560.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA5"/>
    <dbReference type="GeneID" id="33314534"/>
    <dbReference type="KEGG" id="marh:Mia14_0998"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="91" mass="10204" checksum="D81DBD5ADC43B4DF" modified="2017-09-27" version="1">MAEADESIKKNVNFLLEKKNKEYSMDSLKDPKQLKVNDLATSASMAELLNLFVESKKLSEALLENCMVDETYLATVEINAESIKLKSMTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPC8</accession>
    <name>A0A218NPC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820577.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPC8"/>
    <dbReference type="GeneID" id="33314553"/>
    <dbReference type="KEGG" id="marh:Mia14_1018"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="186" mass="22481" checksum="2B38225C5CEC3E53" modified="2017-09-27" version="1">MKYKNVPNDKNLYIQVFPVDIYQNDVHSINNHEIHRRINEGNNLSGYIKDYREEAVSKALQDNHRDAYYEFATYGGYKPDFITDMFVGRRQVILEPHVYFGNDYVRKLKKFCNEYTNFSLIFIMPDKTYKSLDENLINEIKQFSTIWVIDKFLNNKEQMKHSENAISRKIRKLIDKNKSYEMYERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM4</accession>
    <name>A0A218NLM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819536.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM4"/>
    <dbReference type="GeneID" id="33313582"/>
    <dbReference type="KEGG" id="marh:Mia14_0020"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="148" mass="17380" checksum="7A4626D7231FAB43" modified="2017-09-27" version="1">MSIKYWEFEDAPFKEKIKSPHIGDISRLFFDNETEAYRFSLLLLAIKKGGKVRLKDMPKEVPIATAKRYLEYAVRLGLVKHESSYYELTDRYTQPFRNIALYIKAWMSDNSEEDLLQQFATAKMEKQDKRGGRTGQNEKDIGDNKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN4</accession>
    <name>A0A218NLN4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN4"/>
    <dbReference type="KEGG" id="marh:Mia14_0035"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="82" mass="9190" checksum="CBE2A4DCE1408D51" modified="2017-09-27" version="1">MIIMSESQLPAPQFSGFLAEIVSIDMKHKTGMYGEVYLVSCKILEGKDKGRIIRRNMIGPAKPGDVIRLPDTSREAREIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN5</accession>
    <name>A0A218NLN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819543.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN5"/>
    <dbReference type="GeneID" id="33313589"/>
    <dbReference type="KEGG" id="marh:Mia14_0028"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="111" mass="12280" checksum="B101C5B26719229A" modified="2017-09-27" version="1">MSAEENKVEAVNSGDFEEKVLKSKVPVVVDVWAEWCGPCRMFSPIIEEVAPEYNGKVKFVKLNADDNEDIAAQYNIMSIPTSLLVVNGEVKAENVGAVPKAVLKKWIDENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR1</accession>
    <name>A0A218NLR1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819553.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR1"/>
    <dbReference type="GeneID" id="33313599"/>
    <dbReference type="KEGG" id="marh:Mia14_0037"/>
    <dbReference type="OrthoDB" id="6425at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="183"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="421" mass="46562" checksum="43B9033230BB97B7" modified="2017-09-27" version="1">MAEELNPFKIAQEQLDQAAKIMNLDENAHQILREPFEIITVHIPVKMHDGSVKLFEGFRVHHNNARGPMKGGIRFYPTETVDEVKALSEWMTWKCALANLPFGGAKGGVICNPKELTANELEQLSRGYIRAVRAFVSPKIDIPAPDVYTTPQIMAWMMDEYSKLVGHNEFGTITGKPLEVGGSEGRNDSTAMGAMFVLREAAKKLNIDLKTAKIAVQGFGNAGMFAYTLSKKLFGAKVVAISDSKGAVYDEKGLDLDKLEKAKKETGSVQGYEGGKKLTNEELLESDVDILIPAAIESQITAENAGKIRAKLVLELANGPVTPDADKILFDKGILDLPDFLVNSGGVIGSYFEWVQNNEGYYWTAEEVYSKLDTIITKSFYDMMKVQEDYLSKGTKITPRNAAYIIAVDRVAKAMKLRGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS2</accession>
    <name>A0A218NLS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S2P/M50B family signal peptide peptidase RseP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS2"/>
    <dbReference type="KEGG" id="marh:Mia14_0081"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="230"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="480" mass="52849" checksum="0DF2045BE9C7E3B2" modified="2017-09-27" version="1">MAYVILLVVSMFIIYRLYYASYLGLILQWVLAIATLIISGIIITKVDGLNGGYGIYLLKTKRGLNAIRKIAYSNEKFWQLFAAWGMILGFGVLSYLILGNKISKKMYAFGLISLIIITMFVLPYMSYAATFINLPKLSSHVDFITSIKVPGFFTLLYDLAHESPVLVILNIITISTGFAGYVLSSILYNAGDIVYLVIKSIEISSVKPLSSGIPGVAPVIPGIDLPLVAGLIALALLLVVHEFSHGILAALSKVKLKSIGLLMLGILPMGAFVEPNEDEIAKLDNLSQNKISVAGVSANFLFMIIFFIPMILMLPYVVNHIYHTNVVVVGTMKGYPAYGVVKNNSDLLYWNGLKVKNLTELENDASKTYPGELINIATSTGNYSLVAKPYNKTTSLIGIEVEQVTEPLTNTVSKSVIFFFYTLFALSFMLNFLIGAVNLLPIPGFDGWRIYSTSIKDKRKIHLIIAIIIIALVVNVLPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS3</accession>
    <name>A0A218NLS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SBDS family ribosome maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819563.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS3"/>
    <dbReference type="GeneID" id="33313609"/>
    <dbReference type="KEGG" id="marh:Mia14_0049"/>
    <dbReference type="OrthoDB" id="84504at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF4">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SDO1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="3">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="228" mass="25703" checksum="EDC36091297E3D94" modified="2017-09-27" version="1">MESKIVIAKYGVGKDEFEILVDADLAYQYITNKIKDPITVLETEEIFKDARKGERQSEEKLKKAFGTTELPTIVDKILRKGNVPITTEQKNKLLEDKRKQIINIIARNAIDPRTNAPTPSLRVENAMSEARVSIDPFKSASEQIEEVIKKINMILPIKFAVAKIEVSIPPEYASRCYGVLKEYGIKSQQWLKDGSLQAAVEFPAGMQSEFFDKINKLTQGKAVTKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU4</accession>
    <name>A0A218NLU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819611.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU4"/>
    <dbReference type="GeneID" id="33313660"/>
    <dbReference type="KEGG" id="marh:Mia14_0100"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="408" mass="46185" checksum="684342675A1B77D4" modified="2017-09-27" version="1">MANIGEETNSDKKSSHYDEVLNVINTNQQIAYHDIKDALEKEISDSELDKTLKNLENDKKIISRSSGGIMTYYSLYDEPRISKIMIVEDDKNINKLMSISIGKGYDITQVYDGGEALGLIKKIHPNLIILDLMLPVIDGMQICERVKSDPELSSAIVILVSAMDPTSNRFKGIKNGADYYIKKPFDPLELRTLVTLFLKKKGKRFDPLIDLPDEERISAELERSLKQGEKYKIGTLSIENLGPYANRFGEHSAIILLRLISQLLQDLIKNKDLFVGFLNSDSFVIAGMEDDVNKAVEAAQKEFNAVLTFVVQDIGYRQIDLNLDNIFESNEIPKLALTYREAPKELIKERREKILIGKDQKSGDLGSYTYDELQKLFGREDLDVIITRDANGIKLRVGKVNNDKGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU5</accession>
    <name>A0A218NLU5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="10">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gltX</name>
        <name evidence="14" type="ORF">Mia14_0096</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU5"/>
    <dbReference type="KEGG" id="marh:Mia14_0096"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="101"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="576" mass="66032" checksum="3A6D47281643CE15" modified="2017-09-27" version="1">MVNLRDIVYEYAIKNAFSYGKANFGSVLSKAISKVPESKKDMQLLKDTVNEVVNSVNAMSKEDINREYSKYADIFEKEYQEKLETTSKANIKIEGAEKGNVITRFPPEPGGYIHIGNAKQCILSDEISKLYDGKIYLYWDDTNPEKCKEQYISSIKEDTAWLGIKFDKEYYASDNIDKIYDYGRKLITDGNAYVCGCSPEEINNNRRNGIECKDRLRPTEENRELFEKMISGDVEGGKLIVRFKGDMKSENSAMRDPTLFRINKAPHYRQGTKYSVWPTYHMNTPILDSINGITDAIRSKEYEVWDSVDKKLISCLGLRQPRIHYEARLNIEGTITKKRLIREFINKGYIKEWDDPRLVTISALKRRGILPEAIKNFILKFGMSRNDTTVKMDMLLSENKRILEPTVPHLFFISNPLELQVDGIDAAPKLKLNPNDKQNPAYREYPKDDKFYISKNSISDLAIGSTVKLKDFINLQLVSIEDKKVTAKALDGKEHFDKIITWTPYNGKAASSILIPGEIVDKAENYIPESIKYVEGYAEGYATELKVGDIVLFEKFGYCRLDKISEGKYDFIFTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV8</accession>
    <name>A0A218NLV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819616.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV8"/>
    <dbReference type="GeneID" id="33313666"/>
    <dbReference type="KEGG" id="marh:Mia14_0106"/>
    <dbReference type="OrthoDB" id="8831at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="153" mass="17736" checksum="6A1B6D8EB4485B32" modified="2017-09-27" version="1">MRFKKFEYQSHTADVEFLAYGRSFEKVLGNSILAMANTIANTRRINADARKWDSIKVYHIKLTERSEKGSYLDLLWYVLQDALSIADYRGLFIFRVSSIEMHNGKTKDNVRVELDAVKKQDKYSYIEVKGVSKYNMSLKFADGVYKADIVIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX8</accession>
    <name>A0A218NLX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="11" type="ORF">Mia14_0142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819647.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX8"/>
    <dbReference type="GeneID" id="33313701"/>
    <dbReference type="KEGG" id="marh:Mia14_0142"/>
    <dbReference type="OrthoDB" id="35932at2157"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="170"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="7">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="433" mass="49768" checksum="8960A52DA7E97DDD" modified="2017-09-27" version="1">MLTTRYVRDHLDEIKESLKRRRSDYPIEELVKLDSEWREKSTSLQELQAKRNKESLKIAELKKKGEDASEMISQMSGLKDEIANLEKELPEKESRIKYLLWNMPNVLDKSVPYGKDDSENVEIRKWGEIRRKTSKSHEDILNGLGLLDIERAAKVSGSRFYYLKNELVLLEQSLIRFALDELVKKGFTIISPPFMIKRDYYTGVTALGDFEDALYKIADPREASDDKSLERITEEMFLISTSEHPIASMHAGEVFSSKELPLKYAGISPCFRREAGSHGKDTKGIFRVHQFYKVEQFIFSREEDSWKHYDELLGNSESLYQKLGIPYHVVDICTGDIGTVAAKKNDIEAYMPSQGKYREVVSCSNCTDWQSLRLDIKYDEGGERKYVHTLNSTAIATTRTLVAIIENYSNDDGSITIPDVLVPYFGKDRIAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY1</accession>
    <name>A0A218NLY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819644.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY1"/>
    <dbReference type="GeneID" id="33313698"/>
    <dbReference type="KEGG" id="marh:Mia14_0139"/>
    <dbReference type="OrthoDB" id="385686at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022651">
        <property type="entry name" value="S_layer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006454">
        <property type="entry name" value="S_layer_MJ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01564">
        <property type="entry name" value="S_layer_MJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05124">
        <property type="entry name" value="S_layer_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-layer protein outer" evidence="1">
        <location>
            <begin position="39"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="963" mass="100072" checksum="DC958ED3A5801BE8" modified="2017-09-27" version="1">MKHINAKRVAAVAVGTALLGMGLAFAVPVSFQSVPIVSSAGQPVVQIALGYNGTYPASITDGVAAADIAAAIGNLAYTTTPVTVNINASQARSVLKPVVTSSAYKLTDQQVWLNESSSAYVSGSYSFGALIGSVFNRGIKLNTLSATKTVGTVDAYPTTYNLTASPTASPYTATGFVPVSTSVSASTNGGGVSFSSFLNGTDANIMRVTSTNLPSLLSNYGANGENEYLWLTGFPVYDQANSSFALVNAGGAYQINFNKPIPAYTSSNSINHASIMFLGKNWTIANYTLPSGTVSSSTYTTGGKLELASAVSPITTLYLDHFLNSTPFGVELSGFTEPNSSGISQPIYHVFYNGTLVNSTTIKIGTTKLFNVSGHKIYVYVKSAAADVFESASYAKTQLYTNVYNITDGAQLNKTSAPGWYTDILWTNSSTSGTPNELEGIVAYNSTPTTLYPGQSFSFISDPAIWKLDFEGSSLASGDYDHVTSTLTSVSNIKYSNKGAAALETNITEPGQELSVSSSISNAFSFDGQINSTVNYLLTPYELNDTAHTAPANTAAEVSISSPGNYISATNPLSVVLTGYLSSSAVSPTSASVTFNSVSGNVIAPLDFYNLTSIEPQRAIPGMEITAMAGSNTIGVLAPIPTAQILLTPVSGSSVYGLGSAGSVTYSQQNGQPTTTFALSGSQDSNTMHGTQTAYYTYTMNEYDVPSSTNYNDSLSYAILNSSAGADATPLFQLNYSSSATGYSHNNMTYLSSQKNSVKAPAGFVTERGSKVASIAPESAVVDMATSVGELNFYVAPTNVTAVVSHAKTYGPYSIGEATNIPNVTIANVSAKISVSNANYTISGISNLSSAVTTTPSVADVPTNIENMTMPGSPSGLVILDTQAAPTSSLILVGSGYVNTLSAQLQKAYNISVTPTSAPIVKAYPSSATVGGPRILVAGYNASQTMSAAKTFIEDLYANAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ8</accession>
    <name>A0A218NLZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216864.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33313711"/>
    <dbReference type="KEGG" id="marh:Mia14_0152"/>
    <dbReference type="OrthoDB" id="387149at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2780"/>
            <end position="2797"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="621"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="2805" mass="300572" checksum="988BC342D18E33A1" modified="2017-09-27" version="1">MYITKSYIINMAALSQSRLLKTIIAVVLFSSIIYITYSIQIGHTASVAITSNNFNLSNLSSSYNIKDNLVLQNESINTVVNPRNGTNTSKLIADPTFSPPGCFKSYGGISYWYCYVEMNVSSNYDGTATSSPGGSTSTSDTYELYAGNFYYVSPSYSVDISESPSTGYEFVDWTCSGSGCYSGTATSKSLSGLGSSIEETAHFKLIPETLTMNVNPSNDGSTSPGVGSHTYGYGTTVSLSETPATGYEFVDWTCNGNGCYSGTSTNPTVTLKNSITETANFKLIPETLTMNMNPSSGGSISPSVGNYIYNYGTVITITESPSTGYEFTGWTGSGSGSYTGNKSVSSVTMDSAITETANFKLIPETLTMNVNPSSGGTTSPSVGTYTYNYGTSITISETPNPGYTFYDWTCGGYDCYSGTSQSATIKSNNSISETANYEVNLTMEVSPTGTGSTTPSIGIHPYAYGTSVLISETPAKYYEFVKWIGSTNSSYSGNATSTYITLNYPTTEEAVFKVIPLVLYTPSVSASSIEDGQSETITEKLSGGLPNYTYIANIYWYNTSDNAYVKVNSTKIITSNSSSSVTFYSEYYPLGKYKVNYTVTDSESPPVTEISGSNYFEVTLPMSVEIKPEYASYDAGESITLNAIVSGGTSPYSYKWYNNTSGSPSVMSSYTSNSITLSTSNVKSNSTFEYFVNVTDSASSPQTIESKISHINVFYPGLSKPNFTVLPSNNILGVETYPEYTNISFNASGVSGGDPPYTYSFSIYRNSTSGKVLYVSKSVVSSSSFYNISYNFTSTGNYTANVSVSDSATVPEVQSSKTIKINIYSAYGGIVGPAPLTCPKNVKLTPGTTTISGSQTLYSSQCYYNLTVDSGATLTLLSGVNITVLNTFTNNGVITSSGEGESGYSTSNGYGNNGNADYQSYAGGEGGTAVDYNSYDAIDIGATAIGGAGGNGPSIKHANYVHSGNGNLSNGGNYSGAGGAGTGWGTLTGGKPPGFGGSGAAGGFIEIKALNFLNNGKIESNGAEGTPYNVTGAEECVPFTSICAKQISEGEGGGGSGGEILLVAESNSISDVNIGNVEAEGGNTDSLTCGTSGVYYAASGSGGGGGVVIVEARSSVKNGEGSSLTSGINVNGGTAGSVTDQDSTYCYKYGNGNDGTKGNVYTSTLALMAYVPKICRGPAPNGTGLPTLNDGYCYFNESVVTTTQYSDGLSGSLSVTDSEPPSESPSSANAIKNSFSDAGWLITCPNAPQPGDVIEYFMSNKNSYIGGDECLTNNTPSVDGVGLSTFVEWTNSTPAFANVSIYISNDTPTIRNLGYIGEVNYTDIPASSPFSNLNSNEYIISNGYNSQSYMFDSVPDSPEAGIWSWDIKLPDVSSVSISKPISHTLTNLYYYNETGDKGIEDCNITYDYSENATLNNIRNAYIPIPGNVTPKPTVESYFNNSGFYWKVPSVSKSSAFSSGLAYVSCAYYLYQGSSSSTLCPSGSYSLVTNKADFYLNTSGYRTTSDGISLSHNLFLYTSSSGSYYLMSVESSTKGGLDGVLGYTYYTFETPATQPFTDVNATVLPYLLYNISMPATTSDVSGRSELMNLSFDLYSPYNYMTPSGHLDPFNLTTGSGFFATYNETTSSTSHQLVLAQYPSNSIHSSSSSTFDNPDTQFTLSLTQAQRTSNANLSSFLSGVISAIGGSTVGSFLGTGFPNPAFIGESPDDYIYAINYTHTSGWLDFNSKTTTDLAELRYIPKGYYNMLNIQPSEIANERESNLSSWDNAWAVFWNDSLLEQAHNLFITDVIPISNYTTSWFGALNGNTNKEVFQYFVPTSMVTDYAGDIFVVGKFTAPKSIWGDIVNVFDSGASGQFELAAVYSNGTAKSEVDPITSGQSFEPTSEMAVAPGGQYIYLANSSYGYIPFYSGSSLKPAGYQIDTSYNTSTTMFNITSYLAHGGPFDNSTIASFYKGMPAAYDNDSNHHIYGLGEAGGLLYVLDLWNFTINGNSSSILMLQAYNDNGTQVPINPSAYNNMVVDPGQIAPTPITGINNETEYPPYGWPLAANISVGNSGYITYCVADCNYTPSNMKLSQTNGYPPIGPKISAYGLPSGMFPHDFGFSTDFNGTINLLIHDSVLELCTDYSDAGDGQAIPYSYQCPEPVYNEFLTFKMNINNYTEVSLGENSPWNCFINQSEPNLPTQCVIDSNLNKMYAPIEEVPSSFKYIQNEGSPGKFLSISTSFSSIYPNSTKSSQGNSTDVTNPGNGLNNSANASKISAPTYVLSEKSINLTSHIGGYIMIPYYVNYTLTQNYTMVKYSGTACSTTGALPSNSSKTYTYFSAADVPAHSEYVNSTIEGGPTYGEYAYNNEYYTSSVYDNSSIIPPNVLLEMFTNRLFGSAAVNYTTRGSNYIVQDPLNESLAFNYTNETINQSVGNNNYPGYQIIGVIPKKISYTDQTNVPMVFENETSNIGISLFDVYKIDRYTDTISLPLSGMTKLRGYNRLIYTFKDVFNNTIYMPVDVDISNTTSISLNVEPNLNPINSNETNITVSGVATYSNGSVDSLEYLPKGSLIYIYYNRNINFYNATDVNNQDPSSVSNPAAYLAYGNECTVNPTMSGCRLAQPLDKLQQGNGVAEANLTAFNTQYNSTSSNTCSPEPKSLLEKTNYTCNIYGAYGLPKSGTDVRGNVEYCNPIFTNGTGMLTSEEGLVNIVKVGSNGQFNDSFNTCGTGDAKIIAEYYGASGPEPISINQPSMSHSVEFDGNIPSEYVKSYYEYNYTYSPYSSSQTINIGNFSLAFNGVNAVYSMALLSAFIVAAMIYKRRRIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM09</accession>
    <name>A0A218NM09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">S2P/M50B family intramembrane-cleaving metalloendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819670.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM09"/>
    <dbReference type="GeneID" id="33313726"/>
    <dbReference type="KEGG" id="marh:Mia14_0168"/>
    <dbReference type="OrthoDB" id="86131at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052348">
        <property type="entry name" value="Metallopeptidase_M50B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="Rip2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864">
        <property type="entry name" value="ZINC METALLOPROTEASE MJ0611-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864:SF1">
        <property type="entry name" value="ZINC METALLOPROTEASE YWHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="237" mass="26677" checksum="13645D68E1A4A666" modified="2017-09-27" version="1">MVYRYNIPVKEEIKEIVIADLVLTIAFTLSLMGGLFSRSPNFVERFAIYLPGIFIIVTLTFVLHELMHRQVAKHFGAVASFQYSVNGLLITLATGVFGFIFGIPGATVIYTNNFTRKEEGLVSIAGPLMNFAVFVLFFAIFIMSPYINNSYVTLIAALGMFISILLAFFNMLPIMPLDGAKVLNWNKKVYFSSMVIIFILMAVSYLILTGSILDMFMEVAIMIVLASFFSLFYRRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM10</accession>
    <name>A0A218NM10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819663.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM10"/>
    <dbReference type="GeneID" id="33313718"/>
    <dbReference type="KEGG" id="marh:Mia14_0159"/>
    <dbReference type="OrthoDB" id="6533at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="155" mass="18006" checksum="B073CE5690BB09CA" modified="2017-09-27" version="1">MAKLHTKRHGKSGSLKPIMEKGQLPEGLKVNKEEIEKLIVDYAQHGMPPALIGETLKKEKGVGYIKQITGKRLMQILKDNNMKFDLPPDLMDLMKKAVRLNKHMANNHMDVHNKIRLKRVESKIWRLTKYYINEGVLPEGWRYNAQQAELLIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM19</accession>
    <name>A0A218NM19_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="14" type="ORF">Mia14_0164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819668.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM19"/>
    <dbReference type="GeneID" id="33313723"/>
    <dbReference type="KEGG" id="marh:Mia14_0164"/>
    <dbReference type="OrthoDB" id="30963at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.65.10">
        <property type="entry name" value="Bacterial Topoisomerase I, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF26">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="Zn_ribbon_Top1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="13">
        <location>
            <begin position="161"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="740" mass="82919" checksum="B813D568306DA62E" modified="2017-09-27" version="1">MTNTLIIAEKPSVAARIAEAIGDSRPESKSNGRYRYYEINSGGQKIFIAPAVGHLFTIKQKGSAHGYPVLDVEWAPSYAVSKNSAFTKGYLDTLRKLSENCDYFINACDYDTEGTVIGTNIIKDVTKQDLASLNGKAHRMKFSTTTDKDLRESYKNIEPLDLNNYYAGETRHILDWLWGINFSRALTAALWGSLKKPLSIGRVQGPTLSILSTRELEIKDFKPEPFWKITGEIKGVKFTNSKGNIFDKSIAELAFKNTELHLDEGRIEKIDVKEESKQPPPPFDLTSLQIEASHVLNLDPSVTLSIAQSLYEKSYISYPRTSSQKLPYTLGLPSIISEIAKNPEYRDIAQSLLSRKRFKPVEGKKTDEAHPSVFPTGVLPKELSRQEQQLYDLVTRRFLSCFEENASIMHTNISAAFGDEKYKASGARITKKGWMDTYKYAKLSEVELPEFLQNEPVKLDNPNMAELKTQPPKRYTKAGIIAELEKRGLGTKATRAAIVDTLFKRNYVTGQQLQVTDFGLAVYNALLHNCEMIIDEKTTRKLDKDLEEIIDNKITENDVISEGKKLLLEALKVFDEHKVQIGNELKSSFKSVNSLGKCPKCGGDLVIRHSHIGKQFVACSNYPNCTVTYPLPQSAKIVPTGKVCEHCKTPIVKVIRKGKKSFEMDLDPNCITKKAYYEKANKQPQESSNPVNAVTAKSMLDKSTQKPKKTKTRKKSSTKKRATSAKSKAKQAKAPKTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM25</accession>
    <name>A0A218NM25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UMF12 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819689.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM25"/>
    <dbReference type="GeneID" id="33313745"/>
    <dbReference type="KEGG" id="marh:Mia14_0187"/>
    <dbReference type="OrthoDB" id="56622at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="391" mass="42460" checksum="92FCF9FEC4175D98" modified="2017-09-27" version="1">MDLDSSFKFLEYSRASRSAGIIFMVLAFPLYLKLLNLKLVTIGIIIAAIMLVTVIETLALGMFGDRYGYKYSLLIAELLPVIGAFLLFYSSSLDIIIIAMVITGLSGGAGGMRGLFSPGLTALIASNYENESIRVKKLGILTMLTSLFSILGSFMLASESFISRYVGTLMAYRYLFLFADLLLLISFISIIFVKEIKRPKKTSKIMKKESFKYISKIMVINIVSGVGTGISVPLLPLWIELMYSTGATTVGIIFGISYITTALGSYLASKSFGRFNVLNVSSITRTASGIILIAMALSPTVIIAGFMYILRSIFAGFGSPNRSALNVRGIDKEDYGSATSFNGVSSRMSQLSSGLSGYLMDISLPIPLIIGGIFQGASGILYKIFIKEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM33</accession>
    <name>A0A218NM33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ERCC4-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819691.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM33"/>
    <dbReference type="GeneID" id="33313748"/>
    <dbReference type="KEGG" id="marh:Mia14_0190"/>
    <dbReference type="OrthoDB" id="9764at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="354"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="519" mass="58530" checksum="4CB164FF8C2CD5FA" modified="2017-09-27" version="1">MENDFSFIGQCSELVKSKGIEARAYQINIIRSIINGGNTLVVLPTGLGKTLIAVFSIACTLYDGKKALMLAPTKPLSEQHFNSLRSLLNINEDDILLLTGKLPIAKRKVLEERARIIIATPQTVANDLKSSNLDLDQFGIAIFDEVHRAVGRYAYTYVADKCKEKNIKILGLTASPGNSRDKIMELIDTLAIDNIEVRTPEDPDVAPYVKEKNVTKILVEKGETVERISSLLKGLIEEHLYALFHIGLCPFKKLESISKMRILDIGKNIDQLKGSNYKFIAIFHYIYVLDLLHAYDLVTTEGIQPFMSYIDSIRNKEKKNRSVQSMLKNHVFLKAVGIAETALKNGEEHPKMKALVQLITENHIDNKIIIFAQYRYTISKIVEVLNNAGLKAMAFVGKKEGVTQDQQMQVIKDFRDGKFNILVATSIGEEGLDIPSVDTVIFYEPITSSIRSIQRKGRTGRFNVGNIYVLITKDTKDETYFMVSSFREKKMYDMILRIKKSLERMPKPAAAKAGQKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM40</accession>
    <name>A0A218NM40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecA-superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819688.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM40"/>
    <dbReference type="GeneID" id="33313744"/>
    <dbReference type="KEGG" id="marh:Mia14_0186"/>
    <dbReference type="OrthoDB" id="27015at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="243" mass="26928" checksum="14F047F4C3797431" modified="2017-09-27" version="1">MRERTKTGIKNFDDIVGGGIPQGNQVALAGGPGAGKTLFSFEYLYHNAKAGEVSLMFSLEETSDMIVENAKAAFPEFKDIDDLISQNKLIIYGSEKTGQYVQRDTDGGSYSFNELVSGISSIASSYKASNLVVDSITVIKLMIKDKLTYRQLTMDLINGLRSQNITSLMTIELNTATREDIQFKPEFFMYDGIISLYLEGGSNNRVPILEVIKMRGTDHSFRTYPYEIKGDGIAVLSLPQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM52</accession>
    <name>A0A218NM52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U73 family octaprenyl pyrophosphate-binding small protease YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819703.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM52"/>
    <dbReference type="GeneID" id="33313762"/>
    <dbReference type="KEGG" id="marh:Mia14_0204"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="entry name" value="Lipid/polyisoprenoid-binding, YceI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34406">
        <property type="entry name" value="PROTEIN YCEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34406:SF1">
        <property type="entry name" value="PROTEIN YCEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="YceI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipid/polyisoprenoid-binding YceI-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="18722" checksum="2BED7DBD8364C628" modified="2017-09-27" version="1">MELNKLSYPDSKINFTVRHTFSQFNGSFSKFELVMEGNTGDINSLKANLSVDISSLDAGIPMLTKHLITKEEFFNAPKYPNANFVSTKVEKKSEGVLHVKGDMTIKDITKEIHLDVNYKEDESGVVINFNTDLKRSDFGLRTKTFLDRFGIISNTAKVSGVFKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM65</accession>
    <name>A0A218NM65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC48 family ATPase of the AAA+ class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM65"/>
    <dbReference type="KEGG" id="marh:Mia14_0219"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="339"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="590" mass="66571" checksum="5155A45F6E5835B5" modified="2017-09-27" version="1">MFILVQVLAIAGCTLCFYALNCYYFIYFYCYFNLVIMFDSVKFEDILEDLKTLRLDKALKDCQKYEKGFASDSASNKYMTEFIASCVGINKLNSSLARDYAFKLIKIDPNDISKIMLSASYLIENDYENSVKSITDIIQNSSSDSYLQLSYINQKPAMYVIASLVMFGSGDVQDALSMVKYAISEDVKGRFLGSELLIEAMIYVSKNDNARAMADLTNALQLGYKSNQETVDKLLKFARGGNNEYSRLMPIFYDVRTDFIKDLSYDMIYNVVFKSTKNDYYSGEMNTNSTGVTSFASAEKPKERYSDLVDMEDQKDELSKYIIYPLKYSNNLSSYGIKVGGGVLLYGPPGCGKTYVVMATAGEAEVKFIDVKIPDVIDALVGNTEKNIHNLFEYARENSPSILFFDELDALGVSRDETGNAPWMRQAVNTMLSEMNNLYDKGYKVLVVGATNEPWLIDPALRRSGRFGNIMYIPPPTKPIRVKLFQSYLKGKPISDDIDFDKLGELTKGASHSDIKSICEDSSREVWAKSIKSNTPNLPIGMNDLLTSLSKIKFVVPEWYRSAVNYLGDGLNDYPELKDDMLRFFNKGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM69</accession>
    <name>A0A218NM69_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM69"/>
    <dbReference type="KEGG" id="marh:Mia14_0220"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13994" checksum="617EBDB8019FAC14" modified="2017-09-27" version="1">MLCSTYIQAKFTLGVRISNLNNATPEDIDILFVVNSENYLTIKSLMELSEVSLSRYKVLILVDKQVKIPFRKIPENVDFITEESVNSEIMKYKPNYVNVINQDTGLSELYMSTISYYSEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM79</accession>
    <name>A0A218NM79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NosD-like parallel beta-helix repeat membrane-crossing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819743.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM79"/>
    <dbReference type="GeneID" id="33313807"/>
    <dbReference type="KEGG" id="marh:Mia14_0249"/>
    <dbReference type="OrthoDB" id="386422at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="312"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="542"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Periplasmic copper-binding protein NosD beta helix" evidence="3">
        <location>
            <begin position="772"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116567" checksum="9603E58F8B69973B" modified="2017-09-27" version="1">MESDTSEDNIEDEDNTQSGNDYISKLQQNSQEAEQNNSPDQSDEPSSSNDSSSDNDKADDSSPQPTTDNDGNEAITEPPKKKKPKNISNLNIGFKGSNQEAQEGEEANQGNRKPIPEIPNLDAPSKPPENNNEDNSGIKWDTSGYNPHAYVSGSNANNRSSNTNYNQPISSEGKSIANNQPKRKFGFPNNKKLATVKPKVLLTTEQAQKRNKKFLLVMVIILIAIIAVVLASTYLHHKKVIVPPPPPTPKFHYINSCQDVINPGVYYLGVNLTYSGSSGTCITIDTNNVAFICKDKGISGKGPYIVTSTSTNGVVINKKSNVSISGCSIKDFSYGVSIQNSSGVSITFDNISHNTISNVRISGGENNSVINNTLSGAGLDYGSLYLTGNTTDNLVEFNKITSSANYSIYVNSSGNKFYENYINNTPYGFYCNVDYGLIRSNLAKSNICNTNFGCDFVKCSLLNIPDNVSKITLTPSITSCGSITSPGDYYLKNNISAGYAYSNTSSSLVKNISLYYPKCITIKSPNVNLDCNNFTIYNSSEGIYYLGLSNVSIENCNFRNVNKSINVSISNDSKISNIRINDSSIYGVGVVSSTKVDFSNLSISNSTKGINIFADSEYNSFNKIAVSNNFYGIYLNISNLNDFSNFTINKNTFGVFINDSLYNQFNKGTILNSTKIDLYAQPGSIANKTTNLFYSTVCGLSDTKWGVCTYYVLPNLKFYPVDSCLNVTRSGTYALDKNLVTSSSDCIDIKVPDVNLSCGGYSISQLTPGYGSAIYDKGEKNVTISGCAVYTFNKAFDFEETSNINIYNSTASDQTPIYFSDVNHSYIINNTFDISGNTGLILRNVSKSVIYTNKITGNSKGSGLVLNNSYLNLIFNNSIYSNKIGFALYNNSVKNTIFNNTVQISSNYDYYCSPNASPIYSEYKGFNYGQKENDCYWLSALSPTSPSAECYIVSNPTTINLGADYLYKYGTVCMKIRSNDVTFNCDNHTVSALNGGTFINVSNSKNFKLENCYMQGFTAPIQVYNSSGELTNNQILVKSAYKSDAIEISNSPNMSSQNNLVYNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM85</accession>
    <name>A0A218NM85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819739.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM85"/>
    <dbReference type="GeneID" id="33313801"/>
    <dbReference type="KEGG" id="marh:Mia14_0243"/>
    <dbReference type="OrthoDB" id="45556at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004470">
        <property type="term" value="F:malic enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051674">
        <property type="entry name" value="Malate_Decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237:SF4">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="3">
        <location>
            <begin position="160"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="421" mass="45417" checksum="1CA8850069DF1F8C" modified="2017-09-27" version="1">MTTEKDILDAHSIMHGKIEIIPKVKIESNQDLSIHYTPGVATVCNAIKDNRDLAYEYTNKGNMIAVISDGTRILGLGNIGPEAGLPVMEGKSLLFKRYGGVDAIPMCIGTTDEEEIIKFAKQISPTLGGINIEDIESPKSFRIVDRLSEELDIPVLHDDQQGTAMVILAGLINSLKLAGKDLNKVKIVVNGAGSAGMGVVRLLALAKVKNVYVVDTHGIIYDGRNEGMNEFKEEIARLTNPEKDKGSLADAAKGADVLIGLSKPNVFTADIVNGMNEKPIIFALANPMPEIDYDEAKKLGAFVVATGRSDKPNQVNNLLGFPGIMRGLLDSRAKKVTYSMLYDAAVALADSVGDKLSTEYILPSVGNPNESVGVFENVAFAVAETAVKESNSRITDLDAIKSTIRKNLERNRGLHEKLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB4</accession>
    <name>A0A218NMB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome association toxin RatA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819768.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB4"/>
    <dbReference type="GeneID" id="33313833"/>
    <dbReference type="KEGG" id="marh:Mia14_0276"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="274" mass="30764" checksum="C03513CCAAF9F0FD" modified="2017-09-27" version="1">MVVIDNSKLHKRKNNKTPNKRSQSKKNQNNTIRTSKWKYTPKVKINKKALNHDKEVSENIKLKDIAIKVFVIEVIILFVFSAVPISKSYQSKLVSSFNSLAGPIYNQSYPMMVYSIASHNLEVATSELIPVIGPAEFVLSSSITAITAETLGKSENASVPGPLLMFGLFLLPDTWIELIAYSAAVAESIMLLLAILKKTFKHEVKRAVYVWVFIVIDLFVAASLESGALVLKNVVYLMMLWIPAFIIVGLFLVIAKKLRIFTYSKISNRRLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB7</accession>
    <name>A0A218NMB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819772.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB7"/>
    <dbReference type="GeneID" id="33313837"/>
    <dbReference type="KEGG" id="marh:Mia14_0280"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="ChsH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="ChsH2_Znr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052513">
        <property type="entry name" value="Thioester_dehydratase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075:SF5">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_ChsH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="zf-ChsH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 rubredoxin-like zinc ribbon" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="ChsH2 C-terminal OB-fold" evidence="1">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="130" mass="14860" checksum="AB39498405EFBE94" modified="2017-09-27" version="1">MKEPMYNYREDSEKLNFVGNECSKCHKVYFPKRKVCKDCGSTEMTDKKLSGNGEIYSYTRIMVPPEDFSDKVSYYAVVAKLDEGPKVSGILVDSGILPKIGLKVNPVLRLMKKDKETGLPRYQMKFEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC0</accession>
    <name>A0A218NMC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819770.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC0"/>
    <dbReference type="GeneID" id="33313835"/>
    <dbReference type="KEGG" id="marh:Mia14_0278"/>
    <dbReference type="OrthoDB" id="379105at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="144" mass="15729" checksum="6B6D887C055675AC" modified="2017-09-27" version="1">MISGFVISKVDGKLDSVGDLANQRFPKLNINFDSVEKEDKKLKVDYTFTASYSNSEKENSKEIGSIGLSGYITIEDTAENIEAAVSKWKSKHTLPVNIAEEIINGLNFRCSATGTLIAYSLGLIPPLVISQTKIEEPKEEGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG3</accession>
    <name>A0A218NMG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819823.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG3"/>
    <dbReference type="GeneID" id="33313891"/>
    <dbReference type="KEGG" id="marh:Mia14_0333"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="70" mass="8491" checksum="362DAF61533526A1" modified="2017-09-27" version="1">MKNFFKEVKKEKKIEEETGIKFMKDKEYALKFNKFFRSSLEALEKDPELEKELEKNTPNKFSKKTAKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG7</accession>
    <name>A0A218NMG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxycytidylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819833.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG7"/>
    <dbReference type="GeneID" id="33313902"/>
    <dbReference type="KEGG" id="marh:Mia14_0345"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="178" mass="20431" checksum="FBDAC77B90E13C32" modified="2017-09-27" version="1">MRHLSEEEAAAIKAYRDRAEELLKNSDCFESNYGAVIFKDGKVLGEGYNYVPEIKGYTCDKCPRRKQDLHNGIGLELCYSVHAEESAINNMLFDKKLSVEDSEGASMVVVRSKDGKVFKFEELKPYCTRCAEKIYTQSKIKEIIYEDKKGFIAFGNEELFDISVKNLHSSWKEKFGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH1</accession>
    <name>A0A218NMH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891427.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH1"/>
    <dbReference type="GeneID" id="33313895"/>
    <dbReference type="KEGG" id="marh:Mia14_0337"/>
    <dbReference type="OrthoDB" id="85381at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930:SF1">
        <property type="entry name" value="DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930">
        <property type="entry name" value="UPF0200 PROTEIN MJ1399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="185" mass="20956" checksum="E251EB94A3405832" modified="2017-09-27" version="1">MIIGFTGMPGSGKSDASLYLKEHHNFSIVNMGEVVRRTMNEKGIKITNESLRAFSGQLRDEMGRDATAKLTADFLLKLHGNICIDGIRGPEEVAYFKKVLDGKRFYLIAITAPDDIRYKRLAERGRYDDPHTLKGLKERDEKEKGFGVEAAMKMADIVISNTQSPTFFHEDLDKMIVKLKSDWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK6</accession>
    <name>A0A218NMK6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Mia14_0386</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK6"/>
    <dbReference type="KEGG" id="marh:Mia14_0386"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="231"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="533"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="873" mass="99351" checksum="83AA882A314C35AF" modified="2017-09-27" version="1">MMSGMAEVTNLLTGSIKPINYKLVFKPDFNKFTYMGDEEIEVNISKSTDRIAVNCREIAIKEAMVESGKKSYSVKLKYNKLNETVELGLPKKIKGGAVIKIKFIGSNNDKMYGFYRSSYTYNGRQEYMLSSQFEAGDARAAFPCFDQPDMKATFDISFLIPKEFDAISNMPQKSVVNKGANKIVSFRRTPLMSTYLVYLGVGKFDYVNGSLGDLPIRVVTQKGKKPYASMALEYCRKFVDFYANYFGIPYPMPKLDLITVPDFSAGAMENWGAITFRDTVIFGDENSSAVTKERISITVAHELAHQWFGDLVTMKWWDDLWLNESFATFMSYKAVSATIKSIGAEDQFYENEFKNAMYYDQFRATHPISVKVSSPGQISSLFDSISYEKGASVLAMLENYLGEKHFREGLHNYLNSFKYSNAAKEDLWKSLEDESGKRGSSKEVKEMMKSWITKAGYPEVIVGPASLSSESNETLIRVSQKRFIMAGSHDSNSKGTWKIPIKYALVDKKKTSESLFILDRKEGSLKAIGIGAIKLNFGQKGIYRVYYEGELLSRIGELIRNKELSDIDAWGVLDDLYNYVRAGSIKLNIYLHFIERYAMDVGYPANNRIIDSLNSLYTVLYADNGADDVRVLLLDYLKKQFKRYSWDYTPTNNTDEIFKLNVICNLGMLGYAPVVKKARAYYKDLLKGKLGGLHGNLTFAVYSTVAFNGGKKEFDEMLGMYLREKVTEEKFKMLVSLGLFKDISLQEKALSISYSNNVRLQDSLQIPQVISGNITSNSLKHFIANPYGKKIIWRWIKENWSIIRNAYPENSSYWSGLLKVLETVSDPIVLEDVVDFFRTNKPSDVMRPQLAKSVEFMKANIKLFNEYRAKDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML4</accession>
    <name>A0A218NML4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="1">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML4"/>
    <dbReference type="KEGG" id="marh:Mia14_0381"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="411" mass="45317" checksum="5E359D7EE8D2F156" modified="2017-09-27" version="1">MLDQIKHSVINIGTLGHIDHGKTSLVQALTHQWTDRDSESLKRNMTIRLGYADTIINECEDSKGNKVYTVNDKYEGCKNAPVPFMRISILDAPGHETLMATAIASANLINALLFVIAANEPCPMPQTKEHLMIINLLGIKDVIIVQTKIDIVGEKAAEENYKQIKEFIKGSIIEDAPIIPVVSTKNINIDVLLKKIVEMPKPKFDENQDPFMYIARSFDVNKPGKKINKLVGGVIGGTLIRGKLNPGDTIEIRPGIKVSSPNQKREVYKPVITKIVEIDNGSDKLDYALPGGLIGISTLMDPQFSKADGLVGNVAGFPDKLPPVINSMNIAYHSLNRPDMHDNAFSVNEPVILSIGTLTVVGYVEKVRKNSIEISIKHPVCAESGQKIAIMRNINKRWKLTGYATLEKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM7</accession>
    <name>A0A218NMM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819875.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM7"/>
    <dbReference type="GeneID" id="33313945"/>
    <dbReference type="KEGG" id="marh:Mia14_0389"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF46">
        <property type="entry name" value="BLR6921 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="595" mass="64532" checksum="A67989CAB2BFB867" modified="2017-09-27" version="1">MDTGNGTRLNKKKPTSKDESNYEEREDKLEKEEMEKESRYGKHYKWVALTNTTLGALMAAMNGSILLIALPAIFRGLNINPLVSSNFGLLLWLLLGYNVITAIFTVTIGRLSDMFGRVKLYNLGFLIFTIGSIALYISSLYITGVDGALSLILLRLFQGVGGAFLFANSTAILTDAFPHTMRGRAMGFNQIAAVGGGLIGLIVGGLLAAIDWHLVFLISIPFGIAGTLWAYLELHEIASIEKDQKFDIPGNVLFAAGIMLILLGLTYSIVGYNGNPTGWGNPFVYGTIIAGIVLMIPFAYIELKSKFPMFRLQLFKIKAFLFGNLSLLLAGIARGGLQFMLIIWLDGIWLPLHGVHFSKTPFDAAIDLIPFMMGFIIFGPISGYLSDRYGARLFSTLGMLINFVGFLALAALPADFSYILFAIITFSLGLGQGLFSAPNTTAIMNSVPENTRGSASGMRSTFTNISFMFSMALFFTILILGMSTELSTALYSGMVNAGIPANASMQISKLPPTAALFSAFLGYNPMKTLLPASVYSALPNSTKTEVTGLSFFPHLLSKPFMDGMKLVLYIGSGMALIAAIASALRGKRYIYGIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN0</accession>
    <name>A0A218NMN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN0"/>
    <dbReference type="KEGG" id="marh:Mia14_0404"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="71" mass="8107" checksum="2DE2AB49A0769791" modified="2017-09-27" version="1">MNEFPYIFALPISGIRFGSFGIPPEFVPRLLWIGKLLIKIGTPNKDQFLDEMSYLSVLLPRYTSLVFEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN4</accession>
    <name>A0A218NMN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN4"/>
    <dbReference type="KEGG" id="marh:Mia14_0385"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="76" mass="9043" checksum="28CFE30EC091CD54" modified="2017-09-27" version="1">MHKKFKFNLFSIFDRWPDMEGKEINKLTYEIEVKAQLTDAEYKGLANVLKKYNVESIILEEDKQIYKFVISVSHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ2</accession>
    <name>A0A218NMQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819952.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ2"/>
    <dbReference type="GeneID" id="33313996"/>
    <dbReference type="KEGG" id="marh:Mia14_0441"/>
    <dbReference type="OrthoDB" id="57441at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="152"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="333" mass="38336" checksum="180041BB360EBD66" modified="2017-09-27" version="1">MKLNFDPKSNIRSSDYSLIKLNKVNKIKDLLKVRSIVKNWPTVLAFRTGLKNANFIMELRNGIKVKITNPNDYFSWWETIQAQNSILQQAGLDKAIQIDKNKKIIKFKFKSKPVHLFYDSDKQLSNTIGMVREQFLEEQYKWLNVKGKDVIDIGANIGDSAIYFALNGAKHVYAFEPYPYSYKVASNNIKLNKLNKRITLLNEGCSDKEGGINIKTDYQNFGGTDLKEFNKETKINLTTLKGIINRFNIKSPAILKIDCEGCEYSVLLNANNSDLKKFEQIQIEYHYGYLNLKKKLIDAGFEVKNNNPKQTFNKLADNKELFIGLIYAKKNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR2</accession>
    <name>A0A218NMR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DME family DMT superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819930.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR2"/>
    <dbReference type="GeneID" id="33313981"/>
    <dbReference type="KEGG" id="marh:Mia14_0426"/>
    <dbReference type="OrthoDB" id="381581at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="289" mass="32578" checksum="AAB37608E6C14397" modified="2017-09-27" version="1">MYEWLYLVLLSSTFMGISTIIEKYALKEQHASAYSASFSILTFFISLVFLPFAKFNIGIVTVLYIYVNSLLSTAGYLLSARIYKHGNLSISAPVMSSLPMVFIIIISFFALGEKLSLFQYLALAVIIACSYLIIFKDGGKQAFDGRKYIYLLVVVSLIIALGSVLMKYLFMSNLNEFTYIILMELFISLNYMVYMTKKYGGVKEVYSNLTHNFSKIGTISLFTVAYRITYYFSASLMLISVVAPFRNSIYVIITTLAGGIIFKESGLWRRLILVAIMLVAVYYISISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS1</accession>
    <name>A0A218NMS1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS1"/>
    <dbReference type="REBASE" id="210411">
        <property type="entry name" value="M.Mar14ORF435P"/>
    </dbReference>
    <dbReference type="KEGG" id="marh:Mia14_0435"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="4">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="4">
        <location>
            <begin position="158"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="323" mass="37127" checksum="766F451DBA2DF241" modified="2017-09-27" version="1">MQEITQEDYEKFIIDYKKVTIEDTELEIGGNHKINSLQPEDFKLETTTVWSFPKRGKWATHYLNAKYRGNWAPQVARNLILRYSKEGDTVLDAFAGSGTTIIECKITDRKGIAVDINKEAIMVVRDRLNFNTLKSDFQEQKTFLGDARNLNLISNNSIDLIAAHPPYANIISYTKNSNHKSNGDLSKVSSIDEFCYQMGNVASEFFRVLKQGGYCAILIGDTRRHKHQVPISFRVMQSFLDKGFVLKESIIKVQHNTKTAGLWANLSVKNNFLLLMHEHLFVFRKPFETEKQKDLIDSSKWWKNNGINYPKDKLQPDEALGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS9</accession>
    <name>A0A218NMS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820004.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS9"/>
    <dbReference type="GeneID" id="33314027"/>
    <dbReference type="KEGG" id="marh:Mia14_0472"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="298" mass="33996" checksum="3630540342F1D847" modified="2017-09-27" version="1">MGWQGWFAIIVAFAFVMLLMYPTQIYYYLIDQSTAFTAARPVFSFMDDANNMLGITNFMCGQYNYSCIVNTPRVLYEEGGQFSKYLLMDRRITVPNKTYNLTSYITIKNFSINLSNSDIAICLNGYSNGYWLQDCITRNKMANYNDSYYIDEQIWNDNQMVNNHVKIIPNTEGTAQHFELHIHIINGTGAIFSVTNLKDGQTENFLYSNSYLGLMQNGTEDTPTSLWTEVHYNSRSGIPNSINYQTTNYPTSKYTSIQVLLNARSIICEYSTNSSVIDTDEAYCKSVGSIQGDEFATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT0</accession>
    <name>A0A218NMT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ParB/Sulfiredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819955.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT0"/>
    <dbReference type="GeneID" id="33313998"/>
    <dbReference type="KEGG" id="marh:Mia14_0443"/>
    <dbReference type="OrthoDB" id="382902at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="59047" checksum="7097AFF429CE4DCE" modified="2017-09-27" version="1">MDQNKELNEDEVKEIETPDFDNNEWSRKKVKTSDILLDPENPRLNLKPDASQSDIIRELFKQEEIIELIESIIENSGFYPSENIIVIKEENNKYKVLEGNRRVCAAKCMLNPDLAPSKYQLQIKELNSDINLDKIEYFNVIIGPNRESIQKIITARHTQYQIKKWSYISKWRRDYIQFQKIKNITKMSKILGEDPKLIENNLKNYSFIRYILDLSDWTDQERYKLSNNNLKVSVLPYHMSSEIQEMLSINFDNEFNLQTKMDKNEFRYVMIELTRSMFLGKDPTITTRTNKTQIKELIEKWIEAYNQTKIGQRSGQLMDLKIKRDNNNNIELLNKKLPEKGKKPESQPKYFSNLTVSKSLNNSKLEHIAKEISSIDVKNYPLATLILTRTLIENSLIYRIEDKGLWKDFLKSNALRGIARLYNLDDIVKYSINNVQKLFTNEAYRKNAKEAMEKIQQSKDGIRKYLNDMVHESFINPSPEHVQLIADSVRILIQKILLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT5</accession>
    <name>A0A218NMT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT5"/>
    <dbReference type="KEGG" id="marh:Mia14_0473"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="486" mass="55530" checksum="6EBB3DD5DEE54DD4" modified="2017-09-27" version="1">MLPFFTKILYLIFNVTNMITTIDDIVAAYNVAWASVNTYNLYPMLRSSKATDDPTEKELNTFRKEYWGKLDKMTILVPAYKEQKTLYSCVKAINESSYPKSKLEVIILLEKDDTSTIEVANRIASKFKNVKSIVVEDEVNKKGKPRALNYGLKMATGDVIGILDAEDMVSKDAFIRTAYMMQNKDYGVVQGILDMVNEGDGWKNLMLRAEYGYWFNTYLKALKRADYPLPFGGTTNFFRKDTLQKLGGWDSNNLTEDFELGMKIFANNSKIRENVRKNAGKLNTNGNASSEDPIKLGIIRSVTREESPPTMKGWMRQRTRWQQGKIQTLRKEMNDDQLSLRTKAHIFFSSVQPHISVINLTGIGISVYAYLDKALSLPVEIVAGFNAVMVAFYATMNAAGYLWVTKPEKETIKYRHLKAVVTAVTLPAYWAMQWVADMKALKLEYIDKSNVWYKTEHFGRHIDDRQLEKTLAEDMHPATVNNSDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU2</accession>
    <name>A0A218NMU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU2"/>
    <dbReference type="KEGG" id="marh:Mia14_0456"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="292" mass="34484" checksum="3CB0A87F602A3624" modified="2017-09-27" version="1">MNNLSKSTIIINLIVDLSTKTPKFPHVLYDKGFHLDMLEPRFILPQNKQNSSAKEVAPDIEINKNNEYLLFFECKYGSASKDQLDRYKLLTKDDIKRSHTIELASNEFDFDISYIGMTDKEQKLNISLEDSIDRFPLLILGNNSVYFSQNSCKFKMEELNEIFSNLKIPNDFPRSFIPFTVDDNEEIILEDIIQHFTTKTGYDFKPYDLLKELLPSMYNYYSQEGQKSLIGRIKNILDKLIMDEDFKEFITFTNGKYRLDVNEKIKKFHKVCYKFINKYEKNKNQVPLEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU4</accession>
    <name>A0A218NMU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820033.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU4"/>
    <dbReference type="GeneID" id="33314043"/>
    <dbReference type="KEGG" id="marh:Mia14_0485"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="145" mass="16908" checksum="0F1741647FA26240" modified="2017-09-27" version="1">MTVKSKNKNAEIAKIIRANTEDRKYISENNYQKTYLGKPIVFYLPSIKIETDKDRVVEDKLDMFLLKEFGGYTAEKGFILGYWMDGKSVDHTNHIKYTVAVKDNEKIKKLESFIADIGKYLSEKAVYFEMDKSSWLIYPGNEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU5</accession>
    <name>A0A218NMU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820017.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU5"/>
    <dbReference type="GeneID" id="33314034"/>
    <dbReference type="KEGG" id="marh:Mia14_0479"/>
    <dbReference type="OrthoDB" id="25436at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="189" mass="20807" checksum="5D1D7F49D9CB445D" modified="2017-09-27" version="1">MKKVKTLYKLMAIVVIIAAAVLLYMYSAGTFSHKVSAEILSAGEKAPNESFTLLNGSTVNIGNYRGKPILVWLMTTWCSSCAQSTSTIANNMTFFKDHNVTVFEIENYEDLGQSGMAIGPFIDYYAHNSTGADMIKGGISSKGLTFTYNPKGYLDIYYLIAPNGTIYYINGSPVITMNDLKQEVTRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU8</accession>
    <name>A0A218NMU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU8"/>
    <dbReference type="KEGG" id="marh:Mia14_0457"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="241" mass="26803" checksum="0E5C004EBCAD4A94" modified="2017-09-27" version="1">MNLTDEDCHSGAICNFGVHFYQGMSYHEVYPPPSSILETPNSATPPTPNTAYQTLNSTLYVFSPQNIVLNYSYYIPIYVGGNANYSGYCDGGYYNASYSTLNSSLENAGSGIKDNVYNVSCYDPDLDLNITGKGHSILNVDWFNVKSESSTFIVTDSPVEYTETKIIDTPSYDEVPGDQPVNYTYYNLYNSPDRFTNNPLIADDGSSLENPFQNGYTITALYPSSSSVNGYVFYEYDKNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU9</accession>
    <name>A0A218NMU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216881.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU9"/>
    <dbReference type="GeneID" id="33314015"/>
    <dbReference type="KEGG" id="marh:Mia14_0459"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="161" mass="17343" checksum="5E77A7FDB8068D08" modified="2017-09-27" version="1">MKEHPEGWNFTKSTSSTPAVTYYLLTSPQNLYSSLYDNTGISMSSRPLDISMQGTAGQYNGQLGELPLGSSNEGIRKAIMQSPLTLYTNTTQTSSSGVTPLQYLGDIVSTVGSLVRPFTTILNPGTPGGAPLAGGSFPSNYPFKRTNINKLIRIIQLVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV5</accession>
    <name>A0A218NMV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216885.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV5"/>
    <dbReference type="GeneID" id="33314049"/>
    <dbReference type="KEGG" id="marh:Mia14_0491"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="403" mass="46885" checksum="B4F8ADB0513C255B" modified="2017-09-27" version="1">MFFRKPANMEIKPDDLESYNLKMFYTLISPMEKQADAAEASIISGIAGFKESIANFSNSRSDPEMEYIPNYSIEFVKSQKENYCKRLERILDRSFEEEDGRDAYYNLLLKEHFYSGMLDSILKHNAKFRPVVIGYAKDIDSFKKVYSNIEKRINDLKNVIKSKSNEYDRYIEIRDKIDALLQLISDKEYLMEENAKIKEEVREVEMAEVKENSIKELNSEISEKSNEIVVLQDRISGENSKITAILYPLKRLARKYDYISGEKISLSDFLDNPYILSDPGNYSLFLKELNSLKDMVMKGRIEVKKKESFVEQIEEVVNAGLADRIKNLMKVKEELSELQGSLNEARIGVSTEKSIEEDKHARKEQAKENDGKIAEMDLKIEEICKELELLFNKYYKSLIKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW7</accession>
    <name>A0A218NMW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS cluster assembly scaffold protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820041.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW7"/>
    <dbReference type="GeneID" id="33314047"/>
    <dbReference type="KEGG" id="marh:Mia14_0489"/>
    <dbReference type="OrthoDB" id="319865at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01994">
        <property type="entry name" value="SUF_scaf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="134" mass="14724" checksum="9B7321C7A2B42057" modified="2017-09-27" version="1">MSTNLYAEEIISNYEHPHNKGKMEDADASFEEHNPVCGDDIKVYLKISEAKVDDAKFDGEGCSISTAGASMLTDYVKGKSIEELSGMGVKDMIDLLGIEPGPARLHCATISLKALKEAIFLYEHKEPDENTKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW9</accession>
    <name>A0A218NMW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW9"/>
    <dbReference type="KEGG" id="marh:Mia14_0487"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="170" mass="19929" checksum="D40C0DE611ACDD80" modified="2017-09-27" version="1">MIHMAKLTPAEKRKNTIRKKKIKLWLDNLASGKLDEINKEVFKDRDPEEIKTYFLEVDFFWEGGISLGMRKKGLASGGFGGYTDLRFAMGIDFKSPWDGYNIYNGVRRIKSNYRLSDNEISEMLQKDKGIMEKLSEDATKDAIKKYGYGMRAFKKMMLLEFYWNESFRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY0</accession>
    <name>A0A218NMY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820095.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY0"/>
    <dbReference type="GeneID" id="33314082"/>
    <dbReference type="KEGG" id="marh:Mia14_0525"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="305" mass="34665" checksum="63E708D963065271" modified="2017-09-27" version="1">MYANKEVPDKAALGVDSYLALLKLDAVGSIKDSEFDSKDRSSTIRKMTSIINYLSNPGSLMMANSNSKLRNSEISQALEKGQAECELTYLLRTSKRCDPDRVYFDNSLESYLYDNAELLDRIIYKLINGRKLTEKEEMYSKADNNALSDMGVFRLGDSSYLMIMDNYRDSFHLIELSSDESIPINRIMDKKGNVIDITPKNLINVDISPGLISVKSYDLVSSSLDRKQILGKFDIIKSKFLPGWNAASNYRLNVNHYNSKLGDSQIINLSCNIFYDNLTKDRWIAAKLIKFIMFHDNIVSGAEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ5</accession>
    <name>A0A218NMZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAM1 family non-canonical purine NTP pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820075.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ5"/>
    <dbReference type="GeneID" id="33314070"/>
    <dbReference type="KEGG" id="marh:Mia14_0513"/>
    <dbReference type="OrthoDB" id="372108at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="186" mass="21148" checksum="895EC9BEC3B8780C" modified="2017-09-27" version="1">MGKTIYLITKNEAKIIAAKSAFEKYGIELKMLDVDYPEIQADTSMEVARYTALIAAKENSVDVIREDHSVVANALGQNIPGPYANYIIRKMPVERLIQIMKAVGDWTGFFDINAVYAHPDGRYLEYSFKVPIKFSDIQKGDPKGGWHSIMMLEDENRAFSEYNVLERVEVFNKNFVRIAEDISNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN02</accession>
    <name>A0A218NN02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YdcF family SAM-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820108.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN02"/>
    <dbReference type="GeneID" id="33314089"/>
    <dbReference type="KEGG" id="marh:Mia14_0532"/>
    <dbReference type="OrthoDB" id="299909at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="188" mass="21454" checksum="F37A19EB16F5705F" modified="2017-09-27" version="1">MQAGSKIAVVLGSKQYSDSDIDDELKGRLSVAQDLFKNGSISQVIVSGGTTNPSINMSEAEIMENYLVSIGVPNDKIIKEESALDTIGNAYFSMLKLNGLSGISTVYIVTSCWHMKRSKYIFEMTFGDKYKMNFDHCFDYHDEDLDNELQEHEKKSMALAEKFFEGITPGDMEEIKYRLYKFHEYYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN07</accession>
    <name>A0A218NN07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Mia14_0534</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539368.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN07"/>
    <dbReference type="GeneID" id="33314091"/>
    <dbReference type="KEGG" id="marh:Mia14_0534"/>
    <dbReference type="OrthoDB" id="56847at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 15 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="899" mass="102010" checksum="B8E48E3729445287" modified="2017-09-27" version="1">MDNKVSNLNGTIVIASPGTGKTTRLANKVIELLIGGVQSKDILCITFTEKAAAEMQSKIFKMSKDKGIDQSRIADLKISTFHSYALDYLQEIGNSYQLVSNNIMRYSIYKSFEANKAFNYSKDHIISTLMPNTENAIRYMKSFGITPEKIDMDKARENIREIYNDSRIQSVTLEEVEKFLDYFVSAFKDYESSKKEGFIDYNDMLLKFIEHYDRNARHYKWVLVDELQDVNEMEANIAVMSGDSLFLVGDRKQSIFGFQGGSIGNFNHFSKSGLQLEHLSKNYRSKDRIVEYAKNAFINNIKSREEVDSYIEELKDFSSSEEGGKVRMVNSQKSFGPAVKVLKELGDELNDTAIITRTNGQLLAVSRLLDSEGIKYKTTASNSTSEAAKAEIVNYLKGFFYEDTEYIINALNTAFAGLPTYKAIAISKECSTIKEIKSRAPKFFELRESCSGRIGLNRLFQDVIFPISAQIGMDYFITARTVLNSINEFYELIGYNNDPKELFDYISITQEDYQPPTTDEGVTLTTVHKAKGLEFKNVIYIPKQSERNNLSFIDVVTLAVIKATIGIEVRDELSDEESRVDFVAITRAKDLLYIVADAKFLNSHKVDGISEEIDIKDDIMPEPEHRKYDEAYSMFVNKDYEGAMKALSYKEPWAYNEVKDYFSRINAISFSTIDKFDKPADFLKYVILGINYGNVSLSKGLGVHQIAESMFHGNVDEASMDEEEKPYFDNLKAARAELTKTTGAEQVAAEESIAVPLNSLLSSAPDEMSFHGKIDAVYADENGRYILIDYKTDKTEDYNTAHRKQLEVYRKLYSLKHNVQLDKISSKVMYLGLKGKINTGKMEYDIVDTGNSKTLLNNFLKKTNDFLECKKDPGKFVDIVKKAAEGESDLLLERIIDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN10</accession>
    <name>A0A218NN10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN10"/>
    <dbReference type="KEGG" id="marh:Mia14_0556"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="773" mass="88662" checksum="651738BCBF46F66A" modified="2017-09-27" version="1">MIILKINSEFDNIKQKIPIYLVVIILITLSIAQPIFEFKNSIFVHEDTPFIGLTYSFNQYVNSLYNNFFIYNNLDYSGVIQRGMISPLNYLYSLLVLPLAITNGILANILENIVFLLIGSLGMFIFLYKLFEKSGYYIRITSSLIGTLIFFPFIGGESSFLPFCFLFILLILRNFNNKTYKLKNNSLVLFGLIISASFLFTFGGYNYLIPDFILFVLLIIVIPIFTQDKRLNLFFILLLAFVIALLINLIIFYGAYLLSISKSANISYYSFMGSLPEPFATSNILYALQILPFSNNPVIFTLKLLLFALSVSGVLIYLNKIKHSPNSTIIISLLIIFILITFFYNTIYKPFGGIFKFLILNFKSLYAIRSGDGSFSYIMGFVLSVFSSATIIFYRDYLKNRELIFTWGILIFILISIGLFYYNDITPYTNINYFYVKIPNHVYLVSNYINNKSGYFNVGILPSAAGFQYLDTWYTGTNIYSYLINKPVYTGGYIAQSEIFYPVTKYLYDDVSSEIDNNKLNDSYISQIFGILGIKYILVQGNALESSPYDQNYYDPFNLNEVYINLNNTYNIKFVKRYSNTSIYENLDYVPLIYTTNIYNIGNSSDGGLIKSITNQSFDIKTDSVYITHIPDFYNDSDTINASSIPNFKEPEIKFNYNNPTQITVKVRNATTPFYLVFRETYGSPWHAYINGKPIPSKYHIAVNGFANAWYINKTGNYTITLYYTLQTDADVAWIVSFAALFATIGIGIYGWKESKKSKAKSNKRIMVKDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN18</accession>
    <name>A0A218NN18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820137.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN18"/>
    <dbReference type="GeneID" id="33314109"/>
    <dbReference type="KEGG" id="marh:Mia14_0552"/>
    <dbReference type="OrthoDB" id="56381at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF6">
        <property type="entry name" value="UNDECAPRENYL PHOSPHATE TRANSPORTER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="108"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="270" mass="30252" checksum="BBF736372BF35989" modified="2017-09-27" version="1">MPAASSKSDKIRKLPASRTSRIRIESVNSKISKYFYYIATVAIIGIVISALGITNGYFHYFNYKDYYSSEVKVFSPFYYLGYLGIFLIIAFAPPPDYLLVPFYGYLASLNYFNVYLVFIVAVLAMMFLTAIEYFGGRFAGRPLLLKVLLHVGITERDISVADDWISNHGIASIFIATFVPYFKNVTSLAAGTLKMNSLKFFITNAVGFSLRFAILVYIGYEGINVFLPSFDVEFRSILYLIAIASSLILAYAILVKALHNQDKESSAIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN26</accession>
    <name>A0A218NN26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820155.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN26"/>
    <dbReference type="GeneID" id="33314127"/>
    <dbReference type="KEGG" id="marh:Mia14_0572"/>
    <dbReference type="OrthoDB" id="379219at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="139" mass="15879" checksum="540B4E51705A0F94" modified="2017-09-27" version="1">MAILSIFGKEEDKGDEKLINSVPFKLVTEWFPYKLYSSRKSYVTLTMKISNITKEPLLTSVTLRLPNQIAFDETGISHEKSFRLGSLEPNEVKELHVNVYNNLKAEAGDYTTLVIATAHYKDYDHVINSIRKKELISVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN39</accession>
    <name>A0A218NN39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820173.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN39"/>
    <dbReference type="GeneID" id="33314148"/>
    <dbReference type="KEGG" id="marh:Mia14_0594"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="48178" checksum="0D0B1BF3E7971544" modified="2017-09-27" version="1">MLFHIYPIILLLYTVFGIISICYYTINARRSVKYNYRSKSINTTDTYKDVTIVVPVYNENPKTFERCIKSIANQKSNMIVIGDSSYEPYKSITESYGGTFIYKQVREGKRKGLSTAINYVNTKYVLFVDSDTVIPRNTVKSLISKFGPSIGGVGVGVSIRLKNNWISYSAEFFEKMKEVMFRAMAYSGSVMVLDGRCAMYRTDLIKDFLNSEEYRENVIFGIKSNLAEDRHITSHVAKLGYKQIIDYDVYVKTESQKNFKQFWKQMIRWARAGYLYFFKEFSERAYSKRGLFYTFEMMYLYILPIFVLVLGLMRLDFYLVHGLGFVFRDTGMFYSFITANFARMGFGRFIYTLTSILDAFAVFILAVAVYLRLSKNKRKKKTLVLGGVALLMMFFASFYGLFTLWKQRSWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN40</accession>
    <name>A0A218NN40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820136.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN40"/>
    <dbReference type="GeneID" id="33314108"/>
    <dbReference type="KEGG" id="marh:Mia14_0551"/>
    <dbReference type="OrthoDB" id="25266at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="2">
        <location>
            <begin position="41"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="357" mass="40047" checksum="AF046C692FF87894" modified="2017-09-27" version="1">MEKTVFNGSVKYIQVMDENGNIDKDLYPKDLTDKDLVELYKYMNLGREMSDKLVALQRAGLMPTIVPIYGEEATQAGSAYALTKDDWIIPTFRQHLSLIIKGVSIYSIFLYFKGYEEGFQLGAVNNSGPEIAPVGAGIPHAAGVAFSLKYKKKPNVVLTYVGDGGTSEGDFYEGMNFAGVNKVPLVTIIEDNEWAISVPRSQQTAAETLAQKAFAVGMDTIQVDGNDVLAVYKATKDAIDSIKKGGRPYIIEALTYRMGMHTTADDPTKYRPESEVDPWKPKDPITRMKKYLVSKKLWNDDMEAKMKEEHNKLLDDAMDKIKEFKPDPKSIFETALSFMPDSLKEEEDEAVKNNFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN67</accession>
    <name>A0A218NN67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN67"/>
    <dbReference type="KEGG" id="marh:Mia14_0599"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="276" mass="29740" checksum="3DA6EB4572323BCA" modified="2017-09-27" version="1">MEPLVFLKLGGGTITYDSRESTPRIDVIDRLLSEIKKAKEEHGFDLILGHGSGSYAHVPASKYKVNEGLKYEFSRMGATVTCNTAKALNTVIIEEAIKIGLDTYPFSPSSFAYAGNGRIIKGVTDGIRKSLESGFTPVVYGDVLIDDVKGVTIASTEEVFNFLSTEFGPDKIIIGADVDGVFDSNPTQNANAKKIDRVDNSNIDTILKGASGSNKSFDVTGGMHTKVEMLYNMVKGVNEKFGKPSIGYIGNAAKEGVIGKLLSGKPVNECTEFSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN90</accession>
    <name>A0A218NN90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820200.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN90"/>
    <dbReference type="GeneID" id="33314186"/>
    <dbReference type="KEGG" id="marh:Mia14_0632"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="295" mass="32503" checksum="CC64D392EE4F49B4" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILVIAVVLAALYSLGIFNPSTFAPKASAGSCEVVRPFGPTTTTDIHLEGTCTNMLPKYVAQFNGKGSTGITLNTYNFNTTPFTISFWEYYLGYTTCYTSSNGGNCGENVTMYINPNKCSSTPNYLCVIDFDLRTTSLHWFTWDRDIFYPVQTGKWLFITWTYNPANKNNISAYLNGKFVGGNTGSNVVLDGQIELGEGGSMGSIDGYVSNFQIYNSSLSANQISALYDEGIGGDPIDLTHLVAWYPLNGNAQDYSGNNYNGKAFNVSYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN99</accession>
    <name>A0A218NN99_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2023-08" db="PDB data bank">
            <title>Fundamental steps of Minichromosome Maintenance complex assembly are conserved from archaea to eukaryotes.</title>
            <authorList>
                <person name="Noble O.W."/>
                <person name="Degut C."/>
                <person name="Hodgkinson M.R."/>
                <person name="Chong J.P.J."/>
                <person name="Plevin M.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 1-600 IN COMPLEX WITH ADP AND ZN(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820187.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="PDB" id="8Q67">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.59 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-600"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN99"/>
    <dbReference type="SMR" id="A0A218NN99"/>
    <dbReference type="GeneID" id="33314165"/>
    <dbReference type="KEGG" id="marh:Mia14_0611"/>
    <dbReference type="OrthoDB" id="6747at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="274"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8Q67"/>
        </source>
    </evidence>
    <sequence length="687" mass="76126" checksum="78DEF5889D1359E7" modified="2017-09-27" version="1">MAEQQTSSLKLLFDEFLESYYSDEIKDIIIKFPNKRSLPVNISDLEEFDPDTATNLIADPEIIIDAANESLMGKLAGLNFDTYIPHVRFYNQSINTPMVLNVGSAYINKFVSIDALVVKRSDIRPKIRDAVFVCTFCNAKVKANLEKEEIPKVCPECKKRTLKIVPEESSFFNSQKIAVQDPLERLSGSIPTWQLEAWLDDDLVNMAIPGDRIEISGVLKIRPRKDSRGKVDPSIYSMYLNVTSLETKQKEFADIDISEDEERQIKELSKDPEIFNKVTQSVAPSIYGYNEIKQAVALQLFGGTPGKKLVDGGQIRSDMHILLIGDPGSAKTRILQSVSRLVPKGIYVSGKSVTGGGLTAVAERDDFSEGGWTLKAGAMVLGNGGIVAIDEFDKISEEDTAALHEALESQTISVAKAGIIATFNAKASVLAAANPKFGRFDPHKYPAEQFDISPTLLSRFDLIFPIRDIMDTELDKSIANYILNQHEAAGAAIADVESSVAAEEPPIEHSLLKKYIAYAKRYVMPRLSEEASNRIKEYYVDLRRAGSMKGATPITPRQIEGLIRMAEASAKSQLRDVVSVKDANLAISLSEYMLKTLAVDTEGRTDIDTILTGMPREKVDKINVILDAVKKLEEMDGSAKIDRIFEEVAKQGVDKNTANKYINELEQSGDIFSPKMGIIKVVRHEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB1</accession>
    <name>A0A218NNB1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="5">Glu-ADT subunit E</shortName>
            <ecNumber evidence="5">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatE</name>
        <name evidence="8" type="ORF">Mia14_0664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820231.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB1"/>
    <dbReference type="GeneID" id="33314217"/>
    <dbReference type="KEGG" id="marh:Mia14_0664"/>
    <dbReference type="OrthoDB" id="7316at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003107">
        <property type="entry name" value="PRK04028.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GAD" evidence="7">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="624" mass="69607" checksum="02DCB7C7E6C52D1E" modified="2017-09-27" version="1">MDEDYYKSIGFMCGLEIHQRLNTKEKLFCSCTSKPIDDDEKPEASITRYQRAVAGELGKIDAAAKIEEGKKKAYHYNVFKDNTCLVDIDEEPPHQMNGEALGIALSLAAAFKMHIFKELEPMRKEVVDGSNTSAFQRTTIVGLDGRIKVNGHDVLIPSMMLEEESAGIVSNGDDEAVFNTDRLGIPLVEIDTDPYIRSPAEAKDVASYIGMLLRITGKVQRGIGTIRQDVNVSIKGGARVEIKGFQDLGSMDRYIENEIERQRSLILVKGELAKIDWKPEFGNFEDLTDLFVGTSSRLIKASLEKNGSVIAVNVKGFKGYLGKEINPDRRLGSEVSDYAKLAGVKGLIHADEDLKSKYGLSDSEISAIRGRLNIKDDDSFIMVTAPKAKAEKALDYALGRIAYFAKGVPPETRSVYDDKLYTTRFMRPIAGGSRMYPETDAKPILVTEEMIKQAEESKPNLENAINELEDAIKDEALVKNLLLSPRYPLYKEISSSIDVDKKIIADILMQKFTEMKREGIDVDSMSDGTLKSIFEIYKEGKLTKRGIVQMVRAAAEESPSADKGDLYRIAEERKLRKLSKDELLGIVKEFKEKGSKNVLASIMKDHNIDVEAEELRDLLNNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB5</accession>
    <name>A0A218NNB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-glycero-alpha-D-manno-heptose-7-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820207.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB5"/>
    <dbReference type="GeneID" id="33314193"/>
    <dbReference type="KEGG" id="marh:Mia14_0639"/>
    <dbReference type="OrthoDB" id="116110at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="HddA/FKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="7">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="329" mass="36192" checksum="6E0E627853932424" modified="2017-09-27" version="1">MKSYTVTSPLRITFAGGGTDVEPFIEKYGGAVVNSTIDRKVTVTYQPDEYDLEISSRDLVKSIIVPTNNEGIISKIHNLFYSKGINKGRVMINNDVPPGSGLGSSSALTTAIVKLIHTIKNENISGWDLARESYEIERNYLKVALGKQDPFAISLGNFKMMEFQKGKEELHDLSKNAEFLKELQSRTLLVYTGGTRESSKFLKEQINASKREGDAINQKLLALKNIALDMANSVESNDISSFTSLINEGWQVKRELSEGVSNKKIESLIEKAKENGAQAVRLMGGGGDGFLLTIAKEGKLQGLQEEMSKLSDFAIRVSFTDYGTMVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND8</accession>
    <name>A0A218NND8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820228.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND8"/>
    <dbReference type="GeneID" id="33314214"/>
    <dbReference type="KEGG" id="marh:Mia14_0661"/>
    <dbReference type="OrthoDB" id="376579at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="73" mass="8773" checksum="18A2E7177130237D" modified="2017-09-27" version="1">MTTFCERCKREIYRYEVCDYCGRKICNNCMKSSQRATKTKRLVICKDCWSDMEKRKAYKSGRAFNEPVETHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE2</accession>
    <name>A0A218NNE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820242.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE2"/>
    <dbReference type="GeneID" id="33314229"/>
    <dbReference type="KEGG" id="marh:Mia14_0676"/>
    <dbReference type="OrthoDB" id="25266at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="2">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="357" mass="39750" checksum="CB0CCE274BE0DE26" modified="2017-09-27" version="1">MIKEVFNGNIKNMQIMDEDGNIDNSLFPKDLEPKKIIELYKFMSLGRAVSNKLLTLQRLGKVATFAPLNGEEAVQAGSAYAADASDFIVPTFRNHLPFIMRGVPLENLFIAVKGYEEAYSSILQKRLTPEAIAVGSQYTQAAGIAFSMKYQKYKNAVIVYGGDGSTSEGDFYEALNFAGVFNLPIVFVIENNEWAISVPRSSQTASKTLAQKAVAAGVDAIQVDGNDVIAVYKATKDALDSVKKGGKPMVIEALTYRMGMHTTSDDPTKYRPESEVDGWKPKDPILRLRKYLVSNRLWNDSMDEDMQNQNKSLIDDATAKVNEAKANPKAMFDNVYSFMPETLKEEEDEALKNNFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE4</accession>
    <name>A0A218NNE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820249.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE4"/>
    <dbReference type="GeneID" id="33314238"/>
    <dbReference type="KEGG" id="marh:Mia14_0685"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="512" mass="54653" checksum="871EC10FF1F403C6" modified="2017-09-27" version="1">MGSLIIGAVTLIIPLVALFISFMFAKLDALKSAFVGFIVELAMVVLFYPSARIVDASIWGTFETYSIFGVIWTGMIFGIMYRETGLLRRLLDVLHSVIHSGWGLVAALGGVIQGILGAFNGFAVYPIAIPGIKELGYEPWRSATGYLVLASWTIPLVSLWIAGSLASAASHIPVPTMAPFVGMITIPLIFIAVFGGMKILNEKFNKENLTIAALYIISGIVSIIVFAILIPSAYLLTLIASGFLTLILFVLYSKHLKQDSTDIQKFSLSGILKPFGPIIVGIVLILLWTYPLAGLVAKANYVLKLWTYAPVSINLLTTPAFFIFVVALSTYMFKIKPDENKGKQKPATPVTKPLGVWSSLVKGSRMSGNSLLTTFLGATFAGVAIASGQVAAITKLMAEAGSLFYPIVLNIFSWGTGIVFATGTVAAFLISAPQVAVASALTLPVGLLLGVVVIMTMGPANPLKPSLIAYTATLAGAPSKDQSKIFNNALVWMAIELVVALITTFVITYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE9</accession>
    <name>A0A218NNE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAM superfamily RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820252.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE9"/>
    <dbReference type="GeneID" id="33314242"/>
    <dbReference type="KEGG" id="marh:Mia14_0689"/>
    <dbReference type="OrthoDB" id="28569at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="91" mass="9762" checksum="4FE31743F87817B0" modified="2017-09-27" version="1">MNDEGNGNGSYEGHGGFGRRNDRFSGMSSTPKPVKVGDEIDVKIEAVASKGDGIAKKDGFVIFIKGAKEGEEKKIRITDVKERFATGEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF1</accession>
    <name>A0A218NNF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF1"/>
    <dbReference type="KEGG" id="marh:Mia14_0680"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22909">
        <property type="entry name" value="HFD_archaea_histone-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050947">
        <property type="entry name" value="Archaeal_histone_HMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050004">
        <property type="entry name" value="HmfB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043032">
        <property type="entry name" value="archaea_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47828">
        <property type="entry name" value="ARCHAEAL HISTONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47828:SF1">
        <property type="entry name" value="ARCHAEAL HISTONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="71" mass="7861" checksum="9E7075F934443400" modified="2017-09-27" version="1">MGALVYFKKATIKKLFKDAGASRVSNKALLLFQDMIEKQAYKTAVKSVNLSKHAKRKTVEESDIKLAASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG0</accession>
    <name>A0A218NNG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG0"/>
    <dbReference type="KEGG" id="marh:Mia14_0718"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF6">
        <property type="entry name" value="UNDECAPRENYL PHOSPHATE TRANSPORTER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="22974" checksum="490203264168F828" modified="2017-09-27" version="1">MLLIYYLLISLGSLSKALPAIIESYGYASVVLLMALESASLPLPSEVILPTVGFLVSKGLMDFYIALIAALIGNFIGIMVDYYIGYYLGKDFIYKNLRLFHVKKETLDNFDSWFDKNGEIAVFFSRMIPVIRGLISFPAGFANMNKKKFITYSMVGSLIYDALLILFGMYALSVGNIVELMAAISIFAVILIAVYKAFMHYLAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG3</accession>
    <name>A0A218NNG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHA1 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820256.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG3"/>
    <dbReference type="GeneID" id="33314246"/>
    <dbReference type="KEGG" id="marh:Mia14_0693"/>
    <dbReference type="OrthoDB" id="29061at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43129:SF1">
        <property type="entry name" value="FOSMIDOMYCIN RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="433" mass="46784" checksum="D69812F1EF6DF6F2" modified="2017-09-27" version="1">MAGNSNYKSNIFKSKSSSNKAKIFAGASVGHFANDGTLLVFTMLMVYYIKIPHVSVAVLGSIAVAYQLLSGYLSTRVGKYADAKGDYNKLISVGILIEGLGIFLFGISFIFGYLLYVYAFALLAALVLGFGQAFYHPLGGALLSNTFGKSSPKYMGANGAFGSLGRSILPSLIAFSILLFGNTVGLISISAFYLLLSIIIFVLLANKRNNNGSSSMNKVRLLDRSSSTDDITVSQKAMASHKPFSFYKKSVYKLTLVTILRSASIMATLTFIGVYIKIIGKLTPTEVGIFLTVTFFFAVIGQYVFGVIVTKKGNRKTVVYTTLISVIAFGFFLLLRGPVYSYIFYSVFTFAALTSFPVFMSYSANIVEKEYNGYSNSVVWGIGTIVGGALGVGLITILLYFGFSIFIGMVVAEIIGIISIISLPILPKTLNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH1</accession>
    <name>A0A218NNH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820289.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH1"/>
    <dbReference type="GeneID" id="33314281"/>
    <dbReference type="KEGG" id="marh:Mia14_0729"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="243" mass="27492" checksum="3205A360D90480B6" modified="2017-09-27" version="1">MDYRFWNYSLKVYRSNFKLFLFFSIAFLIAFLIPLFASVPAYSDLGSIYLRSSSVYFGSSILGFIVIIISTLFSLLFLSFAIVSINLIVKQQRTSVKLSSKMLKGIEVYISRVFVLLLIFTFVIMGVNLSMYGSGFDGIATAVAILILTPFFIYTPSSIVIEDRKVINAILFGSRFLFKKFGYFLIFLVFGIVSLSVVGFVFDLIPNPVISGYMQLIVDSLFVLPFLVLLLSEMYISKFAMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH4</accession>
    <name>A0A218NNH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820264.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH4"/>
    <dbReference type="GeneID" id="33314254"/>
    <dbReference type="KEGG" id="marh:Mia14_0702"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="64" mass="7148" checksum="FE3568C7E6638661" modified="2017-09-27" version="1">MIILDLFIKAAYAISFELISASSVLLFVSFNGSRKRELRLGIDIAYGSMLLLTIALFVGMIPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH6</accession>
    <name>A0A218NNH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820299.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH6"/>
    <dbReference type="GeneID" id="33314291"/>
    <dbReference type="KEGG" id="marh:Mia14_0739"/>
    <dbReference type="OrthoDB" id="378916at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="109" mass="12426" checksum="9A6D0FBC1F50CC24" modified="2017-09-27" version="1">MSEQNSYTISKADLRKLLINYKISEDTIARFFGELEKSHRHINALAFVSILEKSGVDLDNIVNILRRLGMDDVRINNILNDEDEQKLAAEPGRIFNASVEFSAEDEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL9</accession>
    <name>A0A218NNL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exosome complex RNA-binding protein Csl4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL9"/>
    <dbReference type="KEGG" id="marh:Mia14_0755"/>
    <dbReference type="OrthoDB" id="6768at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034126">
        <property type="entry name" value="PRK09521.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="205" mass="22974" checksum="1BEA4540CF69C436" modified="2017-09-27" version="1">MRVFVKDTEIVMPGDKLATEEEFLPERGIFNENGYLFSLLVGDLFLGRGKIGVKPLLRDIRTFKEENVVICMITDLLPSIAFTSVSSIRLNGKDYVALKEGKIINPSERGHYGSSKKLNFSDYNVGDVLLAKIKYNDDDSYMLDIESSPELGVLFSVCEDCGEPMIYDSKLHMLACSKCKHVNNKDVSTVYGSIEEALKVIEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM7</accession>
    <name>A0A218NNM7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Mia14_0784</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820339.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM7"/>
    <dbReference type="GeneID" id="33314335"/>
    <dbReference type="KEGG" id="marh:Mia14_0784"/>
    <dbReference type="OrthoDB" id="30609at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02798">
        <property type="entry name" value="tRNA_bind_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000042">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007494">
        <property type="entry name" value="PRK10089.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="TRNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI14078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="108" mass="11983" checksum="84A27A6824F3C67E" modified="2017-09-27" version="1">MATIDDLKKIELRVGTIVDVEVHEKAIKPIYKLKVDLGELGIREIAAGIRDKYSKEDLVNKQIIVVANLEPKDIAGFVSNGMLLAAEDDENISLLTPDRKMKPGSKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN1</accession>
    <name>A0A218NNN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain and zinc ribbon domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820342.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN1"/>
    <dbReference type="GeneID" id="33314338"/>
    <dbReference type="KEGG" id="marh:Mia14_0787"/>
    <dbReference type="OrthoDB" id="1266at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081">
        <property type="entry name" value="MUT7-C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081:SF1">
        <property type="entry name" value="MUT7-C RNASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="180" mass="20862" checksum="679CEC82EA2E21E8" modified="2017-09-27" version="1">MHESQPVPLYRLNIVADIMMAKVARWMRLLGIKVNDAKYIDDTQILNYIKRYRHPVLLTSDVEFSRRAEKIRVKAICVPSNIDLNHQVAYVLKRMDIDASRIKAGSLCTSCGARLIRINKASLESDKIPKNSLDAYDKFYKCPKCGKTYWRGSHWSEIDSRINEILSIYKNEKQNKSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN3</accession>
    <name>A0A218NNN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN3"/>
    <dbReference type="KEGG" id="marh:Mia14_0797"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="164" mass="18906" checksum="E0FC71461535EF0F" modified="2017-09-27" version="1">MVQKLKLNPNRCYLLGLYECGSKDLINLKTSDDELAEKFIKLLTSEFEIKPGKLHIEKKENLNVITLYNSKLKKLFDRSLERKSFIFKYLNEYSSAYFAAIFDYNGGRTSNGRIYINRLDAGDSLLLEKLNIHSNGKSKSFMLNPNLFIALIKGYSLKVARVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN8</accession>
    <name>A0A218NNN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN8"/>
    <dbReference type="KEGG" id="marh:Mia14_0772"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="144" mass="17007" checksum="9A7BF20A2AC766DC" modified="2017-09-27" version="1">MIFLEEKRSKEGLEGSRVKKARVVRSTSSIRQRTVYYRFYLVKPNFNTDLQELSMQIMSFKEVAEVYLTEGDSGILVKTKFFNDSKPQAIEGFLKKTIPYKYGILVSPIQYEKYLKNGKPYISKLKHRIAYQNKVKLKSEEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR0</accession>
    <name>A0A218NNR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820345.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR0"/>
    <dbReference type="GeneID" id="33314341"/>
    <dbReference type="KEGG" id="marh:Mia14_0790"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02973">
        <property type="entry name" value="TRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="TON_0319-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02187">
        <property type="entry name" value="PDO_seleno_TRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37170:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37170">
        <property type="entry name" value="GLUTAREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="223" mass="25473" checksum="54A834E2A4C0B74D" modified="2017-09-27" version="1">MVKLKDDDKKAITEKFSKELKGDVNIMYFYDSDKKVCPYCSEMTELLEDLVGLSPKLKLTKYNAADESTEKERKFLKINDQVPALVLGGKKIYNLYYFGIPAGYEFASLLEDIVDVSNGTTRLSEKTKAELKEVSKPIDIKVFVTPTCPWCPRAVRTAHQLAIENPMITSSMIEASEFEEMSTKYKVMAVPRIVINDKSYFEGAQPEQVFMEYIKEELKDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS7</accession>
    <name>A0A218NNS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AEF-2-diphthamide synthase (DPH6)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820370.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS7"/>
    <dbReference type="GeneID" id="33314360"/>
    <dbReference type="KEGG" id="marh:Mia14_0811"/>
    <dbReference type="OrthoDB" id="372052at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="223" mass="24528" checksum="CA65FCF724FB8657" modified="2017-09-27" version="1">MKAVCLFSGGKDSTLALHRAIGKGIDVSQLLTIAPENDYSYMFHKPNIRFTSLQAEALGIPQVIINIKGDKDEELADLESAIADSNADLVITGAIASQYQKSRVDAICDRLGIRDYSPLWGIEPLEELKELSKSFDVIITKVSADGMDKSLLGAHIDGDTIIKLLGIERRFHINLSFEGGEAESFVLNAPLFKKKIVIDKSHVENDRSNGEYIIDSAHLDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS9</accession>
    <name>A0A218NNS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891466.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS9"/>
    <dbReference type="GeneID" id="43457935"/>
    <dbReference type="KEGG" id="marh:Mia14_0853"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="57" mass="6488" checksum="03D0E90B9AD8408B" modified="2017-09-27" version="1">MDKKDVENLMNAIKMTVNVVKNEFDVLEGIDKKDPKKTLDSISKAIDDFLTDLKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT8</accession>
    <name>A0A218NNT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820436.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT8"/>
    <dbReference type="GeneID" id="33314409"/>
    <dbReference type="KEGG" id="marh:Mia14_0863"/>
    <dbReference type="OrthoDB" id="373778at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="209" mass="25053" checksum="A29B457748821B29" modified="2017-09-27" version="1">MIFDTPIDYFYPPDRRAEAVLRAIQDRERKFQHTFTSDLYMALSNIPKEKIHSSNQLKHEWIDKRIDMLANMNFIERLEDETDKRRIEIRTKPEEIYTYMIGRDPMLFWNLIENDYFYFIVRFAQTGGNVLCPKCQRESSISINSTKKKTARYPISDDMHIDVIFTHLIISFNCECCYSYNDEIDMVDPATMEDFLRLMDASNNRRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV4</accession>
    <name>A0A218NNV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III restriction-modification enzyme subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820446.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV4"/>
    <dbReference type="REBASE" id="210405">
        <property type="entry name" value="Mar14ORF869P"/>
    </dbReference>
    <dbReference type="GeneID" id="33314415"/>
    <dbReference type="KEGG" id="marh:Mia14_0870"/>
    <dbReference type="OrthoDB" id="75806at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="360"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="845" mass="98971" checksum="6E2C7282FEE032F6" modified="2017-09-27" version="1">MNPFEEPETRVQTTAPLVEALRSEVRNWRNSGYYGTSKTTRRLLQFWFDDEHKIIDEKFRYYFAQKEAIETLIYIYEVKKFRKMSDLILNYDSTKKIAYNPNEYLFPKYCFKMATGSGKTYVMALAIVWSYFNNIMEDNEEMPRNFLIIAPNIAVYERLKEDFSDSKIFNSGVMIPDEFQHLWEFESVTEDYIPTRSTKGRLYLTNVQRIYERDNAPVNPIQEIVGKKPSDTIRYYDQIMGEINALTSLGIINDEAHHVWDKDIIWNQFILTCNDLLKKKGKELSFQLDFTATPKRQDSGSIFEWVITDFPLADAIRCGIVKSPIIGEVENPHETPSDRADVIYRDYIEAGCRRWSYYNGVMDKVKKHPIIFFMATKTSEAEDINNYLQTKNEFKGKTLIIHTNLKGEISDKEWQKLKQETREIDTSHKYRAIVSVLMLREGWDVKNVCVIVGLRPFTSKAEILPEQALGRGLRLMFGPESGYEETVDVFGTKAFVDYIDEEMRKQGVDIKRYKERNLPTVTNIFPDTLRKSEFNFRIPVLSPKYKRENRSFNEIDISTLPQGKFDLDLETYTNIKSAVGRDALTEKERWRDRWEQPIPENYPSVISYLANIILRACKIPSRNSELVGKLDSYVTNSIFTAALTQDVKDDYRFLQAISEPKIVDFLTELFVKVINKLTILSTEVRLQSESREVKDIRPSLTRKKTYTPKKCILNLVPVANDFEYDFCKFLDNDASDVKKYIKNDNNLNFYLEYVNDKKGLSYYLPDFVVVCDSENYIIETKGEESVEVKNKDKRAREWCEDSTKLTGSKWTYLKVPETVFKNNREVKTVKKLEEIVRSYESVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX2</accession>
    <name>A0A218NNX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX2"/>
    <dbReference type="KEGG" id="marh:Mia14_0847"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22176" checksum="43B787A9A6F08927" modified="2017-09-27" version="1">MAKENNLYSIKNFALKTGSAVITPSEIANILGKSKKFGNAYAARMVKKNLAKRIMRGKYSLVDDNFAIASQLINPSYISIESALLFHDIIQQVPRDIECVTTVNSIRLEELGINYHKIPPSLFYGYKRVERGQSYAFVAEPEKAIIDGIYLGMYSIDQLKEYLGSLNKKRLTELANNYKGYGSKNINKVIASLKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX6</accession>
    <name>A0A218NNX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX6"/>
    <dbReference type="KEGG" id="marh:Mia14_0893"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="75" mass="8511" checksum="F12F20689F935820" modified="2017-09-27" version="1">MNWKLTSILVIIVVAFIFLVPVVPAVGLSPGVAQIQNHPVYFHYYKSISGVFTPFGTSFYGGYYLHPYPFWGYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX8</accession>
    <name>A0A218NNX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GrpB family nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216922.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX8"/>
    <dbReference type="GeneID" id="33314450"/>
    <dbReference type="KEGG" id="marh:Mia14_0913"/>
    <dbReference type="OrthoDB" id="330317at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="190" mass="22338" checksum="CB1E02917E606C57" modified="2017-09-27" version="1">MHHKEIDGKQKYVFKRYSPIYNSFFAVEQKRIYENIGRRTISIEHIGSTAVPDLGGKNILDIIIGIKVCRLKDFKELIKDLGYDFIEDSGTKRRLFFVRDTVYKGKNIRTHLHLVKFDKSDWKQKIAFRDYLIKHKNARIEYANVKKKAVKAANGNKEIYMKEKESFIKGITKKALKPSAERINKNKHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY1</accession>
    <name>A0A218NNY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820483.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY1"/>
    <dbReference type="GeneID" id="33314452"/>
    <dbReference type="KEGG" id="marh:Mia14_0915"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="156" mass="17033" checksum="6122B78F2CCDDB74" modified="2017-09-27" version="1">MPNPKKKAKKEAKGSSDKNRKEIEAIKRLKELDNQLNRTNMENALLPNPSEAEGTATDALESNLLDDLFDKSTKEHSEASEHKKSNSKAITKRPSTAAKHTVSNTAAKAKQIKASSKNHNAKSAPKKAKTNNSSKNKMSKAKPNAKKKSKKSGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ1</accession>
    <name>A0A218NNZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+ superfamily ATPase fused to HTH and RecB nuclease domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820450.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ1"/>
    <dbReference type="GeneID" id="33314418"/>
    <dbReference type="KEGG" id="marh:Mia14_0875"/>
    <dbReference type="OrthoDB" id="24399at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34704:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="3">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="479" mass="55490" checksum="3711FC5EFF4F777D" modified="2017-09-27" version="1">MSQQKFVDRIEEMKILERAMSAKGPSLFILYGRRRVGKTELISKFLGTRGVYFLATAEGDRENINSFKAIMSKFLGDESILMANFDDWHSLFTVLTSSSSFQAKARESKIIIVIDEFPYLIEANRAIPSVFQKVYDTVLREKNVMLILSGSSISMMENEVLSYRSPLYGRRTGQLQLRPLKFRYLSEFVNYGFEDLCNTYFVFGGIPDYLLKLDPDTGFWENVSKSIISKGAPLYEEADFLLRTEFREPRNYMLILRSISYGNHTLGEICAYSGLDKSMVSKYLDVLMSLGLVIPEKPFGASEKFKRRLNWISDPYLKFWFRYVLPHKSEIENSRNEEILKIIVDDFPTFAGEQFENLMKELILEGILGRSFDTVSRWWGRNESNKKGRDVEEIDIVAYSETRGELLFAECKWTNSPVPISIVEALRTKSETLRKQYPGKKYSYAVFSKSGFKWTLQEPISDVILMDLSDIEREIYKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ4</accession>
    <name>A0A218NNZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RelB antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539374.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ4"/>
    <dbReference type="GeneID" id="60640011"/>
    <dbReference type="KEGG" id="marh:Mia14_0872"/>
    <dbReference type="OrthoDB" id="56517at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="58" mass="6769" checksum="E535E48396E76168" modified="2017-09-27" version="1">MTTAKQSRLVSIPKSDLDSLEATVETLENEYVMDQLERSEQDIQKGRVRNVREFLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP00</accession>
    <name>A0A218NP00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820504.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP00"/>
    <dbReference type="GeneID" id="33314473"/>
    <dbReference type="KEGG" id="marh:Mia14_0936"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="474" mass="51058" checksum="074A1463B4A27F6F" modified="2017-09-27" version="1">MADNDDKLKSIYSQNYSDLQVDKKDNPNIKDKKNSPKSYNVIVPIAIVILLLIVGIYALSAYSKPAATPNTNSFVYKQLSQKNLPASNIYAISKNISSTINATNEINASYTGNLTLVAKLGNFPYDFALPLNVSFKKYGNDSILSFGVNTNSLGVGLLSGIVSGNGNLAFAYAKINGSDYYCRRIEENFTVNQSFVGKEVCTKVNSVSTNPINSSITKQFLGNIDNKIQFYNNTVNISKCNNMQGYIFTTNFKLKNISNSKFGTTLGNSSVITGLMSTCLVPSKSDMPAFINLNATILGSSKSPILSLINNLSFGILLNLNASKLSNNMTKSEVDKLPGELVNASELNIAPSAYNSSDMNLNISVLSRINNGTNSTAGDNITFVTSALSHRYYLSKYLSGQVQIESASGNSGFVHVTLTGSNGKVYFSNGTNNWCMGDPDINTISLPPMQYNLTISVGRGGGECGNAEVVISKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP04</accession>
    <name>A0A218NP04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820497.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP04"/>
    <dbReference type="GeneID" id="33314466"/>
    <dbReference type="KEGG" id="marh:Mia14_0929"/>
    <dbReference type="OrthoDB" id="18103at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051538">
        <property type="entry name" value="Acyl-CoA_Synth/Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334:SF2">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="464" mass="49564" checksum="D660BEB281DCB8F5" modified="2017-09-27" version="1">MENEMSKSIGIMMNPKSVAIIGASPDPDKVGYSILKNYLDLKYKGKLYPINLKEDSILGLKAYKSILDVPEQVDTAVIAVPAPITPNVLDECGRAKVKSVVVVTAGYAEVGNSELEEKLVSTAKKYNLPVLGPNCVGVMDLRTGVDTLFLPSYKFDRPEAGSLGFVSQSGSVAGTILDLIGGESIGLSKFVSYGNASVIDETDILNYLADDDDTNVLIVYLEGAKKSKDFIDVAKRIGKKKPVIIAKGGATAAGSKAAHSHTASMAGNYQIYEAIFEQAGFIQSNDLDEMMGMAKMFDKQPLPTGNRVGLITNGGGTGVLATDSIYRNGLALADLTDSSKEYLRKVMPPIVNIRTPLDIGGDADYGRFNEAIKTVVNDDNVDIVAIIALFQTPGADSRVAQAIGNYAAVCKKPMIVISEGGSYTEMHKKIIEQSGIPVYSSPEMAAKVMAAAVKYAEFRKNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP11</accession>
    <name>A0A218NP11_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.132</ecNumber>
            <ecNumber evidence="3">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Mia14_0948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="4"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820515.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP11"/>
    <dbReference type="GeneID" id="33314484"/>
    <dbReference type="KEGG" id="marh:Mia14_0948"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="190"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI14220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="382" mass="44478" checksum="ED7270A55056245C" modified="2017-09-27" version="1">MRIKLAMAQANLTVRGGAERVVLKIAEHYNATIYTAEYRKDATFEEFNDLDIKVIGGRGFYKFLGYGRAAQGLNYGLSFYNYRVRDDYDVLNPHIAPSHWIRHKNSRVLWYCHTPLRDLYDLYYYRQSLRPFAKRSLYSVIVPRIRFIDKRMVSKIKYIVANSENTNNRIKKYYGRNDAVVLNGGIDYKEYKNEGNDRYFFYPSRISPNKRQDYAIRAFKIFKSQNKGLNYRLIISGQVSDDPFYQEYYSKISNMAKSVGGVSILTDVNDKDLVDLYSKATAILYPPINEDYGLVPLEAAASGKPVIVVNEGGPKETVINNKTGFLINNELDMAEKMQKLAEEPQLVEIMGKKGRERVKKYYSWNNFFKEFDKLLYKAKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP27</accession>
    <name>A0A218NP27_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP27"/>
    <dbReference type="KEGG" id="marh:Mia14_0958"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16928">
        <property type="entry name" value="HATPase_GyrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00822">
        <property type="entry name" value="TopoII_Trans_DNA_gyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000002">
        <property type="entry name" value="DNA gyrase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000565">
        <property type="entry name" value="Topo_IIA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004189">
        <property type="entry name" value="PRK05644.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866:SF1">
        <property type="entry name" value="DNA GYRASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45866">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01159">
        <property type="entry name" value="DNAGYRASEB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="418"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="632" mass="70451" checksum="4C88276C8919FD49" modified="2017-09-27" version="1">MPDDYSAKDIMVLTGAQGIRKRPGMYIGSTGSAGFLHLLYEVIDNSIDESISGYCKNITIKLTTEDNTDVAEVSDDGRGIPVDIMAGTNKPALEVIMTSLHSGAKFNNKTYKVSGGLHGVGLTVVNALSEYTQVTVKKNGKLYKEEFSRGLPISSLEVLGDTTETGTTIKFKPDKEIFSVGSFDVVSLIDRLRDVTYLNPGLKITLTDARDEKETKTEFFSEKGITDFMDYIRSGKEEISKPILITKEVNDTKISVSIQYIKSYSEELLSFVNNIKTPEGGMHVSGFHSALTRAITSYVQKNVKKSNINIEGEDTREGLIGIISILMQNPEFEGQTKEKLGNTFVKQIVENAVYTELSYYLEENPAEAAKIVEKVLKASEAREAARRARELARKKSLFEGSVLPGKLADCTENDPSKSEIFIVEGDSAAGSSKQGRDRMYQAIMPLRGKVLNVEKASTEKIFNNAELHTLVTALGTGIKDSFNIENLRYHKIIFLTDADVDGSHIETLLLTFFYRYLKEVIERGYIYAAQPPLYKITIGKEVKYAYNDEQMNQILKENNGKGLVNRYKGLGEMNPDQLWETTMNPENRVLKKITIKDAELADSIFNTLMGANVEDRRKFLEAHSTEVSFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP28</accession>
    <name>A0A218NP28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820522.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP28"/>
    <dbReference type="GeneID" id="33314491"/>
    <dbReference type="KEGG" id="marh:Mia14_0955"/>
    <dbReference type="OrthoDB" id="28948at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="230" mass="25229" checksum="9A89264FC4F882C5" modified="2017-09-27" version="1">MKLNFLTLTPKATVIGLIMGLLIVFLGRGLGLFFFFMMLWFLVLSAIVSFIGKKYKLKRKLFEDTRGIKNVIANGLWPFLLVLAYYFLSSNQFLKYALIFAFIGSVAAITADKFGSEIGVLDGEPIMLLTLKRVKKGTSGAVTWLGISAGILAAFLQSLVMLPWIGYFGSAGISMLWLFVAAILGGLAGTLFDSILGYFEENGKGNKYTSNFFASVFGSIIALTIFLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP34</accession>
    <name>A0A218NP34_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl23</name>
        <name evidence="5" type="ORF">Mia14_0966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780218.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP34"/>
    <dbReference type="GeneID" id="33314502"/>
    <dbReference type="KEGG" id="marh:Mia14_0966"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="83" mass="9667" checksum="AA02904EAD88065B" modified="2017-09-27" version="1">MSILMYPIGTEKAITEISKDNMITYVVDLDSTKYEIKKEFEKQFNVKVDKVRVINTPKNKKHAFIKLKKEFNASDVAMKLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP37</accession>
    <name>A0A218NP37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820532.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP37"/>
    <dbReference type="GeneID" id="33314501"/>
    <dbReference type="KEGG" id="marh:Mia14_0965"/>
    <dbReference type="OrthoDB" id="5987at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="235" mass="25572" checksum="EA9F91F7AFE2F442" modified="2017-09-27" version="1">MGKKLKQQRRGKGSSAYTKLPGTFDISVNYPRLKDKAAEVVNIFNHTGHTAPLMEIVYEDFKTGYMIAPEGISIGDKIYLNKENSFSLGSIMPLSQIPEGVPIYNIEFKPGDGGKMVRAAGSYAFISGRKDGMVSLTLPSKVHIELSENCQAQIGVIAGGGRKDQPLMKAGKSHYMKHAINALWPVNRGVKMSPVDHPFGGKQHHKGKSSLTSRNAPPGRKVGNLAAKRSGRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP40</accession>
    <name>A0A218NP40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820534.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP40"/>
    <dbReference type="GeneID" id="33314504"/>
    <dbReference type="KEGG" id="marh:Mia14_0968"/>
    <dbReference type="OrthoDB" id="6121at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="319" mass="35799" checksum="F5258C23AD680160" modified="2017-09-27" version="1">MAGMQFWNGRRARRRLPRVRGQIKTKDDSPALSSMLAFKAGMVGVTLIENTKAALNVEAFKGATVLEIPDTEVYGLRLYKKDPKSRYVVAAETIYDSKIAEKINLKKVKNDTSTIENFKSKIKDYHKVSLLLVAYPKSISADQNHIQKYESYIIGSSIESNFNFASGLIGKKLQPEEVFKAGEFLDLASITKGKGWQGEIKRKGIRRQFHKATEKIRHVGTLGAFTPGKILYTVPRAGQMGYNYRTEKDKELLKIGDISVDNINPKSGFKNYGLIKNKYLLVSGSIPGTAKREVRVRKSQIGKRKGIKEVNLNYISSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP43</accession>
    <name>A0A218NP43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Digeranylgeranylglyceryl phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820489.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP43"/>
    <dbReference type="GeneID" id="33314458"/>
    <dbReference type="KEGG" id="marh:Mia14_0921"/>
    <dbReference type="OrthoDB" id="11851at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="290" mass="32234" checksum="D7155D07215451C3" modified="2017-09-27" version="1">MALKDYIKLTRAEHSLMLAIAVVAAELITAGKLPSWPIFIIALIPPILIGMASFSINDYFDVKVDKKNGKLKRPLVSGAILPKAAFNLSIALFVIGVAFSALINIYAFIISVIFAVLAFFYSYRLKETLLIGNIYIAFAMAIPFIYGNYIMSTSMNLNILLITLVILLSGVAREIHGMIRDKIGDIKERHSKNLVYYIGGRMSAVVASALYVSAVAISIAMFWIKKPFYMNIVYLIPILCVDITLMYVSAVYLKERISENEFTNTRNISLIAMSAAILIYLIAAVFQVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP57</accession>
    <name>A0A218NP57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L44e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820539.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP57"/>
    <dbReference type="GeneID" id="33314510"/>
    <dbReference type="KEGG" id="marh:Mia14_0974"/>
    <dbReference type="OrthoDB" id="52456at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="93" mass="10795" checksum="540B9D6446066CB6" modified="2017-09-27" version="1">MKVPKEINTYCPKCDKESTHTVKFYTQKPRGGLSVGTRRSERKRKGYFGKVKGQATVKKVSKRQKAILKCKVCSYSVERVFGNRTKKKLEYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP65</accession>
    <name>A0A218NP65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820521.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP65"/>
    <dbReference type="GeneID" id="33314490"/>
    <dbReference type="KEGG" id="marh:Mia14_0954"/>
    <dbReference type="OrthoDB" id="381372at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="87" mass="9789" checksum="158FF321E7610BB5" modified="2017-09-27" version="1">MVGESAKKILKEGEATFEVNRSGIRQKIRFTVKKIKQGNLEYTELFSEKLIGFAELQRISEEAGLPVQSQTARAFPKGMGIKDFLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP95</accession>
    <name>A0A218NP95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_1027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820586.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP95"/>
    <dbReference type="GeneID" id="33314562"/>
    <dbReference type="KEGG" id="marh:Mia14_1027"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="549" mass="59304" checksum="101E89AEFBA4ACE1" modified="2017-09-27" version="1">MAENNFNGQRVLLLPEGSDRLMGRDAQRTNIAVAIAVANAVKTTLGPKGMDKMLVSDLGDITITNDGATILEEMNVEHPVAKIMVDVAKTQDTEVGDGTTSVIIMAGSFLKGADDLIEQGIHPTIIIRGYKMAAEKAEEILNGISEKININDTKTLEKIGMVAEGSKNIGNEDTKKHITEIAINAIKQVMTKDQDGKIYVDKDFIKVEKKAGASVANTELINGVLIDKEIAHPQMPKKVSDGKIALLDVALEIEKTETDARIEITSPDQMQSFLQQEEKMLKEMVDKIAKSGANVVFTQKGIDDVAQHYMAKAGIMAARRIKRSDMEKLAKATGAKMVTSLDDLSASDLGFAGIIEERKISGEQMIFVEKCKDPKSVSIFIRGGSQQVIDEVDRSITDLLGALTTAIEDGRYVVGGGSTETEVAEQLRAYASEIGGREQLAIQKFADALEQIPEVLAQSAGMDPIDTIVQIRSKHKSKEGKSYGVDVYKGAINNMLEAGVVEPTKMKVQEIYSASEAADMILRIDDMISSRSKGGPGGMPQGGMGEPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL1</accession>
    <name>A0A218NLL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819529.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL1"/>
    <dbReference type="GeneID" id="33313573"/>
    <dbReference type="KEGG" id="marh:Mia14_0011"/>
    <dbReference type="OrthoDB" id="8895at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="378" mass="43005" checksum="2317EF864F639120" modified="2017-09-27" version="1">MMNIRDSVFKDIEISELEEKIIDDPNFQRLRYVKQGGFSSLVFPSASGSRFEHSIGTMKITKDISKSVFGEEDEELSLCGMLHDIGHAPFSHQSEPIAKKYLGKSHEDLGYEIIKKSSISDIISDSTVSLNKVLEYFSGKGKGKLVTGPLGSDRIDYLLHDSYNTGVALGIIDYSRLEHNMAYVDGKPAIYRNGIVNAESFFITRYFMYESVYMHHTISIVESMFLKAADSAVEDGYIKAEEFVKMRDFEALYKLSQYKGSDLIDRILRRDVFKRAFYEDIGQAKFDESQLSKLNEYLESNGIPYNSYISKLISFSGADDDIIIVGKGNEKIGKLSEYSYIFNTLSKLLRERKILLVASDKNYKEKIAKLVKEFINSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN1</accession>
    <name>A0A218NLN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819521.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN1"/>
    <dbReference type="GeneID" id="33313565"/>
    <dbReference type="KEGG" id="marh:Mia14_0003"/>
    <dbReference type="OrthoDB" id="46045at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.20">
        <property type="entry name" value="tRNA intron endonuclease, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="tRNA-intron endonuclease N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="1">
        <location>
            <begin position="209"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="390" mass="45806" checksum="81FD522D177B4AF7" modified="2017-09-27" version="1">MALMLRYDSKNHSAYSTDQSTIDILRNGFIGDFKNGRLSLIPEEALYLMDVRNSECVTAKGKYIDFVQLAHKNRKSKKFMARYFTYKDWRDRGLIIVPPWRITQLPEEKRPISVKTYPAEKLKLKKFMASGIFFPYDMVTIIKDESIGKYLYDTQWFGQYGTYKLADHGSLNKLDIYETLFLMDSKRLSVEGYSRSDIIKAGVSMRDDFRKLYSVYKDWRKRGYVVKTGFKFGTHFRIYFPGANPTNQNSEWVHSRHVLHVFPRNSKLLISEWARAIRVAHSVRKTFILAIPGKSRAKKLDIDFILYHREKGKIEDPKTVYPKYSMLSLSENEYIGGSELSAIISKSQSINLELIIAIMDRETAVTYYKVRKINLPMSRYEYYEIDWMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP3</accession>
    <name>A0A218NLP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819551.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP3"/>
    <dbReference type="GeneID" id="33313597"/>
    <dbReference type="KEGG" id="marh:Mia14_0036"/>
    <dbReference type="OrthoDB" id="55506at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="69" mass="8077" checksum="29708017F8A2B6FF" modified="2017-09-27" version="1">MKCSYCSKEIKKGTGILYVFRTGKVNYFCSNRCYVNSIVLRRKYNRKESSKAKETDLSRVIKAEAKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR2</accession>
    <name>A0A218NLR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819570.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR2"/>
    <dbReference type="GeneID" id="33313616"/>
    <dbReference type="KEGG" id="marh:Mia14_0056"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="178" mass="19409" checksum="C74728B67BA311E4" modified="2017-09-27" version="1">MDNKQQAGKALLIIILLLFIALAFLIFIALKVYLPTTIYKTDTIYLYHNYNSSIRANITSDPYMVIIGTLNLKGPGINDSIPIYRSSSGVACPSESTTGLPCPLPNEIILFNELKPLSLYNLSFTGSASPICIKGNICPFVNLNTSALPDYIVALRYSKEIETGPNASTINISVSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR4</accession>
    <name>A0A218NLR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="7">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lysS</name>
        <name evidence="11" type="ORF">Mia14_0060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 8">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819573.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR4"/>
    <dbReference type="GeneID" id="33313620"/>
    <dbReference type="KEGG" id="marh:Mia14_0060"/>
    <dbReference type="OrthoDB" id="131570at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF15">
        <property type="entry name" value="LYSINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="162"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="484" mass="55846" checksum="CD99A618ABD17C70" modified="2017-09-27" version="1">MMAEEYKLNKLNELKSMGINPYPYSYKVTNHSEEIKLNFDKLEDTDVTAAGRIIGLRHMGKLYFFDLLDGEGKIQVMAAPNFSSESSLKILENLDTGDFAGVEGKVTKSKRGEISIAAKEITVLSKSLLSLPEKFHGLTDIELRYRKRYLDLISNTEVRKFFVTRSKILKYMRDFFDSRGYVEFETPILQPTYGGANASPFKTYFNALNQDMFLRIADELYLKRLIVGGFEKVYEVSKDFRNEDIDSTHNPEFTQIEAYEMFKDYEDYMKMTEELLSGMVKYLFGSYKIKYQGKELDFTPPFKRLYWVEVLNEKTGVDVSKLTDKEAKEVAERENLDIPMKNSYHVADALFDKYIKPELFNPVFVLDFPAYMSPLTKDKRGNNKLSERFELYLAGKEDANCYSELTDPIEQRKKFEEQDKERKKGDPEAPPIDEDFLEAIEYGMPPTAGIGIAIDRLAMILTDNISIKEVITFPAVKTEKQNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT1</accession>
    <name>A0A218NLT1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl18</name>
        <name evidence="7" type="ORF">Mia14_0076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT1"/>
    <dbReference type="KEGG" id="marh:Mia14_0076"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057267">
        <property type="entry name" value="Rbsml_uL18_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006342">
        <property type="entry name" value="PRK08569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="182" mass="20432" checksum="7E421DD4C3E3658E" modified="2017-09-27" version="1">MINMIARRRRDSITNYRKRLGLLKGDKTRLVIRKTNRHVIIELVDYKVDGDKVLTTVNSKELEKLGWVSHSNLPTAYLAGVLMAKKAKELGFSKEVLLDMGLYKPMKNGVIFAAAEGCIEGGLKVIGSFKVDKDRISGKHIADYVKEDASKEKLFSSYSEKKLNVKTLPESFKEVKSKINGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT8</accession>
    <name>A0A218NLT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flpA</name>
        <name evidence="8" type="ORF">Mia14_0097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819608.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT8"/>
    <dbReference type="GeneID" id="33313657"/>
    <dbReference type="KEGG" id="marh:Mia14_0097"/>
    <dbReference type="OrthoDB" id="6244at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="221" mass="24999" checksum="FF91118074FA02D5" modified="2017-09-27" version="1">MEFINISDSIFKVDGRLATKNLITGHRVYGEELIQKDNIEYRLWNPYRSKLAAAILKGLKTIAIKGGTHVLYLGVSTGTTSSHVSDIIGANGRLYGVEISKRSMREFLNLCELRHNMLPILSDAMAIDNYKNLVKEESCDVIYQDVSARDQSGILKANSIFLKKGGIAYFIIKSQSIDVGRKPEDVFEDELRKLKDVFDIVEKIDINPFDKLHMFAVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW7</accession>
    <name>A0A218NLW7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819609.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW7"/>
    <dbReference type="GeneID" id="33313658"/>
    <dbReference type="KEGG" id="marh:Mia14_0098"/>
    <dbReference type="OrthoDB" id="3369at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="504"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="734" mass="83055" checksum="C423ECD66F7ABB91" modified="2017-09-27" version="1">MVEDIFINKFLADMINLTNTTDTEYGLKDYLSRMFGIENITVKMFDTERFNQSSLEAYISNTKKSYIDNEINEYSAFPELLNYRNNGYSSCLIAPIKVDNRVIGEVNLFSTHPNKFTPDISSLIELSVTLFGLNLYYSSEKKKVERITSYFDASFNSSVPQALVNSAGDILKFNKQFVNLIGSYPEDKKIASAIGVNFSDLYDLTDGKYIQKAIKNGKPVRINSYKIRDSLIHITLIDQSEHELLSSINSAINLQNQFLILILDDKLDIRNFAGSLYDKFNEIHDLLTGKNLNSFVGEANGKLIDESLKNQQSFKSTLQIEFPNKSINGRISIEKCSMGYAAMITNIEKELYAENLDNTLDDFINTTTDMIIKVNEFGYIEDCNDPTVKNLGYPDKSGLIGKEIKSIYYEGDLETFDTNFSFIRKGEPINSISSNMIKRDGDSIPVIYSIRRIDDKSSQKYILIIHSLETKRELQDMESKLHKSDIQAKHFKSASDLKSEFIYDITHELKTPLTNIKGFAKLMKDGEFGQINEDQASYLDTILEESDRLMLIISQVLDAAKLEADKVKLDVREVNLKELYSNPSIKSMEEAAKNKGLSFTWDIAYDVPNIDADLNRLIQVLVNLIGNSIKFTESGGITVKIFKKSRKSVQFEVNDTGIGISDEDKRKIFKKFYQAPKRGLVKPDGTGTGLGLAITKDIVSLHGGKIRFDSKLGKGTKFWFTLPITYKNKASNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX2</accession>
    <name>A0A218NLX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819619.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX2"/>
    <dbReference type="GeneID" id="33313669"/>
    <dbReference type="KEGG" id="marh:Mia14_0109"/>
    <dbReference type="OrthoDB" id="38899at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052541">
        <property type="entry name" value="SQRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755:SF1">
        <property type="entry name" value="FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="203"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="411" mass="45101" checksum="9697816FCDC265F6" modified="2017-09-27" version="1">MVRLLVLGGRFAGLTAAYTAKRLLGDSIDVTLINDTPYSAFRPNMLHVGIGIAKAEDYEVDLNSALTAKGINFILGRVTGVDAKSNKVSYSTKDTEDEAIEYDYLVFALGAKLGIEHIKGWNEYGASACEPELAKALYARLEKFEGGNIAIGSGLFYQGTLTPRGNYPKNWSTKIDSACEGPVFELSLMIPPFLKKKGVLDKTHITIFSPGEEILTDISKESRNIVKTMYSNQGFDMVWNFKIKEIDKDKIISDDGKEIKADLAIILPPYEANDVVKNSTSDLFDDGGFMVTDEHMRSLNYPNVYSCGDSNQMTVPKLGALATQTARIAMQDLANRLGVPTKIDSYAPDIICIADNPLENTAISIDDTTLYGGDKSIVQASPANHIKKELFAKYFMWTNGDMVLDKYLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY0</accession>
    <name>A0A218NLY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CDP-archaeol synthase</fullName>
            <ecNumber evidence="11">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">carS</name>
        <name evidence="12" type="ORF">Mia14_0125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819631.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY0"/>
    <dbReference type="GeneID" id="33313684"/>
    <dbReference type="KEGG" id="marh:Mia14_0125"/>
    <dbReference type="OrthoDB" id="45383at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003114">
        <property type="entry name" value="PRK04032.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="CDP-ARCHAEOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650:SF1">
        <property type="entry name" value="CDP-ARCHAEOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="165" mass="18015" checksum="CF434C1AC49E0A10" modified="2017-09-27" version="1">MNYLVDIILYPIIYILPAYVANGAPVLFGGGKPLDFDRKINGKRIFGNHKTIRGTVSSLIAGIIIGLLEYPFLHYMLGIAILLAVGANIGDLLGSFLKRQIAFKPGKSAPILDQYGFFVLALLVALPLGHLPDIYGIIFLVILTGVMHPLTNLGAYLLKLKEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY6</accession>
    <name>A0A218NLY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA modification enzyme NFACT subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819642.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY6"/>
    <dbReference type="GeneID" id="33313695"/>
    <dbReference type="KEGG" id="marh:Mia14_0136"/>
    <dbReference type="OrthoDB" id="10943at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="257" mass="29640" checksum="7102F1BA43A006F4" modified="2017-09-27" version="1">MEIKLDFTKSSQENGNHYYEEAKRLEGKIERAEEATSALRAKAEEEKSRESEVKTKIIKVQEKKWYEKFHWFFTTGNLLAIGGRDAQQNELLNSKYFEDHDLFFHANIFGASVVILKDGLNASKDDKEECAQFSASYSSAWNKMQGEVDVYCMRRDQVSKSTNKGSLGTGSFLLKGEREWYRNTNLKLVAIVENEKLEVLPYKRFLHIENTEQIKRVIIEIGRIQKSDAAKKISSILKYDDINTIMQQLPAGTFSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ5</accession>
    <name>A0A218NLZ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891411.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ5"/>
    <dbReference type="GeneID" id="33313715"/>
    <dbReference type="KEGG" id="marh:Mia14_0156"/>
    <dbReference type="OrthoDB" id="372178at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="236"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="486" mass="55817" checksum="843FD9D74D00900C" modified="2017-09-27" version="1">MIGYEYRVLYFIAAHEKAEFDEILNGIGINEDSLRWAIEDLKLRKAITGDDEVKVTYTLTDEGRSYLSEFPEETLAKYINSKGSLEIKNVPGDMRIGFIWAKKNGWIDINDGVLTLTDAGKNSLGNEFNYPLKEALNFINDGKFSSIDDERAKILISRKLIEKKEKAYIGNIKITDEGNKLLSTEKEEDRIGSLSRNLMVHRGWEGKGFEPYSVDAEVAPSYPALRHPMNEFINYIRYKMVSLGFKETSGSIIQPAFWVFDSLFSPQDHPTRDMQDTFFLSSPEKIDIDDEELINKVKNMHLSNWKGKWDINNAKQAVLRTHTTAVSAHSMYNYRNVDFTTPVKLFTIDKAFRNESVDYKHLAEMYQFDGVVIGKDLSMANLIWILKEFFQSLGLEIRVQPSYFPFTEPSFEVHHFDNEHNDWIEMGGAGVIRNDITEALGLKGATVLAWGLGLDRMMLSRAKLNSLSDIYKNNIGWLRTRKKIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ7</accession>
    <name>A0A218NLZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819652.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ7"/>
    <dbReference type="GeneID" id="33313706"/>
    <dbReference type="KEGG" id="marh:Mia14_0147"/>
    <dbReference type="OrthoDB" id="7902at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160975">
        <property type="entry name" value="AF1531-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="193" mass="22526" checksum="5E0AA4510EC9C197" modified="2017-09-27" version="1">MEIQEKREDYAVVIDYMPTGKSFSTRADPTLQLVGTERFTLLEAKPKPNTSFSIGEKVYIGKNERDKIEIIKSRISYDELTQTAKGNLVEALDKLVKENEQRYVDFFNNAKPLNIRQHSLELLPGIGKKHLQAILKERTVKKFESFEDISNRIELLQDPSKLIVERILEELKGNERFYLFTKPFVKRTEQFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM06</accession>
    <name>A0A218NM06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SMR2 family DMT superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819666.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM06"/>
    <dbReference type="GeneID" id="33313721"/>
    <dbReference type="KEGG" id="marh:Mia14_0162"/>
    <dbReference type="OrthoDB" id="383480at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561:SF9">
        <property type="entry name" value="4-AMINO-4-DEOXY-L-ARABINOSE-PHOSPHOUNDECAPRENOL FLIPPASE SUBUNIT ARNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="12">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="119" mass="13201" checksum="8FC8256C425AF6B8" modified="2017-09-27" version="1">MIIYIIIFLTLFAALIASLSQIAFKTSLGKSGLSLLMLIKKVFSDKMILLGLLGYAVSLVIYLFALDRAPLSVVYPIFASSFIFVTLFSKFLLHEKISLIRYIGISVIFLGILIVAISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM11</accession>
    <name>A0A218NM11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM11"/>
    <dbReference type="KEGG" id="marh:Mia14_0169"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="444" mass="50086" checksum="9C79976032C45A40" modified="2017-09-27" version="1">MCLVMVENQSSKASPSANNANAPNLNEAKTNIDRMLALLQSKGRMDVNTLALSLDTPASVIDDWAKILESANMVKISYELGKMYIEPFSNVANTQNIDNIISNKREQLKRDVDVQYILLEKLVNSANSTSADINSAEFKFSKEYPQIRKTIKKLNKTLAELNKYNLKVEGLNKNTSGEYTKVNADYQKLVSNINGLSNGPLENDLKTLNIKLSKTLGDILSKKADLENIRKDNLKEIEDIKRDLQFHYKDALTSINSFSKSLNDQVLKARQEISKNITSINKDKANLNTAIKSYNTMMSLYNKTSGKVDSKKVEEIYNSNKAKIDEYTNEFNKAYDEVSGKLNDITKHFGDLGNLNSQILNLITVLNDSKTRVKDLRKEINDIKREVDTLSIKKNVSREDILKYAEIIEKHSKKTESEINNLSDKIKTSSDALSKSLTSDDTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM15</accession>
    <name>A0A218NM15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819679.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM15"/>
    <dbReference type="GeneID" id="33313735"/>
    <dbReference type="KEGG" id="marh:Mia14_0177"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635:SF2">
        <property type="entry name" value="LAMG-LIKE JELLYROLL FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="893" mass="97502" checksum="D35FD0410DB037D6" modified="2017-09-27" version="1">MNSKCGKSKSQIAIEFVIVYSIVLLIFLVIFALVANERAYSLQEQEYSELQLITQTVAEHIDIALESGNGYLSSITLPSTGTFDNYNLSLSSGGEVIATMKVGNENITALSYSAARNMQISGTPVGYDFYRVPSAGTMEFYNNNGHIIINSYTAGYDYLAEHLMTSVQGYGKVANFDGNADINIPNTSELESNSFTWSIWVNPISWDPNNGGFLGQANSGTGAPYMIEQGTTTNPKLQFSNDGGGGSSTYADISYFKWQNVVGTYNYTSGAMHLYVNGVLIDNTTNTPIPRLSGPIYIGYFPTDGAYFQGSMANLQIYNEAVNSSYVKYIYSSGMNGAPSDFNNLVGWWTLNGNINNYLGNYTSTPQITSKGLTFSNSFILSMNASNILNNQLNGVDLGLVTGTGTLGSPLKFTNYLTSNLISNVTDVVWTNGTDNVTVNAFNGNLFSEDNLVGWYPLDSGYSNTIFDLSGIGNVGQISGNYTWENESDYAKIYVANFTPSSPTYVEVPPSDVLLDIARNNSFTVSAWVYYRGPSTQPETIINDINRTANSGFSLYINKTGDLSLEIGNYPVFSNKTISIPKDKWTFVTAEYNFNTGSERLFENDLLINSSTAAFLPITQYSPYYIGYNSSFYPDGFNGSIANLQLYADELKSYQVAELYKNGMASAPLGGSNLIAWFTLDNTTEDYGYNTTVIDSFSNVRFTSAVFSKHINSRPYLFLNGSSGANSAKINSTIGYWLGTNHNFTVVAWFNSPHNGGPIVGISAPNGWNMPFVSMNRTGYIFGWVYNTGSIPFEGSFNTTYFAALTYNSGSPGVGTFYIDGGEVGSSIGEYSSSGVEDYLTTSIPGTRPPNTPENFTGTISDIQIYNSTLNGTEIEQLYEQGLPPYKKYSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM16</accession>
    <name>A0A218NM16_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaK</name>
        <name evidence="9" type="ORF">Mia14_0181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819683.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM16"/>
    <dbReference type="GeneID" id="33313739"/>
    <dbReference type="KEGG" id="marh:Mia14_0181"/>
    <dbReference type="OrthoDB" id="9944at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10234">
        <property type="entry name" value="ASKHA_NBD_HSP70_DnaK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000071">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="618" mass="66982" checksum="FF8DCD21C980F10D" modified="2017-09-27" version="1">MSEKIIGIDLGTSNSAAAVLEGGRPTIIPSSEGASLYGKAFPSYVAFTKDNQILVGEPAKRQAVANPEGTISGFKRKMGTDFIYHINNKDYKPQELSAMILQKIKRDAEAFLGEPVKKAVITVPAYFNDNQRQATKDAGAIAGLDVVRLVNEPTAACLAYGLDKNDKEMKILVYDLGGGTLDVTIMEFGKGVFEVKSTSGDTQLGGTDMDKAIVDFLVSEINKQYGIDVSKDIQAIQRLKEAAEKAKIELSTVLTTDISLPFLSQKAGQPINFSYKLDRAKLESLVLPIIERSAKPVRQALEDSKIEPEQLDKIILIGGPTRMPITQRYVEQLIGKKIERGVDPMEAVALGAAIQGGVLTGEVKDILLLDVTPLTLSIETLGGVATPIIKRNTTIPIKDSQVFTTADDFQTSVDIHVCQGERPLFKDNIDLGRFTLTGLPPAKRGVPQIEVTFDIDSNGILHVTAKDKASGKSQSIDIVAPNKMNKDDIEKKIKEAQENEEKDKKIREQIEIKNNAESMIYTTEHTVEDLKDKLSEDDKKKLEDLKSKLQDLVSKDDYDAIKAATNELQTALADISSHLYQAASGNSQGPSGGNPGEGGNPSDNSSEGTTDANFKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM54</accession>
    <name>A0A218NM54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819709.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM54"/>
    <dbReference type="GeneID" id="33313768"/>
    <dbReference type="KEGG" id="marh:Mia14_0210"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="251" mass="27673" checksum="1934FA1E6C7BC995" modified="2017-09-27" version="1">MAEKWSDFTDGILNDRSDEINKKYGLNLADLLSNPGNYTDNLAAKANFEKIRDDIYGYLDQIETSIKDDREELNKNLKNCNDVTQKVSSFLADLSKKSNLPIISPANMRYNKDAVDIIYINEFNDSISSLLNKLASSSNFVLDSTDKYDDYSIGEWIFFGNHKSYDVNLLLEANTALDLDSSRNEINYLFANAEFVMGIDNQPKQASDANTGGSGSKGTDVNTVSDSHSINNAGTSKNSDKAGSNGPINPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM55</accession>
    <name>A0A218NM55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF357 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819710.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM55"/>
    <dbReference type="GeneID" id="33313769"/>
    <dbReference type="KEGG" id="marh:Mia14_0211"/>
    <dbReference type="OrthoDB" id="148073at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.90">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="88" mass="10330" checksum="FACEB1BFC38318A7" modified="2017-09-27" version="1">MDENIELRISNDIEYFYKNIKKFDNSELQNELKSNKNLKYVYELSSMYASDAKSYLEKKDFYTSFSCISYAHGLLDALLYLKGLNGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM59</accession>
    <name>A0A218NM59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCA-adding enzyme</fullName>
            <ecNumber evidence="10">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cca</name>
        <name evidence="14" type="ORF">Mia14_0208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:76235"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="Rhea" id="RHEA-COMP:18655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="ChEBI" id="CHEBI:195187"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819707.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM59"/>
    <dbReference type="GeneID" id="33313766"/>
    <dbReference type="KEGG" id="marh:Mia14_0208"/>
    <dbReference type="OrthoDB" id="7378at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160016">
        <property type="term" value="F:CCACCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1550">
        <property type="entry name" value="Archaeal tRNA CCA-adding enzyme catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="entry name" value="CCA tRNA nucleotidyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048833">
        <property type="entry name" value="CAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="CCA-ADDING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643:SF1">
        <property type="entry name" value="CCA-ADDING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21133">
        <property type="entry name" value="CAA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0692">RNA repair</keyword>
    <keyword evidence="9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="11">
        <location>
            <begin position="61"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase substrate binding" evidence="12">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CCA-adding enzyme C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="488" mass="56165" checksum="B5D7B9FD978C2E5D" modified="2017-09-27" version="1">MIMESSKYLYQSNISGLMPHQELSYEDKKKLENLSKLSKLFIERVRPTKTEILNINKYSSELIDRLKKVLPENVEITLAGSTAHGTQVKGSSDIDIFMLFPRSSNERAMEEEAIKLSKNIVREKEGEKYEIKYAEHPYLKLINESKNITADIVPAFKIGNAKELITAVDRTPLHNKFIASHLSKEMKDDVRLLKYFLKMNKIYGAESKTHSFSGYECEILVYFYGSFPNTIMGLSNIKLPLVIDVKNRKFLEDDSRTEYIKRLNSNFIIIDPTDPNRNVAASTSPDSLAKIILISRRLLSNPTEYNLLGMHGKSSFRSIREMLKNYNLSIYAISINVSKEIHEDTLWPQIIKLENQLSSEFLKFGFNPIISLDGIERNKAYLSFIFEKTTKSINLLKGPEVFINGGAEKFYEKHRELGEVFIRGYNLYAIEKSKLHTPIEVLNELNINGKIKIKDMKEGSEIKIFTEKNIPKEMDSIILKNFIDKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM70</accession>
    <name>A0A218NM70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819734.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM70"/>
    <dbReference type="GeneID" id="33313793"/>
    <dbReference type="KEGG" id="marh:Mia14_0235"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="128" mass="14484" checksum="08BD97F8C54528D8" modified="2017-09-27" version="1">MEANYSLVASAIYGLAGAGIGDVANPAITYVLSGGQATSLPYLEIVKINSQTYSDYKKLLLHFGNAFLNKYEDERRRNLFIMTMAKKGYYKAIEDQLKELCFVEIEKIFNKVQELKGRLIDITDNIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM74</accession>
    <name>A0A218NM74_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ORF">Mia14_0233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819732.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM74"/>
    <dbReference type="GeneID" id="33313791"/>
    <dbReference type="KEGG" id="marh:Mia14_0233"/>
    <dbReference type="OrthoDB" id="6330at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000049">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5011123420" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023296777" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="13"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="214" mass="23276" checksum="1B665CB7DF177AFC" modified="2017-09-27" version="1">MDEKALIKYMKGTTTVGIICKDGVVLGADSRATMDTFIASKEARKVWQIDENIGMTIAGGVGDAEEIIRVIKIQNEIYKMNENKMMSPKVVTNLLSIILQQNKMMPFMVQLIVGGVDSEGKPQLFNLDPVGGYTDESKFTSTGSGSLEALGYLEDAYKDNLTVKDGIRIAKRAVSIAMSRDSATGNNIAIAAITKNGYKEYSGKELEKEVSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM76</accession>
    <name>A0A218NM76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAM superfamily RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819731.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM76"/>
    <dbReference type="GeneID" id="33313790"/>
    <dbReference type="KEGG" id="marh:Mia14_0232"/>
    <dbReference type="OrthoDB" id="376767at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="81" mass="9142" checksum="03B0F385B534E70D" modified="2017-09-27" version="1">MKYLKDRVEEGMELDLKVNAKDPRGEGIGRVGDYVIFIKNAKTRVGASYKVKVVKVNRTFGYAQLVDNDKQFFGNGSLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM93</accession>
    <name>A0A218NM93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819735.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM93"/>
    <dbReference type="GeneID" id="33313795"/>
    <dbReference type="KEGG" id="marh:Mia14_0237"/>
    <dbReference type="OrthoDB" id="371768at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="8">
        <location>
            <begin position="17"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="7">
        <location>
            <begin position="166"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="9">
        <location>
            <begin position="403"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="486" mass="54700" checksum="337B1DD855980F82" modified="2017-09-27" version="1">MYNEHEILESYLKSTSIAQQQIDSYNRFISIGIGKVIEANSLVEPDVADFAIKFKGIRLETPMVIESDSSIKKIYPHEALARNLTYSAPMYLTYVPVISGIEKLDSQDEAYVGELPIMVKSNLCYTKNMSRNQLAMDHEDPDDPGGYFIIKGTERVLVGIEDLAPNRMFTSKEKDMYSTRIFSTTLSFRSKCTVNRDEYGIYTLLFPTLSKGIDLILVLHALGLSNDEILASVSNADVKNDLMVNIDVSESKDLSQKEAITKLGKDTAPNQAASYQEKRAEMQLDTYILPHLGSAPEVRKEKGLFLLKMAERSSLLAYKYIKQDDRDHYANKRIRLAGDMMEELFNTAFRAFVKDVKYHIERTTARGRKLTVKTNINPDSLTDKILYSMSTGSWPAGQTGVSQVLDRMNIMSTFAHIRRVKSPLAKKHPHFKARDVHGTTIGKICPSESPEGGEVGLTKYLAVMSKVTVGADENFLQNKLKEMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM94</accession>
    <name>A0A218NM94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system membrane protein GspF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819747.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM94"/>
    <dbReference type="GeneID" id="33313811"/>
    <dbReference type="KEGG" id="marh:Mia14_0253"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="237" mass="27337" checksum="73275FC633B09A2C" modified="2017-09-27" version="1">MKALKYLYLQYPYISLLTIGGLIFYWLFNIYSILLILPFGMTILFIKFINKNYQDMENSHKIRSNFVQSINMLYYETKLKHLSLINGIKETSISSNNKEVCSYFKSISRRVTYGEKLIDALDDKCPNEIYDMVSSIKGNISSGMDFGKSSYSVYKSEINKENDLSEYKAYSAQKYSTLGILASIVMPSFIMFGVIGYSIINSFLKIFWAFSIVLTCIIPPVYLIIKLKMKSVDFNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA0</accession>
    <name>A0A218NMA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819759.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA0"/>
    <dbReference type="GeneID" id="33313824"/>
    <dbReference type="KEGG" id="marh:Mia14_0267"/>
    <dbReference type="OrthoDB" id="24878at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="232" mass="26483" checksum="9198BBF522CDCBE7" modified="2017-09-27" version="1">MNKLVISCMDRRLNDLIEEQYSDCFIIRNAGANVYPVAKEIKDLIKNKDIREIILLAHTDCGAMNKVFGIIKRGKSADPDLEESLISQYRKLDFDSIDELEKDNLNLQVDKLKSEFPETKIDGRLIRIEDIKVPKDDKIHELILANPSKPGYSGLLDQLSLNHFSAYILQSDTNNIMPDLKLAVADLGVKFIHLISIEKENPRDRKVDQQRLNLIFGKDGVKISIYSYPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA8</accession>
    <name>A0A218NMA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-binding oxidoreductase YedY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA8"/>
    <dbReference type="KEGG" id="marh:Mia14_0263"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43032:SF4">
        <property type="entry name" value="OXIDOREDUCTASE MOLYBDOPTERIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43032">
        <property type="entry name" value="PROTEIN-METHIONINE-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="202" mass="23749" checksum="E603F0167D6760AC" modified="2017-09-27" version="1">MTKIPHGQIVTDKFPILSASKTPNIDIKTYKLRIYGSVENELSFTWEQLMGLPMSRVKVDIHCVTRWSRLGDIWEGIKLKYLLDMVKPKGNFLMLRSSYVGYSANVPMSYINEDCMVAFKFNNLPLEKEHGGPVRAFIPTLYFWKSTKWLDEIEVMDEDKAGFWEKRGYNMRGDYNKEERYWDGLNFVNKLVFFGNKDKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB0</accession>
    <name>A0A218NMB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB0"/>
    <dbReference type="KEGG" id="marh:Mia14_0260"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="12194" checksum="1E2553B9108B4025" modified="2017-09-27" version="1">MNHRYMEIYVFWGVKIAFYGILIAITILIAIGTIVQYINYIDSTESINSYLNSYICHLNLGIQERLLSKSNISTIYIDNLKSIGLIDRFSVKEYQNRQFVVVECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB5</accession>
    <name>A0A218NMB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819765.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB5"/>
    <dbReference type="GeneID" id="33313830"/>
    <dbReference type="KEGG" id="marh:Mia14_0273"/>
    <dbReference type="OrthoDB" id="387360at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="149" mass="17167" checksum="4F1BE86963022D6C" modified="2017-09-27" version="1">MIIKADFREDNIHSDSLFIANFIWLSFVYLLLGSLLLYAIVMLSLKVSYGAIFLLWFFGFVTNIIFGLSYMFVPGLMHSKYAAYDTIRAEFYVFNTGIIIFFISNILKYAIAEQLGLALIIIAIFINTINVLNMTLYQKRNKNKKSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC1</accession>
    <name>A0A218NMC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819775.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC1"/>
    <dbReference type="GeneID" id="33313840"/>
    <dbReference type="KEGG" id="marh:Mia14_0283"/>
    <dbReference type="OrthoDB" id="4665at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="191" mass="21371" checksum="C4F765DD7E4F25D2" modified="2017-09-27" version="1">MPKYYTGLGDNEISTIGGSSLSKSDSLLEIIGNLDELNSKLGTLMAFINSDSDSIYELDDINIKEMLLKVQNKIFSINAEFISTVNPIFKPKNLISESDTKELESNISILSSKFPDLKTFVLPGGSIQGALTDEARTLCRRCERSIAKKFDYNSIINRSIFSYVNRLSSLLFVLELYINHKKGSQPIPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC5</accession>
    <name>A0A218NMC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819776.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC5"/>
    <dbReference type="GeneID" id="33313841"/>
    <dbReference type="KEGG" id="marh:Mia14_0284"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="288" mass="33181" checksum="F5B5C96BF5AB19F3" modified="2017-09-27" version="1">MVTNSKEGSIRLENNSAEKLFLSKKSMNVDKFINWAVLENEAIHKSIRKIEYETDIEGNLDAKKDVSAKLRLTSFMDKLNKKENSISLYNMIRSDSNSTKTENFDFDISRINDIEDKILSDKKLSEEEKKMLDDYAGYSGIFSYGIKKIGKSSYLVIENSINSLEFIKLDQEENVEFVENSEFFGGGISPINEIQLSFSVNDGSLSGKYNYLVDIDIFHNDISDVDMRFDKSIYEDGIKKGFDYDYRYYKRGKTSQIELLGSKRLIDPTNDEIYNALVYAIQQENLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC6</accession>
    <name>A0A218NMC6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC6"/>
    <dbReference type="KEGG" id="marh:Mia14_0286"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197:SF1">
        <property type="entry name" value="UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="251" mass="27874" checksum="706E8BAF86161ED9" modified="2017-09-27" version="1">MVISKALITAAGMGTRMAPFTKVCAKALVPIFSKADGKIEVAPIIDELARNFRQIGIKDIGAVVYKDDSNLIKHLEGNGISLFYQNERHGFGHAVLMAKGFSEKDPFILNAEDGILSSGYDSAIKVFEKVNPEALLILRKVPNPQRYGIVEVNDESEIEGHKVYKIKGAEEKPSSPKSDMAIVASYIFTPKIFEALEKASSGESLELTDGISWLIKNNYKVYGMVLNNDEIWLNIGDPQSYYETLKYTFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC9</accession>
    <name>A0A218NMC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain-containing regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819781.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC9"/>
    <dbReference type="GeneID" id="33313846"/>
    <dbReference type="KEGG" id="marh:Mia14_0289"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="364"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="46302" checksum="FCF6F08EFD437D91" modified="2017-09-27" version="1">MVLQDLSDLKGNLNPINSNNILGNNRNLKPLQANNGTAFMKPKNESKVSSNNSANSYLKAGGEAHGAQASITMQELATSQKKALDFIKANGWEGMTFPDIHWIQFEKGSYKLKDEDGYTNKTYKIFVQPDLKHFGEAIEYTAVALDKIIRNHSLSGAIWKIAKVNGVLGEGFGESELRKPTLEKIVIYANSQEDMEEIVRSLNSQFGEKAFDYGTERDLNAYGPSNGAKFTYGISPLVHVRLGGAGHHNNLYYSRQIKGENTSKPQDEWAIKPEIIDELRKDASRFNMEKAPKFKSVNQKINLHNSEITLNPSHGTIDLYLAGEKHLQIVKTRNWNVPYLLIDPAKLDVANERGFKTIREDKEIHIGRDPQINAGRFEFPDTISRDHLTIVLHNGKITIKDISSNGTVILLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF3</accession>
    <name>A0A218NMF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819793.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF3"/>
    <dbReference type="GeneID" id="33313858"/>
    <dbReference type="KEGG" id="marh:Mia14_0301"/>
    <dbReference type="OrthoDB" id="36362at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="2">
        <location>
            <begin position="218"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="584" mass="67757" checksum="12C0A9889C8A89D2" modified="2017-09-27" version="1">MVLDYGVIGNCRTLALVKKDTSIDWLCLPRFDSPSVFSKLLDDKNGGSFKIIPVGEYEIKQEYIENTNVIKTNFSNSTTEFDVIDYFPYYNKGYVTLRNSEVHRVIVRKRGKPIIKVLVDPKMEYNRYVPSKQIDNNKIIFSYKNTSLYLYSNLGLKEILNGTEIELPENSYILIAYNKLKYSTDIRYIMQEMENTINHWRGWSRRIKGGKEYRPLKVRSALVLRLLTYDDTGAIVAAGTTSIPEIKGSVRNWDYRYSWIRDSSFTVEALIKLGLIDQAYSFIKWLNAIYAEYGMSLQVLFKVSRGEYISESILDNMGGYENSKPVRIGNKAYQQRQTDIIGELLNSIYLFYLKENASPRIGEISWDLIFSFVETIINDWRKKDHSIWEFRGTSKDYTFSKVMCWVAVDRGIKIARRLGHNDVIERWSKERKKIKASIMRYGWNKKVQAFTQYYSSSSLDASLLLMPSFGIIGWKDQRMLSTIDAIKKELTNGPFVMRYKDRDEFGMPKSAFIACSFWLVNALYYTGNKEEAIRMFDRAVAFQNHMGLFSEDIDMKTGELLGNFPQAYSHVALINSITALFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG1</accession>
    <name>A0A218NMG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG1"/>
    <dbReference type="KEGG" id="marh:Mia14_0329"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="209" mass="24095" checksum="48A367042A22B1A9" modified="2017-09-27" version="1">MISNRFLLMYTHKDSKASKLAEHGQNAISIEESESRYWQSRSLKFLKIMDELGIQCGKLRVIYSDIPEIGYNKSEDSIYIDGKFLNAIIFSYAVGYKKGIIALMNHEIGHRHDFINGRDTSEMSAELNSINSLGSHPEDGLSQQISISMFASARSNFVKAEKERNKRINIYGLESFLGEEATKRIEYKAMRYYKLLVNYRNSANRLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG2</accession>
    <name>A0A218NMG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819822.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG2"/>
    <dbReference type="GeneID" id="33313890"/>
    <dbReference type="KEGG" id="marh:Mia14_0332"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="307" mass="35285" checksum="C3047002586FEB28" modified="2017-09-27" version="1">MPSVTSDKYIQFDGIKFYLPQVSTKSSPKISGYALSQMIYDFDRKYETSGYLLGKYDASAGAPQFYRYLPMKGLKRLRDSVEVKNGNKELRQLKRLKKKGYTSIIRVHVHPDQDYTKFADNEPGYTDSSAFVGFDSYAKAIGFQEVYSGIQFGGSRLKSSKGLNLYHLTGIGLEKTSYEVVNFDQSKIYKDKKLRKFARSTQGVKHAFSEFRYVTTTDVNKYHFEPGYYKNVLSLKVLKKEVNEMLLNKGIKNIKLKGKRSDLYLKEVVKPYMKLRRGYNPDLLYIIGEQLKSSMANYKSGNLSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH9</accession>
    <name>A0A218NMH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type Na(+),H(+)-transporting-ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819843.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH9"/>
    <dbReference type="GeneID" id="33313913"/>
    <dbReference type="KEGG" id="marh:Mia14_0356"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="186" mass="20513" checksum="DD83AF61EC62636A" modified="2017-09-27" version="1">MAMEDIISKIKENADAEIEKANSDADSKIQQINDDKSKAISDYQSQIDAKLKIELQQIKSQSDSKANTDSRSIYNKALEEKLDEGFKIIKDNFDEFCKTDTYKEVLGAIVKDALKELGAGATITVNPRDKDLLKVPKTCKVKTDESVSGGIRAVSKDGSMGMDETLDDILDSAKDSVAIEFLKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ3</accession>
    <name>A0A218NMJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type Na(+),H(+)-transporting-ATP synthase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ3"/>
    <dbReference type="KEGG" id="marh:Mia14_0362"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="73" mass="8488" checksum="80B657A6ADD43ECB" modified="2017-09-27" version="1">MLKYGGKTLEKYDYVSKYAKYDKYGGRVLDYRDDYAKEQVRRFARIIRISEILKIAVLAALVVIIIAFGVLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM0</accession>
    <name>A0A218NMM0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable inosine/xanthosine triphosphatase</fullName>
            <shortName evidence="10">ITPase/XTPase</shortName>
            <ecNumber evidence="10">3.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate phosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ITP + H2O = IDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>XTP + H2O = XDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the YjjX NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819897.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM0"/>
    <dbReference type="GeneID" id="33313963"/>
    <dbReference type="KEGG" id="marh:Mia14_0409"/>
    <dbReference type="OrthoDB" id="52857at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000002">
        <property type="entry name" value="Inosine/xanthosine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050299">
        <property type="entry name" value="YjjX_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00258">
        <property type="entry name" value="inosine/xanthosine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34699:SF2">
        <property type="entry name" value="NON-CANONICAL PURINE NTP PHOSPHATASE_PRRC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="11">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="173" mass="18699" checksum="8120CB7F07F3FA01" modified="2017-09-27" version="1">MIVAVGSTNKAKITAVRQALNDLGIGYEIKGVEVDSGVRKQPMTDNEGIEGAINRAKNAKALLKSEIGIGLEGSVQETDYGMMLSGWVAVVDNYGRIGLASHERVMLPEKVAERLRKGEELGPVMDSITGLKDIKQDSGTVGILTKGTLNRDESFRLATIAAFARIISKEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM1</accession>
    <name>A0A218NMM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819899.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM1"/>
    <dbReference type="GeneID" id="33313965"/>
    <dbReference type="KEGG" id="marh:Mia14_0411"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="229" mass="27487" checksum="572495E9E96E575F" modified="2017-09-27" version="1">MDTVKNKENNQILNKSDLIEELDAPFYSSKDESGKRTTNISKHPRKSQQLIEMEKLVDNNIAYLKEQAPRQFKEFNALESSILNYFNKLIEELEIGKDKENTHRLFWQVKSVLQNGFDSIMAAEKNALLSDKYILENKLYKNQRNKIYKENTSKFYGLIYKDLPEYIGQFKQRINEFIESKPTYEEIENFFIKNNPTSELSRVQRDSEYHMEWLESFNKERLIRRIFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM2</accession>
    <name>A0A218NMM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819898.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM2"/>
    <dbReference type="GeneID" id="33313964"/>
    <dbReference type="KEGG" id="marh:Mia14_0410"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="354" mass="40996" checksum="A4D60D02BB244B64" modified="2017-09-27" version="1">MEASKSKESQEEIINNMAYYIEKGLKVDHLSKDFKRLNLLVDMALSRPYSSDEKFSSKLIEFLKRSDLQKNDIKFLTNEANSNTKLFIKAFDKIADSNVEYITTCVIMWNLHLKHKPNKNIDFEKIYEISSTPENLIKTLDPKEEFGVLIPIMSLYDRKLIDAISSKHSSLNSTNSIDEAIEFGILTTKYNYLNRVRIGPEEPDLKSTISRKKELYTFIKEVLPIISRNINEEKMFLVHKNDNAAKSLSDIENDLNRRIEVGSIYHPDVARKYSVNAVINSKNMFECMDNLDYILIADIYQLKELSDVMKDLDPGKEMELLKEKIYKVIYTINEDMDRAIENLGAISSHSLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM4</accession>
    <name>A0A218NMM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819876.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM4"/>
    <dbReference type="GeneID" id="33313946"/>
    <dbReference type="KEGG" id="marh:Mia14_0390"/>
    <dbReference type="OrthoDB" id="56914at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="332" mass="36822" checksum="D8F93F306B312AF2" modified="2017-09-27" version="1">MNFSANYLVYLSYSLILFLLILIEYKYKFNLIKKRKASIFRINNLALEKLVQVIALSLVIGAVSLFSHSTLLVLASILIADSSYLLLGLYGVDKKLFIAFTALLIALVILYANNGLLLNLALRSISIGSLFGLEAVYLNFSKKSNGTTHIETDRDLFELTLGVIVISIIFILPKYYMEIIPMLILLGYIFNSYIYDTDKGFASLFHELERRSDIYGFGALTLAFGTMLIISFATVANYAAFFLIVLFFSDSAATIFGIKFNKLKLPYNSKKTVSGTLAFFAIGGILGYLLVGPIAILISVVLALVESLPIKMDDNITLSIASILIFYIIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM8</accession>
    <name>A0A218NMM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTP pyrophosphatase, house-cleaning of non-canonical NTPs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819871.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM8"/>
    <dbReference type="GeneID" id="33313941"/>
    <dbReference type="KEGG" id="marh:Mia14_0384"/>
    <dbReference type="OrthoDB" id="377355at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11541">
        <property type="entry name" value="NTP-PPase_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011379">
        <property type="entry name" value="MazG-related_GP37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006639">
        <property type="entry name" value="UCP006639_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP pyrophosphohydrolase MazG-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="11840" checksum="597EA262B01AAEA2" modified="2017-09-27" version="1">MDLNEYQKASRRTKMYPEKLDGGIYYSTLGLCGEAGELANKVKKIARDNNLDKEGIKGELGDILWYVASVSEEIGYSLEEIANYNLEKLNKRMEEGKISGNGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM9</accession>
    <name>A0A218NMM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX family ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819917.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM9"/>
    <dbReference type="GeneID" id="33313974"/>
    <dbReference type="KEGG" id="marh:Mia14_0420"/>
    <dbReference type="OrthoDB" id="40462at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046">
        <property type="entry name" value="GDP-MANNOSE MANNOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43046:SF14">
        <property type="entry name" value="MUTT_NUDIX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="148" mass="16840" checksum="ED6505D28A9D612D" modified="2017-09-27" version="1">MEEQEKGHLGAYTCIFNNSFSEMLLLWRTKETRNGEEIKGWGNIGGSFEPGETALQTCIREAKEEIGVDLNPNKLIPVGTKTSPEGSAHKWAIYFYATSIDEHTKIKLNDESRGYGWFERDELPECTLDSKEELIGWWDLAETSFENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP1</accession>
    <name>A0A218NMP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Mia14_0394</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819879.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP1"/>
    <dbReference type="GeneID" id="33313950"/>
    <dbReference type="KEGG" id="marh:Mia14_0394"/>
    <dbReference type="OrthoDB" id="40462at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="22">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ASI13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="19477" checksum="99839B5EC90C7616" modified="2017-09-27" version="1">MDDLHKKYDTSKLRQVSLSLIWDERKILLAMKKRGFGEGLWNGYGGKQKESETIEETAIRETNEEIGINSTEIEQVGTLSFFFEGVPSDQNWNQKAVIFRINKWVGDPVESEEMKPKWFDISDIPYDKMWPDDRIWLPKILKGMKLECIFVFDADKRLKESNIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP2</accession>
    <name>A0A218NMP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819880.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP2"/>
    <dbReference type="GeneID" id="33313951"/>
    <dbReference type="KEGG" id="marh:Mia14_0395"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000021">
        <property type="entry name" value="Drug resistance transporter, EmrB/QacA subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="493" mass="52948" checksum="F1AAB8583ADF52CA" modified="2017-09-27" version="1">MNWSKEDTILAVIVIGTLMASIDSTIVLLAFPAMTQALHSTISTIIWVILIYMIVVAVFSTQFGRIGDIYGRSKMFNLGFVIFTIASFLCGIAPTDITLIIFRAVQAIGGALIASNSSAIIADTFERHKIGRAYGFTGMSWNIGALLGILLGGVITTYIGYRYIFFINVPIGIVAVILGLKYVKDKNKTNDKLDLYGMAALGIAIALISYAGINYASVGLNSLNVVMLVIGIISTIIFVIIDRKIKMPTINFSMFKNKIFKNSLLASLFQGLGFMGVTFLLIMYLQGVRGYSPLYASLVLFPGYVVSGVLAPYMGKYSDKFGARILSTIGIMFMVLGVLFYLLVLGVTTPIYYVVIGTIITGLGGAMFWPANNSAVMANVSGELRGSASGTLRLFSSLGLIGSFIIAFVAAASAVPRYLAFEIFAGTSKVIGGIGKGFVAGMHVAFIALIAMLIIAGIFSFAIGKENRMEKLHHPGETGTYAKSRNLSAETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP5</accession>
    <name>A0A218NMP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819905.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP5"/>
    <dbReference type="GeneID" id="33313968"/>
    <dbReference type="KEGG" id="marh:Mia14_0414"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="225" mass="27189" checksum="6089460E39898F39" modified="2017-09-27" version="1">MNISKEMAISDKYQFLDHLKSSNESYDMDKLDDNKKSSYSIFRRGANTKREKMEEKYKNDIEYFKEQVPKQLEEFNEINDLVASYLYKLNKDPNNEKLFAQIENIVQDGFNNVIRAEKNALLSDTYFLDKALYNDRKIEKYDSSFGRFTDIIYRELPEDIEKFKNSVNNFIKSNPTYEDLKNFFMKKDTTFEFFRIRRSSEEYIKWLADFNSDRFMGWFFGGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP8</accession>
    <name>A0A218NMP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216877.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP8"/>
    <dbReference type="GeneID" id="33313982"/>
    <dbReference type="KEGG" id="marh:Mia14_0427"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="203" mass="23553" checksum="BFE662F95D798895" modified="2017-09-27" version="1">MNGDCGDSVYDYLVLLSEGKTIKDSMNSLKKGISTATDNDEVDGTIPEFNGKTVIFRRKEIGRWDYQAFDLPVYKTKNGFMSVLLIRRDLVNSIIAKQLLTDDNDLIVYKKYKFLIFKINRYELERTIKTISYRIAYFYKENLKKKGLPFDQSLLPVYIEKPANDSDVLHAIYGEFQTIKANLEIELKRIADKQYNSTFVSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ7</accession>
    <name>A0A218NMQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DpmII-like restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819944.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ7"/>
    <dbReference type="REBASE" id="210410">
        <property type="entry name" value="Mar14ORF435P"/>
    </dbReference>
    <dbReference type="GeneID" id="33313989"/>
    <dbReference type="KEGG" id="marh:Mia14_0434"/>
    <dbReference type="OrthoDB" id="268803at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007637">
        <property type="entry name" value="Restrct_endonuc_II_DpnII-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04556">
        <property type="entry name" value="DpnII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction endonuclease type II DpnII-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="283" mass="32947" checksum="B5B1BE7A771B59EF" modified="2017-09-27" version="1">MQFKELGYTSEESYFEDFFSNLLSTNRTSQFFVNWEKVYRNIKTHIDEISLINGLINIHDLNERKNHLKQILEKYPKTRLILPLMIATRDNKLDLLVINEKDDITYLDIDFGNSDIEKIIKFCDETHIIELLGNIKDLYSYLLGVEVGTDTNARKNRSGSMFEKMVLEELKAKGLDVRKADKKYQIGGRLKKPDLLLYKNQKEFAIIEVNFFNELGSKPLETIQSFINLQKDIKALGLKFILITDGPAWKTGKSERIKGFEQLDYPLNLTLAVKLMPRWINGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR9</accession>
    <name>A0A218NMR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819987.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR9"/>
    <dbReference type="GeneID" id="33314017"/>
    <dbReference type="KEGG" id="marh:Mia14_0461"/>
    <dbReference type="OrthoDB" id="116925at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="92" mass="10494" checksum="11250CE1AE9FF96C" modified="2017-09-27" version="1">MSENETMEKLTHSPTLNTVLMVESVIKNSENSIITIPEIKRLLPKQVNHRTLMVILEYLEESGKILVTIKGITWIHNSNKKLQDSIKNGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT9</accession>
    <name>A0A218NMT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phd family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819994.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT9"/>
    <dbReference type="GeneID" id="33314021"/>
    <dbReference type="KEGG" id="marh:Mia14_0465"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="75" mass="8775" checksum="FD0C26709326DB57" modified="2017-09-27" version="1">MTEDTAIITVRVPKKVKIAMNKANINISKEIRDYLEAKTRSLELYALLPEISKRAKNRKVTLNSTRIIRKYRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV3</accession>
    <name>A0A218NMV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV3"/>
    <dbReference type="KEGG" id="marh:Mia14_0476"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46588" checksum="255DFE82F87579AB" modified="2017-09-27" version="1">MIVMKTAYKYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYNETGKTLTEFRMNVWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKKQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKIGRINFVNHRNIEGGIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPKVGIDLGIMQYAALSENTILQNAKITKHQRKHSRVLQQNISRKEKGSSNRRKAVTRFARYSEHISRIRLDCIHKLSNELVNSYSFIAYEDLEINNMVKNHRYAKSISESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSISISQRTFVCEKCGMSMDRDVNAAQNILKRALNSISPTTEGHSGSQACRDDIRPSARGAVAYEAGTIWVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW2</accession>
    <name>A0A218NMW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820021.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW2"/>
    <dbReference type="GeneID" id="33314036"/>
    <dbReference type="KEGG" id="marh:Mia14_0481"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004943">
        <property type="entry name" value="PRK06292.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="10">
        <location>
            <begin position="340"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="453" mass="49443" checksum="276BD10A02F5B6B8" modified="2017-09-27" version="1">MEKADVLVIGGGGAGYPAAFRLAESGYNVIMADPKGKLGGNCLYMGCIPSKTVREMAQLKERTERVLKQKISIDYSLIQDHKDYVQETRFLQHSNDLKNFKNIRFIAEKAVLKDSNHALIGDNEVEAKYIIIGTGTTPNKVEFPGSEYCITSDDLFTYKSSIRSLPSEIAIIGGGYIALEVATMYTILGSKVHMLVRGGNLLGRVEPYLVSGLNDNMDKGIDIQMNSPLENVEEKEGRKVVHYSDGQGNKKWLAADMVLLATGRKPVLPEGIEKAGVEIDGRGFVKVNESMKTNIQNIYATGDVNGKSPYFHSAVRQSIVAANNIMANGKPIDYFDSDAVPITIFTFPPISYVGITPITAKARGIDYLEGIYKFKNDAKAQMYDELPGEIRIFFEKGSLRAIGAWVIGIDSPSLINELGIAVANGLGARQIADYADQHPTTNEGISAAARSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ4</accession>
    <name>A0A218NMZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820084.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ4"/>
    <dbReference type="GeneID" id="33314075"/>
    <dbReference type="KEGG" id="marh:Mia14_0518"/>
    <dbReference type="OrthoDB" id="372024at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="175" mass="20318" checksum="3C1F3C781BCA50A2" modified="2017-09-27" version="1">MIKYLLSKNADIMFIGINPHFGSYRRGIPFSNNKTLWYLFSRAGLIKEDEDFLRVDENLKKVYEKEFVDIYNLNFTNLIERPSRDVSDLKKGEEVKGKEYLMESIIKYRPKVACFIGKVTYEKFSGEKLESFGWNGSIGKSKVYVMHFPIRGPAAIRVDELKEIMQSIGRNPIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ6</accession>
    <name>A0A218NMZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ6"/>
    <dbReference type="KEGG" id="marh:Mia14_0519"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="267" mass="29827" checksum="FD66E6D5496B44D0" modified="2017-09-27" version="1">MSDPMKRVKKVFINAKRDYKEISLIKANFETVESPDEKADICISIGGDGTFIESSRMFNGPILPINGLEKGSASYYSDIDLSSMETAIKMLKKGDYKVVELSNKIKVTYKNKSYYAINEALLRNYSGNVYFELYMKLRGKRERLYPYVMAGDGMLITSTIGSTAYNMSANGPIILDEGTMCLTFLNASGPFKNSIIVNSGATIYAKVAKYKGILKSDEKTIATLSKGDEFSVSLSDNALKVVKFNGLYETFSEKLEKLIKSRMLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ7</accession>
    <name>A0A218NMZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820058.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ7"/>
    <dbReference type="GeneID" id="33314058"/>
    <dbReference type="KEGG" id="marh:Mia14_0500"/>
    <dbReference type="OrthoDB" id="34534at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926:SF3">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYL 1-PHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="353" mass="38489" checksum="00838F4A43561513" modified="2017-09-27" version="1">MFHTYLTIIIPSIAAFIITVVMTLFLMSYMKESGVTATDHNKKGNPTLAGSGGIAVALGFSVGLFTYIFGSNFPSPTSPFYQPVASLAVLFSVMLSIILISTVGFLDDINVKRKAVKSTDMMDTRQGLKQWQKPVLTLIGAIPLVAINAGVKTVAIPLIGVINFGLFYPIVIIPLAIIFAANAFNLLGGFDGIATGTGMIAAFGLLLYSLLFGNYTGLLISSVLFASLVAMFIFNVYPAKIIPGDSFTYLVGAALVSDMIVGGMEGFGIIIFMPWIIEFFLHLRRKFKVTDLGIMQKDGTMKAPYGRKIYSWTHIIMNLKKCREWEVSLYMWVVEALFIVLGLAIKLATLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN27</accession>
    <name>A0A218NN27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-oxoacid dehydrogenase multienzyme complex, dihydrolipoyl acyltransferase (E2) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820135.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN27"/>
    <dbReference type="GeneID" id="33314106"/>
    <dbReference type="KEGG" id="marh:Mia14_0549"/>
    <dbReference type="OrthoDB" id="56234at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="428" mass="46493" checksum="9A815057CCB7DD49" modified="2017-09-27" version="1">METVKFADVGEGITEGHIQKILVKDGDQVKEDQPLMQVETDKAVVNIPSIKGGTVKVVAKENTDIKVGDILAYVGTPDELKNAPSAGAAAPQPSAPKAQEQNKTQEASAGAPAKPQAETKPASSPTQQGAPHPEILTTPFVRKLAEQLKVDLAQIKGTGPNGRIMEVDVRDAAKETSDVLKKPRHPEILAEKHGEEIEHVPLSPVRKAIAKNMEASWTIPRASHIDLIDASELNRIVSEAKDKFLKQFNIKLTFLPILIKATVAALKDNPHFNASYDPVNREILVKHYYNIGLGAETKDGLKVIVIKDADKKSIVQIARDLADLRDKLYANTITLDDMKDSSFTITNAGSLGGGFIGIPMINPPDVAILAFSMMKDMPVAVDGKVEIRKILPFTLTFDHRVVDGAEAVKFGNELKGYIEDPEFLEMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN41</accession>
    <name>A0A218NN41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539370.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN41"/>
    <dbReference type="GeneID" id="33314130"/>
    <dbReference type="KEGG" id="marh:Mia14_0575"/>
    <dbReference type="OrthoDB" id="41394at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08230">
        <property type="entry name" value="glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189:SF2">
        <property type="entry name" value="GLUCOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="145"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="356" mass="39038" checksum="2BD182567D856FBE" modified="2017-09-27" version="1">MKAVVVFPLKKDSLHIEDIPEPKPKEDEALIKVIRVGICGTDKEIDEGLYGEPPEGLKRLVIGHESFGVVVALGDKAEGVKVGDKVVATVRRGDNCINCLAGESDMCLTGNYKERGIKGLDGYMSEYYTEKPENLIVIPDELSEEAVLLEPMTIAEKAVKQVFKIQERMLWEPKVAVVFGTGPVGLLTAILLKLRGMKVYAIDRTDHEDDAKGQIISKVGIIHVNSKKESPMGIIEKDKQIDIVVEATGSPEVLPEVFDLAGVNSVIALLSVTGGKFINDMDLARLNYNMVLNNRVIVGVVNANKSYFVNGVSDMARIKSAYGDVLKLFITKRIKIGDLTKDDVKNQKGLKSVIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN51</accession>
    <name>A0A218NN51_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ORF">Mia14_0585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = tri-trans,hepta-cis-undecaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780233.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN51"/>
    <dbReference type="GeneID" id="33314140"/>
    <dbReference type="KEGG" id="marh:Mia14_0585"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="235" mass="27411" checksum="921159805B2EE52B" modified="2017-09-27" version="1">MQNNYLPRSVAIIPDGNRRWAKSHKLQLMRGYDIGINKAISVSLWLNKLGIKELSIWALSTENVKNRSKDELKLLYSLYKRTSTDPKVISKFNKNNAKVVLVGDLKILPADVRRDLRSLEKATSKNNDLRINLMIGYGGQEELVHAVKRLLADRIKRRIKTINESIFRTYLRSACLIDPDLIIRTSGEMRLSGFLPWQSAYSELYFVNKYWPDFNEKDLKEAIEEYSRRSRRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN54</accession>
    <name>A0A218NN54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891442.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN54"/>
    <dbReference type="GeneID" id="33314147"/>
    <dbReference type="KEGG" id="marh:Mia14_0593"/>
    <dbReference type="OrthoDB" id="15220at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39337">
        <property type="entry name" value="BLR5642 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39337:SF1">
        <property type="entry name" value="BLR5642 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="209" mass="24400" checksum="EC24C642C84B5B7A" modified="2017-09-27" version="1">MEKTDSDKNAAKSKHSIYTFGILGSKADKLLSIIKRYNIKEVVDVRFNPETSDNSELEKDNLAGILENSKVKYTHSVDLSSKYKNAKSLMMNSGWKNHMFKTYADYMQTPDFVNGLNKLIVKLKDHNLLIICNEKLPTECHRYLIADALFIRHKVVYHLLDEYTPKKHILTKFAKVSGLRIFYPVYKTNKVTKRSRVNAKKRKQERKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN55</accession>
    <name>A0A218NN55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN55"/>
    <dbReference type="KEGG" id="marh:Mia14_0598"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="35" mass="4139" checksum="554F6547FC0F6007" modified="2017-09-27" version="1">MVAAKMKGDDEEDEEDEDEEDDEDEEDEEDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN71</accession>
    <name>A0A218NN71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PqqD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820191.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN71"/>
    <dbReference type="GeneID" id="33314169"/>
    <dbReference type="KEGG" id="marh:Mia14_0615"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10357" checksum="20D0AE320D08B8C3" modified="2017-09-27" version="1">MNYNQLIIKKREDMGKIYIFFPHKGTILETECNDVNAVYNLLEYIKNKHINELENFSKDKRISKETLDTVKEIYLDLKDIGINFNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN74</accession>
    <name>A0A218NN74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820194.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN74"/>
    <dbReference type="GeneID" id="33314172"/>
    <dbReference type="KEGG" id="marh:Mia14_0618"/>
    <dbReference type="OrthoDB" id="371918at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF18">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="219"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="420" mass="49116" checksum="D680DDB189F2E107" modified="2017-09-27" version="1">MNIENAILRYKDYGKGVKLIDRDATLSKANFINSLIGPRRAGKSSIMLLYMNELRKENKKVIFINGEDIDFEGLTVEGLDKIEIEIRRIYDISSQEKVYLFIDEIQNFPYWSKWVRTLFDENYYNLIISGSTSELSGEQLPIQLRGRSIETLVLPFSFKEYCKAKHINYEKYMNFEDTASILNAFSDFMLYGGYPEVVKSDDTEFKKQILSNIYTMVMQKDLIDKYNIRKKAEFRLFTNSLFASACRNFSIENMLKFLSSKELNISRQAALNYLDYSESVFLIHLIYPYSKKLKVRLTNPRIYPIDQGIMRLFTNDDGKSLEDIAFIELFRRKENVMYYKSNKSDVDFAVVESDEIKELIQVSYSIDEPNAYIRETDSLKNASKETGCTNLKILTFNEESVIKIENLSINVIPVWKWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN79</accession>
    <name>A0A218NN79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HEPN domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0621</name>
        <name evidence="6" type="ORF">Mia14_0624</name>
        <name evidence="7" type="ORF">Mia14_0627</name>
        <name evidence="8" type="ORF">Mia14_0630</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">Mia14</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820197.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN79"/>
    <dbReference type="GeneID" id="33314184"/>
    <dbReference type="KEGG" id="marh:Mia14_0621"/>
    <dbReference type="KEGG" id="marh:Mia14_0624"/>
    <dbReference type="KEGG" id="marh:Mia14_0627"/>
    <dbReference type="KEGG" id="marh:Mia14_0630"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="entry name" value="bsu32300-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="HepT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="139" mass="16094" checksum="3C7DCD336B771489" modified="2017-09-27" version="1">MIDTERIVRRLADIKHYSNVLSKIVPNNYDDYIKSDITTKAAVERYLQLINDLELEVLVLAYKGLDLGISGGDDSLVNKFNDLLSKKAIEGFKKRRSLRNILVHAYFEMHYDKDTFNQANDLSDIKDFVKGIRLILEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA2</accession>
    <name>A0A218NNA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA2"/>
    <dbReference type="KEGG" id="marh:Mia14_0643"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="290" mass="31847" checksum="D1D15AECEFF32A93" modified="2017-09-27" version="1">MTMKSQSAMEYLMTYGWAILVIAVVLAALYSLGIFNPNSFAPKASAGSCEVVRPFGPTTSTDIHSTGTCTNMLPKYVASFNGNGQISVLMPTLSHSITYTAWVNFASLAQSNYGDTGQIIGWEPGYGPSLLFLQPSIYQFEFSVWYANTQQEAVLSGTTPKLNTWYFMAGTYNESSGLIQVYVNNKVYNQTISKETLETGNVLTIGAWPSQLSYFKGELANVQIYNNSISSNQISALYQEGIGGDPIDLTHLVAWYPLNGNANDYSGNNYNGKETNVAYSSTWYRTYSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA3</accession>
    <name>A0A218NNA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820212.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA3"/>
    <dbReference type="GeneID" id="33314198"/>
    <dbReference type="KEGG" id="marh:Mia14_0645"/>
    <dbReference type="OrthoDB" id="383941at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="229" mass="25975" checksum="C2EC0AABD42F79D7" modified="2017-09-27" version="1">MSIFNNIKGKLKKNETKGKITSVKLYWRDTSHSMDGMDISGKVFTVTVPFTNHSDTSELSFLKTTEKRETVTDISTSDPFSIDSIDPKPPVEIKPGEHIDFKISLKAPDYNYNGPLTLRFSAPKNKDDLIDLNINKIVLKSGDKEVNLDDTRYFTNFAKNQIFDISVQMYRILEYKGKVGSIELNEPFKLVKLDTELPFTINDPSSFVVNLSIKGPDFNYSGPLEITFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB3</accession>
    <name>A0A218NNB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891447.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB3"/>
    <dbReference type="GeneID" id="33314206"/>
    <dbReference type="KEGG" id="marh:Mia14_0653"/>
    <dbReference type="OrthoDB" id="41618at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365:SF14">
        <property type="entry name" value="CYTOCHROME BD MENAQUINOL OXIDASE SUBUNIT I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="CYTOCHROME D UBIQUINOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="462" mass="51021" checksum="EE0459E805519EDB" modified="2017-09-27" version="1">MSLLSLYEFTQGFSLGIHIILATIGIGLPIIVATAEYLAYKKNDKYYRALAHRLSLILVVLFAVGTASGTLVALELAFLWPAFMRLVGYVAILPFFTEVFAFFTEVIFLSIYVYFGDKIKSEKLKIASIIIVAFAAALSGVLITMVNAWMNTPTGFNTALFISSGFKTIADVHPLTAFDTPSTGIEVFHVISTSILAGVSVFFSYFAYKLLKTKDNDEREYYKRGLNITFGIIAVIIVFVIISGIMSITTLMQYQTEKFDAIELDLITRSDVPEIIFGTYSPLGHTVYNGTVVNGTVVGGIQIPGLQSILAYGFGKSAQSIVIKGLNAYPKDTWPPLFIHTLFDMMVGIGFLLGGFIWLVMLIKLFIKKNFFENKAVLVLFVIIEAVVLITMESGWVVDEVGRVPWIVYDVMPISAAANTSPSIAYFAAIIILIYIFIIPATAYVLKRLFDSRPLKGELENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC1</accession>
    <name>A0A218NNC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC1"/>
    <dbReference type="KEGG" id="marh:Mia14_0675"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="321" mass="35025" checksum="E539EF30B81D3C4C" modified="2017-09-27" version="1">MMSNMVTALNNALDLCLEENSKAIILGEDVGKDGGVFRVTDGLFAKYGPGRVIDTPLAESSIVGASIGMAISGMHPFPEIQFAGFSYLAFNQLASHAARYRSRTRGNIKIPMVLRMPVSGGVKTLEHHSESPEALFSHIGGLVVMEPSNPYDAKGMLIKASHMDDPVIFLEPTKLYRLFKQEVPEGMYEVPAGKANLVNEGDDLTIITYGTMVRPAQEVVKENNISADILDLRTINPLDESAILSSVKKTGRALVLHEAPLSFGAGAEIAARIGEKSLYDLKSPVMRLGGFSFPYPFSGDEDYWVPNKNRILYSIKKLMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND4</accession>
    <name>A0A218NND4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820218.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND4"/>
    <dbReference type="GeneID" id="33314204"/>
    <dbReference type="KEGG" id="marh:Mia14_0651"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="125" mass="13895" checksum="4FB41683FF92B019" modified="2017-09-27" version="1">MYETPERLKNKNYERKKDNISEDYLEHKNGYLGKILVTAGGALAFIATDLYFHIKEVSPAIYEGSRTIPAQYLSADHGIPWIGIAFTISGVASLGLMALGLKRILRDNEDSEGNGNTDESKETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF5</accession>
    <name>A0A218NNF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820247.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF5"/>
    <dbReference type="GeneID" id="33314234"/>
    <dbReference type="KEGG" id="marh:Mia14_0681"/>
    <dbReference type="OrthoDB" id="385196at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="142" mass="15463" checksum="A1AE05831AA319D5" modified="2017-09-27" version="1">MGNADFKSVFAMVLILVIASANIVNSSVANEQTTVPLVYRAIVGIILIIIIIVALLKFVKYAITGILVFVILVILLSTAYYFFKTGAFSISYSLRFLSDIYNFFVQNGISHYVSNTIVNHTANTSTAVHNSTISNSTANSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG8</accession>
    <name>A0A218NNG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820268.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG8"/>
    <dbReference type="GeneID" id="33314258"/>
    <dbReference type="KEGG" id="marh:Mia14_0706"/>
    <dbReference type="OrthoDB" id="1346at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="147"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="365" mass="41564" checksum="AF3E46819140E13F" modified="2017-09-27" version="1">MQTNILIDRLNKIFRSTDLDAILLFNVNSPFIDSNFYYLTDFNSGIFERSFAIAFKDHVIVGTSDLEYENACIGSNDHISVYRINTTSEVDNFLSRNLKDLKVGYNENFLPYIYYQKFKKYAKFNKLFNASKYLYEARNIKDKYEIEKIKKAVDISKKSLDEIQYYFKKGVTEKELAAQFNYLQLKNGADKNSFGTIVAFDKNTALPHHSPDNTKLKDNAVVLLDVGSKWKNYCSDLTRTFFFKPQKRSLKYKKMADIYDTVEKAQVLGLGLIKDGVDGKNVFEEVTKFINTANGGIYKGKFIHSLGHMIGIDVHDAGAAALSYRSVKLQNGMVLSDEPGIYIYGFGGVRIEDDVLIDGGRGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH7</accession>
    <name>A0A218NNH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820283.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH7"/>
    <dbReference type="GeneID" id="33314274"/>
    <dbReference type="KEGG" id="marh:Mia14_0722"/>
    <dbReference type="OrthoDB" id="385357at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="444" mass="49157" checksum="D379B9C09726A72C" modified="2017-09-27" version="1">MVKKVKKSKKQKASKSTHLSNNNKASAKINKTRGKGRPKAAKKGISAKNKITNKNIKKSIEEKPAVAMQPKAVKKNISESNVKVPEVNIKGNMNLNEETKKKEPLLIIKPASHMGGLDYLHISLIILVVILIALLVVMSTFKVVKTVTTAKVCQYGIVNSTCVQPKYNSSQALTAAETVIAGYARTNSSLSLLPYYIEPNDSSVSYLNNSKEWLVVMPYKDPVARNETLNISILLYSSNLTLVEPFSQLIPPPSPISSNTAVGSGAIKLANKVACNTTEPVPAYYITDPYAYNALTSLSKIMNETSSYKGKINTTYYFIFTGYSQSLYPTYGVNKTQLLGRYLACASSQPNFGMFVNDINKNFNYAPMSNSTLTKYAELSFLNMTQMKSCMYNITDTMDYQAELAKYYNVTQTPEIILNCQYETIPEKFNSAANYTLSQLNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK1</accession>
    <name>A0A218NNK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820320.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK1"/>
    <dbReference type="GeneID" id="33314313"/>
    <dbReference type="KEGG" id="marh:Mia14_0761"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="439" mass="49866" checksum="FE30F3E3B9D42333" modified="2017-09-27" version="1">MKNIPAKISYSFRKLEKIYGRSIDLKLVNGKFCIFEVLKTHSPKGRRNSISLSYIGWITNKGALIPAKPEFRGLDVSDLETFNGVPEPSEPDQKNLDAYDIYDIEVDGLDLKILKILSMNSRLAYPKISKLIGTPVNTVKYRIKKLKKELGIKDTLELNTGKLGFSNYLIAVKFLDQKPEEQNILKATSKNPRVQLVLLTKSIYDLLIFCLAENSSIIESTLDEIRGDPALRSIRSEWYVTSINPNYGFLPLRQEFFDILINKASNGSMMEEKLCLPALNSKEYKVLYELNIDGRKEFKSIDQKYNLPAGSSKKAYSNLINDTKKNLILRPTIIMRSIPKIYDAVIIAKVIDKAEFIKHKDVQIGAIDKPETTTDKFSYICDIGIPDGILYLFSVINDRDLEEVKNEIETSIKGVELESLIIEKNILGDIGYRRFVCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK2</accession>
    <name>A0A218NNK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK2"/>
    <dbReference type="KEGG" id="marh:Mia14_0736"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="273" mass="30844" checksum="475AC2FD9BBDC391" modified="2017-09-27" version="1">MLFGIEYAISILFLVAAIVMPLSIGGYLVKIILFLIAMIFDVIAFTSRYYAYLFIPFIKGRGKRVVLSNEDAYYLSASADSILKKVGDKFIATVYILLPVYTSSTEMNDDQKLEFTQKVSRMVGITRDPARFTTEVLIMNKDDYLRELKDAISQADNEVAQLNLNKNPDKKRMEHYKGKSVMLRNLLNDMGKVTSYEEISYVTVSAYGYKEYEAVANAQQKARELISGISSVFGVPVSIITGNELLKFVEPEYLIPYVTVTTQMNSDLESKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL2</accession>
    <name>A0A218NNL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="5" type="ORF">Mia14_0751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820311.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL2"/>
    <dbReference type="GeneID" id="33314303"/>
    <dbReference type="KEGG" id="marh:Mia14_0751"/>
    <dbReference type="OrthoDB" id="11736at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="67" mass="7557" checksum="7B7C6150904E63A5" modified="2017-09-27" version="1">MLIIKAKELRGLSDKELKTKLDDLNLEEAIEKRKIAATGVSSKVVKIRDIKRTIARILTILNERGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM4</accession>
    <name>A0A218NNM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC48 family ATPase of the AAA+ class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820318.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM4"/>
    <dbReference type="GeneID" id="33314311"/>
    <dbReference type="KEGG" id="marh:Mia14_0759"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="406"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="688"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="920" mass="102562" checksum="28AA55A2BB61B40A" modified="2017-09-27" version="1">MSKHTSDEAIKSSNVKMLIKKRHKAPIFFYNINSFFSEIFSNKHFLDSILMIIAFIAVNAAFPAYPIVIAVILAFIIFILAQFHPYLGIISLAAFLFPISIIEFPLLAWVLLLLISLTLILGYRHYRVIVLLFILASLPFSALGYMLEIPFLIISPILIGFKRSGMLYAVSFLSIAALSAITGIQNTGFIMYTALPVHSYILSQWSRIAPYFSITSFVRPTIFTFIPLALKSSSVLVSGIVTSSISDMITIIAVGISHQPEYLLELLLFIAIAYGIEKVVISSRSKYKGAKASIIGVGFPAIFVGLSIILSSVKINYIVPFISFLIAPIAFYLMELYNYEISNALNIKKNDIRMKFGEAFEDLSSGSTKETFDDIADYETIKAELRESIISPLEQKGVSKAYNIAPIKGVLLFGPPGSGKTKLMRALSNETHSAFFYIKASNIVSAYPGESEKEIVHVFDVAKKNTPCILFIDEIDTIAASRNDESTDDVHKHLISQLLVEMDGFERLDRVIVVAATNIPDKLDPALLRPGRFDKAIYMHLPDFNGRKEIFSMYLKKLPLAGDINISEISKQTQRYSGADIQNVCATVAQEIASQASKEHRILEIRQEDIMKTLKVIRPSTTFAQLEKYNEFDLDFRRQRGIEPVEEADENVTIDSVIGMSEAKNSIVEAIQIPLMHPDLIKKYDIKSINGILLYGPPGCGKTMLMRAVKEDFKGVTTLELNGADVERQGLEKANTTIKDLFYRALDNTPSIIFIDEIDGLIRSREGSSEYSAQITSQLLQEMDGIRKTTGVVVVAATNRPEDLDTALLRNGRFDKLVYTPPPNLKERASIFKEYLSNTPLSKDVRFSKLAAITRNFTGADIAGICRGVKMKALERDLQTGKQVTITYKDLSNAIINTKPSASEAMLTPYLNFMARYGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM9</accession>
    <name>A0A218NNM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ORF">Mia14_0754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820314.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM9"/>
    <dbReference type="GeneID" id="33314306"/>
    <dbReference type="KEGG" id="marh:Mia14_0754"/>
    <dbReference type="OrthoDB" id="3337at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_P1_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="102" mass="10488" checksum="69616AD65C6CA7F0" modified="2017-09-27" version="1">MEYVYAAMLLNAAGKDISEQSMTEVIKAAGLTPDEAKVKSVVESLKGVDIKSVIENAQSMQVAAAPGKAEAKAEGKKESKAEAKSEAKSEEEAAGGLAGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN7</accession>
    <name>A0A218NNN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">Mia14_0779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN7"/>
    <dbReference type="KEGG" id="marh:Mia14_0779"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="340" mass="35731" checksum="37732FE7878DBA11" modified="2017-09-27" version="1">MMPADDRIDDLSAKIGIVGLGGMGSNAINHLFNAGIKSADTIAMNTDIKHLSIINAQKKLLLGKSITRGLGAGGFPEVALKAAESSEDEVRSAIKGYDILFLIAGMGGGTGSGTIPYLAKLGKEQGSLVVSFVTYPFHLERSRRISADASIEKLSKNSDSTIIIENEKLLSYAPNLPIDKALGIVDNVILNSVKGITDTISLPSLINLDFADLKSVLGNSGTALISIGYGSGVDRVEKAIRSNKEHPLLNAELENARSALVHVTGGPDLTIADATRLGEGVTEGMDNKANVIFGARLSNDLGDQVKVVSVITGVKPKLYDPSANKSKPASSEFLSNLYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP7</accession>
    <name>A0A218NNP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820363.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP7"/>
    <dbReference type="GeneID" id="33314355"/>
    <dbReference type="KEGG" id="marh:Mia14_0806"/>
    <dbReference type="OrthoDB" id="6924at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22559" checksum="61A9AF4909382F17" modified="2017-09-27" version="1">MVANIDIGQKIPEVKSKVYYPKEDKIEDITLPVKGKWNVLTFYPGDFTFVCATDLEELEKKYRDFKDENAEVFAISADSIFSHREWAQTSPRVSKSQIPLVEDFKKSMISQYGFLNEESGAARRGLIIIDPEGNLQYYSVFNDNLGKDVDHIYNAFQGLKYLHDTPNKEGHMCALPANWRKGKETLNIDLVKDIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ1</accession>
    <name>A0A218NNQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">Mia14_0780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820335.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ1"/>
    <dbReference type="GeneID" id="33314331"/>
    <dbReference type="KEGG" id="marh:Mia14_0780"/>
    <dbReference type="OrthoDB" id="371908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF9">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="228"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="364" mass="38041" checksum="D1A4045EAA5B3479" modified="2017-09-27" version="1">MTDLVSDLLGGNASVGDDNADKGAVSDEFSSSEIKIVTAGFGGGGANSVNRLIKAGVKGTEFVSFNTDSQHFKIIDDRIRKVMIGKSITRGLGAGGDPAVGKKAAEVDRSLIEKEFQDAQLVFLCGGMGGGTATGALPVAAQIAKDQGAIVISMVTYPFNLERVRKVKAEEGIQELRKYSDSVIILDNNRLVQLVPNLPMDKAFALADEVIAKAIGGLVWTITQPSMINIDFADVRSIMGHGDVGFIAIGTGRGTDKVNLAAESVLKNKLLDVDFEGAGGAIIHVSGGSSLSLGDATKAGEIITERMDPKANVKFGARIIPGFDDGIEIVAIVTGVKGSSIIGKLDTKQRESASDPYSDLEMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ3</accession>
    <name>A0A218NNQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820364.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ3"/>
    <dbReference type="GeneID" id="33314356"/>
    <dbReference type="KEGG" id="marh:Mia14_0807"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050684">
        <property type="entry name" value="HTH-Siroheme_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413:SF7">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="138" mass="15376" checksum="9ECC24E05BE24BF8" modified="2017-09-27" version="1">MFNKIDKDIINLLYYNGDISSDEIASKLGVSKGTVRNRLIRLKDEGVIKNYGIRAKLQKIGMAEVIVGLEIAPENYIQATKDIASYGWVNELYRTSGDHSVVAIIISDSETIQDKVADLLNVKGVKNVYPSFVQDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ8</accession>
    <name>A0A218NNQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ8"/>
    <dbReference type="KEGG" id="marh:Mia14_0792"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="36" mass="4350" checksum="31385CFEF086BB31" modified="2017-09-27" version="1">MKIEFIDFYIINALNEARNIKIVKCKSDYKTTIRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ9</accession>
    <name>A0A218NNQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820353.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ9"/>
    <dbReference type="GeneID" id="33314348"/>
    <dbReference type="KEGG" id="marh:Mia14_0799"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="260" mass="29494" checksum="B1862BB9F27B11CD" modified="2017-09-27" version="1">MDYEKIIDEYEGMINKDQAGKLKYEGYNFCASLSGPECISVEELASLIEEKRDDLIKNEFKNMFYSANIKDRVYRIFNEESIKSYRLFGAKRLVVIGSSPNTLKFFVSSRLSKKLDKANKLVKSSDEIVISNALVNLHNDFLYSGKDTDLKKVDKGRSKQEPYMEMDHSTGNTRIFAKISSLDSSKIIRSGKDSSLELKLDLGSKMLNLILEGSSLKCVKEFNPGDNIFAEFCRLVKADKGLSMVADNYSRVVLIKQSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR6</accession>
    <name>A0A218NNR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR6"/>
    <dbReference type="KEGG" id="marh:Mia14_0830"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="396" mass="43647" checksum="6C06C86C2311D460" modified="2017-09-27" version="1">MFKMAEDYSNRDEKKEEIRKNEKGIKKQKFELNKYLPYILILLVLVVVIVLFASLSAQLNSISSKLENISSSKPTTATNNTAGNVTLSDPSYKITGSLIVPPKSLPNDPIITANASFGSRLTNINQPLNASELAIFNNANDSYFEEAGQMILNGTFGGYVFGSTTGSNAEVKKLDNPFVVNGKPSVIYLGSITCIYCGENRWAMALALGRFGNFSELYKGYSSFGDHDIPTIYWAPSHYNQSAEDLGNFYSSKYINFISIEDTLPITGGFQLNPMSTIQSRINATNNSIYIDAFDLILGLNNFEGTPYTIWGKYNVLGADDADFGFKSEPSGNPSIEYKTHNMVFDNISHPDSEFGYLEYAGADLYIAMTCATINNTAPICSLPVIPKLESYEGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT0</accession>
    <name>A0A218NNT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216909.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT0"/>
    <dbReference type="GeneID" id="33314382"/>
    <dbReference type="KEGG" id="marh:Mia14_0834"/>
    <dbReference type="OrthoDB" id="386191at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="353" mass="38506" checksum="950A5CE18CA569CB" modified="2017-09-27" version="1">MASASIGVIILILIVIVLAIVGYFETGGFKLNKSISVTPPPPAPKHVSKPNVNNSTNYLYGCDNYDLQANAGSTSIGACTWGGGTLGVWVSTGKMGFVNFSIVGSNNKTYVKQEYLPYSCSTFYTEFYAPAQIYYLTLGASNSTTNGPCLNNYSIVTLNTSVKVLVNKTYYSFYQGNLSTGTYIGWSTSGTAFGGLPLNLTYANDVGCYPKDPWENYSGIYYISSYNCSPIESTGNITSSRFLIDKPFLNLQIISPKNSLDYLEIIPSNASTPYITDQVSTYSLSLSNGSLIGQGYKLENATIPLTSLLGKVVRLRIVQESDQKYEYMIAGDIRMSDYPDQGTGFLDNITYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU4</accession>
    <name>A0A218NNU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780212.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU4"/>
    <dbReference type="GeneID" id="33314403"/>
    <dbReference type="KEGG" id="marh:Mia14_0857"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="134" mass="14923" checksum="914B40F357A0189C" modified="2017-09-27" version="1">MIITSKRKFYESILSYSIAWIFLYLSVFLSQHIKYDGNFTSAIPILFPLVFAMVAIGVSILFILGKEYPWFFRTGIMSLAIGVTLFIFGIITYYSGVESLLWGGSVGIGVLFVIAAIVRLTIQGGLSAYRKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV5</accession>
    <name>A0A218NNV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV5"/>
    <dbReference type="KEGG" id="marh:Mia14_0846"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="250" mass="29271" checksum="9091ACF664A9EC5D" modified="2017-09-27" version="1">MIEKNALIEIAKLRGLKAWQEEKRYIQASILNSLYDESIVFKGDTYLWFFNGLPRFSEDLDFTAISDLPSNIMNKVSERLDLFGIYNESKIETNDKKSFSFKVMAQGPLYTSQNSRCVVYVEISKREELINKTLPIKLNFPEYLLPIHVLNGINLDEVGAEKIRAITSRNKARDVLDLYYLIKEKNIKFDINLVNKKLEYIGDRFLPDKFEISLLNKRGIFEKELKNLLFVPLPEFDEVRSVIEKWTKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW5</accession>
    <name>A0A218NNW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDF family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820465.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW5"/>
    <dbReference type="GeneID" id="33314431"/>
    <dbReference type="KEGG" id="marh:Mia14_0888"/>
    <dbReference type="OrthoDB" id="269083at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="16"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="283" mass="32012" checksum="19F0339E17E34BAB" modified="2017-09-27" version="1">MSSNQGNTPYRDLLTASIYWIILGIFLYSYFQTRNPLSLSVATDRVVDALSISFIFLVNRIARKPGDEYHSYGFHRVEVILNATVILLFVAMAIYSALMTTQLLLTNAIRSPASTVVSSIVTVPLLLLAAFTMQRDKKSNFRVMFIHTLQDLEIILVTLVFSLASEYFIGPSLSYIGSYAVILIILYGNRNMFRRNFNMLMEGSQVSVREVEDRIKKEFPNAHHLHIWDICQHQRVATLHLSVLPCTKIGELDKTNAAIKSLLSKYGVNHVTIQFESADPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX5</accession>
    <name>A0A218NNX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820473.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX5"/>
    <dbReference type="GeneID" id="33314439"/>
    <dbReference type="KEGG" id="marh:Mia14_0900"/>
    <dbReference type="OrthoDB" id="382997at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="86" mass="9206" checksum="23E9451582B5F7CC" modified="2017-09-27" version="1">MNEKKVEQKEDGVEVMLPEKIGINEAKEVVSSCASGTSACCSSDCSDFLSDKKIGAFEKNGKAVIKITGNATKEEVEEKLKSCSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX7</accession>
    <name>A0A218NNX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820435.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX7"/>
    <dbReference type="GeneID" id="33314408"/>
    <dbReference type="KEGG" id="marh:Mia14_0862"/>
    <dbReference type="OrthoDB" id="55932at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="86" mass="9691" checksum="AF41C672FDB0E26A" modified="2017-09-27" version="1">MVKFHPINKTMTVGTFMFIGSMIIIALGALFHYLHYSASIYLSFFFYGLGIFFLSAIILFIGTLLAAKSGKLQKRASDIFNNRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY8</accession>
    <name>A0A218NNY8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="7" type="ORF">Mia14_0905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820476.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY8"/>
    <dbReference type="GeneID" id="33314443"/>
    <dbReference type="KEGG" id="marh:Mia14_0905"/>
    <dbReference type="OrthoDB" id="53273at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00264">
        <property type="entry name" value="archaeal-type nascent polypeptide-associated complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="118" mass="12841" checksum="69054231A96A8E06" modified="2017-09-27" version="1">MMPNLDPRALKSMMSKMGITTLEVEADKVVISTKGKDIVIENPQVTQINAQGVVTFQIAGNVTEVSKEEEIGEIEVSDDDIAVVSEKTGITDKDLIRKALEESNGNIAEAILRLKEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ3</accession>
    <name>A0A218NNZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane-associated trancriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820495.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ3"/>
    <dbReference type="GeneID" id="33314464"/>
    <dbReference type="KEGG" id="marh:Mia14_0927"/>
    <dbReference type="OrthoDB" id="384931at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="297" mass="31771" checksum="B7F5B5A59957558E" modified="2017-09-27" version="1">MVDEINFSDLLALKKISADTIVEKFGSTINSSFFDAANILGSLKIKGLVDYGTNTPGQNVISITDVGNKLLGDADIRSKESIDNLDMEIIHQLGAGKRELSDVSNSINVSQTDLAMHLNKLLVNGYADASFRNGVVNINLTDKGFNLEKEPPASNEEKNNVPSSEPAPEAKEGELMVEPEDDSAKYVAEAENAQAPEEVPKREEQQPSVPNSTPQAAVNASGVSAPVATANPGTGKEEVKEMDDLKSINGKLQSNDEEIETELKSHLTKKSKKPAVAIAVVVILIIIVVVLKVKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP01</accession>
    <name>A0A218NP01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820480.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP01"/>
    <dbReference type="GeneID" id="33314448"/>
    <dbReference type="KEGG" id="marh:Mia14_0910"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="300" mass="34672" checksum="30830DBDC4746A07" modified="2017-09-27" version="1">MQDKTKNVDKSKGLVFEVKPEYLKMLDTLLDKKSSKEIINLLKLVDYYNLNDEIKNLTASLIGIASHVNDNNMNDLEEYYNSSLNDFGKMIDSQVKKIGVGKPDFLKLNKQYVELNKKLNGILKGKSYMDPRKVDELLDPLNSLVDQMNLPKTAEYLKAFDKQMLEKLKNACTKDDKFFAVPFMLVLYHSSENKLYGISKLNYISGKLDEFAKNGLAGNEILDYLLHEIRSNYEDVLESGIIKENPFKDLSNESVALNLLFNYKFRLLSVNGEEPKTLESIEIDDYKYKKMERDNSDMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP09</accession>
    <name>A0A218NP09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820496.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP09"/>
    <dbReference type="GeneID" id="33314465"/>
    <dbReference type="KEGG" id="marh:Mia14_0928"/>
    <dbReference type="OrthoDB" id="18103at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051538">
        <property type="entry name" value="Acyl-CoA_Synth/Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334:SF1">
        <property type="entry name" value="3-HYDROXYPROPIONATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13549">
        <property type="entry name" value="ATP-grasp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="212" mass="23597" checksum="1DE4E8DC08CCBFCD" modified="2017-09-27" version="1">MMEENNKMMDFMEAVQLLKKYNINVVGSKYVESADDAVSFSNGDPIVMKVLSDKALHKTKSGVVKLDLSKPEDIKAAYDDLYSKAQELKPYKILAQKMIKGGTEIIIGGNTDPQFGKAVLLGFGGIYVETFKDVSLRVCPLTDYDAYSMIDSLKSKNIIAPDKESRDMVKGLIINVSKMLMENQNISELDLNPIILHDGTYDAVDLRFILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP36</accession>
    <name>A0A218NP36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820520.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP36"/>
    <dbReference type="GeneID" id="33314489"/>
    <dbReference type="KEGG" id="marh:Mia14_0953"/>
    <dbReference type="OrthoDB" id="384246at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="118" mass="13573" checksum="B6E3D8FCB3A8ADB7" modified="2017-09-27" version="1">MEKKDIKIAFSPGKLKSLQKNEILATVKLSNNSDKYCWYEFDVNLNSPLSLTYDQELDKGRFRVGILEPKTVKGKDFKIFTMDDLKPGIHKINFTIYVYDGDAVISDRLDYEIGIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP63</accession>
    <name>A0A218NP63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820519.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP63"/>
    <dbReference type="GeneID" id="33314488"/>
    <dbReference type="KEGG" id="marh:Mia14_0952"/>
    <dbReference type="OrthoDB" id="376391at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="152" mass="17665" checksum="C7160FC4F531F9C4" modified="2017-09-27" version="1">MGLNESKLIESEIILRNLRLTSEVLETRRSMVRWLAISLGIINPGESRLNAIYVFDAILYFQFNEKSDPSVNDLSEYISKNWSAINEKTLRYHLLQFSNLGLISHSKGKYFLVLPEDAKKYDESEWLGNLIDFKINPIKEKVLTVISELKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP79</accession>
    <name>A0A218NP79_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820529.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP79"/>
    <dbReference type="GeneID" id="33314498"/>
    <dbReference type="KEGG" id="marh:Mia14_0962"/>
    <dbReference type="OrthoDB" id="9126at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02411">
        <property type="entry name" value="KH-II_30S_S3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000001">
        <property type="entry name" value="30S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI14234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="254" mass="27823" checksum="22B35AFDEED23620" modified="2017-09-27" version="1">MTMEYKFIDDAEIKLNISKYLGKELDKAGFSRVDIQKTPMITRISVHVLNPGRVIGRAGKSINELTEAIKNKFNVSNPQISVIEVDNKMLEPLLVAKDLAFKLERSMNPRKIVEYTLKNIMSNGAMGAEIVLSGKLAAKGARSRVIRKSIGYIPKAGAVTDLVNTGHATAYPKYGAIGVYVRIVPPGTIFPDKVNKKSVENNIILSTETSEPEIKSEASEQAKENKEEESKVETENPESEGAVTGKVEDSDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP98</accession>
    <name>A0A218NP98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC2-1 family ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP98"/>
    <dbReference type="KEGG" id="marh:Mia14_0985"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43471">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43471:SF1">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE PROTEIN NOSY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="264" mass="28554" checksum="A763CE27B599D268" modified="2017-09-27" version="1">MQFFKALTLMKKDLKETFSSISIYGPMLGIPIFFAIILPVMTFYITLYAAPTITSKLLPTTIKVSSSVLSSSIRSIKFMEFFSVNVLGPVFLTMPIFTASVIAADSFAGEKERGTSESLLSTPISKSELLSGKILASFVPTILLTLAIFGIYGAVTDYFSISVFHFAILPTIPWLLMLGTAPFLATASIGLVVLVSSHVKGVKEAQQISTLLVLPILVLPFASIIGLAVLNVEFLVSAIVILAILDAIIMYLGIKSFRKESILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA0</accession>
    <name>A0A218NPA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA0"/>
    <dbReference type="KEGG" id="marh:Mia14_1019"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.91.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="210" mass="25446" checksum="34E35181E5FCA76B" modified="2017-09-27" version="1">MNSLQKVFISSFRLIIMYGIRGSKQKERLYDSLVRIDKDNEHSIYNTDPYDSSIKNLKNGLLKNYREEAVKDALLMAGANAYYEHKKYRINEKNSYFPDFITNIYFKGRQVILEPHEVFDRNYVSKMDKFTREYPNFYLVFIVSSDKYRYLSKHITKELKRFSKIWIVKDFKNQKEGLEESTRQILEKINELRNRDFDYKAYLRNRDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPC4</accession>
    <name>A0A218NPC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPC4"/>
    <dbReference type="KEGG" id="marh:Mia14_1008"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="59" mass="6816" checksum="1686CCF0ED01289C" modified="2017-09-27" version="1">MILKIPTLYHLVHLLITKTKQNITDIVKNMITKDARCIGLSKRQLFGLKKTIKKLIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM3</accession>
    <name>A0A218NLM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">30S ribosomal protein S7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM3"/>
    <dbReference type="KEGG" id="marh:Mia14_0032"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="6">
        <location>
            <begin position="140"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="299" mass="33770" checksum="6D9B9057383CE9FF" modified="2017-09-27" version="1">MISMPVDKKNTKNSKESKSKEKEKEQKPEIKSKASEEKHEHPAAKEAKESKKEQAAEAKEEKLEEKAEERKEKKLEEKEEAKSEKEKEKSEKSEKSSSINKIKLFNKYDYDVSVDDLSLRNYINLKPMVNPLTYRRGSGKPFSKANINVVERLENSLMRGGTGSRIGGHTIRTEGRLQGKKIKVMKIIEDAFDNVHNQTKLNPLAIFIVALENSAPIEDTTRIRQGGTVSNISVDVSASRRLDIALRNIATASIIGAFDNKRKISDALASEIILASRNDINSYSIKRKNEIERMARSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP9</accession>
    <name>A0A218NLP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819562.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP9"/>
    <dbReference type="GeneID" id="33313608"/>
    <dbReference type="KEGG" id="marh:Mia14_0048"/>
    <dbReference type="OrthoDB" id="9421at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01911">
        <property type="entry name" value="proteasome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="231" mass="25408" checksum="FB86AC9815A91FCA" modified="2017-09-27" version="1">MYPNIQAYDRGVMFSPDGRLFQVEYAKEAVKKGSTAIGIVADAGVVIAAHRNINESLVVPETLQKIFKIDPYICATYSGMISDGLHLVSMMREKTQSHRMIYDETEPVETLAREMAEEMLTATEYGGLRPFAVSTLVGGVDTKPRLFEVDPAGALAGYKADAIGSGKKTATEILSKEYKDGMALDEAIKLAVSIIKKINENKLDSNNLEISTISKGKGFKFFDQKTIESYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ1</accession>
    <name>A0A218NLQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ1"/>
    <dbReference type="KEGG" id="marh:Mia14_0062"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="86" mass="10261" checksum="5AADD155C5AD7326" modified="2017-09-27" version="1">MNMMNKILIGSRLLLFILLLMVIVFIVIIVEAVIFILEHILIFAAIILVLVLLLFYLKHRIRKHFFIEYKKPEDKNAYDAKYKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ4</accession>
    <name>A0A218NLQ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="11">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">priS</name>
        <name evidence="14" type="ORF">Mia14_0061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216858.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ4"/>
    <dbReference type="GeneID" id="33313621"/>
    <dbReference type="KEGG" id="marh:Mia14_0061"/>
    <dbReference type="OrthoDB" id="31125at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.160">
        <property type="entry name" value="DNA primase S, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 11 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="384" mass="42896" checksum="C0D6EFB9EAC4F995" modified="2017-09-27" version="1">MPLDQKVADFVTPLIRKYYSRVKIDVDHLSEREFGFGSFESKITTRHHAFQDKGQLQDYLVANAPPFASCSPSLYERPAARPMEAKGWKGAELVFDLDSNDLHLSCQKEHGSSWVCDNCFTAVKDEALKLIEDFLISDFGFSENEIRINFSGNRGYHIHVISDEVMNLNSKERKEMSDYISGNNIDIEAFFPTINERGAHLDGPKLSDFGWGGRIARGVVGALNSGENSLKLLGIDSTNSRRLVRNKAKVIPGIEAGNWDKVKITKKSEFWNNVITNMTIKQSDAIDKNVTNDTSHILRVPNTLHGDTGLIARKIKSIGALEGFDPMKDALAFSDRTVKIHAISVPKLRVRDVSYGPYKDEDVEVGLAAAVYMMLKRVAVLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR6</accession>
    <name>A0A218NLR6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">30S ribosomal protein S5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819590.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR6"/>
    <dbReference type="GeneID" id="33313637"/>
    <dbReference type="KEGG" id="marh:Mia14_0077"/>
    <dbReference type="OrthoDB" id="38155at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047866">
        <property type="entry name" value="Ribosomal_uS5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003125">
        <property type="entry name" value="PRK04044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="230" mass="25424" checksum="E3F160DC92100091" modified="2017-09-27" version="1">MAFRRRNNRDNESDLVNLEEWAPKTQLGKDVKEKKVTSIEQIFNAGKKIEEIEIVYSLLPNMKSEVIDISSVQRMTKNNRKQKFRVTVVVGDMRGHVGVGSAKDIEVKKAIDNATKNAKMNVIPVVLGCGSWQCTCGTSHSLPFNAVGKCGSVEVTLKPAPRGLGIVASAPVKKMLELAGVKDIWSFSRGRTRSKYNTLLAVQRAFESTISMKNLTPEEVAYKPQAAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT0</accession>
    <name>A0A218NLT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA-processing protein FCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT0"/>
    <dbReference type="KEGG" id="marh:Mia14_0091"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="128" mass="14377" checksum="8267E8B1DD55BE2F" modified="2017-09-27" version="1">MLMEVIIDTSSLVFSARNKCDIISRINSEIPNAEICVSKGVIRELEGISKGNGGNSIAARTAIEILKNKKVKVYNNNEYVDQWIYNHALENKTQGIGQVIVTNDTEIYNRIKSEKITVKKSTIKCFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU2</accession>
    <name>A0A218NLU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M79 family prenyl-processing membrane peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU2"/>
    <dbReference type="KEGG" id="marh:Mia14_0085"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052710">
        <property type="entry name" value="CAAX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435:SF1">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435">
        <property type="entry name" value="SLR1288 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="147"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="237" mass="26365" checksum="02783CC8187F1DF0" modified="2017-09-27" version="1">MPLESSKPNHNEACPNEAIEKQGKDSYKARYIFYFFSILLISIAIASVVLYYDSILSNNSADIISTISISLLFPSIVISYMMAKGNNISGIIKSLGLSRDKLNFKYIIIGIVLFAAIMGLDLAFSSIAAYLHISFPTNVKQVFSGMPLYFLIFSFTVAPIDEEILFRGFLVPRIGVIQSAFLFAILHFGYGSISEILFAFIFGLMAGYAFKRTKSLYISIIGHILVNMLTIILLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW3</accession>
    <name>A0A218NLW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819629.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW3"/>
    <dbReference type="GeneID" id="33313682"/>
    <dbReference type="KEGG" id="marh:Mia14_0123"/>
    <dbReference type="OrthoDB" id="381468at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="92" mass="10841" checksum="5D0D195DBD8F605D" modified="2017-09-27" version="1">MVEKEKRIIVEIDPAREYSRRLHYLEKHSRWEAFKSVFWGVFIFVAGAILVYTNGIIQTNVYFGFMMMLFAVFLMIYGLAGALHHKLMKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX1</accession>
    <name>A0A218NLX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819634.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX1"/>
    <dbReference type="GeneID" id="33313687"/>
    <dbReference type="KEGG" id="marh:Mia14_0128"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="209" mass="22860" checksum="693395AF016C40C1" modified="2017-09-27" version="1">MANKKNQPKGNDVLDDVDVSGVVNSPYEGNSAIKNNVKPPNYTPPPSPSSLSNVYEQKSYETDFTEEGEISGPLTLWIGAMVVGIVLIIASTLSIFGPVQSIMYKIGYYIIYLPGTFIFPLIVGAWLGNKTARPNMLKSIKASLINSIYASIIYSIAVLIIYLILYYTSNLLSKITVSNFSTMIIGIPILIVIIVGAVINFLRSARHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY5</accession>
    <name>A0A218NLY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819646.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY5"/>
    <dbReference type="GeneID" id="33313700"/>
    <dbReference type="KEGG" id="marh:Mia14_0141"/>
    <dbReference type="OrthoDB" id="381593at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="17909" checksum="C67FCFC20449CA32" modified="2017-09-27" version="1">MHDNKKVKAQSAMEYLMTYGWAILVIALILGVLYALGVFSPSSLAHNECIFPAGYSCLSTNLHQSGNFTLNLQQVTSSPINVTGVGCATNVSTAYIVRLPHQITIGIGDNYTFRSNSSFPLHCVDNGTVFARPIGSIFNGYVIVNYTNLQTGFPGIVTATLVQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ2</accession>
    <name>A0A218NLZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Mia14_0132</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.</text>
            <dbReference type="EC" id="2.4.99.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ2"/>
    <dbReference type="KEGG" id="marh:Mia14_0132"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ASI13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="812" mass="89747" checksum="A7AB6A61B0793CD6" modified="2017-09-27" version="1">MVSQSDSLDEKPNILENINSTNTTQDSQSAVKIPKPSFKEGVLRNQNLIIAILFLLILILTIYLRTGMMKYEGFFSPDGFYKYAVLQQAILHNYTIPETLIYSGFPTHNYISNRLGGYYVSLYPYIILKGLGVSLYTIMRDIPLVFALLDAIAIYFLMQYLSKSKVLGLLGMLMVAVSPANLSVTSALVYRGDIFISVFAIVAFILLIKAYRSRTAKSEFEYAVLTSIVLGFGTMIWGGAPFTVAIYFLAIAIMVAVGYIRGDKKSLKISSILAATIIIEYLMEHIFEALGIIRVPEFLSGASFFVFYLPLVIGSIIALYIIGYREKAAAAGEKINPLISKISMSPISRAGFVVAIAIIVAIIILVPFSSVIKVIASGGGLVSAQTALEKTIQELAPPTTTFIWDSYNLEIILFVIGVAAYLLFASDLGSRTQTSSYKNIYKRITGNFTPEFVIMVSYLLVTGYLQSQATRYGSLFSVPVAVFSAYALYSIGIVISRKFNSINASKYRITKEFGSWNYIYYGLATGLIIIMLMYAFTTTATNAPSDNINSQFLSALSWMKNNTPSNSTVLAVWPDGSEVEGWANRQSVMDSVGGQNPKSIKGFSLFLFNDSPDIQYLNSVHNPDYIVARNYWWSEIGGIEVEGLLSNSSSPGYAGNEKNFSVVMFPSSTESKYSNGYVFLMNITSINLYTALIYNTSDINKSYAIEYTPGGRSYKYIKHILIYDISNFDHILINSSEPGALNSTLYVETSAEGTQFIYLLGPKFLNSNFVKIESLCNSTACNYDANGSVKLKMVYGNDDTKIFKVIYPNAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ6</accession>
    <name>A0A218NLZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819664.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ6"/>
    <dbReference type="GeneID" id="33313719"/>
    <dbReference type="KEGG" id="marh:Mia14_0160"/>
    <dbReference type="OrthoDB" id="30639at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="188" mass="21455" checksum="C8D436C60A21AD5C" modified="2017-09-27" version="1">MALQKKDNWKFKKWFTVYAPAVFGGNIVVGEMPANSDKNILNRNIRISLNSLTNNPSHMYTTAVLKVNEVNGDNLNTKLSELRLPYSYLRSLVRRYRSISNSRVEGVTKDGIKTVIKSLVVTRERSPHTKIVGIRKEMTDYINKTLPNLTYDEVVKSIMEGRLQSDIKSSVEHIAKVNRVEVVALEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM31</accession>
    <name>A0A218NM31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819684.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM31"/>
    <dbReference type="GeneID" id="33313740"/>
    <dbReference type="KEGG" id="marh:Mia14_0182"/>
    <dbReference type="OrthoDB" id="8967at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000034">
        <property type="entry name" value="Chaperone protein DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="370" mass="41463" checksum="438C886393332EB4" modified="2017-09-27" version="1">MTKDYYSILGVSKNASQEDIKSAYRQLALKYHPDRNKDPSAEEKFKEINEAYAVLSNPEKRKQYDAYGPEGFNRQYNQEDIFRNFNFEDIFRDMGFNVGGNFSESDDFFDTIFGGGRGGRQRDDQGKDLLTKVNISMEEAVHGTSKRIKITHIKECDKCKGTGVEPGYKIKKCPTCAGTGQVRNVRRTPFGMMQTISICPTCGGTGNIPEKKCTKCNGTGRLNASETIDVEVPRGIATGNRLRVSGMGDYGKDGQGDLYIEINILPDKRFVRRGDDIYMEAHVPFYTAITGGVEKAKGIDGEVEFEVEPGTQDSEQVLVKGKGMPHFNKGGFGDLIIKIKVDIPKKLTSEQKELIEKFKDLDSNKKSWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM57</accession>
    <name>A0A218NM57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819711.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM57"/>
    <dbReference type="GeneID" id="33313770"/>
    <dbReference type="KEGG" id="marh:Mia14_0212"/>
    <dbReference type="OrthoDB" id="372177at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="376" mass="41991" checksum="957F5C7B13FF5857" modified="2017-09-27" version="1">MEIYEEGKARIKFNSQSFLNPKAQLSRDLSVAFVKYKTKINPKATVIDTTSATGIRGIRYYKEGGAKEICMLEINNSAFKDLKGNMNYNKMNKDSNVRYYNTSIQEFANSSVRESFDIIDLDPFGSAAPNLTDIMKLARDKSSLMITATDVAVLCGAHYKACLKTYFAQPLHNALCHEVGIRILLGYIARIASLFNFGIEPEISISYLHYVRLFLKLDHGAAAAVKNYESIGYALYCKACGNFALNSPIPHSLNCNVCGHEYSIAGPLWVGRIQDKTVINGVKEVMSQDKVKNDEMTFMSNLSSELDTPLYYSIPALTKMMNVESVSYDRLKEELQSQGHSISKTHMNKESIKTDAGISEVKAAILKVLKSRNMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM61</accession>
    <name>A0A218NM61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
            <shortName evidence="9">EF-1-alpha</shortName>
            <ecNumber evidence="9">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor Tu</fullName>
            <shortName evidence="9">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tuf</name>
        <name evidence="11" type="ORF">Mia14_0223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819722.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM61"/>
    <dbReference type="GeneID" id="33313781"/>
    <dbReference type="KEGG" id="marh:Mia14_0223"/>
    <dbReference type="OrthoDB" id="371718at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="426" mass="46765" checksum="665067A7DAA04918" modified="2017-09-27" version="1">MSDKPHLNLIFIGHVDHGKSTTVGRLLYETHVITDRDIARYKELTQQLNKPTFEFAFVMDQLKEERERGITIDIMHKDFNTDKYYFTIIDAPGHKDFVKNMITGASQADAAVLVVSAVNGIQPQTREHAILASVLGIGQMIIGINKMDAANFEQAKFEETKKSVLDMLKSLGYQNLDKIQVVPYSALTGDNVAAKSDKLPWYNGATLLQSLDNLVVPSKPVDKPLRLPIQDVYNIPGFGTVPVGRVETGVMKPGDSIVIMPSGIKTDVKSIQEHYTDLPKAEPGDNVGFNIKGVDRKDIHRGDVVGPSSNPPAVIADFTALVTILHHPNVITKGYTPVFHIHTAQVACTFIELLEKKDPKTGETLEKNPTTIKQGDIAIVKIKPTKPLSAEKFSDFAPLGRFAIRDMGETVGAGKILDITPAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM63</accession>
    <name>A0A218NM63_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ORF">Mia14_0224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819723.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM63"/>
    <dbReference type="GeneID" id="33313782"/>
    <dbReference type="KEGG" id="marh:Mia14_0224"/>
    <dbReference type="OrthoDB" id="371736at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="102" mass="11294" checksum="7622B72E15509B63" modified="2017-09-27" version="1">MAGVAVIKLSSISGSDADSIMNQIKSIAQQLNIKVRGPIPLPTKHIIQTTRKTPAADGSHTFERWELRVHKRMIKVFASDQALHQILRITVPDTVQIEISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM78</accession>
    <name>A0A218NM78_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819736.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM78"/>
    <dbReference type="GeneID" id="33313796"/>
    <dbReference type="KEGG" id="marh:Mia14_0238"/>
    <dbReference type="OrthoDB" id="6009at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019969">
        <property type="entry name" value="RNAP_Rpo2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03670">
        <property type="entry name" value="rpoB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="10">
        <location>
            <begin position="149"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="521"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="613" mass="68847" checksum="FB8694B635DEF658" modified="2017-09-27" version="1">MPSKNNASVNEKCPVYLDGKLISYVKDGSEFVKEIRKNRRMGLISNEVNVYYNAKINEVHVNADNGRVRKPYIIVSNGKSLYTPELKEKLKKGEIDFNYLVHHGVIEYLDAEEEENIYCALSEKDITEDTTHLEIEPSIMFGVTVSSSVFPEFNNVGRHPIAWNFMKQSQGFYATNFNYRYDARAFLMYYPQEPLVTSSAYRSLNLSKHPAGQNFVVALSTYYGYNIKDALVLNKASVNRGLGRSVFFRTYSDEEIRYPGGQQDKFVIPPATSEGYRGEHVYAKLGEDGIVEPEVDVEEGDVIIGKVSPPRFLEEQTSYGVSEERVRDNSAELRSGESGVVDSVLLSESPGATKIVKVRIRGIKTPEAGDKFASRQSQKGVTALLVPQEDMPFTKDGIIPDLLLNPNSLPNRMTYGHMLEMLAGKAGSLEGKKFDGTAFSANGSDLVKEYGRILQSHGFEEYGDEEFYDGRTGKKFDAKLFTGVVYFQRLWHMVSLKIQVRSRGPVQILTRQPTEGKPRKGGLKFGEMEREAIIGYGASLVLKERMLDQSDKAPVWICKSCGDLGYFDYIKNTAVCPTCGSSDLEEVEISYAFKLLIDELKSMHILPRIKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM91</accession>
    <name>A0A218NM91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit Rpo1N</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit A'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpo1N</name>
        <name evidence="13" type="synonym">rpoA1</name>
        <name evidence="16" type="ORF">Mia14_0239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds at least 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819737.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM91"/>
    <dbReference type="GeneID" id="33313797"/>
    <dbReference type="KEGG" id="marh:Mia14_0239"/>
    <dbReference type="OrthoDB" id="371812at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00863">
        <property type="entry name" value="RNApol_arch_Rpo1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012758">
        <property type="entry name" value="RPO1N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02390">
        <property type="entry name" value="RNA_pol_rpoA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="202"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="840" mass="94843" checksum="BC618D9A7F58E593" modified="2017-09-27" version="1">MQAEIIDSIKFTTLSPDTIKKMSVAKLIVADTYNEDGYPIDGGLMDQRLGVIDPGLKCKTCGGRAKSCMGHFGHIELVRPVIHPEFARFIYMLLQSTCEKCNRVMLSKELADDVRSALKEINLNADEQKEELLFNDIVKKLKTLKKCPYCGSDQHKRKFERPTFFYLNGETLKPDTIRDWLANIPDEDLVSIGIDPNATRPEWLILSVLLVPPVNVRPSITLESGERSEDDLTHKLVEIMRINERLSQDIDAGAPQIIIDDLWELLQYHVTTYFNNETPGVPVARHRSTKPLKTLAQRLKGKEGRLRYNLSGKRVNFSARSVISSDASLTINQVGVPMKIASVMTIPLYVTKWNIEAAKKFILNPDYPKALNVISKGGIRKRVTETNREDLVASLEPGDVVERQLMDNDLVLFNRQPTLHRLSIMAHRVKVMPGKTFRIQVSAAYPYNADYDGDEMNLHVPQTLEAQAEAMYMMQPKNLMLSARHGQPVFYAEEDEIAGAYFLTKGDTYYTKDEAALMLAYIGIFDLPDESEKGLYNGKDIISMLFPKDFNFTGNNMKGQVIIKNGKLIEGILDARMIGEKGSTLISKLFIDYGPDFIERFILNLTKISLRAIYKRGLTVSVKDYIVSNEMISERDRIIKEVEDKANKITEEYNDRTLESLPGYTRKQTMTTLLFAQLSEARDIAGKYLNRTMNTTNNAFLLASIGARGSIMNVIQMSMLLGQQSVRGKRPSRGYSGRVLPYFRKNDKDPRAKGFVTSCFFEGLTPTDFFEHAMGARDSAATKSLVTAVSGYMYRRLVNAMMDFYISEDKSVRGSGMELIQPLYGGDGIDPMYVNVEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM92</accession>
    <name>A0A218NM92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class III signal peptide-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819750.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM92"/>
    <dbReference type="GeneID" id="33313814"/>
    <dbReference type="KEGG" id="marh:Mia14_0256"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13982" checksum="1F2395A388E3C7AB" modified="2017-09-27" version="1">MDKHAQISLEFLIYLAISAISLLFILSIYIEGTSELNSSVNNAYLGSFVSAINSNMNYYESNVQLYVPKSICNCTSSNEYLSCAYEKFKLYGNLSITKEICLNSGSIETMDLYYSNGKYMLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM95</accession>
    <name>A0A218NM95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class III signal peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819749.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM95"/>
    <dbReference type="GeneID" id="33313813"/>
    <dbReference type="KEGG" id="marh:Mia14_0255"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8735" checksum="7651E1F20F8A4C9F" modified="2017-09-27" version="1">MKQYLNKIRKRFEMAGSKKGQGSIEYLLMLSAVSIIIVIALAMIVQLKGDAIGIFYNSSTNQSLANEIGREIANISSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA5</accession>
    <name>A0A218NMA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819756.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA5"/>
    <dbReference type="GeneID" id="33313821"/>
    <dbReference type="KEGG" id="marh:Mia14_0264"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="328" mass="38205" checksum="FC6B2C2451B68A1F" modified="2017-09-27" version="1">MKYMFVNQNNDKSDCKNGSFNSTSNRQILDTIYKKDKKFINSCYLDILEKSFEGDIRITKSSDYLFEISKKFVNQAIDSTYKIFTKAFPDFAHYNKGQIAVEKFDYKGLRYKDGEYEASGIYKNGTICINMDYLIKDEVIAIKRLAKKYKSKEEFIEALKSNNTWGNNLMKSLLYLYSTTCHEVFHHLQYVYVSPNIDEKDNPKSNWLYIEGSASYFDNFMMHLLINGPDTIIDNLKYSAAQDLYKIAKNLDGLKNPKAKDKYGNHHLGSALFSIISCRLDFDIVEYLKFLKILSSKRKLSDNNLISLIEKEYGPEFDKMLNVAKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB9</accession>
    <name>A0A218NMB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819777.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB9"/>
    <dbReference type="GeneID" id="33313842"/>
    <dbReference type="KEGG" id="marh:Mia14_0285"/>
    <dbReference type="OrthoDB" id="386904at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="178" mass="19547" checksum="2F5ECBF1160B2B43" modified="2017-09-27" version="1">MVQRARRKENSSKRLKRRLTPAVLAGATLAILVLLLEYFRIDLLYGIGTSAIIFTSFASSIFIMFITPNSRAAKAGKFVKSYLLAAIVGYIGGFATIILPLFVVAGIVIFVLIVLMILTYSEHPPAAAIAFAFVLSHIGLAGIAIIIIGIAIVLALRFFLEKSIFEFERKIEKIEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD6</accession>
    <name>A0A218NMD6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819785.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD6"/>
    <dbReference type="GeneID" id="33313850"/>
    <dbReference type="KEGG" id="marh:Mia14_0293"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="94" mass="10397" checksum="044F594AA3EE6364" modified="2017-09-27" version="1">MKQRDLPSNRKASFIWILVSAIPFDIGSVIAILWVLSSTNKNKAYSLLYLIPVIGPIISYVLTESKDEYLSSMAGWVFLGQILGGIILEVLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME2</accession>
    <name>A0A218NME2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819806.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME2"/>
    <dbReference type="GeneID" id="33313873"/>
    <dbReference type="KEGG" id="marh:Mia14_0315"/>
    <dbReference type="OrthoDB" id="31096at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13189">
        <property type="entry name" value="Cytidylate_kin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="200" mass="22681" checksum="42E9C5285E6F35AD" modified="2017-09-27" version="1">MYDKTIIIFGFSGSGKSTSANEVGKTLKLRVVHPSSILRNIIEKKEVDTKHTTHNEGFWESREGMKMFMDRLNEKVPPDVISDRIILREAEKGNVVIDSWSLPWIARKGIKIYLKADITTRAKRVAARDGISYESALNAVRIKDKETRRLFKKVYGFDIKMDLKVFDSIISTDGKSRKEVIGEIINVIGINKVSGKSHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME9</accession>
    <name>A0A218NME9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819798.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME9"/>
    <dbReference type="GeneID" id="33313865"/>
    <dbReference type="KEGG" id="marh:Mia14_0307"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="26576" checksum="874E32B091E25055" modified="2017-09-27" version="1">MNYKEMIKKLKELDHPVFTTEDISNLTGKSGDYTKVYLFGLVKKKIIGKIERGKYYIISTSPYVIASRITKSSYITLISAAHIYNITTQIPNIIYVFSPTYHKPIKIIDNYKVKFIKVDKRIIYGYHKYNGVYLAEPEKLFIDDIYYHKSLFYDEELKEAIDKGILDINKIQEYIKRIKSERIREREYTILEARLDGHFVKRIADRRYVKNLSNNSIIRHKKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH4</accession>
    <name>A0A218NMH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neprilysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819827.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH4"/>
    <dbReference type="GeneID" id="33313896"/>
    <dbReference type="KEGG" id="marh:Mia14_0339"/>
    <dbReference type="OrthoDB" id="115724at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="446"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="650" mass="74897" checksum="B158DB3BBE7FD990" modified="2017-09-27" version="1">MPKNIGFSIKDMDLSVDPFEDFYKYSAGSWIKSHPLPKDKIRIDSFYELHDRNQLILKEITESCAYGKARYKNAKIIRDFYLSYIDDKTVEGLKFKPISSIMDKIASMSSKSQLPEIVASIIPFGAMPFFDINSSPDDRNSSVYALYLWQGGITLPERDYYLSKNFSAILEKYKEHIEEMFRIYGKAYKSPELSAKAVLKLETSLAKASRSSADTRDAIKNYNKASVKEVSSKYANFNIIKMFKSLGVNKIPYFVLGQPEFFTAFDKMVKESSLDDIKAYLQWNVLHASAPLLHKKVKDESFRFFNKELLGQKKRSPKWKRALSLIESLIGEALGEVYVKDNFTDRSRKEAERLFKDIKQSFRARIQKVDWMSNQTKSKAIDKLDSINAKIGYPIKFRDYSKLKTSPKDLFGNKMNAYMLEFNRDMSRIGKEVDKNEWLMNAYEVNAYYDQSKNEIVLPAGIFQPPFFDYKKDFAINYGAIGGVIGHELTHGFDDQGSKYDKFGNINEWWTKADRKNFGERAGKIVELYDSLEIMPNVKLDGRLTLGENIADLGGISIAYDALKSRMKEAMPYKAGGFNREQLFFISWSQLWKGNTSEGALKMLSKVDPHSPDKFRGTVPPVTHPEFPGTFKQKSKLKKPKYKFKYVNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH6</accession>
    <name>A0A218NMH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type Na(+),H(+)-transporting-ATP synthase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819845.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH6"/>
    <dbReference type="GeneID" id="33313915"/>
    <dbReference type="KEGG" id="marh:Mia14_0358"/>
    <dbReference type="OrthoDB" id="24971at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="116" mass="12861" checksum="AF199D59E8C13687" modified="2017-09-27" version="1">MQLEKIAVLGERKIALGFELVGIKDVFISEDPKGMHDKLFEIINGKAYNLILASDSVEKYLGEDELRSIETMMKPVVIFIPVSSDVENKESVEKLAKRILGIDLSNLKNSPAGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI2</accession>
    <name>A0A218NMI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable thymidylate kinase</fullName>
            <ecNumber evidence="8">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tmk</name>
        <name evidence="10" type="ORF">Mia14_0336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891426.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI2"/>
    <dbReference type="GeneID" id="33313894"/>
    <dbReference type="KEGG" id="marh:Mia14_0336"/>
    <dbReference type="OrthoDB" id="43083at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF4">
        <property type="entry name" value="UMP-CMP KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="192" mass="21257" checksum="F61BBAD74A02B430" modified="2017-09-27" version="1">MFIVIEGVDGAGKTTQVNILKGKVVGGKSVRTTKEPTDGKIGKLIRELLSGKNLDNLKMQLLFAADREEHLNSLIKDSIDSNEILVSDRYIFSSLSYGIASGLDAQWLIGVNSQFPVPDMTIIIDLEPDVSLSRISARDSKEAFENIKFLTEVRKAYKFLAGKYSNCFIIDGSKSIDEVQQTIIELINTNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI4</accession>
    <name>A0A218NMI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819839.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI4"/>
    <dbReference type="GeneID" id="33313909"/>
    <dbReference type="KEGG" id="marh:Mia14_0352"/>
    <dbReference type="OrthoDB" id="11767at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="338" mass="39884" checksum="2D41F9D598813BB5" modified="2017-09-27" version="1">MNKEEIKIMSYLSDNFGNGGSILEMSKDINRKYGPAYYSNIYSTAKKLERKGIINIERQGNSRLIKLNIENPLSNYYISEVENYKNQKISTSKELLDSILSLTQEFDILSICSLGLEKYQKINRLELLILTRNHDENSNLIKSLLKVESDYNIKIDPIIFTIDEFIKTMKSDELDLIKDLLLDKNILYNSNGFWELIKLYKIDTKYKKFNKFLQDLTRDELAYNYNRFGYQLNEDIKPNKKIAIEPIIFSMSINKETRINYGAILLLYKDIGKINLAYLYYIYKRYDSLGKLKGILLSLVNLINEPYNNEIEYYIGLIPDKPYIYDSKLIKRYIELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI6</accession>
    <name>A0A218NMI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDGSH-type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819854.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI6"/>
    <dbReference type="GeneID" id="33313924"/>
    <dbReference type="KEGG" id="marh:Mia14_0367"/>
    <dbReference type="OrthoDB" id="5781at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="106" mass="12232" checksum="C66E4A10BDC6E17C" modified="2017-09-27" version="1">MRFIRHDRNHPYVLKLKDLPFIQTLLGNPKDDAEKEKFEKIGSYSIYLCACGLSKNKPFCDGHHAKTMQEKPEPAYIYDNDGNVVTTLEKLLDSSGKELNLPKEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI9</accession>
    <name>A0A218NMI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type Na(+),H(+)-transporting-ATP synthase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819850.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI9"/>
    <dbReference type="GeneID" id="33313920"/>
    <dbReference type="KEGG" id="marh:Mia14_0363"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="121" mass="12909" checksum="F1AD2E35937E3207" modified="2017-09-27" version="1">MSEKDSSSSAKGVQQDAADLKVLSDIKKAGDDADASIAKAKADAAKRVEDAQKSAEEEIAKSKESAMESYSSAIAKAKDESKESYDVAIREAQEKAAKISSIDKDKAMGVFEKIMKELFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ6</accession>
    <name>A0A218NMJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">A-type ATP synthase subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpB</name>
        <name evidence="12" type="ORF">Mia14_0360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The B chain is a regulatory subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819847.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ6"/>
    <dbReference type="GeneID" id="33313917"/>
    <dbReference type="KEGG" id="marh:Mia14_0360"/>
    <dbReference type="OrthoDB" id="32941at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="9">
        <location>
            <begin position="132"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="11">
        <location>
            <begin position="356"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="459" mass="51153" checksum="C79A76DBA4BB9421" modified="2017-09-27" version="1">MENVYYKTVKQVTNVLLFVEGIKDAAYNEIVEITLENGSVVRGQVLDTKDGIAVIQSFGDTTGMNLGNTKVKFTGRTAKLKVSTDMIGRIFNGMGRVRDGGPEIYSDEEADINGSAINPYARDEPSEFIQTGISTIDGMNTLVRGQKLPIFSGSGLPHNRLAAQIARQAKLLGSDEGFSVVFGGIGLNSEEANFFMNEFRNTGALDKSIVFLNLASEPSMERLMLPRMALTAAEYLAYKHDMHVLVILTDMTNYCEALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGKIRDKKGSITQIPILTMPGDDITNPIPDLTGYITEGQIVLSRDLYRKGLYPAVDVLLSLSRLRNQGIGKGKTREDHSNVADQMFAAYAHGKDIRNLTEIVGEEALSDADKEYLHFADLFESKFVKQEYYDDRSIDQTLGIGWDILSNIDKSEMKRIKDAYIEKYGKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK9</accession>
    <name>A0A218NMK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891428.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK9"/>
    <dbReference type="GeneID" id="33313922"/>
    <dbReference type="KEGG" id="marh:Mia14_0365"/>
    <dbReference type="OrthoDB" id="372251at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833">
        <property type="entry name" value="URIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833:SF4">
        <property type="entry name" value="URIDYLATE KINASE PUMPKIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="10">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="216" mass="23968" checksum="424C86106AB4F75C" modified="2017-09-27" version="1">MSTLDNSRNFVISLGGSYLFSDYKHLIDLKKIINHSGRRFAIVVGGGKLARDYIEFGREIGINDTGLHRIGIRSTEINAYIISIFLKAKLYVGDPRKIKLDSKSIATGGYKPGWTTDVGAAYAAVATGSPVVFNISKEKGVYNKDPSKFKDARMLKKMGFKELYKLTGGRRMPGMNYIFDPEAAKICEKNNIEVVVTNDLNDLSRYPDNVKGTIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN1</accession>
    <name>A0A218NMN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN1"/>
    <dbReference type="KEGG" id="marh:Mia14_0422"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46603" checksum="CF29DC6E8CE624E9" modified="2017-09-27" version="1">MFCMKTAYKYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYNETGKTLTEFRMNVWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKKQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKIGRINFVNHRNIEGGIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPKVGIDLGIMQYAALSENTILQNAKITKHQRKHSRVLQQNISRKEKGSSNRRKAVTRFARYSEHISRIRLDCIHKLSNELVNSYSFIAYEDLEINNMVKNHRYAKSISESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSMSISQRIFVCEKCGMSMDRDVNAAQNILKRALDSISPTTEGHSGSQACRDDIRTSAGKAVAYEAGTIRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN5</accession>
    <name>A0A218NMN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216875.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN5"/>
    <dbReference type="GeneID" id="33313956"/>
    <dbReference type="KEGG" id="marh:Mia14_0400"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="67" mass="7376" checksum="BBAE24BD2D4DDE34" modified="2017-09-27" version="1">MVVLWNQQEAVKVIALGNGVTASEIINRILNNNREIKMIKSAIKIEAESESGVFAVPGPKSKLRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ5</accession>
    <name>A0A218NMQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0437</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819946.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ5"/>
    <dbReference type="GeneID" id="33313992"/>
    <dbReference type="KEGG" id="marh:Mia14_0437"/>
    <dbReference type="OrthoDB" id="23397at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="346"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="698" mass="78201" checksum="1E1671E423E66C79" modified="2017-09-27" version="1">MIQEMHINLNSGAKAPIDLVGGKGSSLLKLSSKFMVPKGFIITTFAFDAFIQENGINKLLIIDDKSTHLNLGKVRSRCKTSKLPKVLLRDIKKLLKENGISNVPLIIRSSATIEDSGKASFAGRFRTVINVKGMRNIENAIKEVYASAFTKDVLSYFNGIDKGIERIKMAIVIQELIIGEVSGVMFTRDPNTSDEKTLIEAVVGLNEGLVSGKITPSKFVYDNNRYTVENAEYIKQPNAFAIKKAGIRIIENSRDIRDFLNSKKIKEIGQLGQKIAEIFGAPQDIEWTMSDGKIYILQSRPITTYKSIYVDQTQVSNATDVFKGYAASKGVAKGKVKLVKSPRDWIPKGSILVADVLETDYPIDTIKKASAIITEDGGILSHAAIVARELRIPCVISVKNAMKSLKDGDYVVVDGSAGVVYKGENSSMAFDTVRSIDYSFIYDFSRMSKLGGTGAYYEEFDKLIIYYAEKEIRTSELESNLKGGFKGKKIIFGSGPKYFIYKMFLLNNKDPEMYKLSIGAIKASNSFNAKKFDSFSDILLAEAEHYLEDSKKFSNNKTTTGKRKALLNLMRAGWCYTLLNSIMCEGYAITAIYKRLQYTFKGNESEILDFLSDLDSGEAYENDKLGLRQKSRLEKVKEFYAAVRKWRLNSYPMFKDRGATGELYYKKLNKLIEELSKPKETMDKVREEAIAFSNPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR7</accession>
    <name>A0A218NMR7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CoB--CoM heterodisulfide reductase iron-sulfur subunit A</fullName>
            <ecNumber evidence="6">1.8.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HdrA family.</text>
    </comment>
    <dbReference type="EC" id="1.8.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819933.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR7"/>
    <dbReference type="GeneID" id="33313983"/>
    <dbReference type="KEGG" id="marh:Mia14_0428"/>
    <dbReference type="OrthoDB" id="168847at2157"/>
    <dbReference type="UniPathway" id="UPA00647">
        <property type="reaction ID" value="UER00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498:SF1">
        <property type="entry name" value="COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="438" mass="47683" checksum="B6DAFC8BF35605B3" modified="2017-09-27" version="1">MDSYDLVIVGGGPAGLGAALAGAKNGLKTAIIERNPMLGGNWTHSYVVSILGVYTYDGSEKIVGGIVDEIVETLKGFGGTKGKVGNFIPFRPDEMKLAVSHLADKYGISTYFNSLVIGCKLSGNRITSVTVVGKDGTHEVSGKEFVDSSGDADLSYYTASNAMEGKEGEGWHQEATIPFRIANVNEAELINFSKEHPELISAPLIEGKVSKIHINPPLVEKAKKENKLYLPNENTEFLFNTSREGEFICNATHAKIKDYKSGQEVAKAINDLRHQVASDFEFLKKNIAGFENSYLMDSSPGIGMRETRRGIGEYVLKRDDVLNGGRFEDHIARCGHPLEIHDPNKGLVYIHLNKGDSSWYEIPYRSIVQKGIDNLFIIGRCLSAEFDAQASARVSGTALAMGHAAGVAAKMCIRDNTPAKEVNVKELQQTLKEQGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS3</accession>
    <name>A0A218NMS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819942.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS3"/>
    <dbReference type="GeneID" id="33313988"/>
    <dbReference type="KEGG" id="marh:Mia14_0433"/>
    <dbReference type="OrthoDB" id="9194at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="169" mass="18764" checksum="9B0E62507B6610BD" modified="2017-09-27" version="1">MGKALLVIDMQEGFRHKASEAIIDKIAELVKGFDGKVVFTLFVDEPGSMFDTELHWPKFQSKDMQKLLKELEPVAKGKLEAEHKGYTVLTDGLSRMLKENGIDTVYLSGVYTDVCVVKATMDLFDKGFKTKVVADACASLHGDNNHKYAIDSLKHIIGRGNVIETSEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-11-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS8</accession>
    <name>A0A218NMS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VapB antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS8"/>
    <dbReference type="KEGG" id="marh:Mia14_0439"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="88" mass="10292" checksum="B6C0ED6EF278423D" modified="2017-09-27" version="1">MKLRFLIRLNKTKVYTDIDMYIFGVSMAKQIMVSNEVYRLLSKNKKNKSFSDVIKMLLKSKEQKRPKASSLAGLLKNDKKLLKLKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT4</accession>
    <name>A0A218NMT4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein Mia14_0446</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819961.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT4"/>
    <dbReference type="GeneID" id="33314001"/>
    <dbReference type="KEGG" id="marh:Mia14_0446"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="78" mass="8613" checksum="5E615B100145BB20" modified="2017-09-27" version="1">MKILVSVIPNSRKSEVIKISDSSFKVKVDAPPVEGKANSRLITILSDYFNVPKSSITIVKGSLSKRKVIEIDDNILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT8</accession>
    <name>A0A218NMT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820031.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT8"/>
    <dbReference type="GeneID" id="33314042"/>
    <dbReference type="KEGG" id="marh:Mia14_0484"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="238" mass="28421" checksum="CA884B7F72DA41EC" modified="2017-09-27" version="1">MEKYKTIKDKFKKEISELRENNKDFILTMDFENNKLINFEMSYKPKHNQKFDLLRHNLGLGFDRFEYKLQDKHNAEYGVISPYSMAKKKHEYWYIFPEYEGFKVKIKKIDDKIINDGQFDTLLFASNTHIRLHLLSSTIRKGNVNPNNVPAYEFFRKTIKDVNKYLSYNGISPNKLTIEIESFPVPSDYYKSINGELRKEVIGFMTGRFPELIVIRKLDKKKFGVKNLLRKEKKEKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU7</accession>
    <name>A0A218NMU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NifX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820049.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU7"/>
    <dbReference type="GeneID" id="33314052"/>
    <dbReference type="KEGG" id="marh:Mia14_0494"/>
    <dbReference type="OrthoDB" id="55683at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="Nitrogenase accessory factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="115" mass="12694" checksum="A81B5B715E0CAFD0" modified="2017-09-27" version="1">MKIAIAHDKDKNIVPLQDAESIAIYNDEDHSIEEHDNEGFGSKEATMGSILRLEPDAVAVKEGILCPGSYMMSQGMIKYLVVKGNTVDDVVAEKGQDSELTEWLDESMYAEGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV2</accession>
    <name>A0A218NMV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tricorn core peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820002.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV2"/>
    <dbReference type="GeneID" id="33314026"/>
    <dbReference type="KEGG" id="marh:Mia14_0471"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07562">
        <property type="entry name" value="Peptidase_S41_TRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060:SF22">
        <property type="entry name" value="CARBOXYL-TERMINAL-PROCESSING PEPTIDASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32060">
        <property type="entry name" value="TAIL-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tail specific protease" evidence="1">
        <location>
            <begin position="167"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="404" mass="46582" checksum="9F060C377B84C38B" modified="2017-09-27" version="1">MAKSKTALSEIPLKERIKIFSKTLYAIDRYFGHWEGVSFKDTDELYDRYINKVIEAKDRHRLFMAMSKLIADLNNGHSMYFDDILGSKHIGFLAFYHDRLRKWVVHWSVVAGIVPGDTIKSVDGIPVERFYKRLSKHIYGSSERMRRNDLFWPIYFPESFKVGLGNGKAIEVKKRSYPRELLKRKRISHSRIDENIGYLRIKDFCTEDGINSEAEAIKAVKGMMDCESLIIDVRGNNGGSTPRRLMRLLMDREWEGEIFAYTKQNSTKDVIESTYSGKKLKSHEYAYERQEHYKPSANHYKGRLFMLMDHGTISAAENFLMPFKMSKRAVIIGSTTAGTTGEPYPLEFGDIRVTIGAYRCWLPDGSEFEGIGIKPDIVVYPTLKDIRDGKDPVLDKAIRIIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV7</accession>
    <name>A0A218NMV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820065.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV7"/>
    <dbReference type="GeneID" id="33314063"/>
    <dbReference type="KEGG" id="marh:Mia14_0505"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="356" mass="40160" checksum="BCCEE2CE3FDC971F" modified="2017-09-27" version="1">MDKTKDKNFGAERLSSMTGEEFDSKFSKFFMEEKDSLDKNEIGKYKHDGSMNITEGPSKKSVKKLLGMRLMDPVNRPISKLELPSSKGVSLNRSLEALVSSIENAPIVILKEDRLNEAQLTLENNQIFYGNAAKGIIEEAKDINRDILSKIAFGKRYAELSDSEKYGLIINRLFRMHTHGFKMELTVPRFEAYGNLVDLAAKTNPMFISIHENRSLNSPVLDAVIDRFEGRGKIEDFLKALATEFYKELKARNEKPINDRKDKIKSVVNFITGGSLSGGIGAELYLPGNGSDVSIELEKLAADAYYPRFVLVHEGTGDKFPVLYYIAGTVSGEKMIKDILNLAIERKERERKMLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX8</accession>
    <name>A0A218NMX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX8"/>
    <dbReference type="KEGG" id="marh:Mia14_0527"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016645">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008471">
        <property type="entry name" value="MnmC-like_methylTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05430">
        <property type="entry name" value="Methyltransf_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MnmC-like methyltransferase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="290" mass="32741" checksum="ABA9E3E8293AB0EA" modified="2017-09-27" version="1">MVADTIFMETGCCIISGYHIERILKNDDGEFDLSLDLGLTRSKVIKSNNAVELPDGQRIGIELLKKINRRRQLSDCFMIKDSSLLFIYLFDGNSSYKLYEPGIDLSPTLWINGSVMHMISHSIPIEESRMKVNLLGKLHGNVLDTCFGLGYSSIELSKKGADTVHSYEISESSLEIAKVNPWSREAFSNPKIKLDNMDVAKGLRSSKDEEYDFIFHDPPNIKMGGDLYSLDFYKDLFRALKPNGILYHFIGSGREEGKHKSDYVRGAMSRLRMAGFKKIKRSYAGVIASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY6</accession>
    <name>A0A218NMY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891438.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY6"/>
    <dbReference type="GeneID" id="43457931"/>
    <dbReference type="KEGG" id="marh:Mia14_0510"/>
    <dbReference type="OrthoDB" id="377820at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="50" mass="5833" checksum="60CE75E95A2E73C5" modified="2017-09-27" version="1">MGEYDKEFLDYMKEKYGITIEDAAKGPESKIITFAVAWDVWKHAKSIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ3</accession>
    <name>A0A218NMZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820086.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ3"/>
    <dbReference type="GeneID" id="33314077"/>
    <dbReference type="KEGG" id="marh:Mia14_0520"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="342" mass="39292" checksum="08450E213354467B" modified="2017-09-27" version="1">MATKSKNLEVSSNHKDVAEVIERGINKIDTDESLGSTRLVFRDLREKLWPLADKYAKRKEKTSIRIAYEGKKSASLEIKDFKLLDPYLYPHDVYYHSNELYSPYTVRDIELTYGINSYLGIPGGFTQVISQLMFLNNGYNNIRNVTICDINQNQLFLNLVQVVKLDRQPDYVNPLLYVRPNEALKAEDGSYSIYNLPEKINFTLKDQDIREGLREANNGKYFIYSSNAFEIKLDVMSNIKEESQHLECSNDFGWYKWPAGYEVLQAISSNEKIKNGSMYMSASVETTRAVIMEKQKAKMLLYSYSDGSYGNTGIHPSLVLNKDGLSESVKDHPGKRLKSYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ9</accession>
    <name>A0A218NMZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ9"/>
    <dbReference type="KEGG" id="marh:Mia14_0523"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="194" mass="22738" checksum="A884F2E5CA346A21" modified="2017-09-27" version="1">MVILSTKRKEIDKNKDAAKMDTSTFDMEMERSRQLLAECSKFDRAIDDPRLVKLDERFQMYYIDYNSDFDPNMLFVESDNPTDIYTAKANTIIKGINILLKSYSEIDKRDRKKAKEISDQLMEYFNRYPAETELVLLGHKRLKVRGVESTAFLIHINKNAKADNMIKLDINKDYQKVFNEVLQLNADGNFDREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN04</accession>
    <name>A0A218NN04_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820110.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN04"/>
    <dbReference type="GeneID" id="33314090"/>
    <dbReference type="KEGG" id="marh:Mia14_0533"/>
    <dbReference type="OrthoDB" id="44091at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:RNA 2',3'-cyclic 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561:SF1">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="20404" checksum="4EAFEFB1C04ABC6C" modified="2017-09-27" version="1">MRAFISIDIPDEAAGGITEFQSGMRKQLGVSFAAADKLHITMMFFPDLDSNGLASLASNFSMLKFNRFKVSLNGVGLFTPRIPRVLYIGASSEHGEMQQLYKMMHSLALDKGINFDEKRFVPHLTIGRIKGHVNRIKLLNAIKRFEGYDFGSFICSGFSIKESTFVDRSTEYKDLFTKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN13</accession>
    <name>A0A218NN13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820132.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN13"/>
    <dbReference type="GeneID" id="33314103"/>
    <dbReference type="KEGG" id="marh:Mia14_0546"/>
    <dbReference type="OrthoDB" id="33550at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="390" mass="44074" checksum="3BE1F37BC56A41B1" modified="2017-09-27" version="1">MHSIKSDLIEKGFAFPDYGSSNMELAKEVADGHGKLIGGKRKRRFLLFIDGLGYDLLKSAISNSRQLKGISSKMQVDKISTVFPSFTPTVFTSIDSGKTPAEHGIIGSPIPIREYGMMKDMFSIPWSPSVDEVSGKSETISPFPISDNLLKAGRKKDFLYLQSEQVARKNAQTYVYNNINYTGYISFDDFLFQSMDLAESDQYNTIYAYIPEIDHAQHQYAKSSRLGLGITTMMLERLMEKLLPKLKDNGWELLMSSDHGQVSSKNDDIIDLNAKSEVLKYLRSPPWGTDRVMFFDTVEGLSEKFEKEFSRNFSKSFVLYDSSEAIKSGLFGSTKVSDSLRYRFATHIAISKHNKLFHYRYPGGKEWTSELSGHHGGLSKEEMEIPLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN17</accession>
    <name>A0A218NN17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-oxoacid dehydrogenase multienzyme complex, dihydrolipoamide dehydrogenase (E3) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820134.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN17"/>
    <dbReference type="GeneID" id="33314105"/>
    <dbReference type="KEGG" id="marh:Mia14_0548"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="338"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="456" mass="48202" checksum="5C08BDF8031CCEB8" modified="2017-09-27" version="1">MGVVGSLPEEVDVVVIGGGAGGYTAAIRAAELGKSVALVEADKLGGSCLNYTCIPAATMINIADKFQYAKGNKDLGITGSPQIDFKKAHEYRMGVSKKLSSGVESLCKMHGIEVFNAMGSFLSSNSLQLSDGVTLNFKKAIIATGTKLEQPEKLKVDGVKVLDHKSVLSLDYIPKSVAIVNDDYAAIEFSSMFAKLGSKVYVISEKGIFSRIDQELIAVPKKKLADMGVEVYEKDPIKSYSDGKITLESGKEITADIIALSPERVPYTEGLGLDNTKVQLNEKGYIKVDSHLQTTDPNIYASGDIVGQPMSATKALRQGVIAGESASGLNSEFDNVVVPETILSDPEIAVVGKLSGDGIKTIKFPFSASGRAIADDATEGFTKIAYDENGVVKGVGIVGQNADVVIGEATLAIEMSAMLEDIADTIHPHPTMSEGLEEAAEGALGRPIDFYVAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN20</accession>
    <name>A0A218NN20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820144.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN20"/>
    <dbReference type="GeneID" id="33314116"/>
    <dbReference type="KEGG" id="marh:Mia14_0559"/>
    <dbReference type="OrthoDB" id="57526at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="258" mass="31007" checksum="F5DE6C2D49E70393" modified="2017-09-27" version="1">MKTLYVYGTVYNNRDIIEKSISSLYPLTKQFKLYFSIIDNFSSDGTYQWLISNSNKYKNMTFNIKQVKCNRGKGRSLALNQILKVANPNSFTFYIDFDTIYLPRYLDYIIDFVSHKYRNKIGIGHLSLVKYNYKVGWKSLNYGEDVERTAHFRLDGYKIDMIRHEDYSFAINQDRGNSAKEREAHYDKGLRYYIRIFFNAVDMERGWAFPNFHEFYNVSKIKSKSRYIIFMLAYLVANIEGIYRYSKKENNWDFFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN22</accession>
    <name>A0A218NN22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820153.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN22"/>
    <dbReference type="GeneID" id="33314125"/>
    <dbReference type="KEGG" id="marh:Mia14_0569"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="275" mass="31514" checksum="632753783DC73967" modified="2017-09-27" version="1">MDFEKELHEYLIYSYKRAIGISLVVFSLSLLAGSLLMYAIGYVNYNTPSATAVWLSIIIVTIVISIASFVSLKINRMIRLWEKTVGKGSIRRSTLIKMLSLAVFMGIVIVIASVLMLNSYLESLFILLGFGELFWIVYMISSIVMGHKYTEIAFGSMAFIAIFMILVISIRYTEVVYNFGKYYDIALIFPSLAFASSIFGLIVICGIVGFVMLFDSFGRIKGRTRKIIIRHFESAQEKKTKLSINQRSLRNEKRIEKVKPMKSRSKRRNKRNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN30</accession>
    <name>A0A218NN30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820147.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN30"/>
    <dbReference type="GeneID" id="33314119"/>
    <dbReference type="KEGG" id="marh:Mia14_0562"/>
    <dbReference type="OrthoDB" id="26910at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051914">
        <property type="entry name" value="FAD-linked_OxidoTrans_Type4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42934">
        <property type="entry name" value="GLYCOLATE OXIDASE SUBUNIT GLCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42934:SF2">
        <property type="entry name" value="GLYCOLATE OXIDASE SUBUNIT GLCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="475" mass="51938" checksum="01620FC8E47A55AC" modified="2017-09-27" version="1">MVEEKYANFTKGLVGAIGAENVLLDDSKKEPFRHDASDYVGEMPIAVCRPGSTDDVSKVMKLCYDNDIKVVARDSGTGLTGCTVPVKDSIVLDLTRMNKVLEVNLPARYVVTEPYVVLDDLNAQLAKDGFFYPPDPASSKVASVGGSLSTNAGGMRAVSTGVTRTWVLGIEVVLANGKVLQLGSRTVKDNSGYNLTQLIVGSEGTLAIITKAILHITPIPEATFRIGCYFKTDESNGEATQNILKTNLQVISAEFLGESAMAAIKRNRANIPFPEGANAVLMVDIASQKAALDSEVERAKEVLSKSNPVFMEVTTDPAKMADSQIFKVRQDMYYVLHDESQKLHQSLIAGDVTMPTTHLIDAIREINALIDKYKLNMTIFGHIGDGNIHHSIIVDLKNPEEAKKADDVQREISMIAVKYGGSMSAEHGIGYEKKEYLKDELKYRDSLEVLDLFRGIKKAFDPKGMLNPGKIFDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN33</accession>
    <name>A0A218NN33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216888.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN33"/>
    <dbReference type="GeneID" id="33314098"/>
    <dbReference type="KEGG" id="marh:Mia14_0541"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="329" mass="35072" checksum="201F1E17CC05F836" modified="2017-09-27" version="1">MHAKPIILATTVFLISALFLFNFVYAAGYGTSKVSLTQYSVNVSQGGSANIGFTISLFSGSYWGTSLAESPSSKYITFSPSVSNSDPTYNGTLSISVANGAPSGKYKFNISAVGDDPSVSPVVLVVNVLNSTKASNSTNVSRTVTPPVTSTSKPKNYFAYVGILFLVLIIALSGLSLSMKAKFVKAAGYAMGGSILLSLIAAAYLLVFDTLLRVSGMLHYDILIVFFILTIILSYLIYGNRKMRRNALLVLGALSALFVLAMFLDAILGLPLTQVSGSLSYGFNYLFGFGAPNTYSAFGTSFGFSLLLLSVTATSILSLSMYFFENRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN42</accession>
    <name>A0A218NN42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="12"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820152.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN42"/>
    <dbReference type="GeneID" id="33314124"/>
    <dbReference type="KEGG" id="marh:Mia14_0568"/>
    <dbReference type="OrthoDB" id="6188at2157"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050862">
        <property type="entry name" value="RdRp_reductase_class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371:SF1">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371">
        <property type="entry name" value="VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="9 12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="762" mass="84878" checksum="C89524933FE9FB8C" modified="2017-09-27" version="1">MSANKISTKVVKRNGNVVEFDENHIFDAILKAFKSVYPDKSASYTKEHTEEVTKSVVNAISGMKKAKIKVEEIQDIVESKLMGSEPKVAKAYILYRHKHAQVRLFKSSLGIEDDDLKMPLNSLIVLAARYLLKNEDGSLKETPKQLFTRVAKAVASAEKNYGKSDEEVEKIEREFYEDMTHFNFMPNSPTLFNAGTPLGQLSACFVLPIDDSMGGIFDSLKNTALIHQSGGGTGFSFSRIRPENDFVKSTGGVASGPISFMKIFDAATQEIKQGGKRRGANMGILRIDHPDILNFIVAKENEGVLRNFNISVAITDDFMRTLQSGSDYNLINPRTQKVMGKLNSNAVWNLIVTMAWKTGDPGLVFIDRMNSTYSNPVPKYGPIESTNPCGEQPLYPYDSCNLGSINLANMVRREDGKREIDWSKLKHTIQLGTRFLDDVIDANKYPIPEIDRVSRAIRRIGLGVMGWADMLIELGIRYDSNEALILAENVMGFITETARKASEDLAKEKGEFPEFKNSIWYKLGYPPLRNSTVTTIAPTGTISIISGGVSQGIEPIFSVVYMRNVHESLGSDLIEVNNEFENYSIEEGFYSDELMKKIAGKNSIQEVEEIPESIRKIFVTAYDVPPEWHVKMQAAFQKHTDNAVSKTINFPSYATPQDIEKAYLLSYKLGCKGITVYRDKSKSVQVLELVNQQSSKQSSLAESRAKHTAGTSHEVSLDEVKRSAVNYQISGDKETLCPECGTPMIASEGCYTCPNCGYSKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN46</accession>
    <name>A0A218NN46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tricorn interacting prolyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820171.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN46"/>
    <dbReference type="GeneID" id="33314146"/>
    <dbReference type="KEGG" id="marh:Mia14_0592"/>
    <dbReference type="OrthoDB" id="7466at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="235" mass="25766" checksum="904ED6AAFFEB145D" modified="2017-09-27" version="1">MKETIDRMEADTSFGKIFYLHRNGDLPLLFIHGLGAISNNWLPLFDKLDDRFELIALDLLGHGRSAKPNIEYTLDVQCKAIDELLGGIGINDPFAIIGNSYGGEIAASYSINHMAPKYLVLVDSSLAGINSMDSSDIDAFLKKLDAIEPGNDLGIMRNIIMNSEESGVHLDDLKNIDSKTLIIWGSDDPEIDVKYAGMIKNSIEGSSLYLIDKGGHAPMISKPDEVSDIINKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN50</accession>
    <name>A0A218NN50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EMAP domain tRNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN50"/>
    <dbReference type="KEGG" id="marh:Mia14_0581"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02798">
        <property type="entry name" value="tRNA_bind_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000165">
        <property type="entry name" value="Chaperone CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02222">
        <property type="entry name" value="chap_CsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007494">
        <property type="entry name" value="PRK10089.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="TRNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="129" mass="14170" checksum="7478502BDAE107C4" modified="2017-09-27" version="1">MLILDSFKSKSFKFIKCVFMADFSNFSNLDIRVGKILEANEFPEAKVPSYKLKVDFGSGIGIKNSSAHITNYNIKDLEGKRVIGVVNFPPKQVGHFLSEVLILGVMTDSGVKLLSADDIDNLELGSKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN57</accession>
    <name>A0A218NN57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820167.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN57"/>
    <dbReference type="GeneID" id="33314141"/>
    <dbReference type="KEGG" id="marh:Mia14_0586"/>
    <dbReference type="OrthoDB" id="371918at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295:SF18">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33295">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="260"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="443" mass="50750" checksum="92AF614CE862B6C1" modified="2017-09-27" version="1">MDLSRIANQNPWWNDRSAIEKDEKVKTVLDTKGRIDVQLKEENQVLVGPRQLGKTTALKYDIYKKITKEHTDPKHLMYYSFDTSRNFEDISEVMSAFVNATSGKSFLYLDEVSFVDGWQRAVKSFLDSKESSNSILYITGSSSINLKKELMPGRDIKFIEFMPLSFREFLISFGSESLKQFLGKNKATDLKSAIELAERSMAYFEEIGSLFKIYLNTGGYPDAIFDYMTNGYVRDSIYDIHWNAFVSDISKAGKSIEIATAVVYGLVESYSSKVNLSRIAQMQGIKSHVTVREYLEMLDDLFTIKSIFPIAEKKYVFRKDRKVYFDDPFLYNLFAKKLNIIGKNAESKKVEGVIFNSLYRFANKGKQISEPKVKVGFYSGKKEVDFVVNGFGFEAKWQNDVSHRDFPNIDIRNKILLSKGTFKIDNDVDKAKILPASLFLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN59</accession>
    <name>A0A218NN59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN59"/>
    <dbReference type="KEGG" id="marh:Mia14_0603"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46697" checksum="28B0D49BF071E8FA" modified="2017-09-27" version="1">MFCMKTAYEYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYKKTGKTLTEFRMNVWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKRQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKVGRINFVNHRNIEGRIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPKIGIDLGIMQYVALSDNTILQNAKITKHQRKHSRVLQQNISRKEKGSSNRRKAVARFARYSEHISRIRLDCIHKISNELVNSYSFIAYEDLEINNMVKNHRYAKSISESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSMSISQRIFVCEKCGMSMDRDVNAAQNILKRALDSISPTTEGHSGSQACRDDIRPSARGAVAYEAGTTLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN66</accession>
    <name>A0A218NN66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820184.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN66"/>
    <dbReference type="GeneID" id="33314162"/>
    <dbReference type="KEGG" id="marh:Mia14_0608"/>
    <dbReference type="OrthoDB" id="386898at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="205" mass="21816" checksum="941CE13FDB10306B" modified="2017-09-27" version="1">MVSKSEQKREKSIAEYGLAIIFVMIIAVVVVALLALNGFRINNEGNPLAIPSSSSIKTSCTAAKGAICAMPSSYPGGFLATLGQLSNKNWKFATIAFVPNGSVMPNNLSSLYSYPDKSVLAREIVNGIVNNDTEFSDLESGYIMHATFNDSYSIDSDVISYSTIIPNKSGSFVSGSIWAIYTINGSIAKGPFHSIELANAVIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN75</accession>
    <name>A0A218NN75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820193.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN75"/>
    <dbReference type="GeneID" id="33314171"/>
    <dbReference type="KEGG" id="marh:Mia14_0617"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="299" mass="32712" checksum="D8653933AA54487B" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILIIAIVLAALYSIGIFNPNTFAPKASAGSCEVVRPSGPGTTSDLGLEGTCTNMLPKYVSVFNGQNIYANANLSRVFKDEGQPFTITIWRYNEKGTDCEDSELRLTSNGHSLFRAGLSGTGGLDSFPANDEEMFELWNNSGSQYNYFGNKSTNLNTWYFLTFTYNGSYVKAYIDGNPDLNEDFGKTNTGGNIIRFGTDLGTGCNDLFDGMMANVQIYNTALSTGQVEHLYQEGIGGDPIDLTHLVGWWPFNGNANDYSGNDYDGKVSGTIGYSSTWYTAYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN77</accession>
    <name>A0A218NN77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Presenilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN77"/>
    <dbReference type="KEGG" id="marh:Mia14_0612"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010545">
        <property type="entry name" value="SPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06550">
        <property type="entry name" value="SPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="321" mass="36038" checksum="85A04C7D7B21E810" modified="2017-09-27" version="1">MFLSLKLIGTRQFLQIIIMFMIVQFFGLFLVAIQFNGISVSDITAANVVNTPITAIYFVIYIVIATAILLIVLKVYRNIFKLLELFVIFLTGFYFFIELFSPFEVSTTSLYIGMVVAGLLGITLILLKRKWPNLRNSVAIISAIGFGTILGIGFSFEIALAFMAIMAVYDFISVFVTKHMLTLANTAIENNLALLVDSTEVEAVPRSELSAEQLKEYEQNEKEASKKSKTHLFEVFDKQGYAEVPTSSALGTGDMIFPLMVAVSAFKVNYNFILPMFIVMGSIFGMLFTMFLLNRYKRALPAIPPLLFGILIFLLIYLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN86</accession>
    <name>A0A218NN86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nucleotide excision repair helicase XPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Mia14_0634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820202.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN86"/>
    <dbReference type="GeneID" id="33314188"/>
    <dbReference type="KEGG" id="marh:Mia14_0634"/>
    <dbReference type="OrthoDB" id="27512at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="618" mass="69890" checksum="13289FE02B49F9A5" modified="2017-09-27" version="1">MTEFLFRFDEARGSQKEMMKDIYSSLSDGKDILINAPTGIGKTDASLSAAITYAIKNDKDILFLTPKISQHRIAVDVLRGLKQKFNLGISFVDVVGKRNMCINPDVNNIYDSSFYNACENLIKKNQCPYFNKLKHFDLDGDYEMLNSFSEGHNAILSQSYKEGLCPYEVSMRFAKKADIIIAGYSHILNPYTKETFLKKLSHDLSDTIIIWDEAHNIFNSAVSYFSTSISENVINRAAAELAAITSDIDISFLSFELNKLAAKMLSIEKNEAFVDSSDFLSGEKDMLGDIISDMEKAGMMYIENKHAKRSSLMHIASFLQGWESSDAATTRIIARGGGRVELKLSNLYPERALSVFKEAYANVFMSGTLIPLEMYRDILGVEGADTKSYKSPFSKDKQFVAIDSTVSTKFTGRTTDLYRSIASKINGIYSSIPGNTSVFFPSFSMLESTYRYLDLGRISEAFIQRKAMSNIEVERLINEFKASKKGLMLGVMGGSLSEGINYDNNSIKCIVIVGIPLTKPDLELQARINYMNKKFHESGIEYIYTIPAVIRAIQAAGRAIRSESDKASIIFMDSRYEWKNYKMLIKNFFALYEGKDYLERMKQFWSSESIEWKSRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN89</accession>
    <name>A0A218NN89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0622</name>
        <name evidence="3" type="ORF">Mia14_0625</name>
        <name evidence="4" type="ORF">Mia14_0628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820198.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN89"/>
    <dbReference type="GeneID" id="33314182"/>
    <dbReference type="KEGG" id="marh:Mia14_0622"/>
    <dbReference type="KEGG" id="marh:Mia14_0625"/>
    <dbReference type="KEGG" id="marh:Mia14_0628"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635:SF2">
        <property type="entry name" value="LAMG-LIKE JELLYROLL FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="286" mass="30864" checksum="3EC56CCA7F5133D2" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILVIAVVLAALYSLGIFNPSTFAPKASAGSCEVVRPFGPTTTTDVHLEGTCTNMLPKYVASFNGADSGITISSPSEFPASSEPGISIFVWIKTTRSSEGVFEYYSPSNNICEGSVRLEVSPKLQADFSCDAISNGPVLDNNTWNFVGWTLKSGTSKVILYVNGIPYGPYQITPINVPTTGLEGLIGAPYPGWPYYYGSMSNVQLYNTALSSNQITALYDEGIGGDPIDLQNLVGWWPLNGNSNDYSGNNNNGKATNIAYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA0</accession>
    <name>A0A218NNA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0620</name>
        <name evidence="3" type="ORF">Mia14_0623</name>
        <name evidence="4" type="ORF">Mia14_0626</name>
        <name evidence="5" type="ORF">Mia14_0629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820196.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA0"/>
    <dbReference type="GeneID" id="33314183"/>
    <dbReference type="KEGG" id="marh:Mia14_0620"/>
    <dbReference type="KEGG" id="marh:Mia14_0623"/>
    <dbReference type="KEGG" id="marh:Mia14_0626"/>
    <dbReference type="KEGG" id="marh:Mia14_0629"/>
    <dbReference type="OrthoDB" id="91340at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052930">
        <property type="entry name" value="TA_antitoxin_MntA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43852">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43852:SF3">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase beta nucleotidyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="19027" checksum="097764B1E66A3181" modified="2017-09-27" version="1">MNTKVYIDDKLAEKWKELAMKRFGYGRGSISKAAEEALSMWVEKEQIVTTAFEKLKEAAIGEKNILALLLFGSYARKEPYHDIDIAIVIESNADKLKVLSIIESSVPEEPRFDFSIFNDMPMNMKSRVLNECIVIYNRKDYDLKEVSSDIIIKWSDIKPIIDSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB0</accession>
    <name>A0A218NNB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DrugE1 family ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820222.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB0"/>
    <dbReference type="GeneID" id="33314208"/>
    <dbReference type="KEGG" id="marh:Mia14_0655"/>
    <dbReference type="OrthoDB" id="31298at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000589">
        <property type="entry name" value="ABC transporter, ATP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DrrA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DrrA1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="338" mass="38436" checksum="CBE40A4E8C5822E9" modified="2017-09-27" version="1">MKSTDYSIHVSNLVKRYGDFTAVDGISFDVKEGEIFGFLGPNGAGKTTTVHILTTIIDKTSGDAYVSGFDVSKHKDEVRSKIGIVFQDPSIDDRLTGYENLELHAMMYGIDKETRKRRINEMLEMVELSDKANVVMSSYSGGMRRRLEIARGLLNEPKVLFLDEPTVGLDTQTRRHILEYVKKLNEKYHLSVLLTTHYIEEADYLCDRVAIIDHGKIIVCDTPQKLKEGLHGDIVKISLKEEKEVKFLQKNIKKFKNVVSIKVDEADKKIAYLNVKSAASDLPEIIEQAFRSKLSITSIDIRKPSLEDVFIHYTGKSIRDEEANPNERIQAVIRSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB9</accession>
    <name>A0A218NNB9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="11" type="ORF">Mia14_0663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820230.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB9"/>
    <dbReference type="GeneID" id="33314216"/>
    <dbReference type="KEGG" id="marh:Mia14_0663"/>
    <dbReference type="OrthoDB" id="371959at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003217">
        <property type="entry name" value="PRK04183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="GatD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD N-terminal" evidence="10">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="446" mass="49446" checksum="226C1C05349DEF8B" modified="2017-09-27" version="1">MYNGLVKELLDKNGLKIGDFALIEFGNSKEVVKILPNSEFTEKGILVVKLESGYNFGISVDEIDSIEKAEHKEKSDDPSESELQSIELNKDLPQVSIIYTGGTIGSKLDYRTGGVHMLLKPEELIANVPELSNIAMLHPVHLFSIASEDMTYLEWQRIASTVAEEIKGGSRGVVITIGTDTMHYVSSALSFMLKGLNAPVVFTGSQRSSDRGSSDSFMNLICSVRIAAESDIAEVGICMHKDSSDDYCQLIRGTKARKMNTSRRDAFRPINDLPIAHLGIKGEIHYDSDYNKVKSSAEGITIMDKFSDKVALLKVYPNSDPDIINYYKNKGYKGIIIEGTGLGHTSVSGRPEKSYLNNIKEAIDSGMIIGMTSQCLYGRVNSKVYTNLRLLSNAGVVYCEDMTPETAYIKLGWLLGNYNRDEARQLLNKNIAGEIRDRTLYDEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND2</accession>
    <name>A0A218NND2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type III restriction endonuclease/helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820226.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND2"/>
    <dbReference type="GeneID" id="33314212"/>
    <dbReference type="KEGG" id="marh:Mia14_0659"/>
    <dbReference type="OrthoDB" id="6396at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D-like" evidence="2">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="195" mass="22450" checksum="B9CFA754AC7CAA36" modified="2017-09-27" version="1">MGHGESSSYSGNESYRYIDPLVSNDDRYLFIISPFISKNYIKKLVKMSSRKEIKVITSKAAASGEVAKDYIAKSHAKYLIYAAMIFVILSLALYFTKMMLLLSIVVYAAALAIIIYVLIISFNRYPKRRRHIEFKFVEGRFVHEKLYIGEEEAITGSANFTYSGLHKNIEHIEVVHDKKKIKELTDHFYSVWNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE1</accession>
    <name>A0A218NNE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820259.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE1"/>
    <dbReference type="GeneID" id="33314249"/>
    <dbReference type="KEGG" id="marh:Mia14_0697"/>
    <dbReference type="OrthoDB" id="386765at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="339" mass="36095" checksum="4B76C36F4162F09F" modified="2017-09-27" version="1">MLGYTIDIYALSIMIAIGGILLGLGYAFNDLNLKRYGKKELLESLVNGIMIGALILAFGQGGVIYNAMESTVTSVSPAIGCGSMSNNYAICFAYNFLINPAYISIDGRSYPSLIDDSLGLLVPLSTIYTILGIIGSMSFSLGVVSITLHSVMAPLLSVGRDIIEILTFANISIYMQAALLKVIGLISLSLLMPIGIVLRSFYFTRRLGGSIIALTIGLFAVLPMMYLLNAVIISNYSTASAGSMATQSLATATAFEGSIFSDIIGNSAAGIGIASFYSSLSGFAKEMNQFFESIVDALAILIIEVVFLPVLSIIMTIISTRELARILGTEISFGRFDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG2</accession>
    <name>A0A218NNG2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Mia14_0692</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820255.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG2"/>
    <dbReference type="GeneID" id="33314245"/>
    <dbReference type="KEGG" id="marh:Mia14_0692"/>
    <dbReference type="OrthoDB" id="139771at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="229"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="522"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="845" mass="96346" checksum="F7A3C48754CC270F" modified="2017-09-27" version="1">MEFIYDGLSKDILPIKYKISLSTDFNKFAYEGNEKISIEIKSLTDEISIHSYQIKIKSSWIVSGSKKVKASKILYNENSKIAKLKFNQKFSGKCDLLINFEGLNNDKMYGFYRSSYSINGKQEYMLSSQFEPNSARSAFPCFDAPIFKSRFDISLEVDEGYDAISNMPVKSIKHIKSKKRKIVSFETTPKMSTYLVFLGVGKFEYLKGNSGRLKFRVVTTKGKSKDGKFALDCARKSISFYEKYFGFKYPLKKVDLIAVPDFAAGAMENWGAITFREASLLANEKTTPESTKHNVADTVAHELAHQWFGDLVTMKWWDDLWLNESFATFMSYKALENIYPSWKIENDYYDSTISALLSDALKNTHPISTQIKESGEADSIFDVISYNKGGALLNMINDFVGDKVFSKGLNIYLNKYKYKNAKKEDLWDSIQEASVSDPELKGAEIGKILKNWIEQEGYPLLEVKMPKGSIEISQSRFMISGSPKAKQSLWKVPIKYLIDGKESKLILENKSIRVKEGNFKHLLINPNQSGFYIIKYPEEYAKSALSYVEKERLPDLSKAGLLLNFYLLYKSGSIPIDNYLQQIKQAIEIINYPSTKIVLSNLYSIYLTANGKNKSEELRKIMTSISKRAINDVGLNMKKGEPLQNKELRASALMNLVLLKDKKTSSELLKLFKMNENKLDSIDGNIRGAMYINIAINGGEREFKELEKLYKNADSSEKPLIVSAMGSFEKPEMVKDVLNYSISGNIRMQDSYRLVRSAGLIKGNLKIYWDWLKDNWGRLKEIYDPSTLMLGDFVIELSGVSNAKTKSDILKFFNKKGALRQDVEKDFKKTMEMIENNIDLSKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI7</accession>
    <name>A0A218NNI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216901.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI7"/>
    <dbReference type="GeneID" id="33314289"/>
    <dbReference type="KEGG" id="marh:Mia14_0737"/>
    <dbReference type="OrthoDB" id="379481at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="277" mass="31231" checksum="3106235C260A0031" modified="2017-09-27" version="1">MMDETTMIYLALTLVVLLLAFGTIGSIAKGIYYDIAILLIIITAGLIVIISQVDYVMFTMLTSLLGTTIKPANNYMINKKQDSIVKNVNNLYYATGYVTANLFPYVFKNENPPEDEEDRMSQAPELWENIVRSLGFPFKFHVFSIGLNVQASRDELEGKRSYQEFQLSRALQGNANETVITSLQRQIRILQSKIDMISSGEKPIATIMYIETTAVGITDQEALDKLSSQVTAIQVAFSSFDVELRRIVGRELYEIFKFNFALPLTVKDASRLFDQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI8</accession>
    <name>A0A218NNI8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820310.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI8"/>
    <dbReference type="GeneID" id="33314302"/>
    <dbReference type="KEGG" id="marh:Mia14_0750"/>
    <dbReference type="OrthoDB" id="11182at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002096">
        <property type="entry name" value="PRK00939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="101" mass="11176" checksum="D8A140B86266036E" modified="2017-09-27" version="1">MSEICPKCGLPKELCVCDVLDKETETKIKIYKKKAKFNKVMTVIEGIAANSIEETTKDLKRLLACGGTYKGNQIELQGDHREATKKALINIGYKASGIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ6</accession>
    <name>A0A218NNJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ6"/>
    <dbReference type="KEGG" id="marh:Mia14_0725"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="297" mass="34006" checksum="CC9707C4882FCB6A" modified="2017-09-27" version="1">MSKVFTYNKKLVVYLPYDVISGLGIEEGDDVDFFKYKSKYFIFAKKSDITDLLVKTYQNDKQKLGISVGELEVLKKLDTIRYNYRDMENIKSKLSDRDIEILEQLVNKKIVVPLANKEGVRLYSISNDIYNKYLLRNKNLANGGYQEKREQVKEEPASLSDGKTIPVNTGRTFIKQDSKNEIIDESQKFIDELRAKGYIVVETESEATNISIALEDSIRQGLVVGTRSFNKKFYIALKSFIVNNSTKVLPLLKDEAKSISDISKETGIDEDGIRTMLYILSENGEVTELRRDIFKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK3</accession>
    <name>A0A218NNK3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein Mia14_0757</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK3"/>
    <dbReference type="KEGG" id="marh:Mia14_0757"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="Endo_dU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518:SF2">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="Endo_dU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="192" mass="21366" checksum="EACECCE02292A215" modified="2017-09-27" version="1">MLLKWCSTLKQGSRIISIAGGPIRSGKFALLVGIVGEKNTIEGVLSSKIRVNGSDSTHKIIKMISASRFKDEIKIISLNGIAMAGLNVVDLVKVKEELHIHFLVMTRKRPRPNEIANALKAFSSKSGDDVKPKMDRITEFGEYEFYGDKNIYVLSDLPKQSYKQVLDFCIEFQRIAHLVARGISEGESKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL1</accession>
    <name>A0A218NNL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein with KH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL1"/>
    <dbReference type="KEGG" id="marh:Mia14_0745"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="2">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="177" mass="20266" checksum="B5C6F6342D660CFF" modified="2017-09-27" version="1">MVNMQEVYIPAERLKLLKSNHDLLKRLEDTCNCHLKISQGNSIEIEGDAFDEFNAKNILYAFGRGFSIEIAEKLLNDEFYFTFIDLADYAKNKNRRTEIKARLIGNNGRTKKYIEEVSSAYLSIYGDTICFIGKADNIAEAETAAKTLIEGGSHRLAYRRMEAAHKRYRKAPESKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL4</accession>
    <name>A0A218NNL4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="6">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">top6B</name>
        <name evidence="9" type="ORF">Mia14_0744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL4"/>
    <dbReference type="KEGG" id="marh:Mia14_0744"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003218">
        <property type="entry name" value="PRK04184.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase VI subunit B transducer" evidence="8">
        <location>
            <begin position="320"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="541" mass="60489" checksum="0B5779093E46F5DD" modified="2017-09-27" version="1">MIAMPPINNANETVGSADSIFNKFKEHSISEFFKKNKQMLGYSGLAHSMVTIVHEYVTNSLDACEEAGILPEITVSIKDAGENKYWISIEDNGPGIPKKYIGKALATILAGTKFNSYKQQRGQQGIGAAGCTLFSSMTTGKPIHIESTTLNESYACDLSINTIDNTPVVSNMSDINHSGTGLKVEGVFGEIKYERGDRGVYEYLKRTALVNPHCQIAFIDPESEKYIFTRSINAIPKKPKEVKPHPLGLSINDIIEFSQVSQEKKISTFLQNSFTRVSPKKIEELRKVCNIDFDKPPSEINWDDAEMLINAFKKIDWIAPDASSLSILGKSQIKTTVLNILNPEYISVTERKPKVFYGGIPFIIESAIAIGGNAGKKTEDNDYTSNIMRFANKVPLLFDAGSCAITEAVKKVSWKRYDIDLEKQPVSIMVNMSSIYIPYSGVGKESIQQDQSIVNEIKFALMDCAREMHHYLKNKERDKIEMSKYKSIIKYVDHLSSDLAFITDMDRGMIKEKLSTLVESHYIKKKDIEETDSGESGEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL5</accession>
    <name>A0A218NNL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HSP20 family molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891458.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL5"/>
    <dbReference type="GeneID" id="33314327"/>
    <dbReference type="KEGG" id="marh:Mia14_0776"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="221" mass="25188" checksum="E65132C80687B018" modified="2017-09-27" version="1">MPKKKSWSIDLNNPDSLNDLIKTLNEMLKSNPEYLNALKDMIKENPDTLNNIINEFRYLFAAEEEKDINPGLPELKIRVEIKNHDDMDHKDNKHGAVNSSKLTFNNGEANVPDYPHEITLDPYNPTYSNNEPIFDVLSKPKGVSIVADMKNVSSSDINIYVDGSEISFDVDTEKVKFHKEINLPFLISPEKIISTYKNGVLEMEISENERKRPAKAQIKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN5</accession>
    <name>A0A218NNN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VIT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820324.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN5"/>
    <dbReference type="GeneID" id="33314320"/>
    <dbReference type="KEGG" id="marh:Mia14_0768"/>
    <dbReference type="OrthoDB" id="42847at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="309" mass="34731" checksum="CDEDAA9EAA810D34" modified="2017-09-27" version="1">MNEYKKNAFLVKIYKGELMHHYVYSRLSVMETDKELKEILKKLSKTEEQHAELWKEVLDIEHIHLRKTKATPTLALILFLRKIFGLTLLINLIEYGERDLYSKLKYIIKENNFSEKEKKIIGKIEEDERENEKPIEDKILKMSPVLNNIRDIIFGMNDGLVEVTAAVAGLGSALYYANYILLGGFIIALSGTMSMAGGAFLSTEYEKNLNIKKDDNKPKSSAMYVGLAYILGSLFPLSPFIFGINGYFGIAISLIITAIVLSIVASIISIISNKSISKSVTKTLIISMGAATVTIILGYYARVFLHITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP6</accession>
    <name>A0A218NNP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820337.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP6"/>
    <dbReference type="GeneID" id="33314333"/>
    <dbReference type="KEGG" id="marh:Mia14_0782"/>
    <dbReference type="OrthoDB" id="380653at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="154" mass="18181" checksum="333F6CCFF9319E9A" modified="2017-09-27" version="1">MTERVYSVDKEEVESLSKLLSYDPYLDNTLIPPIPEQWNKEDYLEKHPEFKQQAEELNKKRAEALEKIKTDKDLNTIFAREQCELKESSYYGFEDDKYYLYIKANEEFLDRAEDMFKRKFKTIKRADAEKGGIVIKRLNEEESNANAGVGFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ0</accession>
    <name>A0A218NNQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820613.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ0"/>
    <dbReference type="GeneID" id="33314365"/>
    <dbReference type="KEGG" id="marh:Mia14_0816"/>
    <dbReference type="OrthoDB" id="146626at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09073">
        <property type="entry name" value="ExoIII_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="253" mass="29135" checksum="5EBACC03AD4B9326" modified="2017-09-27" version="1">MELKIISWNVNGIRSATAKGLTDFIKNEDADILCFQEIKAGESDIPQALRSEGYELFVNPAEKKGYSGTMVMSRIKPLKFQKGIGESRDAEGRVEVLEFEKFYLLNIYFPNSKPMLERLDYKIQFDHELLNYLNDLKKRKGVVACGDFNVAHKDIDIAQPQNNINHAGFTKEEREWMDEVISSGYIDTFRYINGNKIKYSWWSNFASARQRNIGWRIDYFITDTSLKENIKSAEILDQVKGSDHAPVKLTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ6</accession>
    <name>A0A218NNQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820375.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ6"/>
    <dbReference type="GeneID" id="33314366"/>
    <dbReference type="KEGG" id="marh:Mia14_0817"/>
    <dbReference type="OrthoDB" id="18492at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204:SF1">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="246" mass="27047" checksum="6DBCB78F2C136801" modified="2017-09-27" version="1">MILEIKNLHVKIGENEIIKGLNLTIKEGEMHVLMGPNGSGKTTLAKVIMGHPAYKVSEGDILADGKSILNLSTDKRAKLGLFLQFQEPVEIDGVGFVNFLRSSIESISDKPVNVRSMLNDVKSEESELKVNYSLIDKYLNKGFSGGEKKKSEILQMSLLKPKIAILDEPDSGLDVDAIKIVAKNIERVAKETGMGTILITHYNRILSYMNPSFVHIMEKGRIVKSGGMELVSQVEKSGYQGLGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR5</accession>
    <name>A0A218NNR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease III</fullName>
            <ecNumber evidence="11">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nth</name>
        <name evidence="13" type="ORF">Mia14_0810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820368.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR5"/>
    <dbReference type="GeneID" id="33314359"/>
    <dbReference type="KEGG" id="marh:Mia14_0810"/>
    <dbReference type="OrthoDB" id="84708at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359">
        <property type="entry name" value="A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359:SF18">
        <property type="entry name" value="ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="226" mass="25548" checksum="DCF31B8419B2F16D" modified="2017-09-27" version="1">MKVKSRRFIGLVIKRLKAAYPDQMHTQLEYSNKWELLIAVILSAQTTDVSVNKVTKKLFANFPGPEDLLDLKPDDLYPYIRSIGLYRGKSKRLIEAAKMLVSQFDSKVPTNTKDLMKIPGVGRKVANVVLSEGFGINEGIAIDTHCITVSNRLGLANTHNPEVIERVLIKITPKDEWNNISHLFIALGRDTCQARKKICERCVLNDICISSTVKNDTYKNRNIHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS4</accession>
    <name>A0A218NNS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF192 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820380.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS4"/>
    <dbReference type="GeneID" id="33314370"/>
    <dbReference type="KEGG" id="marh:Mia14_0821"/>
    <dbReference type="OrthoDB" id="6763at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="entry name" value="Protein of unknown function DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953:SF1">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="132" mass="15448" checksum="A0F77FC76CA51AFF" modified="2017-09-27" version="1">MLRFLKRFQRYQEKLIAIGDIELNAVIADNFIKRMIGLMYRDSLKENSCMLFIFDSAGKLGIWMYNMKFPIDVLWIDKNMAIIDIKENLQPCRSIFNCDIAYPKANSKYIIELNAGYVKSHDIKLGTKINLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW7</accession>
    <name>A0A218NNW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820423.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW7"/>
    <dbReference type="GeneID" id="33314398"/>
    <dbReference type="KEGG" id="marh:Mia14_0849"/>
    <dbReference type="OrthoDB" id="372285at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="22955" checksum="008670CB42FD4DF7" modified="2017-09-27" version="1">MIKLVIFDLGGVIIDFNEAYYCRYLSERFNVDFKKVIDTFKPLNKSLEKGEIELNDMYSGIKKGLGIKGDVDWNKIFYQKSSLDLNMMNLVNKLSKSYKIAILSNISISRYLLARKLYLYKLHYDRAFLSGYLGMVKPEQNIYKHVINQFNIKPEESIFIDNLKVNTYAAEELGIKAITFVNYDSLLPQLKRYGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW9</accession>
    <name>A0A218NNW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase TruD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891472.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW9"/>
    <dbReference type="GeneID" id="33314442"/>
    <dbReference type="KEGG" id="marh:Mia14_0904"/>
    <dbReference type="OrthoDB" id="1798at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01291">
        <property type="entry name" value="PseudoU_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3160:FF:000001">
        <property type="entry name" value="Probable tRNA pseudouridine synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="163"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="417" mass="46906" checksum="9F824DF4B031B871" modified="2017-09-27" version="1">MISVNKSKSFGKIKTAPEDFQVEEIEKGNKVLEIGKPLSDNPISDGASPSEGDFSVFVLQKTNWNTVQALIKIAKIFRHGKKSVGFAGTKDRNAVSTQMCSIFKVNPSDLLNLHVKDININGAWFSNTPIKMGDLLGNRFTVTVRDLKFADNIEGTDKTLGGLFPNYYGEQRFGMHGDNFDIGFDIIKGDYESAVMKFLTNTTNETNESAIYARKRLLEDRDFKSAFDYYPKYLKYEKMILEYLSKYPENYANSLRKLPRQLLLMFVHSVDSTIFNKELEERVKSNSISPLDSDLVCPKDGFGYPDMQKVMTYEEYKSNKNHDGTDPFIVGNIVGYNTKALNDVETGIMGSLNLDKGEFKIQGIPELACNGNYRVLFAPYNGFSYSINDSKDTAVLKFSLFSGSYATALLNEFLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP12</accession>
    <name>A0A218NP12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216925.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33314482"/>
    <dbReference type="KEGG" id="marh:Mia14_0946"/>
    <dbReference type="OrthoDB" id="387746at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="358"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="437"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="583"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="647"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="723"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="903"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1359"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1777" mass="187475" checksum="BF9449DAAB8EB9C4" modified="2017-09-27" version="1">MHMKEQSAIEMITTYSWAILIIAIVIAIILILIGFKPPSDYLQSECNIDPLLPCVDTLLVYNSTGPMEYTIIFKNDLGRSINISSNGFNLTTTNIGRSTGTNNYLGNCTPEYVTSGGEVMCRVNITGPVKAAVGTSTTTPFNFEYKICSSSSKCGDTVYKTTGYSTQIVAPTGISFLELNFQTYPNIGSISVNGVPYASGTTQFFIKGEYSLFASPPSGYVFYSSNPGWKSSPSSLKIGNPYNQSTNLTIENSGTIYAYYTLPSNIPPPPPKDERYLNMSTFPSTAAKTLTPGAGHDLENYKSSLTISEVNNTGYKFENWTGHGTINYTGTSTSGTVQMYTDIDEQANYDVYLTELASPSTADSSLSPGSGWYVPGSYITLSEVNNTGYKFENWTGYEDSTLSKLQMQVPGQPFTEQANYDVYLNELSYPPSGVKAGTLLQGSGWYDPTSSINISEQTNSGFQFINWTGYEKSTSASFTMTVPSVPFTEQANYYSCLIEVSNPTGGAKSLLPGSGCTYTDGDTITISETNNTGYEFINWTGYEKSTSASFQLVVPGKGFNETANYDVYLTELASPSTADYSLSPGSGWYLPNSSITLSEVNNTGYKFENWTGYEKNSSSSFTMTVPSVPFTEQANYDVYLNELSSPEGGALSLLPGSGWYDPTSSITLSESPNSGYEFINWTGYEKSTSASFTMTVPSVPFTETALYYIYLKVYVNPVGDGTASDAGNLTTNNESNAYPYGTTVNINANAYTKYGFSDWAGVGTGSYTGETNKTSVIIESPIIETANFYTLQSCNNYILSTSDYPTTVHGECYWTGGDLSLYTGGGDSDYSHVYVNGSNGANYLEESGTSTYLQYNTMNSLPLQNYYLSLTDGSGGGSGGNATAKLNNTAPFTLKVHSENSGTATASPGGSTSTIATYYEPDGDSIPISEVENSGYSFTEWTGTGSGSYTGASTSASVTIDSNVTEVANYNVILTLNVNPSGDGTATASPGGSTTSSGAYSVASGDSISLSEDNNTVGYEFVNWTCSGINCYSGTSTSPSFTIGGPTTETANFKLIPETLTIESYPSVGGSTGPSTGTYTYNYGTQVPLSESSNSGYEFTSWTGTGSASYTGTDPSPTITMTSKVTEQANFGVYLTTNTYPSSGGSVSPNSGYYAYDSQVTITESSNPGYTFTGWTCNGDGCSSADSSSITVTMGNPITETANYGIGLTMSISDSNAGSISPSSGSYQELYGSQVTISESTNSGYEFTGWTCSGTNCYGGTDSSYTLTMDNPMTEQANFDVCLTMGVSSGSGSVSPGSECVPYGTNVGISASPSTGYEFTGWTCSGTNCYDGTDSSYTLTMDNPMTEDANFKLIPESFTISTNPSAGGSITNPSGGSGTYTYSYGSTVSFSESPSSGYSFTSWTCTGNDCYGGTDSSATITITGSVTETALYDVCLTMAISPSSSAGSISPGAGTYCDYSTGQGVSISESTGLGYEFTGWSGSGTGSYSGSATSTTIYMDGPITETADYESIPDCNGYSYSTGAYQTSYTGECYWTGGNLNEWVAGGNSGAAHGTLVGLSNGDTYFGQGTNGRCYTFIGIDNLPEQNYEVEFGDGAGGGSCGNAGVEFNTVAPLTVSASGSGSVSPSGTNDYQDGSSPGISESAGYGYYFAGWSCSNINGSGCYSGYNNPAYPTINGNIRETAHFNPNPESDYIYVNKGTGSVSPSGTIGENYGSNVKISATPGGRCGFLDLYAWHFSGWTGSYSSSSNPYTFTQPDYGISEGANFVCNIWGWGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP20</accession>
    <name>A0A218NP20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDCD5 family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820500.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP20"/>
    <dbReference type="GeneID" id="33314469"/>
    <dbReference type="KEGG" id="marh:Mia14_0932"/>
    <dbReference type="OrthoDB" id="377951at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="103" mass="12214" checksum="E45B9E92A6E2BD10" modified="2017-09-27" version="1">MPEENQGQDDNRYYQKAMEKLYRKAQEEEKIKSLMRQLLDPDAYERMMNIKASNGDLYMQFANLLIQLVQANQIKGRISDSQLRSLLERLTSRPDPKINIKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP25</accession>
    <name>A0A218NP25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CARDB domain-containing cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820518.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP25"/>
    <dbReference type="GeneID" id="33314487"/>
    <dbReference type="KEGG" id="marh:Mia14_0951"/>
    <dbReference type="OrthoDB" id="386170at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="585" mass="64222" checksum="7092B06EB68901A5" modified="2017-09-27" version="1">MSDSKSKNKDKKTNEGQKSSIAIWLYAIAIIIAVAIIYVSYSFTQAGSYSVKVEFSPVNYHANTTMYPFNTLSAKLTVINIGTSKLSKLPMLVYVNGNKLHSYVITLPPKSEVNLSISYTFNNSGNYTFEAVADPANLLNLKNRDLSHQSFAVPVAVPEKPDLYVSIPNLNITSTKEFTLYPKGIAFSSIEALNYNISYFKNLFGPAYPAVGNSITDLALLVHIMNGVYANYSSGARISSLWMNGNITAQYLNTLLRKNTLSYSAFNLSGTDGVYFKYSNFTSICTSQNNGWVKVLSVYNASGNYTCRNIISSNYTPKEASVLEASLNSSKALMNYSSGFLYTNSTYTGFSTSINSNSISQMNLFENPYGNFASNISKYNVSLKDSNMTCKGQISSNSSENLELCSYLISPVYQASAFANYSMAESNEVGNRYMLSMYSFTYTNYSSSIVPNAAHLIAALKVNQSVYPWKPSAQSSCQLSNSTLSCRFDSYNQSTSKANFTIKNNGDSPVKITSAACFMPGLEKHYKEDTTINATKEGSISVECSSVLVPLDVAYDNYNLTLNYTENGKPYTISGTAKIAVPYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP33</accession>
    <name>A0A218NP33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820527.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP33"/>
    <dbReference type="GeneID" id="33314496"/>
    <dbReference type="KEGG" id="marh:Mia14_0960"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="489" mass="53849" checksum="1A2CC894117EF78F" modified="2017-09-27" version="1">MDYEESRSFDPKKVLYLIIGIIIIGIGIYFIVTIPTKVTTVPSTTVTTFAPANKTIAVELTDPLSAPPGTSSLVLNYTNFSVLTENGIKENFSAYGSVNLMNLSNYSDVIAVVKIPSNTLIRSVAINIKSGYIVIDNNTYPLNIINGSSQIAVLSFIKNDTGLMIRLNPGVMEFYNATNNQTKFGLEPYGQAFGLTKHYANSTTARIHMHIQINSSIRSEFGNYRPNVTITSTYLAINNSSNETNLRITVRNNNNYPIIIRNVMLYGNMQLEGINYGRISPMMPFNASYKVKPIFVLGANSSTNHTIPQNMTRNNQIIQGLSNFLPKNIASSINVSVYSNLKRYNMSNLSISAEVANAEMFRYQYHNVLNFLVLSNGSLELPFNYQFPYAQKGYVISPHSNETFTYYGSLSPIRGIPSPIIRGAGSASANGSGKGFNVSGNFTMRSRVNGTLIHLPFHNPIIMPIEGEQYKVVVMGENGVFASANVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP38</accession>
    <name>A0A218NP38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP38"/>
    <dbReference type="KEGG" id="marh:Mia14_0959"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="216" mass="24270" checksum="DAE89576638455B6" modified="2017-09-27" version="1">MINLRKADLTTYIRTAVMILIVYLVVIKFNAWVIIVLFALDLASDALDGFFAVSEASKGKISLITYIKSAIGNKKEHKRVVAYKQSVSKIAPYGPRLDIAGDRVTEYALWATFVFLHVLPLFVILIIIVRHSFADAMLASKGTSSKMKSKFTEALFSSNASRFGIQAVKFVTFSYLMLVWILNYPIIIGYILTAILVTYIVIRGISEIYEGFQSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP45</accession>
    <name>A0A218NP45_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820530.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP45"/>
    <dbReference type="GeneID" id="33314499"/>
    <dbReference type="KEGG" id="marh:Mia14_0963"/>
    <dbReference type="OrthoDB" id="314984at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="NCBIfam" id="TIGR01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="248" mass="27729" checksum="2D10CAB09EC6687A" modified="2017-09-27" version="1">MNFSYNGDKNKVAFAGRSDINASYKDLGAVCESIRYKSIPYALKVLNDVINEDKPIRFRKHNKGMGSRHELGGNKGRYPKRCAKIVKNILSSAVANAINKGFDETKLVVIHTSANKNDIIMRTPPKGNLSWGRGMYGYSSLRRSDLEFAKVEIGVANPEDIELSKKAKDLIHLFGKHSERLPADNEKSKKAKPKSKKAKDESKDKEPKTPKLAEEKKEISNEKAVANSTKPNVNNKPIKNTNLGNDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP58</accession>
    <name>A0A218NP58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WHTH transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820509.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP58"/>
    <dbReference type="GeneID" id="33314478"/>
    <dbReference type="KEGG" id="marh:Mia14_0941"/>
    <dbReference type="OrthoDB" id="147738at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="106" mass="12007" checksum="1258BECD4BE6893B" modified="2017-09-27" version="1">MKGDQTLILKDKQSRILLLLLKDGQRDWSIDALSKESNTTYVHTCNFVLECERQNLVVGEKHGKNKIVKLTEKGSKIAESISNIYNLLDYRKEEALDNGKGPESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP59</accession>
    <name>A0A218NP59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820545.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP59"/>
    <dbReference type="GeneID" id="33314518"/>
    <dbReference type="KEGG" id="marh:Mia14_0982"/>
    <dbReference type="OrthoDB" id="372136at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonyl-tRNA synthetase editing" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="137" mass="15748" checksum="2824CB9A185C8FED" modified="2017-09-27" version="1">MKFMMWHVDYFKATPADQGRSTLVGDSSSLDVKNALLFFISFEKSDNDDYVNIIDKAVNEIQSISSQLGVYTLVLNPYAHMFADLTDPGHAIKMLDLLEERLSQRNFKVYKMAFGRFYEIELKAKGHKLSRISRSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP71</accession>
    <name>A0A218NP71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U62 family protease subunit TldE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP71"/>
    <dbReference type="KEGG" id="marh:Mia14_1003"/>
    <dbReference type="OrthoDB" id="84520at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="entry name" value="PmbA/TldD superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43666:SF1">
        <property type="entry name" value="CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43666">
        <property type="entry name" value="TLDD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="Putative modulator of DNA gyrase, PmbA/TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloprotease TldD/E C-terminal" evidence="1">
        <location>
            <begin position="217"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="447" mass="49448" checksum="CB9C7240D02690EE" modified="2017-09-27" version="1">MMPKDILYYSNKLKFDDILVDIVSGEATYLKIANSKIDSVVNDNSTNGSLFLSKSKKLISEDLPDVSDKSVKSTLKKAAKTIGKLSPKNDYYGIAEGPFNYKGRGKPDAKISGFQIKDVVDVAEQIISELDYKDVKDIAGMVTLEKLKDSLMTNKDVNANSSTAYIKVTAHITTKEGFSYQETAAFSKYSEINIKKFCDNLYYTVSQIKTKGKIKSDTYDLIYKPSSASNLLQEVTAAATMSEIENGSFLKGRLEHKVADENVSIIDSGIAKGMISSSCYDDEGYPTKDNSVIENGILKTYLYNWSEAKKHNTESTGNAGLIESEPNTLIFKHKNPKKSLDSLISEIDKGILVTNTWYTRFDNHSTGDFSTVPRDLAIYIEKGEPKFAISQIKGTQTVGIRVNDNIIRMLKNIESASKSPVQAISWDAEEPALVPDILVKDVKVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP74</accession>
    <name>A0A218NP74_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12 13">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="12">APRT</shortName>
            <ecNumber evidence="7 12 13">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">apt</name>
        <name evidence="15" type="ORF">Mia14_0997</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7 12 13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820559.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP74"/>
    <dbReference type="GeneID" id="33314533"/>
    <dbReference type="KEGG" id="marh:Mia14_0997"/>
    <dbReference type="OrthoDB" id="8323at2157"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="NCBIfam" id="TIGR01090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI14265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="173" mass="19267" checksum="23D87A88F8DFAD1E" modified="2017-09-27" version="1">MDAEELKNYIRNVPDFPKSGIMFKDITPLLKDKYAFSASIKLLADHIRNLDYDYIAGIDSRGFIISAALANELNSGLLLIRKKGKLPYHTVSIDYQLEYGSDSLEMHEDSIKKGDKVIIVDDLLATGGTSGAAAKLIEKLGGQVSELTFMIELSDLKGKDKLKDYPIYSLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP87</accession>
    <name>A0A218NP87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA replication complex subunit GINS51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820538.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP87"/>
    <dbReference type="GeneID" id="33314509"/>
    <dbReference type="KEGG" id="marh:Mia14_0973"/>
    <dbReference type="OrthoDB" id="384532at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="188" mass="21253" checksum="C1A00B339DF3AE24" modified="2017-09-27" version="1">MEGKIDYSSIWKLSVQEDQTNELQPLSKDFYDKSISLINQIKDPEMGRSPKANSLKLLNKLFEKRKQKITIYAAYNKPLPNPIPKEEQDLYVELITLLKGVTLNKNPASAEYPYTKEASTERGDAENVIEQPEYLSEAKQVKALQDMPELLLPSGNKVGPANKGDIIKISNENDIKFLISNSLCEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP91</accession>
    <name>A0A218NP91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820568.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP91"/>
    <dbReference type="GeneID" id="33314544"/>
    <dbReference type="KEGG" id="marh:Mia14_1009"/>
    <dbReference type="OrthoDB" id="384502at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22806" checksum="35F8A4BEDEE02DCA" modified="2017-09-27" version="1">MSFVVVDFDGCLVNDVSESFNKYLRSSDSKIENAYKEAIFTVIDNVPFAFSRAAKKIDFKKMLNQNVINGLKELQDKGMEIIVRTANTNLGNDDIKEIEDELQKDGLKVKIERAKDNEKCRLENGEKPSLIIDDNPKVILNAVKNGINSIIILTDYNKIEAKLLSKISKHIIVSDQNKLKDKLKEYDKFSRPLPSRNVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP99</accession>
    <name>A0A218NP99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820550.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP99"/>
    <dbReference type="GeneID" id="33314524"/>
    <dbReference type="KEGG" id="marh:Mia14_0988"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="189" mass="22147" checksum="3F68A5D719DA8D16" modified="2017-09-27" version="1">MLLDLQIFNKIMPKLADETPIVITWIYNTIKTLVPSNKISPLLLILEEPYVYSYTSIEEIKPAFPKPKDPTRTKSKNKIKVIKFGLITKTNFYPLNNKIQAHKEVPKLKDQIPKLFEKNFILYFKRKQNKHDVYYIYFNLKSLEKGKGSNNYIDTILSYFKSKELKKVLDISNDQLEKIKTALAQKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPE0</accession>
    <name>A0A218NPE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_1028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820587.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPE0"/>
    <dbReference type="GeneID" id="33314563"/>
    <dbReference type="KEGG" id="marh:Mia14_1028"/>
    <dbReference type="OrthoDB" id="8297at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="272" mass="30011" checksum="D4F99399FC416E6C" modified="2017-09-27" version="1">MADLIDNSEDKTIPMHPSFAGVFDKKQAIKKKLSSIRYKIGVYSAKGGVGKTTVSVNLAYALKDKGYKVGLLDADIDCPNIPLFLGITDKINATRLPLRTFEKDGIKISSTGMLVGDIEKPIIWRGPIIAKMIDDFLLNTDWGDLDFLIIDLPPGTSDAPLSIMQLLDLTGFVLVTTPQKISGENSVRSGLMAKRLGIPILGIVENMSRDYDARFTNEVSNKLNTDILANIGYDEKFNHFSDSGKVAIESDGKIKDEFYMLADKIIKLYITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL4</accession>
    <name>A0A218NLL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-binding GTPase Rbg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216856.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL4"/>
    <dbReference type="GeneID" id="33313583"/>
    <dbReference type="KEGG" id="marh:Mia14_0021"/>
    <dbReference type="OrthoDB" id="372125at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="364" mass="41004" checksum="2BF24EB10D9A9308" modified="2017-09-27" version="1">METKDKLEEKLEELKDEYAKVKDNKATNKYVGKLRAKIASIKKDIVIASRRRHEKGFFVKKTGDATIVLMGFPSTGKSSLLNDLTKSNSKTAEYAFTTIGIVPGTLNYRDAHLQILDMPGIINDAHLGAGNGLSVIAQMHVADLVAFVVDAQQPSQLKYLINELNALHIYIKEKPEIIIIENKSNGLSIINKSSLRLDHIKEIFNGFGIYNADVRIYSELSEDELIGYVSHSSTYLKAIVVLNKIDLVKDYEKVAKEIKSQYPMKVVTVSALNRIGMDNLKWELYSALDLIRIYIKPRMSDEKSPITLDKGSTAYDVAKMLHSEFADEIKYAYITGPSVKYPNQRVSIKHRLEDGDIVTFVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM1</accession>
    <name>A0A218NLM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819531.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM1"/>
    <dbReference type="GeneID" id="33313577"/>
    <dbReference type="KEGG" id="marh:Mia14_0015"/>
    <dbReference type="OrthoDB" id="11309at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003079">
        <property type="entry name" value="PRK04005.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="113" mass="13295" checksum="604C0B58BEB7AAFB" modified="2017-09-27" version="1">MKINVERDDIKEWLTSTKGEKDHKELWEKINKMVSVTKRKRVTVNLYKLNRYTKEGDNIIVPGKVLSFGKIDHKVNITAIDFSDKAKEQLQKAGSKIYDLNEFKKFKNIIIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM6</accession>
    <name>A0A218NLM6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl30e</name>
        <name evidence="7" type="ORF">Mia14_0030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819545.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM6"/>
    <dbReference type="GeneID" id="33313591"/>
    <dbReference type="KEGG" id="marh:Mia14_0030"/>
    <dbReference type="OrthoDB" id="10759at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="104" mass="10970" checksum="F1624C558A869997" modified="2017-09-27" version="1">MTESTNNIRLAVDTGEAALGLNSVIGSIKNNTAKLIILAKVNDNDILEDIQHMAKVAEISVQLFEGNSMDLGSLCGKPFSVSALSIINPGASDILKGLEKKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM8</accession>
    <name>A0A218NLM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM8"/>
    <dbReference type="KEGG" id="marh:Mia14_0010"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34573:SF1">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34573">
        <property type="entry name" value="VKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="144" mass="15951" checksum="52C42D677A81C7B7" modified="2017-09-27" version="1">MVYMELRQLKYILIILLIVGIVDEIYESYIYFSPKSLVCPDTGIINCGVVLSSSYATVIGIPLAILGLTWVIVALVITLYTKLQRTFVPYLWIAFGALGVAYSIIAQSLIGKICIYCTLLDTIIILSVAILYYILRNQSATSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP4</accession>
    <name>A0A218NLP4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl13</name>
        <name evidence="6" type="ORF">Mia14_0016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819532.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP4"/>
    <dbReference type="GeneID" id="33313578"/>
    <dbReference type="KEGG" id="marh:Mia14_0016"/>
    <dbReference type="OrthoDB" id="7668at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005004">
        <property type="entry name" value="PRK06394.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="145" mass="16403" checksum="D6AA13C31A801E27" modified="2017-09-27" version="1">MEGYKVIDATGLILGRMAGTVAKQLLKGDNVIVVNAEKAIISGHKNDIVEKYRTRLNLQEKGNPEHSPYWSRRSDLLVKRVVRGMLPYSRATGRKVYKNLKVYMGLPEEFKGNEIEKIAMKDPKSLYSGYITIKELSELLGYNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP5</accession>
    <name>A0A218NLP5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="5">PNP</shortName>
            <ecNumber evidence="5">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819554.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP5"/>
    <dbReference type="GeneID" id="33313600"/>
    <dbReference type="KEGG" id="marh:Mia14_0038"/>
    <dbReference type="OrthoDB" id="7681at2157"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000012">
        <property type="entry name" value="Probable 6-oxopurine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="276" mass="30158" checksum="2D9369215EB4457A" modified="2017-09-27" version="1">MAEAIPVHSNAKIAIIGGSGLYSLFEGQTEEVEVQTKYGSPSGKISLGKINGRDIAFLPRHGINHTIPPHKINYRANIEALAQLGVERIISTTAVGSLSVEIEPGAFVFPDQFINSTHRSEETFFDGPQVAHISTADPYCEEIRSIAIDDSDNLGINYIDGATVVTINGPRFSTKAESKMFRSLGGDIINMTQYPEIALAREKAMCYFSIAIVTDYDSGLEGREDINPVTTDDVNRKFAEGIKSLRLLLDSLAKDIPEKRGCSCSHVLDNAFMNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ5</accession>
    <name>A0A218NLQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819559.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ5"/>
    <dbReference type="GeneID" id="33313605"/>
    <dbReference type="KEGG" id="marh:Mia14_0045"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02928">
        <property type="entry name" value="orc1/cdc6 family replication initiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="7">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="405" mass="45870" checksum="CD2E2F7558DB3E08" modified="2017-09-27" version="1">MQTLNDLLAESKIFQNREVLSPHYIPKKLIFREKEINDIEKAIAPSLKGEKGRNLFIYGKTGTGKTTCTKYVINEISTLPNIKTKISYINCRIYNSRYRVLNKIVSDHLPNYAKRGFGTVDLYEKLINWMEEDTKVLVIALDEIDMVKDLDDLIYTLTRINSDIRFGGVSIIGISNNVSFKDDLDPRSLSALYESELVFPSYYANELYAIIKDRVIEGFKENAISDEVLHYIAAAAAKEGGDARFSLNVLSEAGEYAELNNEDSVKMADAEKAIQKAGEDAVYELISTLPYDQKLVLYSIVLIAESGGSYKKLSDGIDTYIFSGEIYSRYKSLAEGLHKTFKSERWYRNYISELETYGLISSFESGKGIRGHTKLIKLIYPSKKIKKVIESDLFSVSDPKSPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR3</accession>
    <name>A0A218NLR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S14p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539379.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR3"/>
    <dbReference type="GeneID" id="33313631"/>
    <dbReference type="KEGG" id="marh:Mia14_0071"/>
    <dbReference type="OrthoDB" id="5615at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="52" mass="6183" checksum="100D4E65F4E25089" modified="2017-09-27" version="1">MKVKEEEKYKGKGIRKCKICGTSRGLIRSHNLYICRRCFREVAKSLNFRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR8</accession>
    <name>A0A218NLR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819576.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR8"/>
    <dbReference type="GeneID" id="33313623"/>
    <dbReference type="KEGG" id="marh:Mia14_0063"/>
    <dbReference type="OrthoDB" id="381941at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="123" mass="14100" checksum="C6EB6751F0E63976" modified="2017-09-27" version="1">MEDKINNSSESKKLDKDYVVNHLVSCFTNANKEMSDALNEKVPDDELNARVKIYLGDVFRKCNVDFKNPTKGGIKKAMEECKSNIINTLGEERGTELVNKYYPEMDSVVERMKDNDSDPEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS6</accession>
    <name>A0A218NLS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SpoU family RNA 2'-O ribose methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819599.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS6"/>
    <dbReference type="GeneID" id="33313647"/>
    <dbReference type="KEGG" id="marh:Mia14_0087"/>
    <dbReference type="OrthoDB" id="372184at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18093">
        <property type="entry name" value="SpoU-like_TrmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF2">
        <property type="entry name" value="TRNA (CYTIDINE_URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="242" mass="27208" checksum="3036269E1380B73D" modified="2017-09-27" version="1">MNAEEAHTACGWKDVTLILVGSEYQINLGYIARAAKNFGISEIRLVNPKCNHLGKQAIRFSKHARELLESAKIYQSLNDAIEGSDFVIGTTAIWHKAEEAKSNIYSLDSFKKNFKSLGNASIIIGRDGTGLTKEELGLCDASIYIPGNKEYQTLNISHAVSIILYELTKGKFDDNLLSTKYANTKDITSVSYLFKEFLKNNHHIRNKPKVASVFMHIIKRSYPTKEEVNTLKSAFTKRKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS8</accession>
    <name>A0A218NLS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819593.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS8"/>
    <dbReference type="GeneID" id="33313640"/>
    <dbReference type="KEGG" id="marh:Mia14_0080"/>
    <dbReference type="OrthoDB" id="18264at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07391">
        <property type="entry name" value="MPP_PF1019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00024">
        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323:SF1">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="249" mass="27756" checksum="5F0A328A7A81FA76" modified="2017-09-27" version="1">MRVTNDIELVDGLPIAYVHSLDSLAVADLHLGYEGVMAKRGILVPKANLKSIEKSIKSAVESTSAKNIIVDGDIKNDFSDVDVEEFNELFELIHFLKDLGLSITLIKGNHDNFVERYKDTFNLKVYRQETLIGKYLFLHGEELPAEDKLIQSSTLIMGHEHPAISIYTEAGAKEKLKCFLYGKYKGKPILVLPAMSYFSGGTDINIVPKNELLSPLFKDIDIDSMEAYPVGYGSTMDFGTVEIIKKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT2</accession>
    <name>A0A218NLT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S ribosomal protein L19e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819588.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT2"/>
    <dbReference type="GeneID" id="33313635"/>
    <dbReference type="KEGG" id="marh:Mia14_0075"/>
    <dbReference type="OrthoDB" id="11624at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="157" mass="17966" checksum="6F041F539E0241B4" modified="2017-09-27" version="1">MSVKLTKRVASSLLKRGKNSIRIKEDAIESATKAITREDVRDMIKKGEVYAKPKKKVQSLYGKLLSKKRKKGRARGPGRKRGTLKARTGDLYMKKVRAQRRIIKKMREDKVIDNEVFKKFYALVKGGSFNSKASLLNHMKGDGVNIDDEMYNKLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT4</accession>
    <name>A0A218NLT4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps24e</name>
        <name evidence="4" type="ORF">Mia14_0083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819595.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT4"/>
    <dbReference type="GeneID" id="33313643"/>
    <dbReference type="KEGG" id="marh:Mia14_0083"/>
    <dbReference type="OrthoDB" id="27533at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="100" mass="11624" checksum="831E8CE19A0A46B8" modified="2017-09-27" version="1">MELKIAKNEDNELFNRKNVTFNVIGYDATPSKEVVKEELCKKINALPDMTVIVNLSQESGMRRLNGMAHVYSNKEDIDKYERDYILKRSEKKNAKKEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT9</accession>
    <name>A0A218NLT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819612.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT9"/>
    <dbReference type="GeneID" id="33313661"/>
    <dbReference type="KEGG" id="marh:Mia14_0101"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="19662" checksum="A3C85874842BD94B" modified="2017-09-27" version="1">MYKRSQAALDFLVSYGIAFLVIAIAIYIIFTSGIFSPSITPTSCTPSPGFECLPSLLSTNGTIIMRILQVTGSTIRINGIACTTLLENATNQIPLYGNINITGPAASPQFYPNGYEIPNGGIEYSDNYTTLEAKCYGGKSSLATGKLGNIFKGYVVLNYTMENSDRPYIKQEVAYLTIKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV1</accession>
    <name>A0A218NLV1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV1"/>
    <dbReference type="KEGG" id="marh:Mia14_0108"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="140" mass="16171" checksum="49807B5A1FE14D1D" modified="2017-09-27" version="1">MDDGGIIIYKCISGSPVFLFLRRAEGWLDMPKGHIEKGETEMQASIRETFEETGIKVESMDPDFSYIDTYTFANGNSEIKKSVMFFMSKVNPAIEVKISKEHVGYEWLGYKEALEKIEFKDEAETIRIAYDYIINKRACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV2</accession>
    <name>A0A218NLV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819615.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV2"/>
    <dbReference type="GeneID" id="33313665"/>
    <dbReference type="KEGG" id="marh:Mia14_0105"/>
    <dbReference type="OrthoDB" id="33505at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="120" mass="13808" checksum="B02A3D31A0F8B766" modified="2017-09-27" version="1">MQLNKSVVKALKQIKKYSRETYNRTILNLDPRDTTQECSSCHYIKRGEEKLTLKDRIYCCNICGLEMDRDINASINILNRATLGQRGSHTQGENVRPQQEAVFEELRTDKTHPLLDAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV9</accession>
    <name>A0A218NLV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMD3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV9"/>
    <dbReference type="KEGG" id="marh:Mia14_0120"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="25771" checksum="8581B6B75697160A" modified="2017-09-27" version="1">MNSKVFFITKYCPKCNRSSDDVRFIGQFCEYCVIDRIGSDLPKEIKIPLCRSCGRIKTHIGFVASSPDSLDDAVRFSIHRPDFEVSLVSYDKATSIAVVQFEKEVEGEPVQFTKDIEIKFTNILCPLCNRERSGYYEAEIQLRGIYSKLSVMEKRILDFVNKNGSFVSQIKEDKNGVNIYIGSRDVANAFFQSNKKLKPIKSYELYGLKAGKRVYRNIYSLRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX0</accession>
    <name>A0A218NLX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819630.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX0"/>
    <dbReference type="GeneID" id="33313683"/>
    <dbReference type="KEGG" id="marh:Mia14_0124"/>
    <dbReference type="OrthoDB" id="10538at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="265" mass="30604" checksum="D8AEC8F47DF5FC83" modified="2017-09-27" version="1">MGILDDIRSSLFGEVIYSHNGGRRIRIVRRYTDIVLLVDDVPFSRIRENSVFVDGYWDFFILLPLLYDNPKSLMIGLGGGTVLYQYYKVFRNPDIEAVDIDKDMITAENRMLDNQIKAKVTLEDGAEFLHNTTNTYDIVILDAYNNYNMPAVFLTEQFLSDAYDKMSENGILAINYIPIEENSKILKLESSKRYNIYMIYMKSSANQILLFSKKLTKRQILVELESKLKRSNSTINSVEIKSYITSAYEHMVGINVNDGRHKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX6</accession>
    <name>A0A218NLX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stress response regulator YchF/OLA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819635.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX6"/>
    <dbReference type="GeneID" id="33313688"/>
    <dbReference type="KEGG" id="marh:Mia14_0129"/>
    <dbReference type="OrthoDB" id="5875at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01669">
        <property type="entry name" value="TGS_MJ1332_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000002">
        <property type="entry name" value="GTP pyrophosphokinase (RelA/SpoT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007171">
        <property type="entry name" value="PRK09602.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="391" mass="43100" checksum="85F8DDF3F9EC5281" modified="2017-09-27" version="1">MLIGIIGAPNKGKSTLFSALTMHDAQVADYPFTTIDPNKGLTYVAVECPEKRLGTKCNPRNSLCVEGTRYVPVNIVDVAGLVEGASEGKGMGNQFLNDLSIADALMLVVDASGRTDSSGNPCSNCNPVDDVNMVNDELHKWLAGIIKKHIKAISRREDGIDALYEILTGMKITRAEIEDTINELKLSSSRINWDDAQIYKFAEKLIEISKPVLVVANKYDLDTATAKANVESLKENFKDVEWCSAVIEYALRKANEKGVIKYSPGMKSFEILNSEISEDQKKALSFMANFIKGEGTHVQDVINYIVFKLLKEIVVYPVEDENKFADHFGNVLPDAILVPEGSTAYDLAMKIHTDIGNNMLYAVDAVKKVRLAKNYVLKDGDIIKIVSAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ4</accession>
    <name>A0A218NLZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L21e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819653.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ4"/>
    <dbReference type="GeneID" id="33313707"/>
    <dbReference type="KEGG" id="marh:Mia14_0148"/>
    <dbReference type="OrthoDB" id="6295at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="94" mass="10716" checksum="97CDB1714670A70B" modified="2017-09-27" version="1">MTKRSGGQFHGKTRNLVRHHKLSTLSIADKIKTFEIGDKVAIVPKSNYRDSPHPRYKGRIGEVIEKRGSAYVVRVRIMNATRKLVVPVVHLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM00</accession>
    <name>A0A218NM00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819667.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM00"/>
    <dbReference type="GeneID" id="33313722"/>
    <dbReference type="KEGG" id="marh:Mia14_0163"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="90" mass="10224" checksum="592C55C9DD190754" modified="2017-09-27" version="1">MSQEELGREFFISIITVLMTIISIIVFIIYGGNYLFYIFISLTIIIGVVNAWMIDKKSNKEELAKGKPSKKEKLPSAKVRNGKKQNPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM21</accession>
    <name>A0A218NM21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA(1-methyladenosine) methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819669.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM21"/>
    <dbReference type="GeneID" id="33313724"/>
    <dbReference type="KEGG" id="marh:Mia14_0165"/>
    <dbReference type="OrthoDB" id="30774at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="212" mass="23760" checksum="A28A41238C942112" modified="2017-09-27" version="1">MSNLIYIPPSYKKLKRGPQVILPKDIGIIIAYSGIDKNSTCVDAGTGSGWLAVSLAKVCKKVTSYELREDFAKIAEKNKVIANVPNLKIKLQDITKGIKEKDIDLVTLDFPGSEKAVRTAHKCLKSGGCIVGYLPNVEQVKKFVTKLNYYKFYEIETFEVIVRDILVRKEGVRPSTKGVWHTAYLTFGRNHAKIKNQATAKPKFIEKQVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM22</accession>
    <name>A0A218NM22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819680.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM22"/>
    <dbReference type="GeneID" id="33313736"/>
    <dbReference type="KEGG" id="marh:Mia14_0178"/>
    <dbReference type="OrthoDB" id="198277at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="152" mass="17689" checksum="B0F7E2F8B529055E" modified="2017-09-27" version="1">MENKKEENRVKLYDPFDVFSGMDRFMRSALWSLHPERYFDIAENGFNIPDADIIDKGDSLQIKLDMPGVDKKNLDLKVKSDRIIVKAEKSENKEIEKKNYYSKERASIGYYREISLPEEVKSETAKAKYENGTLTINVDKSDRAKENSIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM38</accession>
    <name>A0A218NM38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b subunit of the bc complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819692.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM38"/>
    <dbReference type="GeneID" id="33313750"/>
    <dbReference type="KEGG" id="marh:Mia14_0192"/>
    <dbReference type="OrthoDB" id="55795at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="488" mass="55622" checksum="520DB375371DBDCC" modified="2017-09-27" version="1">MPIAESDSSESESGSSIKSEIKSLLKFFYINEVPSYGNNFFFTLGVYLLELFAILAVTGIIMLIFGPYWWDLTTVGAFVRSIHLWAAEAFVTIMFLHLFVQFSTSAYKQKKLVWMIGVVLLLLVLLEYAFGIGLEGGFVSQWNDKAGADLWDGLGLGYWINPLNNGALLGWHVAIVPILLIFLIFTHFMLVKNKGLNKPYKKGIPYTMVPADHKSMYKRMVYIFAIVLVFAILLRSPYVPPLTIQSVAQSNPNIMAITLLSELNQSSHTATYLDTIDPYTFNTSTVYVVSPYDTYINSSYNARNYMAEYLSESPKERSISFSEANSFFSKNWSMQDASQSSDPLIVSIAELVKMAQAGTYQEILQSEETSGLNYTYVIRFLSDTREFQSTASAYGLRTVQWGMLKAGGMWWQVGSYWMAPYDYMEIITSGLPWWNDLENGIVATVALILLLFLPYLPYLRDIPDKLRLYKIFWNRFTIPEMKKIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM39</accession>
    <name>A0A218NM39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM39"/>
    <dbReference type="KEGG" id="marh:Mia14_0206"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="104"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="270" mass="30057" checksum="068684544A9B252D" modified="2017-09-27" version="1">MGLCIMATGDWLGTYLIRYKGVLATILYNKSNTNGKLVLLAYGMPGFPPKISDGYIIKLVKLGFSVGIPEYLGTFDSSGRFNFENAATSLAVVASGIKENKCTDLISSSPVSLDIEHVTLIGASFGGSVVLVAAAKSYSVDSVLAIAPVTDYSKKFMEYYGNESVDSTMDLLSKLQKFTWKFDKKDVKLLNEGKLDINPLRHMHELKSKRVALWHGKLDRSVNYLSSVDFFYSLKFFGCDAELNLFPRYRHMGLGMLNNRNLQAKLIKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM45</accession>
    <name>A0A218NM45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM45"/>
    <dbReference type="KEGG" id="marh:Mia14_0209"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="229" mass="26095" checksum="A87360F7FE8CAB47" modified="2017-09-27" version="1">MKSVGGIERILLKCRIMKTSKDKPFLIAVTGSPASGKSYFSNELYQGLLDSFKPLDVKLIEVNDLVDKYNIYRGIDEFGSKLVNTVALKKVIEETVEDFDGVVILVGHLLADVKLPYDIAIVKREHLRKLESRMIKRGYQRGKIRENLISEALDYCGENIASPNSVLEIRSNKDIVQSITFIQCKISARFKIRKDIDCSKVLDIYKHPFKFDEMDEFQDIITSGNSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM49</accession>
    <name>A0A218NM49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819715.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM49"/>
    <dbReference type="GeneID" id="33313774"/>
    <dbReference type="KEGG" id="marh:Mia14_0216"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="126" mass="14529" checksum="6CF316A0276F18E0" modified="2017-09-27" version="1">MQNISVLSLKSLFDKLKYAFDNFGQIAGKMKSNYDSVSKEELVELIKFTSSKLDNGEETVENKKILDALDAFYKNRSLMNQLEENRKDLVELVNSIENYLSQNKSDDEELNGQISDKLDQVKKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM60</accession>
    <name>A0A218NM60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819724.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM60"/>
    <dbReference type="GeneID" id="33313783"/>
    <dbReference type="KEGG" id="marh:Mia14_0225"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="60" mass="6636" checksum="D94EB01343E9D22F" modified="2017-09-27" version="1">MTKTFACRDIGMDCDFKAESDSEAELLGKIAAHAKSAHHIDNIDENLMKKVKAAIKDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM84</accession>
    <name>A0A218NM84_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819738.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM84"/>
    <dbReference type="GeneID" id="77386054"/>
    <dbReference type="KEGG" id="marh:Mia14_0240"/>
    <dbReference type="OrthoDB" id="372142at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="9"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="352" mass="39104" checksum="CCFCD9E20207AAD2" modified="2017-09-27" version="1">MATKKEDETYIKDVKVQYGEPVGVVAAQSMGEPSTQMVLRTFHSAGIATTISSGLPRVIELVDARKKQASPTMTVQLEPKIRKDYDAVKKLAKKFQEIRIRDVILKHIENLKESKLELVLSKSKMEDNLLTEEMVIEKLNKKFSGISIEKKSNHLIISQKKPKDIHSTRIAFVHIMDFQLSGIKGINKAVIMQNDDESFYIFTSGSNISEAMQLDGVVPEKIYSTDPFDVLKSYGVEAARNAIAYELRNTMQHEGVKVDFRHMGLIADSMTLTGTIIGVGRHGLAGTKASVFARAAYEETVKHFVNASIFGESDLLKGVSENVLIGKQIHVGTGLVKLAIKKDDLKKIKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD7</accession>
    <name>A0A218NMD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819786.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD7"/>
    <dbReference type="GeneID" id="33313851"/>
    <dbReference type="KEGG" id="marh:Mia14_0294"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="154" mass="16676" checksum="C7430C8A000A1A45" modified="2017-09-27" version="1">MENENVVGYIDNLVSFGIIAPKRKSVIITNQRLLILDANSTSSAAASVGFSYLFGAFGRGAANRIAKDDVLDKTKALSQEDLDTALKSNSENVAIDNSNIDSIRISRKNIEIKAQGKTFKYGLANPDAKKKGKGVYEGYIQTLQNIFGSKVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME5</accession>
    <name>A0A218NME5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYTH-like superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819796.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME5"/>
    <dbReference type="GeneID" id="33313861"/>
    <dbReference type="KEGG" id="marh:Mia14_0304"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="175" mass="19958" checksum="53AA8010E8E9B799" modified="2017-09-27" version="1">MIEIETKIDDINESEAREALNRLGAEFKGDKFYRRYIFDLGSNEGEDKFIRLRTDGNKSTITYKDRKGGTLANTEEIETGVEDFNAAAKILSAALPNLLYQESKRSLYNLEGVEISIDQWPKLPPLMEIEADSEEKVMETIKKLGIKGKAIGNIGWEKVYSMYGMDLNDFKILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF1</accession>
    <name>A0A218NMF1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4932 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819814.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF1"/>
    <dbReference type="GeneID" id="33313881"/>
    <dbReference type="KEGG" id="marh:Mia14_0323"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032560">
        <property type="entry name" value="DUF4932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16286">
        <property type="entry name" value="DUF4932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="37687" checksum="37B4C62B4A2F23DE" modified="2017-09-27" version="1">MKITIDPRIELLMSIELQNDLTNPGFAGLTKVETTYKKQFIDYFSSYKNSESTKHYLKICNGSCSMDFSAATIFHLSNPPDLKVVRPFDRYGRQYQSFIKILRDFAVETDFMAFFVKYKGMFQKVTESARKELKSKDIVLPIESYYGMGLNSYNIILSPLFREGGNGFRINSIKNWYDGYAIVGPTKVKNGLPYFDSRLVGTLWHEFGHHFVEPITEQHTAALRRKFSKVKLSLWGYPIWQNVINEYIIRAISNRIEFRVKGEENTVLKWIREEEKGGFVHMRELYDYLKIYEDNRDIYPTLIEFYPEIIKELERLLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG8</accession>
    <name>A0A218NMG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819815.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG8"/>
    <dbReference type="GeneID" id="33313883"/>
    <dbReference type="KEGG" id="marh:Mia14_0325"/>
    <dbReference type="OrthoDB" id="19148at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050833">
        <property type="entry name" value="Poly_Biosynth_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250:SF11">
        <property type="entry name" value="O-ANTIGEN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250">
        <property type="entry name" value="PST FAMILY PREDICTED COLANIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="528" mass="58415" checksum="2B0C5676329ABD31" modified="2017-09-27" version="1">MISAIAEDSTLESYEDEEGIGVATAKNSMLYISSKVLSSLVIIIILIFLARILKPEYYGFYTIVIAFSTLLGAGGNFGVGTTFRKKLAEIGVSLKEKSNIISSGITISFLIGFILMVIGIVFSRYIAYSIYHEPLLYIPFIASSIIVLLTVIYGVTSAVLFGINKVKHASYINIAYSISQAAAVLILVLLGYGIIGALIGIAISLVIGSIISIYYIVKFVHYRFSFQPRSRLRGLFNFSTPILVSNLVYLGLTSFAITFLAIFVSPSIVGSYGVAFRFGRIIEVITASLSFVLLPAFSSVISNKERRESISRVFNGSIYYSFLFLAPLTAYLISVSKPLMYLLFSSSYHDSYIFFSFIVLGLFINIIGVLSGQLMVGYGKTKSFMKYQLLTLVIELSMLLVLTPIFKVYGVLLSLFVIGPVLFSFIYVIALRNEFKMNVKLSKLLLISISAVILFAIGYAITAFLHYSYISILANLVLALVIFIPIAVFLKGVDSENVQFIERIGKRYKKIKFATDAVARYARFFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH7</accession>
    <name>A0A218NMH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type Na(+),H(+)-transporting-ATP synthase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819844.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH7"/>
    <dbReference type="GeneID" id="33313914"/>
    <dbReference type="KEGG" id="marh:Mia14_0357"/>
    <dbReference type="OrthoDB" id="4272at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050873">
        <property type="entry name" value="V-ATPase_V0D/AC39_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682:SF1">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="357" mass="40901" checksum="173BD40BA05E56A3" modified="2017-09-27" version="1">MDTTYLGKYGQLSCLNTEFLKNSDLESLINLETEKEFLSYLENRFYKVEVQKFSNSYTMPDLYTMIINYHMVSHIKDALQSLPYGGKAFVSAYLNKFDTENIKVILSSKSLNYKVDQFEPFLMINDMPVGYITGSIPEEEYKALMEQPDVEGIVNSLAEYGYGVALMERLEDFRSQGNLIGMFNTLDSYYYTRLFEQFNMYVGSQPSIGNYLRSLVDIHNVSLLAKRIVSSNKDKDIDDLDDFIVDSGSITKQELLNSKFDTIESLAGLNIPGASKAVEAYNRSGLLGSIETEMKYALYNEYLPKLKMSSMGLNTVMYYIIRSEIERDNLRVIMLGKYYDMGNEFIRSNVIKLSNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI0</accession>
    <name>A0A218NMI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819837.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI0"/>
    <dbReference type="GeneID" id="33313906"/>
    <dbReference type="KEGG" id="marh:Mia14_0349"/>
    <dbReference type="OrthoDB" id="8628at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00281">
        <property type="entry name" value="SMC-Scp complex subunit ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298:SF2">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="160" mass="18155" checksum="BEDEEF2575AEC8DC" modified="2017-09-27" version="1">MVIKISSLDSDTRKLIEAALFISAEPLSLDDLSKIVNISSIGYVKNMLQDLIDDYAKRDTAMKIEELDKKYLLTLKSPYMEKVSSLAAKPDLSKGALRILAYISKNEPILQSKIVNIFGPSSYSYIKEILEKSFIESSKSGRTKKLKTTEKFKEYFELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI3</accession>
    <name>A0A218NMI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome segregation and condensation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI3"/>
    <dbReference type="KEGG" id="marh:Mia14_0348"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969:SF2">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="277" mass="31868" checksum="11ECBA883022553C" modified="2017-09-27" version="1">MQRKPTLLAGGRMSHPRYNLNIFTHNYNRPVRDFMASSEEEAVVAEDFNLEEFIKNATWKELLIHLVETNKLDPWNINISEIVEKYTDTIKKIKMLNLIIPANMVLAASVLLRIKSDTISIADTSVEEVSNPEEDESGSIYVERPNLEPLVFKIRPAPSRKITLEELMQALDQSIKKEIKREETLKESNIVLEFKVDRSDIDKKIDSAYQLIKGNADSYGVAMFSNLSRNFEDKSTILLDLFVPMLFLAKYRRVSISQEEFFGDIMIKLKESKTDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI5</accession>
    <name>A0A218NMI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF373 superfamily multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819840.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI5"/>
    <dbReference type="GeneID" id="33313910"/>
    <dbReference type="KEGG" id="marh:Mia14_0353"/>
    <dbReference type="OrthoDB" id="42796at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="138" mass="14992" checksum="9F3405195140BC34" modified="2017-09-27" version="1">MAKKAVAKSHIVPKHMVVNIISLIVEVLLLIGLVAVLINAAEQIVQSIGVSMFQVVDVTLENALLLVVFIELYLSMVDFFDGNGRSTIYIIDATLSFLLRETIIIILDSGLVVGSMIALAVVIAAVAFARFMVTYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ0</accession>
    <name>A0A218NMJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819855.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ0"/>
    <dbReference type="GeneID" id="33313925"/>
    <dbReference type="KEGG" id="marh:Mia14_0368"/>
    <dbReference type="OrthoDB" id="6862at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="196" mass="22511" checksum="6CF5F1F2B68EE7F2" modified="2017-09-27" version="1">MIQDERLTLGIDIDGTLADTVGLVLELYNSEHKFQASKEDLKLYEMAKNLPEIDGGKVKEYFENSWDRWNEIAPVDNAASDVIRKLAELYNIRIITATFGDTGNVKRWLEHNEIVYNDFVHCDSSEKYKYCDILVDDRVSCINAVAEHGGRGILMEQYWNKADPTEEINENVVIAKNWNHVYDICINGLDIASNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ5</accession>
    <name>A0A218NMJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ5"/>
    <dbReference type="KEGG" id="marh:Mia14_0377"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="346" mass="38737" checksum="2D1F492B6D201318" modified="2017-09-27" version="1">MRKSKPGKDSGQRIVDLVTGSTSGVGKHLIIELLNEGHEVRVILRNPPDESGDLLKMPPGVIPYISDITFKRESDEQNLIEACKGVDNVFHIAGATYNSKYTFNELVNINVVGTENLLNSLVKATSGSKKSVRFIFAGSVTVYGYTRKEEKLTESSEFNPKSPYSESKVMAEQVITSICKANKNINYTILRFGIFYGYDYKGPFYKVFSLVHKGKAYYVGNKGTNHLILVSQDDAVKAMILAMKLNVSKNSVYNISDGIPYTLRDIFEFVAKELNVPPSNRTIPRTVANLAKHIMNINKDEFEFLTSDRVLDISKAKADMGFQPKDTIYTEGKNLIDSYKKEVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK8</accession>
    <name>A0A218NMK8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">A-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819851.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK8"/>
    <dbReference type="GeneID" id="33313921"/>
    <dbReference type="KEGG" id="marh:Mia14_0364"/>
    <dbReference type="OrthoDB" id="85892at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="656" mass="73381" checksum="004F5862AD9FC46B" modified="2017-09-27" version="1">MFMMPERMVKIRIIVARDFYKPAISYLYDLGVMQINEMPQELNTVIKRDENAGYNEISKYSAKFRTLKSTLYQRPIVKKYKFESLKDLIEQADSVKIYDEAIETTKEMERYNAIISNDAKAKSLVQKLPKLEVDLDALNTDIIISYAVFKNHSDKAYRASMQKFLNELKGKLGDSIIVENESLYLVVIKRSEEGVFGKLASNYKMLVEVIPHLEGTAEEAVKALDSDIKSAEEKIKKLQSSMNAMSDQYYDLVAALDEQFDIESQELSIMNKLGITKYMVILEGWIAKKSLGSLEKMLDKATFGKYIIQVLKTDEVAPTKMDNNKHIRIFESFVKFYSLPQSNEIDPTFPFAIVFPIFFGLMVGDAGYGAILLLLSLFLMWRVKKPAKVPKKESKISSFIHSIVSDNGLAMIAKGILPGSILAIIFGILFNEYLGFSLPFYQGFNLETNLSTMLVIAGWIGVVMVAAGMFFGFINALIVNNKKRAAGRIGWILIEIGIVMVGLMLLHSGVTELSTLPAMIYYVLIVIGLGIVLYSEGGGSLIELPSLISNVLSYMRLIGILLSTIILAEVIDQIFLKSLSQSILFAIVGVIILLVGQIFTIVIAAFEPGIQGVRLIYVEFFSGFFKGNGMPFKPYHGERVHTIGLIGEMNEKLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML6</accession>
    <name>A0A218NML6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819867.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML6"/>
    <dbReference type="GeneID" id="33313937"/>
    <dbReference type="KEGG" id="marh:Mia14_0380"/>
    <dbReference type="OrthoDB" id="7793at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="134" mass="14317" checksum="B7F4B6E12B63434F" modified="2017-09-27" version="1">MKVVYSDPKTGLTAQKEVSDEILASLIGAKIGDVVDGSLFGLNGCKLKITGGSDDSGFGMEKSVSGSMKVGVLRRIANAGKDKGQYERVTVAGNTINEKVVQLNTMIVDYGNANISEMFPKKEKAENEKEAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN2</accession>
    <name>A0A218NMN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN2"/>
    <dbReference type="KEGG" id="marh:Mia14_0421"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="290" mass="32507" checksum="AE3CDBF2BB9F0B6E" modified="2017-09-27" version="1">MHLYYINIIKNGIFMRQIWWLFICLAIMILLILFATFIATGSLMPLSLSGSINPVVQSNEAAFFMISNFINDGWTTFGFVIIGIVLAFVSIAVSEMSPIFKKVLVYSIIIVILANSAYSVVSRTMGRGISGLAMVEGGIVLAFLSYIVNSYMKMNFNYVSAAAMLFAISYIPFIYGRALFSLLTIIIAIALLLYAKLRIYNHDRSGDAKDKENPKRKAITVWSMEAMFLDLSFLVLLLISAFPNIAVASKYHLDIIIHYTDFIIGFLVSVLYIYLSNRKSPFSKNKPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN9</accession>
    <name>A0A218NMN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN9"/>
    <dbReference type="KEGG" id="marh:Mia14_0432"/>
    <dbReference type="OrthoDB" id="104705at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="171" mass="19995" checksum="3AB16FD97304B3D0" modified="2017-09-27" version="1">MISMRKYHSVKFDVVEEKVKLPNGTEYISSIVVHKPVAVIIPVLNGKILIERQYRHSPGGWMYELPAGFLQGKITLEGLAKKELHEETGYIADKLTFLFKAYAAPGTSTEMYYYYLAENFRKEKQHLEKYEIIKTRWTSIEQLLNMIKKNRITDGKTIIGILYYYNFCKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP9</accession>
    <name>A0A218NMP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DrsE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819926.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP9"/>
    <dbReference type="GeneID" id="33313979"/>
    <dbReference type="KEGG" id="marh:Mia14_0424"/>
    <dbReference type="OrthoDB" id="55761at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DsrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="11706" checksum="AEFA8715DD019F7E" modified="2017-09-27" version="1">MKILLTVDSEEKIAMSIMAVQHLSEMDDTEEVEVVYLNGGIAAVVEKNRIKPLLENKKVKVVACGTSMKARNISEDELAEGVIYVPASLKEVIAKKHENYEYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ3</accession>
    <name>A0A218NMQ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cysteine desulfurase</fullName>
            <ecNumber evidence="3 8">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ3"/>
    <dbReference type="KEGG" id="marh:Mia14_0415"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="418" mass="46130" checksum="09B9580171EA3B4F" modified="2017-09-27" version="1">MAADQEINAGDIKKDFPIFKIKMSGKPIVYLDSAATSQKPKQVIDSIVKFYSEYNANIHRGIYDIAERATDEYTNSKGKLAKLIGAKSIRNIVYVRNTTEAINLVALSWGNANIEKGDHILISDMEHHSNLVPWQLLAKRKGAVLDYIKLDKSSEKLDMDSFKENLENDPKMVAVTQASNVLGTINDVKYITKEAKKHGSVVLVDGAQSAPHMPVDVQSIGCDFFALSAHKMLGPTGIGALYGTEEILNSMEPLFGGGDMISAVTRQTHSWNSLPWKFEAGTSNIEGGIAFGAAIDYLNSIGMEKIRRHEEKLTKHALESLENVKNIEVYGPKKDEINIKSGVVSFGIKGVHPHDVAQIFNNEGIAIRAGHHCAMPLVTEVLRQGAVSRMSFYLYNDEDDIDKAVAAIDEVKRIFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ4</accession>
    <name>A0A218NMQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ4"/>
    <dbReference type="KEGG" id="marh:Mia14_0408"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="253" mass="29430" checksum="FC2837B9FA29B11B" modified="2017-09-27" version="1">MKYFNYTGGKMVFKNKDLEICNKVLYIADAEKSLREIRNMLHDYDIGIKGDMYISGSMNESLDIYYKDEKVAEVGYSLGDKEYYKLTVYKDNDWKEKLNDIYKMTRLIAKNRVKERNKDPNSSLVLDYKRVAKDRTEEAKRKLYRGSLNDLLDESIYVYGASSKFGEVKDALDKKGIDIQFKSNAKNDTYIDVYHNGKFAAKISRYGNEGLLGKKLAAAIYINDGWQKDLYEIYSRSKELEGEDNQKSELRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ6</accession>
    <name>A0A218NMQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819910.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ6"/>
    <dbReference type="GeneID" id="33313971"/>
    <dbReference type="KEGG" id="marh:Mia14_0417"/>
    <dbReference type="OrthoDB" id="378732at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="448" mass="51534" checksum="3849939C12D2F852" modified="2017-09-27" version="1">MVDVPEKVQEAFDELKNIYGNDLEIKSVNDKFCVFRINVNDASEQADCYMGYITANGIVILEDSKQASASSEGTNIKERRSKAKNAVVWNSIGEDDINLLKALSMNSRLSFKRLSEITGISIHALEYRIERLERLLGIKYTLELNMNNLGFSEYMILAKFTGNKLNLKDIKGVLKKNLRVQLALATNGIYDLVIFCVAENNNIIADVLDDVRNSEYLKYLEAEWYITPISSDYGFIPLRQEFFDALKEKIWQRKKKDEHPNSSSLMYREYVLLRELTEDSRNSFSFIDKKYNLPAGSAKKAYKDLTNEEGKNVIVRSTLTISIPEKKYDGIIIANLTNKGKLAETKNKHRNYIIGEPNKIVNKFSYICDMETPDGIFYLFPVLEDGNREKIESELSQTIGGVKFNSLMVEKIISGSIDYRKFDNLYSRQYINLVKDKSIKVRERIIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ8</accession>
    <name>A0A218NMQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819972.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ8"/>
    <dbReference type="GeneID" id="33314009"/>
    <dbReference type="KEGG" id="marh:Mia14_0453"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="120" mass="14368" checksum="E48107E6590D232D" modified="2017-09-27" version="1">MDNNENRSKDQNNGIQVWVNKIKLDKEDEEDKDKEDRRDRKWYTSSSEYCIKEGYVAIGYGVREYPLDWEIYKEEVKKGYGKNKFHGKFKNDLENVIIPFHDLVKKMIYVGLEQKIEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR1</accession>
    <name>A0A218NMR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819924.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR1"/>
    <dbReference type="GeneID" id="33313978"/>
    <dbReference type="KEGG" id="marh:Mia14_0423"/>
    <dbReference type="OrthoDB" id="379734at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="291" mass="31939" checksum="ABE6F01297E934A0" modified="2017-09-27" version="1">MKIVFALMAIGVVLYAISGTVDYLVVTRLPLSAAIISISIGILIGFIAVKFVFRLKVKAESKGQYAFGALTALMIIAYTIPLFIAYKSYTLASIYPLVGLSAIVFFVIDVVKYRRFLALKQTAILLAGVLLIVVGIFYAESNGYQFQIGTLPFVFLITVFGGIGYYMEFYKLKKYSIGTKMLFQPIFLIMAALFIGGPIYIGSLYFVIGVLGGITFSFASVMELHAMEMTKTRGTANMLIKRNFINDFEYSDTLLVLLGSIIIGSFYPIEIFGGILMLAGIIVISSLSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS0</accession>
    <name>A0A218NMS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819934.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS0"/>
    <dbReference type="GeneID" id="33313984"/>
    <dbReference type="KEGG" id="marh:Mia14_0429"/>
    <dbReference type="OrthoDB" id="57234at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="6"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="404" mass="42693" checksum="A9B9F23973A5D449" modified="2017-09-27" version="1">MNKWTKLLPYWFLLFTIGFGWFILAPLVPVLSTSLGVGTASILLLVSMYGYTMVVLGLLAGWISAKFTVKTAIYVAAALSIIGLIGRSLFLTNYAGFLVFQIIAAAAYPLALAPVGSVADSIYKEHAHSIVGISVGILFFGLAIGAFFASSIAAAISTVGLLWFTAILAIIAAIWVVPGIKNYPTNYKGKSLKGVFKVGMIKNWWVGFSIASMSVMFGGIASTMLLHFHFALGEALTYGGLLGGLAFLGSALGAIILPPIFERYNQIRAGLISTSLLSLISVSLLAYSLGFGPNLGLLVAAFFLFGFFGNAFWSMALTSTTNYVSDPAQSGFATSMYSVITNLGVAFVPVFLGPEFAVDATIAVIVVFVIEFIAFILSPMLKTKNDAESQQPPKAAAAKAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS5</accession>
    <name>A0A218NMS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819982.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS5"/>
    <dbReference type="GeneID" id="33314014"/>
    <dbReference type="KEGG" id="marh:Mia14_0458"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="238" mass="26113" checksum="B2C8929398E77BEC" modified="2017-09-27" version="1">MGILGKIIGIIMVMVIVFSIVYYYDKLMTCSLVNSVSPGVGKALGCSTPTTTNSTSKTAPPSQIINNLLGNNPNAEYKSQYAFAENITKKYNETIKKLILFTGNSSNKAIEMSAEEEFSVQGSSVYVIKYGGFYVPTYENISDEYFNGSSYLPSLLGKVVYVEFVDSNYNNSTLQIPYKVQSETIDRADVSWYLTQATGIPNSTAINILDANNTIFNKGISGVIGIYYNGTEILFPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS6</accession>
    <name>A0A218NMS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+ superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS6"/>
    <dbReference type="KEGG" id="marh:Mia14_0438"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43566:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43566">
        <property type="entry name" value="CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="429" mass="49828" checksum="B52331310A3E6E75" modified="2017-09-27" version="1">MYYIIIDIMAAKERFFYRDIEDRIVPFISRDEIIIIRGPRQAGKTTLMKLISDKIKDKKEFVNFDIPSNRSNISESPIDYVRKIADGNKITLFLDEVQRLDNAGEILKIIYDTFKGEVKIFASGSSSLEIRQKVLGFLVGRAIIFDLYTFSFGEFIRSKDTGLYNIFKERNDSLINFIENGEEVLHTAFSEDLLKMWKEYVVYGGYPEVVKADNFDMKKSLLLNLVNLYIEKDIISFFKIEDTKEFENFLRILSFNDSQMLTISNVANDSGLSFYKANSYLEIIENTYIASRVYPYYNNMSSSIKKTPKVYFFDLGLRNAVLDNLLPYEKRDDIGKLAENFVFGELVRLGKKVRYWRTKAGAEMDFVIEYNNEVIPVEVKLGGSKAIGKSFYSFLEVYKPKMALVITLDEFSKKEVNGTLIYYVPIFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT1</accession>
    <name>A0A218NMT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF302 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891435.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT1"/>
    <dbReference type="GeneID" id="33314029"/>
    <dbReference type="KEGG" id="marh:Mia14_0474"/>
    <dbReference type="OrthoDB" id="157520at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342:SF2">
        <property type="entry name" value="INNER MEMBRANE OR EXPORTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="126" mass="14289" checksum="9C9789F12DB253ED" modified="2017-09-27" version="1">MNVRIESKYDFEGTFDNITNFLNSKGFTIFCVVDHGKNAKDAGLDFINSKLIIFGNAKGGTILMKKNAELGIELPLKILIIEQNKRCYVIYKDYAQISKEYNLDNKDIIDQISGLFQNLKGSLEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT6</accession>
    <name>A0A218NMT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820035.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT6"/>
    <dbReference type="GeneID" id="33314044"/>
    <dbReference type="KEGG" id="marh:Mia14_0486"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118834" checksum="B7BEF25499579120" modified="2017-09-27" version="1">MKMPKNKTKINDGFTERQLLDDTNAKIAGLSRLSDNDTAKLITDYLKENFDPSEADKRLSEILDFVESLDQRDTRYRYFHAIWSTKAVKELTSERTMKFANSIGVNNSYGYFYAIENTKAVKELTSEEFTNKKTADFINLIGNYSNFEYFNAVGTTKAVKELTSKRVFDFAKLIGINVDKYFYAVGSTKAVAELTSEEIANRRIADFINLSNNSFGYEYFGAVGKTKAVKELTSGEVIDFAKSLGSNIDKYFSAIESTKAVKELTSKEVIGKRIADFINLIGRTSASEYFNAIGYTEAVAELTSGEVVNEGTVNFIKSIGSYGSNRYFYAIGMTRAVKELTSKRVRDFAISLGNNNVYGYFRAMADSKAVAELTSGEVINETITNFVDSIGGDSSYQYFYAIGMTKAVAELTSERVRDFARYVGYNASFEYFRAIRKTKAAKELTDEVFLSWLKDSYTMNDFMDILTGIANILYYSDNHNLNKGLTFLEDPIIRLIKFENASKDPNRFKAEVLGWSNLIKNLETIENGNLGSIDEAKFDRIVKLYSRTGGSVEYLSIASNFIKTKEDFETLFSGEKGKIDNIIVNGANSYFNNLKGLPKSVEGWGGIKILRLVWENKNMFTPEFLVESLKRRSNPSELHIDEFKHIDSLLPEFNKQYIKTYDLHQEKKTEELTREETSKIISDSISIIKGVFPENAVDVPQALGQIQTELASLRNSVGRGLRSRIDYIVGKSDIDDNPESVNFQKAIFLAKGLKKIEKDINNIADENKGDALYSYGRILNAVEGVMASKYYREKIGDQENALEEARRSLMEGAEMPKEEMELYIKKADEALSNIYQYMTDPDMFIVDSPGRRMLFGLYLNTISEDSEKLDKSLPTAGVLTIKSWKRSLDDIFGGRYSGDCTAPPNESDYSGIHFDANFRWVKDPATLILNFYWKEKLEDVPQPIGRTYCFAAEVDGKPMLFIDSLEFLSSFYPGIEVQKALPEMIKDLAKHFNVPVVINTGRVSNREWVNDVIGNAGFNKKTISIKKLGNDVFAEHIETSLLRKEQYFVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU6</accession>
    <name>A0A218NMU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820052.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU6"/>
    <dbReference type="GeneID" id="33314054"/>
    <dbReference type="KEGG" id="marh:Mia14_0496"/>
    <dbReference type="OrthoDB" id="131570at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005054">
        <property type="entry name" value="PRK06462.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF48">
        <property type="entry name" value="ASPARAGINYL-TRNA SYNTHETASE-RELATED PROTEIN (N-TRUNCATION)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="84"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="303" mass="34777" checksum="751A388E5BB7A73D" modified="2017-09-27" version="1">MEESKIVEKLVVTSEVIKHTIDYFNDNGFVQLLPVILGKSTDPLGPDPNSSILKTPEIEYGGQRLYTMNSMILHKQIAIKKLDKIFILSPNIRLEKPERKSSGRHLFEFTQLDFEIRDAKSKDVMALMEGYLVYLSKMLKSDEKAKSAFKELGLEVFDFKPPFKIYSTGELAEKYGEDWEAKMSRSSTQPFWVTDHKREFYEKEDTGRPGHYLNYDLIYPLGFGEALSGGEREHEYPVITRKMGSDRLNMDVYKAYLSEAEKGLYPSAGAGFGVERLTRFLTRSKHVGDVELFRRVPGEEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV6</accession>
    <name>A0A218NMV6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820050.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV6"/>
    <dbReference type="GeneID" id="33314053"/>
    <dbReference type="KEGG" id="marh:Mia14_0495"/>
    <dbReference type="OrthoDB" id="8615at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861:SF3">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="211" mass="22057" checksum="66AC526FBC2FC179" modified="2017-09-27" version="1">MEDTDTQNVNNVEENKVNTVNDANAPSNAADSQNAQAANQSAAAKPKKKNKGLIVGSIVVVIIIIAVVAAYLLTSSSASTVKSGDLVEVYFKGSFTNGTVFQEGNFNFTAGSNQVISGFSNAVIGMKLHQIKNITLTPQEAYGEVNQSEIVSVPLTDFANQSIKNGTVVTSSTGLSGTVIAVNATDATVNFNPPLAGDTLNFEIEVLKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY1</accession>
    <name>A0A218NMY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820063.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY1"/>
    <dbReference type="GeneID" id="33314062"/>
    <dbReference type="KEGG" id="marh:Mia14_0504"/>
    <dbReference type="OrthoDB" id="182126at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07062">
        <property type="entry name" value="Peptidase_S66_mccF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237:SF4">
        <property type="entry name" value="LD-CARBOXYPEPTIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="MURAMOYLTETRAPEPTIDE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LD-carboxypeptidase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LD-carboxypeptidase C-terminal" evidence="4">
        <location>
            <begin position="210"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="347" mass="39765" checksum="6E0E56050FC0B9D1" modified="2017-09-27" version="1">MRIINPKRLMEGDTVAIVSPSSGTAVEFPHIYENGLDNIRKYLKLNVKEYGTARKSSEYLYKHPHERAEDINNAFDDKEVNAIFTSIGGDDSIRILDYLDMKVIRKNPKIFMGFSDSTTLSDYIYYKTGLVTYYGPSVMAGFSQMDKFPKSFLDMFGNIMFEPIENYEYHSFPFRSDGYPEWSKKENVGKINNRHRNDGWHWLQGKGSAKGVLFGGCADVLEFMKGTHFWPKGDFWNDKILFLETSEDKPSADTVKNWIRNYGSQGIIDRIAALLIAIPFGYSTKEKEELESDVHSVLDVEFGRGDMPLVTNMDFGHTDPKFLLPIGTMAEVDPSRKRFRLLEKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN01</accession>
    <name>A0A218NN01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN01"/>
    <dbReference type="KEGG" id="marh:Mia14_0530"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="272" mass="30190" checksum="05558937C13BAE81" modified="2017-09-27" version="1">MFMDGIGGLDLGYGNKKSINLVTDLNGTIGNGTLTGENADAFQRLVNRGINVIPATSYSLASAFETYFSRLSVKPNILIVERGNAIAVERGNANIISRFAKAGFRNERADEYGYIEYVFGDDNEELSRKVLDVSKELGISIGIAPMYGCSAAIKIMFDENKTSSRQLEDRMDKLGISMHRNGQGTATLVDDRFNKWTSYLELVSKGIIDDGFLIGIGNDLNDVQLLNHSDISILVGRKINPSRLAKEASYKFEGPWEWHKVESIIERLLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN14</accession>
    <name>A0A218NN14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820128.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN14"/>
    <dbReference type="GeneID" id="33314100"/>
    <dbReference type="KEGG" id="marh:Mia14_0543"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="237" mass="26508" checksum="AB800136CC910145" modified="2017-09-27" version="1">MELSKEHDNSTNAQNAAASSPGEGIVIKEIPPSADLPFTLDKGEKIIYYAKPDKDIYVHNLTSSVKYVVGIALLILALLIIGFIFFIIESLIGLVNAAIYSIAVIIIMLLIEFLAAYFTKKSALFGYQYQNYWITTKRLIRQVGITTVISQALDVMPLDTVSEVEIRDLHLSKMFQEGWTVIAHPIAFTGYMSSSGQAYGGQSLIRAFPHMTKEQAEEFKKYLVYERDLNNPNLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN16</accession>
    <name>A0A218NN16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820130.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN16"/>
    <dbReference type="GeneID" id="33314101"/>
    <dbReference type="KEGG" id="marh:Mia14_0544"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="197" mass="21633" checksum="8F8E247B571837EC" modified="2017-09-27" version="1">MLGYIIIAIFLIFDFVISLWDAYASGVNKGMLEKKQTFASMFTKVLFVYAGVGIAFFGMTYVLVIILSLILYAIGYIGASLLVYTLNFSFLVFGLMIISFGVLVTVQSILVAVHRRSLGSIAISIFNVIIILFDISMYASGFKGALRVVRNGRSRSAGFYEIIIAALILAYVLIHTAYKKGINSVLDKGGMGVQKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN19</accession>
    <name>A0A218NN19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820122.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN19"/>
    <dbReference type="GeneID" id="33314096"/>
    <dbReference type="KEGG" id="marh:Mia14_0539"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="419" mass="48150" checksum="81C109A199D1163E" modified="2017-09-27" version="1">MAYKIKDLNNQESDANLKSLNRDRKDHRSAGQSKEEELNRHFKESDIERFKDAVKIVYRNSVEGYKGLVQKYRTGFKAPILYFDFDDSYKTASGFIDDSRLSFKVLGAYDFISNRIIIKPGLLYKYVNHGCKTYSIEHTVNHEIAHSLVKQLGLADESMEEGKTDFHGIVKGELLANLFAAELEVAKQGLPISNESMARQLIKDDSDLEYLSKDIDAAKAYFRWLNKYSREAQNAIEHISYEVYKYIKKSEGSGKVIDYDAVNDYYSEKVDKVLKNYLVNIMRNYAISVYSAPVLGAAKALLSERKGVEEIINSVSKDMSSVKEIRRYLKGSFASVDLRSMSITKPGSIKRIPIKLVTESLKNEGIYFDYKSTFSRIADSVEDEFDEIGHYLSKNLRTERKLLRDLSRMEKRFGINSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN21</accession>
    <name>A0A218NN21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820139.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN21"/>
    <dbReference type="GeneID" id="33314111"/>
    <dbReference type="KEGG" id="marh:Mia14_0554"/>
    <dbReference type="OrthoDB" id="56830at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050834">
        <property type="entry name" value="Glycosyltransf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43685">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43685:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE TAGX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="341" mass="40366" checksum="6101872F42A13BC6" modified="2017-09-27" version="1">MEKTPNSIIKLKEQNKNNPIISIIITAYNRKQFLKYAVQSVLNQNFPKHNYEIIIVKNFITEFDKEWISKGIKIIYKKEGSVGQFLALGIIHSKGEIISFLDDDDTFERRKLKVVSEMFSKYKDLVYYHNDFKVNYEDKYNKPLKMPNINIKRFIPTSSKRYIYKFVLFGYYFNLSCVSIKRQISINNIDYIKKIITDPDDFFGYLAMSIKGKILCDNLKLTNYRIHKNNTSRSNPFGRNGHYDREYKMYHVLFKDFLLKTNQKIALKALYSRAIRNELDYRVLNSKDIKISKLMDYVKNFSIPYLIYCGKLDLFIILIILNRISKSKAQAILVEREGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN56</accession>
    <name>A0A218NN56_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">Mia14_0596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820174.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN56"/>
    <dbReference type="GeneID" id="33314150"/>
    <dbReference type="KEGG" id="marh:Mia14_0596"/>
    <dbReference type="OrthoDB" id="85118at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000801">
        <property type="entry name" value="PRK00055.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="303" mass="33714" checksum="5A238E6B2C8CDDEE" modified="2017-09-27" version="1">MFKLTVLGTSGAAPTKSRGLAAVAVENEGDLYLFDCGEGTQRQMLKSDANMFKVRAIFITHTHGDHIFGLPGMLRSLDLYGRDYPLSIYVPKGYEDRIEALARFDSFRPRYEINVIPIVPGEIYRNKSINVTAFELKHSIASYGYRIAENDSLNFIKEKCDSLGIKGKMYRELLEKGKITVKPDEGSSLPKEVRIEDVSIPKIGKKIVYATDTMPTEGTIKASAGVDLLIHEATYTDEFKDLAADRMHSTATDAANIAIKAGAKELMLIHFSTRYKSTSQLVRQSRTIFKNTIAAKDGMKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN72</accession>
    <name>A0A218NN72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820186.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN72"/>
    <dbReference type="GeneID" id="33314164"/>
    <dbReference type="KEGG" id="marh:Mia14_0610"/>
    <dbReference type="OrthoDB" id="371856at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="415"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="549" mass="62563" checksum="1E4A79FD656E9008" modified="2017-09-27" version="1">MSKYIITSALPYAEGVPHLGNFVGSILPADVFYKYIDMKGEDAIFICGSDQHGTPIEIQAIKKGITPKELAESVHEKIKEAMARFECTFTYYGKTDSEKNKETVYWLFDKLYKNGFIVEVTDIQPYCNTDKLFLADTFIEGTCPFCGYEKARGDQCENCGHLLNPTDLIKPHCRICGGTDISFKETKNLAIDLKKLQPEIKDFIDDRKGNNWSITAINKPLSYLEQGLKPRDITRNIDWGFDVPMEGFKDKKFYVWFDAVIGYIGITREWDEGKWEQYWKSKDTKLIEFMGKDNIEFHTMMWPGILIGSMDNLVLPYTIKAYEYLTARGLKFSKSNGIGMNVENSLGVMDPDYLRFALIYRLPETSDADFSIDLLLEVVDKIMNDKIGNFVNRVLTIAKSNSEHIGRIEMSKDYGSKIKSIIEKYKSDFESISLREALHDLIDLAEEGNSLISGSEPWKMKKDLSDTEVKNRFSEVMGNLIYTVYAIGVLSYPFTPKASGDILDYFGISGKPKLGLLDAGINLDYSKEVKPIFKKATKEQIEKLKMFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN93</accession>
    <name>A0A218NN93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820203.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN93"/>
    <dbReference type="GeneID" id="33314189"/>
    <dbReference type="KEGG" id="marh:Mia14_0635"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="286" mass="31538" checksum="E758D8A1EDA8D71C" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILIIAIVLAALYSIGIFNPNTFAPKASAGSCEVVRPSGPGTTSNLGREGTCTNMLPKYVALFDGNDNYITSPIPTNKTVNVSFSLWYQSDNSNYFAPLFLLSPNGGDNIGYGLYLSDNEFNILESSIRWIYTSEYINSSRWYNIIFTISPASGGDVVYSIYLNGKRLYVSGPESPSYRPADEMRIGNDPGNGDYLEGMMANMQVYNIALSQGQVNALYQEGIGGDPIDLTHLVAWYQLNGNANDYSGNDYNGNAINVEYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA6</accession>
    <name>A0A218NNA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ACPSF family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA6"/>
    <dbReference type="KEGG" id="marh:Mia14_0650"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF49">
        <property type="entry name" value="BLL1145 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="323" mass="36613" checksum="A215C7AEC765431F" modified="2017-09-27" version="1">MQKGRLMIRINNLNISLDRKEEGSDFDFISHAHSDHIMAAKSSKSVIASDETSDLIYSGYKIGINRAAYPDFIRLIDSGHMLGAKQIAIEDYDSGNKIIYSGDYLMAKSKASNPIKVEGCDILIIDSTYPSEQFVFRDREEVEYEIQEWVERTVRKGIILFGVYPMGKAQEIIKILNEIGIKPAVNRKISAISKVYNKYGQNLDYGSIYEGDEDLFDGDFVGIIGTRSLKKVKHMLSYLHHKPVYTAETTGFSKVFSLSVEKQFELSDHSDFKQALRYIDFADPKKIYTYGENSHIFSANLKKLGYNSEPFQSLKKLGNATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA8</accession>
    <name>A0A218NNA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820219.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA8"/>
    <dbReference type="GeneID" id="33314205"/>
    <dbReference type="KEGG" id="marh:Mia14_0652"/>
    <dbReference type="OrthoDB" id="57311at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="210" mass="23331" checksum="61C6CC4E4B22EA67" modified="2017-09-27" version="1">MSILTSEAFVEISVFVILLLSLGLTIIMTKRYLKSKIKPLLFWSTGMWFFTIGVLIELFFSFGYYNVLVGDLYLLFVSIIVEMLAMGSVQLLKSRKASIAYGAFMIASTAILLASLLTSNIKDIVEHYIVFSVLPLSVVLSSSLVTFPAAILLIAIAVVSYLKKKSYKMISIIIGVLVVSVAGTLYIAEIPVFLYYSEFIGILLLWYGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB7</accession>
    <name>A0A218NNB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820232.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB7"/>
    <dbReference type="GeneID" id="33314218"/>
    <dbReference type="KEGG" id="marh:Mia14_0665"/>
    <dbReference type="OrthoDB" id="386898at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="204" mass="20869" checksum="706C1C2D3A3E7F34" modified="2017-09-27" version="1">MTKNFKAQSAMEYLMTYGWAILIIAIVLAALYILGVFNGSAFIGTTCTATSGALCTSPIASPSTFSVTLGQVSTTDWAATTFAFVPTGSVMPATTSMTSYPANSVLGVPSGTVNDIIPYAGGTSGDVPGASSMTSGFTTTVTFDAATDCLTSQDNNAISKCSSIPSAVGSTTSGEIWAIYTLPTTNDSSPFYAQELGKATMKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND3</accession>
    <name>A0A218NND3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication factor C large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820234.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND3"/>
    <dbReference type="GeneID" id="33314220"/>
    <dbReference type="KEGG" id="marh:Mia14_0667"/>
    <dbReference type="OrthoDB" id="8658at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="413" mass="47301" checksum="395573721848AE66" modified="2017-09-27" version="1">MDIDELYRFDSLDEFYGNKESIDSITLYLKNFSPKEKRKPLLVYGPTGTGKTSIVKFLAEKLGYNIINLDASDYRDKDSIEKQLFYASNSMSLSNKRNMILLDEIDNLDLKFDKGASSAITELIKISVSPIIFIANDAYDKGISFLRDKADKVEFKKLNEINIRKLLSGKADKFGIRPKSELIDYIAKAVNGDARAAINDLYAVYAGGIEDDGEYDGYNVVGLRDKTDDIFSFLNKVFSSITFSSPLHALSLIDLTPDMTMQWLAENIPKIYKGNDLASAFNMLSLATVYNSRAVRRQHYAYWRYMNIFMTSGVALSKSRYYTSNSRYSYPKMIKERGIRKDSNAKMNEISIDLKHMINESVFTIKEYYLPLIKEMIRSNSKDGILDPESYEFFSRKYGLNAKEVDWIKDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE5</accession>
    <name>A0A218NNE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820254.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE5"/>
    <dbReference type="GeneID" id="33314244"/>
    <dbReference type="KEGG" id="marh:Mia14_0691"/>
    <dbReference type="OrthoDB" id="27596at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="366" mass="41192" checksum="F0ED0B686D32A744" modified="2017-09-27" version="1">MTLNWLLTAYTSFLSLVFLGLLGIAIYPYAKKKQPEVIYKGNQKEKVLVISPCRGVDLTLKKNLSSLKSQTYKNYSVICVVDDLNDPSVPIIKELGLNLIVSDSDIGKGSGKVKAISTAIKKYPEYSVYAIADSDVEFTNYWLERMIAPFSESNVVATTSYPYFNPVGGFWSKVKMVWSFVGNGMMESDTTLFGWGGSLAFRSSLMDSKSLSEFSNSLSDDIYITRKSKSKGKLVYIGDVGLTVNTDDKFNSFMEWSNRQTALTMLGSKSNFKYGVILYSGQELLFFSSIILSISVSYLFLIFLIPFAIGEIKTYMRAPKHKAYALFIFLFINIIYLVNLAYARSMSKISWRGNDYKIVQDLSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE6</accession>
    <name>A0A218NNE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SP family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE6"/>
    <dbReference type="KEGG" id="marh:Mia14_0695"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="442" mass="49784" checksum="D073FCE171D5B764" modified="2017-09-27" version="1">MAVYNTIEDLPETPMLKKITILSSIGIMVDGYTLTVFSYALLYLIKVMNLSSYQISIMGISSIFGVFFGSMIFGKIADLYGRRYIYIYDLIIVSIFLFLTGLSTNYIIFSIFQFLVGIGIGADYPISSSIQAEFSPKKVRGRYLLINIFSFSIGSILFLIIAVPLVLFTGINAWRFMYMIGAIFPLIVVYSRKKIPESPYWVEYRYGKKAEKIVKEEIKEDTGLKISRMPKLEKGGTKLSDIFKGKYLAYSVFIAVAWFSYNVISYGIWTYSPLIFSTEIASHYADLYVVFTGMAESIPVIVGFLIAIYYVERLGRKPLLLIGFLGAFITLIIFFFVNEYMVVGLLMTFGAFGMVHLFDNIGPSPMTYAYPVELFPTRIRGTAMGFATSISRLGSIVAIFSFPIIDSLYGLKTVVLCFAIFALIGFLISLKFAPETKDKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE8</accession>
    <name>A0A218NNE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820253.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE8"/>
    <dbReference type="GeneID" id="33314243"/>
    <dbReference type="KEGG" id="marh:Mia14_0690"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="99" mass="11072" checksum="9971D9587BFF0EA1" modified="2017-09-27" version="1">MVKNDTQEYGLNIESPIRNEIKGRVLTALRKVDFEKILNSTMPYRKPVDKSAGIALSELLAEQAVDYIIKAIEISKDKNMERVGPAALIIAADEIRNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF8</accession>
    <name>A0A218NNF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820261.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF8"/>
    <dbReference type="GeneID" id="33314251"/>
    <dbReference type="KEGG" id="marh:Mia14_0699"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12846">
        <property type="entry name" value="AAA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="5">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="451" mass="50701" checksum="29DF2D983F01D38A" modified="2017-09-27" version="1">MIYDKFYNISNSVLLAKQIKISAMSESKLCELPGSDGFYVGKSSIYNLPFFINFDKLMNKHIISLGMTGSGKTNLLKNLILKIFVYETSPSITIFDWSGEYSDITNYTVGIRHDLKSLGINLLDLYGTDLFKPLVINALENFCGLSSNDCNEIYDKISNGLGKGKRDFNEGISGFFRRIRKPGVGKKVLALDHYKLFNQHPGIDLNGILDKFLCFDLSSLDEFGKSNFSKLLLLLLKLEIYRKGISTGKTNYLVFDEAWKYIKDDSILNGLFREGRKYGVSLLIATQMASDVSNELLSNAASVFIFRLHKEDYKVLGNYGIDSNRFSGITENLGRGSCLVSQILKGGTFSQAVISDVKHFNLSDYLLVSGDNMNYISRIRFKNAVEKYCTNSGSILRFMEENSKLDLSKLIEKLISDGNDRVVIVTLLRSVGIDDFVIASGFDNLRSVYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI0</accession>
    <name>A0A218NNI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NodU family carbamoyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820287.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI0"/>
    <dbReference type="GeneID" id="33314279"/>
    <dbReference type="KEGG" id="marh:Mia14_0727"/>
    <dbReference type="OrthoDB" id="42122at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="entry name" value="Carbamoyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051338">
        <property type="entry name" value="NodU/CmcH_Carbamoyltrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34847">
        <property type="entry name" value="NODULATION PROTEIN U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34847:SF1">
        <property type="entry name" value="NODULATION PROTEIN U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbamoyltransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Carbamoyltransferase C-terminal" evidence="3">
        <location>
            <begin position="393"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="568" mass="63774" checksum="FBCAE25DCB8AFE66" modified="2017-09-27" version="1">MYVLGIWDGTDSGSALIDNEQIIYASNEERFTGTLLEPTFPSNSIKAALKYAKIKPSDVNEIAFCSTDTKGNARRISKRLNEKIYNYEIGNYGSPNFEHFKRKIGYISEDAGVSPLCRYLGKKNVYRNLNALGFKDFNLHEVNSQMAESALSAFTSPFSDSLVITMDLTGGSLSGMVSTFKKGKLESQINIKSKDSVGRIYSQASSIIGIHGDPNAKRLMEMSVYSYPYSMNDNVIKGLLDVDGTYMHGRYGPIKEYKLLREIAWKYPPERFSYMVQQEIEYLFSKFAASVIDRYGVKDVAIGGEMASNTKLNYSIANLENIGRLHVSPYPSKGGLALGSAMYLNYKLNGICQYNFTPYLGESYGEDEISNAAKSNRLKPERENPRDQAEHAAELIEEGNYILWFQGRSEYSRFGLGNRSILSSTNNDLSKGRMDKYIKREGLFHNYGASLLSEDAPYLIDYKNGEGRDFMNIAHYVNEDAKQAMHSVMRLDGSVDTQTVSDENQNFEHLLKHLKNLSGYGSVLNTGMNLSLRPIALSPEDAIYTMLVSNSKYLFMDGFTFARKKGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI3</accession>
    <name>A0A218NNI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI3"/>
    <dbReference type="KEGG" id="marh:Mia14_0742"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="47" mass="5590" checksum="DA80F2B12B4BB3AC" modified="2017-09-27" version="1">MNMIYNVRVNQKLKYVRVYRIVKRLSKGENGLTKLFVKLFAKKGNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI9</accession>
    <name>A0A218NNI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UMF4 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820281.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI9"/>
    <dbReference type="GeneID" id="33314272"/>
    <dbReference type="KEGG" id="marh:Mia14_0720"/>
    <dbReference type="OrthoDB" id="371889at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052714">
        <property type="entry name" value="MFS_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23531:SF1">
        <property type="entry name" value="QUINOLENE RESISTANCE PROTEIN NORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="396" mass="44214" checksum="3B7EAA8BF18CE97E" modified="2017-09-27" version="1">MDKNKFYLLYSMLILIAFTFAVRSSNNAFMTTIPLFVKQYFNFTETDVGILAGFSSLVTFISTAFVNSRLCSRTRRYLFIVANALITISFVLIFFSNYLSIWVYILILSFSAGIIMPNIITSAGVSEDRKIRERMMGIYTLALSASLIAGPFIESIVLDYFPLKYAFLLFAPISLVALILSPFMKFPIAKSEDSGKGVKVWKNHGFKLAIYSILMYNAPFAMIVFFSGIFAEQSLGLSSSAVMLMFSLLFTISFISRLALSYFVPSNLWRYIKLSMLLTAIGLLTVFLSKDLFLYAIGIIVLGVPHGLTYPLSISAIGRSFDMSSRNKANSYFFAVIMLINIVVPTIAGGLISAVGFRETMLLVVPIIIILFLLARPEAKVLKALKENKMQSKNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ0</accession>
    <name>A0A218NNJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="5 14">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="5 14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ0"/>
    <dbReference type="KEGG" id="marh:Mia14_0749"/>
    <dbReference type="OrthoDB" id="14397at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106059">
        <property type="term" value="F:tRNA (cytidine(56)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18083">
        <property type="entry name" value="aTrm56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197:SF1">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="HD" evidence="15">
        <location>
            <begin position="193"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="353" mass="39697" checksum="01EB1DA4691FD9F1" modified="2017-09-27" version="1">MAKIYVLRLGHRPKRDKRVTTHVGLVARTFGADRFVLVGSDSKVVSGLNSVSNRWGDGKFEATSTKDAKKYVEQWKKSGGIIVHLTMYGLNLSGFDMNKVRGKDLLVVVGAEKVEPWYYENADYNIAVANQPHSEVSALAMFLDRYYQGRELDKGYTSKLSIKPMENGKYVTLIPNELECIDILKNEKVDDKLLLHSKAVYELAVEIGKRANANLNLITAGALLHDIGRSKANGLDHGHIGAEILRKKRVNEKVARIVERHIGAGLTKEDVVKNGLYIPKKNYVPITYVPITLEEKIVAEANNLIYGSKRVRIEKTIERYKKEGLNNSAEHILKLHKELSKKCKIDLDDLCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM2</accession>
    <name>A0A218NNM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase II large subunit</fullName>
            <shortName evidence="14">Pol II</shortName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="14">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">polC</name>
        <name evidence="18" type="ORF">Mia14_0771</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 20">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 14">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EC" id="3.1.11.1" evidence="14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820327.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM2"/>
    <dbReference type="GeneID" id="33314323"/>
    <dbReference type="KEGG" id="marh:Mia14_0771"/>
    <dbReference type="OrthoDB" id="7529at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056172">
        <property type="entry name" value="PolC_DP2_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056171">
        <property type="entry name" value="PolC_DP2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003103">
        <property type="entry name" value="PRK04023.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210:SF1">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24846">
        <property type="entry name" value="PolC_DP2_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24844">
        <property type="entry name" value="PolC_DP2_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase II large subunit DP2 N-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 central" evidence="16">
        <location>
            <begin position="299"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 catalytic" evidence="17">
        <location>
            <begin position="722"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ASI14065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129058" checksum="DB401777336F870C" modified="2017-09-27" version="1">MYIDDYFRSINEGVKKAYELAERARSKGYDPETFVEIKPAPDLASRVEGIIGIDGLAKIIEKEAEGVKSNEELAFNVARYICKDTRFDDRSIEKRLLLAARVGLAILTDGILVAPTEGLQNVELHKNLDGTTYAAILYAGPIRGAGGTSAALSVALLDAARREFGIGDYKPTQTEIERFIEEVGIYNSRVARLQYLPPDEDIRTILQNCPVCIDGLPTEDIEVTMHRNIERLDANGNPQLMTNRVRSGICLVSCEGIAQKAKSVLKHTKNSGLPWDWLTKIIKVDKGTTTTSSAAPKTAVFLQELVAGRPVFSYPDHPGAFRLRYGRSRFTGIASKGFNPVTMSMMNGFIATGTQLKVEKPGKGCVAVPVTSIEGPFVKLDTGEAFRIDKYQEYLKYKDRIQKIMSVGDILVTYGDFKKTNTPMQPTSYVEEYWYLQLTANGYSGGIPEVNSFKDAYEFSKKYNVPIHPKYLYDYSDINISDMKFLINKLKGLKFESDNLFDVKSIEFSGTDLERARNILEVICIPHFDKSDKIIIEQDDAQSLILSAGLVDDEKVNLNKYDLSSYNDKVDSLSLLNSVSPIKIMRRSTRIGGRMGRPEKAKERMMKPSPNVLFPISDYGTRERSIYKALMQEYKNLGNKYINVEMANFICDKGGEPVTSFYCTKHKCRAHIEKICKNCGNKVEGDKCEKCGGSPISYSSRSISLVGLMEEAMKNVDVNIAPKNLKGVMGLVSGSKVPESLDKGILRAIHNITIFKDGTSRFDATDTPLTHFYPREMNVSVEALKKLGYDKDYLGNPLEKDDQLVEMMHQDVIMNNRGAEYLLHIAQFIDDLLVRFYRLEPYYNIKTAEDLLGHYVITLSPHTSAGVVGRIVGFTKANVGFAHPYYISARRRNCDGDEDTTMLMMDALLNFSKSYLPTTIGGTMDAPLILTVNVKPEEVDDEVHNMEITKSYSKEFYDKTFDYVSPSDEKVLIVEDNLDTDKVYSHVEFTHLSDINSIDEAPLKSAYTTLKTMQDKIDMQFELMDKLYTIDKKDTARRLIMSHFIPDLMGNLHSFSKQTFRCVTCNAKYRRVPLSGKCTKCGGKLVLTISKGGIEKYLNVTLSLIARYSLEDYINQRVLLIKDEIETVFGGIGEESLPTNQFNLSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM3</accession>
    <name>A0A218NNM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216905.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33314343"/>
    <dbReference type="KEGG" id="marh:Mia14_0793"/>
    <dbReference type="OrthoDB" id="387626at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="573"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="635"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="791"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="861"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="934"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial repeat" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1365" mass="147287" checksum="E76FFB42EFA78505" modified="2017-09-27" version="1">MADRRNKRDSKKSMKRLEKKIETDSIKEHSEAQSALEYLVTYGWAILIIAIIVSLLYFFVAVPSSVIPNSCSFTTGANCEDMELGSNSISHTSTISLLLTNSKDYAIKDPSITVEYNKVNVTHSCYPSYVLPGGSIICIANMSTYLPTNAYAYGNLYLNSDDCALSNSSSCTNAPKQIYAGKFNAHVALVVKPSLTISLNASSGHNGRWPADNYPDELTANVIFLGYPLAGSTVNFTEVPDEETLFPTYASTSSQGIAHSFVYGTTIGNIKVNATFGNYTSHYVYINFSPVTQYHLIFNVPYGKVTITTPINSTTFTKNATGTTICNSELNYSTPSQVTLVSNEAYENFTYAESNGVKYYNSTGSIPIYCNSTTVSFNYTTYYKLNENVNPSYSSGVVSSSPLSSNGYYKKDSSLQLSAKSSNPKEWVFANWTCAASTSIGSTCYSGNSQSPTIIMSNPVNETANFDPMLSLRVIPGGDGTITASTPSGTSTNSSTFKSYPESYGSKVTLGESPANSTFKFYGYSGLGTGNYTGDNTSPTVTMDYPINETAEYDVYLNELASPSSAASSLLPGSGWYAPDSSITLTEVNNTGYKFAGWTGYENNASSSFTMVVPNTDFTEQANYDVYLTELSSPSNGAKTLSPGTGWYAPDSSITLTEVNNTGYKFVNWTGQFSSTNNQLSITVPSTPFTETAEYAVALKLSVYEHGDGKATVSPGGSTNSSSIFWETPGASLYFTETNTTGYKFAKWVGYDSGNSSNFTMTAPNSPFNETADYDVYLTELSFPSGGAKKLSPGSGWYLPNSSITLSETNNTGYKFVNWTGYEKSTSSSFTMAVPNTDFTEQANYDIYLTELSFPSGGAKTLSPGSGWYFPGNSITLSETNNTGYLFIGWTGYEGSTSSSFGMTVPTEPFTEQANYDVYLTELSYPSNAAYSLSPGSGWYAPGTSITLSGKNNTGYKFVNWTGYEKSTSSSFGMTVPTVPFTEQANYDVYLTELSYPSSGVSSLNPGSGWYFPGSSITLSGKNNTGYKFVNWTGYEKSTLSQFSLTVPSVDFKEQANYDVYLTELSSPSGAAYSLSPGSGWYFPGSSITFSEVNNTGYKFVNWTGYYNPSHVANQCTQYDSCGGSDCPSGISSSDCYTTVQGECNVVLCTYYTYNTTLTVKVPTVPFMEQANYDVALILLVSPSGDGTATASPGGSTTSSSTYWETPYSDISLSYSTSNSCATFNGWTCSGNNCWSGPEQQTTYPYTSAFVVMSSPIVEAATFSLKTYELGLSSSGPGSVSPSSEEVNCGSTIEIEALLKKPPSCSGRTCYVNYLNNWTCSGNGCYSYPGDHPPYTPNPPPYTINVTVYNNMSETANFDTYSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP0</accession>
    <name>A0A218NNP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">thymine-DNA glycosylase</fullName>
            <ecNumber evidence="11">3.2.2.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.29" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP0"/>
    <dbReference type="KEGG" id="marh:Mia14_0808"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359">
        <property type="entry name" value="A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10359:SF18">
        <property type="entry name" value="ENDONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="47"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="221" mass="24885" checksum="1CE156C8C06F7150" modified="2017-09-27" version="1">MKIVVKMEMVNDKKFNEIVSILENKYKNVGYYLNFKTPIDLLVAAILSPQTRDTTINKLTPKLFENYHTAADYAHADKAELLSYISSVTFANPKAERIIEACRIVDEKYGGRVPDEKEDLLKLPGIGEKTAVTILINAYGKVEGIPVDTWVIKLSERIGLADSKNPDKIEEELKSKIDKKYWHNFAYILKEHGKELCGSIPHCSKCPLNGICPKNGVTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP3</accession>
    <name>A0A218NNP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase II small subunit</fullName>
            <shortName evidence="15">Pol II</shortName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="15">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">polB</name>
        <name evidence="17" type="ORF">Mia14_0770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EC" id="3.1.11.1" evidence="15"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820326.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP3"/>
    <dbReference type="GeneID" id="33314322"/>
    <dbReference type="KEGG" id="marh:Mia14_0770"/>
    <dbReference type="OrthoDB" id="372039at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003118">
        <property type="entry name" value="PRK04036.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="16">
        <location>
            <begin position="242"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="506" mass="57189" checksum="33E9C30A11C5D6DB" modified="2017-09-27" version="1">MEDSRIKEFSERLSKVKMLPKSEINSEVIGNVDLDRLVDRLILDIGSFVGFHFVTLEEVTQAIGEINNAKIPMPVEVIKSSSFKPIASEYHEKFEIENRDVEHANGNVNDFVDYFRDRLHRIRRILETHVSTDGIPVGNLSLLKDMVGRDVYITGIVSSKITTKKGNIMVVMEDETDSVKVIFSNSPSEIGKRLYNEASTLVDDEVIAVKGKLINQFVIAKQIIWPDVTITERKNVEEDLGIAFISDVHVGSKLFLEQNFENMIKWLNGGAQDERSKEMAGKVKYLVVSGDVVDGIGVYPNQDRDLSVPDMYMQYQMFFDLIEDIPDYIHVFVLPGNHDSVRRAEPQPAFPSTIIKDYKKDNIHFVSNPSYLTLNGIQVLAYHGTSLDSIISSIPGMSYDKPEYPMLELLKRRHLSPIYGGNVIVPSKTDKLVIDKVPDILTMGHVHKNAISKYKGVTIINSGTWQARTAFQVKYGQIPTPARMPVFEMKTYKVTTVNFSSDSNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNQ2</accession>
    <name>A0A218NNQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216906.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNQ2"/>
    <dbReference type="GeneID" id="33314351"/>
    <dbReference type="KEGG" id="marh:Mia14_0802"/>
    <dbReference type="OrthoDB" id="11879at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="675" mass="74128" checksum="1E2C198A585098D7" modified="2017-09-27" version="1">MKSFNYLAITLIVLLSLACLENSANAQYWFQSGVFGSRATEYNYGGSVQIETVSQVTPKIGSLGFWTGETLQNGAFIQIGYMVPNETGLYPDDCTLSGCSGNVYLTKGTPTWFYEYFPKGYSGSFLGEIGPNGAAGSNGQFNTYAFNSSGNGIWYFYFNGNKVGSVNLGTPQSGPNELTGIGEYSNAKNDTYNIIPVIFRNLSFYNGKVYLQVPKGLSYVGYGTGSDSSIPNDYGVSEVDNIIDEFEVGSGINLPSNGTTLWNLGFKLNILSQYGNLSASDMYNAYSTVNISEPEYYYVNGSEREVFVGWSGEGFGSYSGDSRTAQVTMDSNISETAEWQRQYYVTGNSSIGGVNGSGWYDANSTAELGINKTILAISGKERYTFVKWSNNSTTDPIYFKVTKPVKLTAELQKQYYVGVSSKYLGASGEGWYNDSSYANISVDSPFIGINSSSRYALSKWLINGNLLNTSSPGISILVNESYSIEPIYQKEDRANFIIKNLENENADITEIIINNETYNTSPFLDAGQSYNVEGAEYDRNSIPINKTITAADASYYLTVPLYNVRITALSYMFDSPLDATIDAKFENGTSSVYHTSRNGTVTISNVYGNYSLSLKSNLALPVHVESGSNAEEIYMVTIQAILSIVVLFAILIIAAYEAVRLKKIKRSKDHKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR2</accession>
    <name>A0A218NNR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Preprotein translocase subunit SecY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820395.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR2"/>
    <dbReference type="GeneID" id="33314381"/>
    <dbReference type="KEGG" id="marh:Mia14_0832"/>
    <dbReference type="OrthoDB" id="371914at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="479" mass="52043" checksum="13B0667F6C333EA6" modified="2017-09-27" version="1">MTFEFMDKISKYIPVITPPKKPLSLREKMVWTAIILGIYFLLYNTYAIGVNITDVTQPVLQLISIIFAARIGSIITVGIGPIVLSSIVLQLLNGSGIIHIDMDNPIEKGRFQSLQKFSAIAIAVIESVAFVLSGYVPVSNPGLAGVVMLQLALGAIAIIFMDEMMSKYGITSGINMFIAAGVSYAIVAGTATVIFPEVIGAITAGGAAAPANAVLAFGPLIFAIIVFLVSIYAYEMKIELPLSFGQMRGVGGRLPIPFLYVSVLPVILATALEESFTVWFKFLSGITGSFANFAKFIAYYQNGALSGGLVYLISPSFPLPYSAPYGIGGYLPYFSYLLTHTSDLFLPMGGMILVPEWIHVIVYIVVLEILCVVFGKFWIEMTGQNPEKLAQQLQDMGWQIPGFRRDPRMIKKLLDKYIPDITVLGSLFVGLLAAIATLTGAIGTGMGILLTVGIIYMVYQQLEQENLYETYPILSKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR4</accession>
    <name>A0A218NNR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820377.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR4"/>
    <dbReference type="GeneID" id="33314367"/>
    <dbReference type="KEGG" id="marh:Mia14_0818"/>
    <dbReference type="OrthoDB" id="42697at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="101" mass="11313" checksum="C6E9C0B797B6CB87" modified="2017-09-27" version="1">MIYYEIFLKKFLPSFRSALAIKMNEKFNIKESDIAKELGVTQAEVSKYLNRLNVVSPSYKIDDSDIESIAALMIAGDSANAQKQVCRICPVGSNVKCTFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU5</accession>
    <name>A0A218NNU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820429.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU5"/>
    <dbReference type="GeneID" id="33314404"/>
    <dbReference type="KEGG" id="marh:Mia14_0858"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="75" mass="8147" checksum="8F00BF8E55EC93CC" modified="2017-09-27" version="1">MHTEKQRIRAVFLLSFGTVFLISGIAGLLSLSISYNIKSFGTVIASLSVIAGAYFLLNAYFVWNNTATRGLGEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV0</accession>
    <name>A0A218NNV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820452.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV0"/>
    <dbReference type="GeneID" id="33314419"/>
    <dbReference type="KEGG" id="marh:Mia14_0876"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="184" mass="21293" checksum="F68E546EB7017847" modified="2017-09-27" version="1">MNQTMNAMANGNWFVRNMAGYKVIMRVLFGVVWLADAWLKWQPAFFSGFESMIQSSMIQQPSWMMPWFQFWINVTSYDPYLFALLIALLETLLALAILFGLLRKIVYFLGAIFSFFMWSVPEGFGGFYIYGATDIGTSIIYVLVFLLLILINGAFGTSKYSLDYYIEKKYRNWSKLAEINSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV6</accession>
    <name>A0A218NNV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain copper/silver-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV6"/>
    <dbReference type="KEGG" id="marh:Mia14_0878"/>
    <dbReference type="OrthoDB" id="37898at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="46" mass="5385" checksum="F46CF10D8C8319E2" modified="2017-09-27" version="1">MATDVICGMKVKENTDLKSEFQGKTFYFCSSHCKEEFDKNPLKYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV9</accession>
    <name>A0A218NNV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV9"/>
    <dbReference type="KEGG" id="marh:Mia14_0838"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="353" mass="39064" checksum="B2FC9B5728F8D393" modified="2017-09-27" version="1">MLSKKKKADYKDAKAGGNRPSQAAEKPSKKQGIKLLPFYIAFFISIALYLVFSGYEYLSIILGLLSFIFLVLIIGLELEQSVREEGSKKVVIEIFGTIIVVAVIWLALMYGLNTRYPINVVPSCSMLPYLHRGDIIAISGISNIKQIKAPMVNVTKSEIGYIMSQGYPDSLSCVAYKYSGTQLEVSQYYEEGWAIGLYKEGSSGDEILNNTSGYPISYNCGVRSIRYNNGTEGEEAYLESIRINNKTIKGDANNSVVVYQTEPSDLFYKEGDSFIVHRAYAILNQSGNYYILTKGDNNPGLDMQYDNYPPNSSEVEGKVVGVAPYLGYLKLLISGKFTAPAGCNSTIIHSWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW8</accession>
    <name>A0A218NNW8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW8"/>
    <dbReference type="KEGG" id="marh:Mia14_0899"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9235" checksum="72FA95F3769941FD" modified="2017-09-27" version="1">MLIHMIIMELTGREKNVCGIICGSERIRFTDIKKRSGLHQEILSRILRRIKDSCDILRLEGGYKCIEVDHNDLCKYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX4</accession>
    <name>A0A218NNX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RelE toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX4"/>
    <dbReference type="KEGG" id="marh:Mia14_0871"/>
    <dbReference type="OrthoDB" id="371669at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="86" mass="10475" checksum="25C2232AFD8A061D" modified="2017-09-27" version="1">MSYTVESTEAFEKEFSRNHKDKKEWLQHMAERLEQEPQSGKPLRGKLHGLWQLRIGPFRVWYEINEEQKKVTLRAILHKDEAKKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY9</accession>
    <name>A0A218NNY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY9"/>
    <dbReference type="KEGG" id="marh:Mia14_0924"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="83" mass="9902" checksum="9E68BAC6DD744853" modified="2017-09-27" version="1">MEFLETYSLYLNLINKKTDEKLDLSKLTFIDPMLILLLFDYLRNNEYIPPDNPPTRNYIDIMIKTYNKPNPNNRSYLPVTSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP02</accession>
    <name>A0A218NP02_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820486.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP02"/>
    <dbReference type="GeneID" id="33314455"/>
    <dbReference type="KEGG" id="marh:Mia14_0918"/>
    <dbReference type="OrthoDB" id="9418at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="130" mass="14807" checksum="A0D24EE57B268AAD" modified="2017-09-27" version="1">MVVRKERRSRKYFGSRHWGLGNIKNGRGSGDRGGVGKGAVKPRWTWTTAKHPELIGKRGFHHWGQEEHKWIDLYAINGMLEKEKKETLDLKGYKVLSRGELNFKVKIKASGFSKKAMEKIKAAESTAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP07</accession>
    <name>A0A218NP07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820469.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP07"/>
    <dbReference type="GeneID" id="33314435"/>
    <dbReference type="KEGG" id="marh:Mia14_0895"/>
    <dbReference type="OrthoDB" id="371748at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="90" mass="10595" checksum="24CA5695ECEEF75E" modified="2017-09-27" version="1">MADIKKRGLDSLISGNSHSGPQTSESSEKYTKTVGFKVTEKQYETYRRYSKYFGIDDLIKKWRADLDKIEQEKGRDMENVETEIRKRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP19</accession>
    <name>A0A218NP19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system ATPase GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820508.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP19"/>
    <dbReference type="GeneID" id="33314477"/>
    <dbReference type="KEGG" id="marh:Mia14_0940"/>
    <dbReference type="OrthoDB" id="33500at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01130">
        <property type="entry name" value="VirB11-like_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050921">
        <property type="entry name" value="T4SS_GSP_E_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486">
        <property type="entry name" value="TWITCHING MOTILITY PROTEIN PILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486:SF15">
        <property type="entry name" value="TYPE II_IV SECRETION SYSTEM ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="3">
        <location>
            <begin position="183"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="479" mass="53842" checksum="48156C6C7F25BC39" modified="2017-09-27" version="1">MDNDNNENNNLDKGKEDQLAQEGDSELKNDDDKKSDAMENRLTADETLIEDKILEMLIGKFSNIDKQSEKFGLVEGAAKSVKPDISDELIKKIYDDITYIGKIEELVTNDDIEDIAVNNTIGIFAYFSGGRSVNMDYKFKTKVELARFVKKIRLYSTNEEANGNIIDVHMENGSRANIISSPRGYDITIRNFKKHTLSVLDLVNFGEFDYSIAARLWLYMDGLKVKPANILIAGMPSSGKTSLLNSLFSFIRPNERVITMEETYELDTSMANNVVNLETSQDMPMRELVKNSLRMRPDMMIIGEVRGPEANDMITAMNVGNICLGTIHATSSRDIIDRLENSPMNVPQGVIPTIDALMVLSQVYINGKPIRKIIQMSEISGIETKILLSDLYKYDYKSHTSSPILPSVTYRDRLAKAVGVPPPDILAEENVRMQILMQLNRLGIRDIKSISQVVQDYYDNPDALLAKIGLNGLHPIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP35</accession>
    <name>A0A218NP35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease P protein subunit aRpr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820543.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP35"/>
    <dbReference type="GeneID" id="33314516"/>
    <dbReference type="KEGG" id="marh:Mia14_0980"/>
    <dbReference type="OrthoDB" id="10058at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="12269" checksum="864CB7A85B69F90A" modified="2017-09-27" version="1">MHKHKSSININKIANDRVRILFDTALLNEDNRDYAAYCISEMRKISSHHRIKLSRSVKDRFCRKCNSLLVPGETAEVRILKKGKEILYKCNRCGTKKHIITDIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP47</accession>
    <name>A0A218NP47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820553.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP47"/>
    <dbReference type="GeneID" id="33314527"/>
    <dbReference type="KEGG" id="marh:Mia14_0991"/>
    <dbReference type="OrthoDB" id="34774at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058247">
        <property type="entry name" value="DUF1453"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07301">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="172" mass="19228" checksum="6AB3A0287F6983A8" modified="2017-09-27" version="1">MELEYIYLIVFIALIMLLRLRRQKKGYKASTARIFRYPAIYIVLSLILVASAFNIVIFAVALLAILVGYAVGTIFGSKSSIFYSNGKIMYRRSNEIFAIWLAAFVARIVIEFMLPDDLGLQALTTTASSAFSGIGFWYSLVDILLAFSAGMLLGESIHLYRKYKNAKHDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP56</accession>
    <name>A0A218NP56_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease</fullName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820511.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP56"/>
    <dbReference type="GeneID" id="33314480"/>
    <dbReference type="KEGG" id="marh:Mia14_0943"/>
    <dbReference type="OrthoDB" id="33866at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07180">
        <property type="entry name" value="RNase_HII_archaea_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="234" mass="25919" checksum="C8114D7B312EF208" modified="2017-09-27" version="1">MIIIGGGDEAGRGPLIGPLILSLVLIKSSASIKLSGIGVRDSKMLSRKKRDLLYNQIKDIAFDIKVDSIEAEEINNAMKSNISLNELEAVHFAKLFDSVSDDTFVSKVYLDSPDRIAEKFGIRFSASSYKNTVVQNAKQSTKKGVKYTKIIAEHKADVKYPVVSAASIIAKVTRDIAMDEISSSLGIDLGSGYPSDHKAIDNLRENLSNKELSKYVRTQWSTMKTIRQMKLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP67</accession>
    <name>A0A218NP67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP67"/>
    <dbReference type="KEGG" id="marh:Mia14_1005"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="95" mass="10631" checksum="EECCB0F9AC0661AF" modified="2017-09-27" version="1">MDCLIFIMESVKPKPKSNPVLIAGFGWIAAGIVMIYTGYLIYLDRITSSNFREDIAFGLLLMIIGVLILALRSKINKIVEEKTAEANLKKQQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP78</accession>
    <name>A0A218NP78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arylmalonate decarboxylase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820571.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP78"/>
    <dbReference type="GeneID" id="33314547"/>
    <dbReference type="KEGG" id="marh:Mia14_1012"/>
    <dbReference type="OrthoDB" id="38446at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="22840" checksum="1B32FB1F08CA2E88" modified="2017-09-27" version="1">MIDLNLIVSSENHNLVTYMRDRFKANIFYQEFVPGHGESNSELKANYAALSSINAGIKKGSKIMYARSYSAFSKKGWSNIREALKGNEVSISTESIISSLNSIKAHRIFLISLYNQKRHDYEIKWLAGFHFDIIGSIALGRTGGKAITKVSKEDIMDSIKVGKQSDADAIYIACTLLPVLEPKELVSPVPVITPINSMARELGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP84</accession>
    <name>A0A218NP84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC2-1 family ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_1014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820573.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP84"/>
    <dbReference type="GeneID" id="33314549"/>
    <dbReference type="KEGG" id="marh:Mia14_1014"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050763">
        <property type="entry name" value="ABC_transporter_ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711:SF5">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="300" mass="33789" checksum="5E92E2D4019DCFB9" modified="2017-09-27" version="1">MENEIKIDNLSKNFGNLHALHDISLDLKGGMHIVLGPNGAGKSTLLKCIDGHYKLDRGYVRVNGLDPYTNDKIRDKMSILSDNYSLYDELTVIDNLKFFGRLYGLKDKEILENVSEFLNEFDAARYLKSKVSTLSRGTKQKIAFCRALINKPEILLLDEPTAFLDSRSSQLMHDIMQEYSKNGRIVLFVTQKLDEISRFNSELIILRAGTVSDVTTTSNIYSTILKDTIINIRLASGFDPNKVKGIPNLYNANNASPNFIKVKIKNYKDINDTVAYLIENGGYVIGVDYIEPLIESLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL8</accession>
    <name>A0A218NLL8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="6">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisS</name>
        <name evidence="9" type="ORF">Mia14_0029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819544.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL8"/>
    <dbReference type="GeneID" id="33313590"/>
    <dbReference type="KEGG" id="marh:Mia14_0029"/>
    <dbReference type="OrthoDB" id="8659at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="424" mass="48104" checksum="10A8E68E096437ED" modified="2017-09-27" version="1">MVDLPFPKGFRDMLPNEALFRSKMLRRIEDIFQLYGFMGIYTPKLESMKLLRAKESIGEENKLIFELKNEGLGLRYDQTVSLARYFIMHSNLPLPFKRYSIGEVWRMDEPQRLRYREFTQADIDIIGGDSVKADAEIIAAASKVYEAFGVDYKISINDRKMLDEFFAKLKISKENQLKIMRAIDKIDKLGITGVKELIKESELKEEQVNEIIKLISFEGTNTEKLNYIKSLIGEEPASEIENTILLLESYGIKAIPSIDFSTVRGIDYYTSIVFEFKTSGENAALGGGGRYDNLISNYGGKQIGAVGFAVGVDRLLDVLKFQESKEITPAEVFISNIKKENYQYALKIANDLRSHGIKVDLNDSDRNLSNQLSYSNAIGFKYTIFIGPSEQESGKAKVRDMKSGTETLVEIQKISEFFKASTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN8</accession>
    <name>A0A218NLN8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819546.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN8"/>
    <dbReference type="GeneID" id="33313592"/>
    <dbReference type="KEGG" id="marh:Mia14_0031"/>
    <dbReference type="OrthoDB" id="45154at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="142" mass="15953" checksum="A150730E296CBDE5" modified="2017-09-27" version="1">MPNGQFAARKLLTERKHQRMLKKWLKRRKLKLKAKYDPVGTNPRAKALVLQKYSVEQKQPHSGQIKCVKVQLIKNGKVVGAYVPNEGAINFVDEHDEVTIEGLGGSQRGQMGCIPGLKYKVVEVNGANLRLVAKGKKQKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS0</accession>
    <name>A0A218NLS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease P protein component 1</fullName>
            <shortName evidence="7">RNase P component 1</shortName>
            <ecNumber evidence="7">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnp1</name>
        <name evidence="8" type="ORF">Mia14_0065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819578.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS0"/>
    <dbReference type="GeneID" id="33313625"/>
    <dbReference type="KEGG" id="marh:Mia14_0065"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="129" mass="14875" checksum="71ADC252F2872381" modified="2017-09-27" version="1">MNKASPKEKGSVTKADIANEINEIYRSYNNKNIVLEELIGLRVSVYKSVDQKRAGIKGHVFKETKNILQIKCKDGSVKTIPKKGATFKFHILKNSFKVKGEEIGFRSYERTKKSLKFYRIRKNLSKQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT3</accession>
    <name>A0A218NLT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S27ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819596.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT3"/>
    <dbReference type="GeneID" id="33313644"/>
    <dbReference type="KEGG" id="marh:Mia14_0084"/>
    <dbReference type="OrthoDB" id="25142at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="4">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="52" mass="5982" checksum="72AA615F7841BB23" modified="2017-09-27" version="1">MANDKENKKFKAYSSGKMCPKCNSKMASHKDRYACGKCGYTEFKHKEGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU8</accession>
    <name>A0A218NLU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ORF">Mia14_0093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819604.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU8"/>
    <dbReference type="GeneID" id="33313653"/>
    <dbReference type="KEGG" id="marh:Mia14_0093"/>
    <dbReference type="OrthoDB" id="275101at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041664">
        <property type="entry name" value="RNAP_arch_Epp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="3">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="64" mass="7073" checksum="EE7097EEFB0BDC10" modified="2017-09-27" version="1">MDELACRNCKFIISSHSSKCPICGSDDLTSKWSGYIIMLNVDKSELAKTSNIKTNGVYAISIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLU9</accession>
    <name>A0A218NLU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell division protein SepF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819600.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLU9"/>
    <dbReference type="GeneID" id="33313648"/>
    <dbReference type="KEGG" id="marh:Mia14_0088"/>
    <dbReference type="OrthoDB" id="6148at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="entry name" value="SepF-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="122" mass="13720" checksum="A5A9B8A768257BBB" modified="2017-09-27" version="1">MSLFGKLGKDLGVSKEINIEDYMNSQEMENVDVLNEPADFYVKPLNLESEDDLAAIEDELNKKNILLLDISSMSARPKTLKDLVDKIKDYVNKIDGDVGRIDTGKIIITPAKVKIIKKKKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV7</accession>
    <name>A0A218NLV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819601.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV7"/>
    <dbReference type="GeneID" id="33313649"/>
    <dbReference type="KEGG" id="marh:Mia14_0089"/>
    <dbReference type="OrthoDB" id="7940at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052552">
        <property type="entry name" value="YeaO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22752">
        <property type="entry name" value="DUF488-N3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="126" mass="14921" checksum="11EE1821F8A5105E" modified="2017-09-27" version="1">MIKIKRVYDRIDIHDGTRILVDRLWPRGVRRSSANIDLWLKNVGPSDDLRKWFSHEPDKWPEFKKRYISELKTNPVFDKLLDIAMTTDPITLLYATKDPDKNNAAVLMEQLNIRIKKIQSLTYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX9</accession>
    <name>A0A218NLX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819645.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX9"/>
    <dbReference type="GeneID" id="33313699"/>
    <dbReference type="KEGG" id="marh:Mia14_0140"/>
    <dbReference type="OrthoDB" id="24581at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050764">
        <property type="entry name" value="CbbQ/NirQ/NorQ/GpvN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759:SF1">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759">
        <property type="entry name" value="MOXR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002849">
        <property type="entry name" value="AAA_ATPase_chaperone_MoxR_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="310" mass="34292" checksum="948679D01C654645" modified="2017-09-27" version="1">MMEAVDVKDIYQKIETEIKKRIAGKLDVVKLMFVAMIANGHIMLEGAPGVAKTTMTKTLAETVQASFGRIQGTPDLSFKDIVGYTYMDDKNNVQLKKGPIFNNILLIDELNRAPPRTTTALLESLEERQVTMGDSTMPLPKPFIAMATQNPLNIEGTTSLPKVLTDRFLMRVAVDYPSMEEEQQMLRIKESEEHTTVNKVISVDDILSMQQLVKSVSMPEKIIKYITEIVDATRTDMHVVMGGSPRAEISFMQCGKALALVEGRNEITIDDIKYLAKPVLSHRIAVRATGAIGVNGIIDGIIANIPTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY2</accession>
    <name>A0A218NLY2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">Mia14_0122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819628.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY2"/>
    <dbReference type="GeneID" id="33313681"/>
    <dbReference type="KEGG" id="marh:Mia14_0122"/>
    <dbReference type="OrthoDB" id="85411at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_A">
        <property type="entry name" value="SecF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048634">
        <property type="entry name" value="SecD_SecF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024921">
        <property type="entry name" value="SecF_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081:SF8">
        <property type="entry name" value="PROTEIN TRANSLOCASE SUBUNIT SECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PROTEIN-EXPORT MEMBRANE PROTEIN SEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Protein export membrane protein SecD/SecF C-terminal" evidence="10">
        <location>
            <begin position="207"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="387" mass="41948" checksum="76E3F0B07C4FCCD6" modified="2017-09-27" version="1">MFNIYTYKNYKLYIIVPLILLLISLFFIPKIILDTSLTGGTTVQFSTANSINVKSLTSSIDALIPGTTVTVSKIGGLNHISLIALPNKSITSGQAELLNLTSLYSNYSSYSADIAIIRGNLTASPGNVTDENQLVNYTGKLSSTISSMDSTLDLELHYFSPFITPSSYIFNSTNATSMIDIGRNADSNASSAYQSGLIAKIRSVIPFSTYSYDSVTPTLGAYFLSKVIDIIIAAFIIVAIVVFIIFRTPIPSFAIVFGAANDMIIALGAMGLFHIELGVASVGGLLMLIGYAIDTEVLSSVRVLKRTDGTNEERAFQSMKTGLTMTGAAIITFGILFIVSYIAFVPTYIEISGVVLFGLIGDIFTAWLGNTAMVLWYKNKRDSRWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY7</accession>
    <name>A0A218NLY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY7"/>
    <dbReference type="KEGG" id="marh:Mia14_0137"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="105" mass="12030" checksum="BF29592DE5E83912" modified="2017-09-27" version="1">MRILCFTYCASFFIACLQNRLSNFGDLLNFATILGYAGMLILLASIYLLGRNEHKLGWSTQIVGDFVLFVYSILLQLNVFIILEAAFTIVASWNFIKLVRNRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM01</accession>
    <name>A0A218NM01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819648.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM01"/>
    <dbReference type="GeneID" id="33313702"/>
    <dbReference type="KEGG" id="marh:Mia14_0143"/>
    <dbReference type="OrthoDB" id="1011at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="399" mass="44482" checksum="3066103F264566D1" modified="2017-09-27" version="1">MKDAYDLKKELKILKSIRGSGTELISIYVPPGFPISDEVARLRSEYGQASNIKSKTTRLNVQNAIERIIQYLKVYREVPQNGLAVFCGNVSNVQSKTDIELYSMNVPQPLKSNIYRCDSTFLLEPIEAMAESTDNYALLVMDGREATLAILKGTEIVIDKNIKSFAHQKVHKGGQSAARYDRAIGESIDDYYKSIADAVNDLFLKWNFKLKGLVVGGPGPSKENFVKAKNLNYQIKVLGVFDTGYTDETVGLNELLEKAKSLLSQQQAIIERTTMEKFLNEVSHNGLAVYGYQKVKDALFRSNVSKLLISEDAELYNVSYKCSNCGVEFTKLEKGNQRETQHECGGALSVTNEKDAIEELIDIADKNGIETLFISSDSQYGKELLLGFDGVGALLKYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM02</accession>
    <name>A0A218NM02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819649.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM02"/>
    <dbReference type="GeneID" id="33313703"/>
    <dbReference type="KEGG" id="marh:Mia14_0144"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="19407" checksum="D0770E9EE3F34B54" modified="2017-09-27" version="1">MAIDDKLDKGGNNFTSSNKAILGSVIIVVAAIIISIAIISLHTGAQSNNLAAFESYYKSSPNLNIYVNATNSSSFVNTLGCADSLIEVIIENKTIHKSPSDINLFIMNNTSCIYSKGLVNVENYSNASISKCLSYSNSSPTIMINEGPINKTIVSGKRISYYGTPAFIENCGIAYELSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM05</accession>
    <name>A0A218NM05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM05"/>
    <dbReference type="KEGG" id="marh:Mia14_0171"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="233" mass="25991" checksum="9FCF8719A865CFD9" modified="2017-09-27" version="1">MIKVGIMDEDVDYDKIKDFINNIYGSSSQNPTSESTPITINISEVVDNPESNQNRMSYADVIKMINSLDYGLFRNNRITNLYNPIAPSKYIIGEQTQRTRETTATPVVNISSSAQQNQVVSEAQANPAKGIKLKDLVKKINYDDLVLPSLPISDQISEINRINDGLRNNIFDHDHLIIVMQEIYGIKRISDKEKSDLGSKMSKLGDAEKALLSARDDKISEGINLIDKMVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM20</accession>
    <name>A0A218NM20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM20"/>
    <dbReference type="KEGG" id="marh:Mia14_0184"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="163" mass="17867" checksum="E5D3CD71F5FDA749" modified="2017-09-27" version="1">MVFMEEGKSLMQILNDDIGFTRDLISFLLTAQVKRGLAEINSYIPANLAGNVLPYFVAAGVLDITGKDINRNNIERLFNAIGVPVNRDILNGIASIKFKNHLVYVISILFILTSGQEATMDKIINMAIAFDVDPDIALARESVDIFNQVGKEHGFPAIKLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM24</accession>
    <name>A0A218NM24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dimethyladenosine transferase (rRNA methylation)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891414.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM24"/>
    <dbReference type="GeneID" id="33313751"/>
    <dbReference type="KEGG" id="marh:Mia14_0193"/>
    <dbReference type="OrthoDB" id="9883at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="266" mass="30561" checksum="AFE15E748B36C82B" modified="2017-09-27" version="1">MNLPHIKKSLGQNFLNNRNIAAIESEYGRNRNVIEIGPGRGILTEELCKRAKSVLAVEKDSSLYEELLSSLAYEPNLTLLNMDFFEFDIDASKYEIIISNIPYNLSSKTLKWLADNHKEALLCVQKEFAERLTAKPGERNYSKLSVFAQLNFSVYKIMKVKRGSFYPVPKVDSEIIYLKPVKNKVSASEYRILDLIMEHKKKILKNAILDSQKNLGLTQERIAQVMRILNEDNNLKGIDLSKTKVFKINPEALLKISQFINQYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM26</accession>
    <name>A0A218NM26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819677.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM26"/>
    <dbReference type="GeneID" id="33313733"/>
    <dbReference type="KEGG" id="marh:Mia14_0175"/>
    <dbReference type="OrthoDB" id="387369at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="614" mass="66164" checksum="13D0B547F2545F02" modified="2017-09-27" version="1">MTNKKGFIFTLDAVFALIVAAAAISILLYIHFIAPISYQSSISQVEDDLQVLTSTPLGGYLSALDNPFSGYTRSYNTFGAASFDGYNSYISSQLSVPAAENLTYVAWIYLNYIPDNNAGIISAVSSYNYGSMSIFLNGNCNIQVLVTNNTGNTFADDSPYCLKPHRWYQVVATENESISQDGKVIGGNYTLYINGEWNLTQKFSGALEGATGFNIGLFSYQGAYFPGYISNVQIYGSRLTRTQVSSLYDEGTMGIPLRSSNLLEWYPLNSESNPNVFKSYNVTYFNTGDISIGNVNLTENQSMLSAIADLYLNDQAPEADIIMDNLYHNEDTGIYINSTYAPDLKVAYFDGTAGFYAPNFTYPGKNYTINQWFYLSQADDPTSGVGGGQSPIVDIYNGSANGGIGGSQNLDFGGTWAGGSSNNFGIGEDWPSDWEFCSTNAGTVFPNKWYNAVVSVVNYTNVTIYLNGVEAKNCLLTVPISGMEYPTLGIGDNPPGGNELATAAISNVQVYDSAVNANQAVTLYDEGIAGEPVSSSVIGWYPLLGNFNDYSGIGHSGFGGNGGSLNPDNVRFIESNFTPPGFASSDIISQASSPELLNVNGTMNVYNVSVLSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM27</accession>
    <name>A0A218NM27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone GrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819682.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM27"/>
    <dbReference type="GeneID" id="33313738"/>
    <dbReference type="KEGG" id="marh:Mia14_0180"/>
    <dbReference type="OrthoDB" id="372230at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="231" mass="26256" checksum="F3C9265FB758EECB" modified="2017-09-27" version="1">MDDKKDSKKEKVNSADNGIQGSNAKEDKDVKESRNEENKSEETSEGNKGDNHLVEVEEDLKARTEEVKEYKERMLRMAAEFDNYKRRVQVDLNNANSLGKLDVVKKLLPVIDEFELALKAVEKSNDKEVKEGIEMLYKNIMNILKKEGLEEIQSTGKYDPYLHDIAVVKESNDPDGHILQVISKGYKFNGNVIRPASVIISKKENDKGQGEKKENKDSKGSPSDNEEHNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM41</accession>
    <name>A0A218NM41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DrugE1 family ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM41"/>
    <dbReference type="KEGG" id="marh:Mia14_0197"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="328" mass="36031" checksum="283C7D0B6A11A592" modified="2017-09-27" version="1">MYPMVKNALEIKNLVEKFGDFTAVRDISFNVKEGEIFGLLGPNGAGKSTTLNLILTLLTPTSGSINLYGIDIHKEVHRAKKMIGFMTQETVVEQDLTPRQNLEIFGELYHIENIKDKIAESLKDAELTDFADYKAGSMSGGMQRRLALVRSMIQDPKIIILDEPTTGLDVQNRTALWEKIRSLNKKGITVLLTTQYLEEADALCDRIAIIDKGEIKAIGTASELKASVSSGDIVEIVTQSDATGKVASVLEDFGLSPVVKIDIVTAAIEKGEIAKFSDITKELIKENIPILGISMHLPTLDDVFIKLTGTGLRDKAEGKPQIQMRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM42</accession>
    <name>A0A218NM42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHA01755 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819694.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM42"/>
    <dbReference type="GeneID" id="33313752"/>
    <dbReference type="KEGG" id="marh:Mia14_0194"/>
    <dbReference type="OrthoDB" id="101984at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="417" mass="46089" checksum="FF2F0063A7CDD6BC" modified="2017-09-27" version="1">MLSKQLKSQSAVEFLSTYGFVILIIGIVISLLFAYISLPKSIIPSQCDFYNGFDCLSSGYSVNYSTKIGSVFTLIASDTEPGSVKITNFSVKIGTYNSNYGFCTPNVSEGGQKIYCYAYFNNFTPVIGNQYDGLFVLKSDYCSAPPQNLSDVNCLSKPANFTFDGSFRVQAADLNYSYDPYYANISITNSGGKIPAGYQANITIDPASFRSAETQNLGNIRFYYNGKELYSWCQDNCSSSFSQATFWVKLPVSLYSDESIPITMEFLPKTANYSGDYSGEAPQLSLPYAGYDNGDKVFDFYSDFNGVVLNNAKWNTTPDAIYTVDNGLTFSSAGSGYIESLPKFNSYTEKEAYVYPKSDTWENFTEKGNYYFNYSEGPIFIYPSGSSGKMLYILVRNIPPSGIAPNIGIGSLEKQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM44</accession>
    <name>A0A218NM44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819700.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM44"/>
    <dbReference type="GeneID" id="33313758"/>
    <dbReference type="KEGG" id="marh:Mia14_0200"/>
    <dbReference type="OrthoDB" id="382630at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="307" mass="35904" checksum="395A6034FB060253" modified="2017-09-27" version="1">MVMQRGIKEVLKNYNMPLWISDYVDAYIREDPLNSMKRATSFINVKRKRGSVTSTYVILPNGIKFSMSDISKILSLFYYGEKQVELMAESWSSRPDPVHVNYVKHFINVGKAEKRHLRAIKNLMDGLMRKPEEPPQIIKDVFSYIMNLDQWEERFIALYMIMRYSYSAIFGQVFYKVFYFVMPEFMRSFGKVYIDENGDLKWALEETRNMIKNGSISESRVLKISEDLLSLIEASVKYEISITKDLEVEKEIRLMLKVAIAYPLHELKDLGVNVDIKKEESTIDTLSDNLLKQNNKNEQDKAVPTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM64</accession>
    <name>A0A218NM64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819716.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM64"/>
    <dbReference type="GeneID" id="33313775"/>
    <dbReference type="KEGG" id="marh:Mia14_0217"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="126" mass="15089" checksum="835902E33A1BE5EB" modified="2017-09-27" version="1">MESITNTEPYRKIEHLSKLSEGEFLKYCSNNDIKPIIREYCSMLVRKISEKFGKPVEYSSIPNFLFERDLIDPSLYPQLKEMLLFVDNLENEPLPEIYYNLIRILETIEEAYEQIDLKFSKKRDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM68</accession>
    <name>A0A218NM68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780224.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM68"/>
    <dbReference type="GeneID" id="33313794"/>
    <dbReference type="KEGG" id="marh:Mia14_0236"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="77" mass="8773" checksum="2BCA9816D5CCFA3F" modified="2017-09-27" version="1">MSSNPILVEKHVILSDSEADEVLKKFKITPDKLPKIYDDDPQILKVKGKPGQIVAIDRDDDGKKYTYYRLIIKKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM72</accession>
    <name>A0A218NM72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819730.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM72"/>
    <dbReference type="GeneID" id="33313789"/>
    <dbReference type="KEGG" id="marh:Mia14_0231"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="187" mass="21068" checksum="6FEA9B0BFBDAF44F" modified="2017-09-27" version="1">MLRSHASKAVFAAVLLLLIIFLAYAYGSERLYGGPSVNTSIYSVNNINNFSEVYNTTLKYVTLVNKSSYIVFYPNLKGAYANLSKAKNLSKENPAVAYSLLEDSYKSASLQLKRIGTYRLPTLIILIVLTALSSLYLYYLMEPVKRQPKQKPYADVKKEKGEKPRKAASHRKNMAKRGKKGAKRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM73</accession>
    <name>A0A218NM73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">Mia14_0230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819729.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM73"/>
    <dbReference type="GeneID" id="33313788"/>
    <dbReference type="KEGG" id="marh:Mia14_0230"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001658">
        <property type="entry name" value="PRK00423.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="159"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="253"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="342" mass="38158" checksum="713DE3FED511213A" modified="2017-09-27" version="1">MANEINKDENNEKISKKRGRPKGSHSLTAKELSDEEAVTAGPIKVCPSCGSTDILYDSERGELVCNNCGLVIEDEITDTGPEWRAFDSDQRNSRSRTGAPMKYTRPNKGLVTEIDLYNKDIRGVRIPSKRQAQLYRMRKWHKRASIASSSERNYLIALPELTRVSSYLGLPENIREQAALMYRKCVQNNLIRGRPIETVVQAVIYASCRKAGMPRTLDEIANISGLPKKEIGRAYRAISHELNLKIPLTDPISYVPRYINSLKLSGEAQEKAIELLKEAMKKGLVSGRSPTGVSAAAVYIAGALAGERRTQKEVADVAGVTEVTIRNRYRELKEQLNIDVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM77</accession>
    <name>A0A218NM77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription termination factor FttA</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fttA</name>
        <name evidence="16" type="ORF">Mia14_0234</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Terminates transcription on the whole genome. Termination is linked to FttA-mediated RNA cleavage and does not require NTP hydrolysis. Cleaves endonucleolytically at the RNA exit channel of RNA polymerase (RNAP); the 5'-3' exonuclease activity of this protein degrades the nascent RNA released from RNAP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions, which are required for nuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with RNA polymerase (RNAP), interacts with the Spt4-Spt5 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. FttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819733.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM77"/>
    <dbReference type="GeneID" id="33313792"/>
    <dbReference type="KEGG" id="marh:Mia14_0234"/>
    <dbReference type="OrthoDB" id="7155at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22532">
        <property type="entry name" value="KH-II_CPSF_arch_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00870">
        <property type="entry name" value="FttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="TffA_KH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF51">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_TffA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 12" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="200"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="15">
        <location>
            <begin position="439"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="KHa" evidence="12">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="KHb" evidence="12">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Metallo-beta-lactamase C-terminus" evidence="12">
        <location>
            <begin position="593"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="651" mass="72352" checksum="C18BDDE8505BCBE2" modified="2017-09-27" version="1">MEDQVKKEDQSKIKATEIFNQIKSMLPASADYVKAEFEGPDIVVIVKNIKAVYNDESIVRNIASLIKKKLIIRSDSSVLMNPEQALERIKELIPKEAGITSIKFVPEFAEVYIESLKPGLVIGKEGSTIKSIVNDTKWSPKILRSPTMNSDTIKGVRQLLYNESAFRKKFLLGVGKKINNVLMKSEWLKATALGGFREVGRSSLLLETPNSKVIIDCGISPEPGIKGLDANAGSEGNKAFPYLDSANITMNDIDAVILTHGHMDHIGFVPYLFKYGYDGPVYCTPPTRDLAALLLNDYTRLVAHSGGTPLYDEKDIRKMLTHMITRDYKEVTNVTDELKLTYHNAGHILGSATVHLHYGEGMYNIVHSGDMKYGFTRLFDPAATDYPRIDAFFTESTYGGPHDITQDRHDSEKNLMSIIKKTTDNGGKVLIPLFAVGRSQEIQLVIESYFKSYGLDVPVYLDGMIIEANAIHTAYPEYLKEGLRRKILNNNSPFESEIFEVIKGERENVIDAQGPAIILASGGMLNGGASVEYFRRLAGDERNSLIFVGYNSANSLGRKIQNGVKEVPLPDPDGRFVPTEVKMGVNVVEGFSGHSDRRQLMDFAKHLTVRPKNVFTMHGEESKCVDLADTLGRALHANARAPMNLDTIRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM80</accession>
    <name>A0A218NM80_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819726.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM80"/>
    <dbReference type="GeneID" id="33313785"/>
    <dbReference type="KEGG" id="marh:Mia14_0227"/>
    <dbReference type="OrthoDB" id="32917at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="215" mass="24964" checksum="FCFA64B5D0539EBB" modified="2017-09-27" version="1">MEGENLPKELLKKYELPQLPYKLDALEPYISKDIMDLHYNAHHKGYVNSSNTFVDRFNKVIKGDLPAGDYDMQGLMRGLVFNINGHKLHSLYWNNMGEPGNKGGGTPGGELADMINKQYGSFDKFKGLFNEAANSLPGTGWTVLYYETENSNLQIMTFENHFQNHIAELPVLMIMDEFEHAYYLQYKNKRADYVNAWWNIVNWEEVDKKLRKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM86</accession>
    <name>A0A218NM86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819748.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM86"/>
    <dbReference type="GeneID" id="43457927"/>
    <dbReference type="KEGG" id="marh:Mia14_0254"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="249" mass="28705" checksum="C5C180D06C2BBCAA" modified="2017-09-27" version="1">MKYKFYTMLSALNSISIVLNYRYLYISAPILLANILVLAKPRLGNRNLKQQSEEFLINLASQQNSNDKQILNKVLKSINKEFKFGKDITRALRYYHFSGSLEYLSNLKYNESKLLERIKEIIVYSIHSGTDIYKPILTLKSEYYKSDVISRRSRALVKSSEAIMIMGNLVFIPMFAGISANILKFTSTISSGAILEFLTIIIFYLLMVNWINAEYSNKRDYPVLYLSIFYTAVASFALFSTYNVASRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM89</accession>
    <name>A0A218NM89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819753.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM89"/>
    <dbReference type="GeneID" id="33313817"/>
    <dbReference type="KEGG" id="marh:Mia14_0259"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="429" mass="48627" checksum="156D54F0F8A6F0B7" modified="2017-09-27" version="1">MKIQTTIEFIIILAAISSLIVVALSVYNGISSDAKETFNAVLSSAVNQSNSALYNNQSQTFEISYYLNSTLPYNMSSLGYIEILSQAPIKILNVSYTTNDGYIDLDKGLKNTTVNGFSIDEFYYIPNRTGLSKIQFNFKIKYKNNTVHKNISINTSVYNILKYSKSEYTVSININNSSVTYPIENKNKIYKFNIKTHCSAMNNGVELPINEQCGNASYDLFIFSNYCFYDQNAESRVICIYKDYNNLSLLSLSNNESKLSYNGKFKFNAPNISIYSNFSSSNYRSLNFDSSGYPSGYYGKLELAGAHASSDNYSNQLLYRNGSLWRINSSSAEDFYVQKAELNSLLAFYNGTGVDGKQWEYISENINAYNESIPKSSQPFEQDNCGLSYHLNYKCKNIPIKFSNITAEIKNYNIENETVIYGNYTINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM96</accession>
    <name>A0A218NM96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819751.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM96"/>
    <dbReference type="GeneID" id="33313815"/>
    <dbReference type="KEGG" id="marh:Mia14_0257"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="66" mass="7672" checksum="D556C7F9A516587D" modified="2017-09-27" version="1">MKMQVSFEIVISMAIGILFISSIMYMYMQVNARISDFKNSLNINYLQSVFNSSSWSDKYLVIKMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM97</accession>
    <name>A0A218NM97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC48 family ATPase of the AAA+ class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819754.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM97"/>
    <dbReference type="GeneID" id="33313819"/>
    <dbReference type="KEGG" id="marh:Mia14_0262"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="269"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="563" mass="63113" checksum="F4536D54F0E99969" modified="2017-09-27" version="1">MAIENNLPDDEGNADDSDMLETDNLAKNTNDNNEKAVNPEAKDHWKKGNGFFEDDEFEKAISEYNQAISIDPKYADAYFNKALTERIQKKYNEAREDLEKVILLQPSSYDAPLLIGDILESQKDYPEARMWYERSLAKNPDYSEAKDRIKNIDKLIHSEASSKIGSSSGLGNSYPNQSSSSTENLDDIGSELDRLSKGGNLWPGAGDNSTEDDNKEEIEEGQIKKVPFYKSNMTFKDVVGEEKLKRFLNDNVVLAIKNPELFKHYGKKLGVGLLLYGPPGVGKTYTVNAVAGEAGANVIIARTNQIVDMYTGNTEKNLHAIFEQARKNTPCIIFFDELDALGVKRGGGDSGGEGSALRLAVNQFLVEMNGVEKNPEGIYVIGATNQPWDIDPALKRSGRFGDALYIPPPNYKERKHLFEFYTSNKPHKKLHLGRLSRATIGYSPADIEKICDKAIMIPLLKEYNTRVKTKLSTGDLVKVIKGKVDENVGSSLDEWYLMVKKEVISKTETQIVDGKKQTIVKEGKLDAQEKILYKSMVKDIKKNTSSFHKFEKQMTRGFAVHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM99</accession>
    <name>A0A218NM99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891421.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM99"/>
    <dbReference type="GeneID" id="33313827"/>
    <dbReference type="KEGG" id="marh:Mia14_0270"/>
    <dbReference type="OrthoDB" id="308128at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07344">
        <property type="entry name" value="M48_yhfN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053136">
        <property type="entry name" value="UTP_pyrophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YGJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399:SF1">
        <property type="entry name" value="UTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="YgjP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgjP-like metallopeptidase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="251" mass="29767" checksum="FC786A1862DB9DAA" modified="2017-09-27" version="1">MDEINTSENFVYVNGKKYVLDIKFLNRKTATGFIEDDKICLKLPLRLNAKDKIKYISILKRRLIKRIIDGQIYRELRFKDGDLIHITDRSFLIHSSIDQFIKRPMTKLTGNLLYVVIPASEATKANYILNDRVIKFLIKLVLPYVIQRVNHINNEFFGFKVSRIKVYRPKKVVLGSCNYGNKTLSFNLRIFLCPENIIDSVIVHELCHLKVPNHSQQFWKLLYSVMPDYDEYRKWINKNLYSATLPNRWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA3</accession>
    <name>A0A218NMA3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lig</name>
        <name evidence="17" type="ORF">Mia14_0250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 14 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819744.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA3"/>
    <dbReference type="GeneID" id="33313808"/>
    <dbReference type="KEGG" id="marh:Mia14_0250"/>
    <dbReference type="OrthoDB" id="31274at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07901">
        <property type="entry name" value="Adenylation_DNA_ligase_Arch_LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000007">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000012">
        <property type="entry name" value="Probable DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="330"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="591" mass="66745" checksum="B2F5A5E7BE8D709E" modified="2017-09-27" version="1">MLFKTLSDYYEKLSKTQSRIEMVNILSEMFKQAAKGEISKLIYMTQGQLAPNFIGIEFGVADKIMEEAIMIATGYNKEEVESEYHKQGDLGEATENLIKSSKLARMSSKKYDVSDVYGSMYKIATISGKGSKEIKIRMLAELIAASDPIEAKYIVKYPLNSLRLGVGDETILEALSLMSTSERSNKSILDRSYNICSDLGEIGEIVLEGGIEAAKNMKVSLFKPIRPALAERLPTASEILNKMGGKCAVEQKYDGFRCQVHKDGNKVKLYSRRLEETTSMMPDIVKAVQDSIKAEKVIFEGEALAYNESTEEFLPFQETIQRKRKYGINEKIKELPLHLMAFDIMYLEGEDLLNKPYETRRELLEKAITGSDVISPSTRIITDSPKEFEEFFENSVENGLEGIVAKDLRSHYIAGARKFSWIKMKRSYRGELSDTLDLVIIGYYRGKGSRAELQFGGLLCAVYNKKRDMFETITKLGTGFTEDQMRKLQELLTKIKVDSKPARVDSLIEPDFWVYPKYVVTVKADEITESPMHTCGRSMQPDGTEAGYALRFPRLVGEEAIRADKSPEDATDTSEVIEMFSQQKKVSLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB1</accession>
    <name>A0A218NMB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB1"/>
    <dbReference type="KEGG" id="marh:Mia14_0271"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="585" mass="66222" checksum="DDF4EB395A42FEAA" modified="2017-09-27" version="1">MNRYLLVVLLMLVLVPITSSSATINSTSVLSQSKSLEYHMNIGEYTYEELNISNESTIVISYNTSSSAALLLVNASNYASYANNERTEEIYSSKVENSGVKELNVSPGSYYVILKAEYKPINYSFYIFVSPPSKLKSVNFSNEYTDNFSLSNYTNFSIDLISNKEIDMILPNYYNYIIQPYEEFQITAYLNRGPQKIIFKTNSSSRLFFYINSTNEIINPVSLINKSSPNPMGIASYGTYLKQGKLQTFKIKTNEIIGTANITSIYAYSSDPPENTSPYGASIQLNAMMNVISDNKTYQYWLQDVMSLNTSSLEYQIYSNMWNDTKLGANLSKSQLIGDGYIGTTYIKYNNSKIKTSFYGSYDSNNLNNKLSYPIYFSPVITVNNTSIGPRVNFGYYTQNGYRFFNNVTIKILNSTSYIEVTPYYEAGNGNSFDVGLVFGGESNDESSKFYNMNSTEDLYYVSNDSLIAFPYLYTFGINTGESASDLSTSVINNKIITEIGSPNYNEIITESQHYNSNKTYALQNESKAFINPTSGYEVDLQNGNPSISQIYEFVYKNSFKLLILILTIIILYTIKFLIFKNHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC3</accession>
    <name>A0A218NMC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819784.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC3"/>
    <dbReference type="GeneID" id="33313849"/>
    <dbReference type="KEGG" id="marh:Mia14_0292"/>
    <dbReference type="OrthoDB" id="25735at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="4">
        <location>
            <begin position="41"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="251" mass="28293" checksum="3B0489A5100D8086" modified="2017-09-27" version="1">MKQSELSKILDERWEEPWKLREEREKALSKSHGKIVKLLASAPLPTEYGYFTYMVFGDYTTGEFHNAVVYGDAKKSIKKEGMLVRVHSSCGTSELFHAINCECREELDEAMKRISKNKSGMIIYLNQEGAGNGIAPKIKAYSKSLVWKGNKVVGAKDKKGKPITAYEAYTMLGYKPENRSLLVAAEIIKFLGIKSVRLMTNNPKKIEELRKYGIKVEPEGIHVKPKSKIVKDSLKAKAKILGHNITSKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC7</accession>
    <name>A0A218NMC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYTH-like superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819782.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC7"/>
    <dbReference type="GeneID" id="33313847"/>
    <dbReference type="KEGG" id="marh:Mia14_0290"/>
    <dbReference type="OrthoDB" id="46040at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="199" mass="22429" checksum="4059B20A3B0FFE55" modified="2017-09-27" version="1">MVEEYTQEVEKRALLDRSEYNKVKGKLEELGASYNGIAHVKDVYFCKKDAKSFSEVEMNDIGSFSLRLRGQRNGNMGPAEATMNVKIITKEGDHNSWEEHETGIESIDEASAIFKAIGFKPFCTIEKDRSKYVLDGTNILLEDIEDFGLGVEAEIITNKEDSDAAKEKIDKVLAKIGISKSDIVEKSITNRIMKEKSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC8</accession>
    <name>A0A218NMC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819779.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC8"/>
    <dbReference type="GeneID" id="33313844"/>
    <dbReference type="KEGG" id="marh:Mia14_0287"/>
    <dbReference type="OrthoDB" id="4907at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053578">
        <property type="entry name" value="UDP-sulfoquinovose_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041015">
        <property type="entry name" value="UDPsulfquin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="386" mass="44031" checksum="B5C9DF53486B658A" modified="2017-09-27" version="1">MKIMILGIDGYIGWALGLRLIANGHDVIGVDNFYTRKAVREVGSDSALPLPSMETRIKEAKKVFGKEIQFYNLDIKNFAKISELIKRYKPDAIVDFAEQRSAPYSMVDAEHAIYTMHNNIEGTINVLYAIKQFSPDTHLVKMGTMGEYGTPKFDIPESAFVNTSINGKEDLITVPKWGGSWYHWSKVHDTNDILFANKIWGITATDIMQGPVYGTRTKEIVNKKLFTRLDFDGVWGTVINRYCVEAILGMPLTPYGKGGQTRAFLSLEDSVESLKRLIENPPNKGEYRVVNQFTEIYTVMELANEVKAIAEKLGINAEIKPIENPRVEAEQHYYNPERNVLPKLGILKPSRTLPDEVYAILSDLKNYRKRLEKYRDVLMPKVKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD8</accession>
    <name>A0A218NMD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819788.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD8"/>
    <dbReference type="GeneID" id="33313853"/>
    <dbReference type="KEGG" id="marh:Mia14_0296"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="183" mass="20552" checksum="D2233F2900FD26AC" modified="2017-09-27" version="1">MVRDIRDLYNTYWRQESIRLKEDAYHSIEFSTTLMFLSKYLPKGGLILDAGGGTGVYTMELAKKGHDVVLLDLSKENIDEAKKEITKLKEKRRVKDTIVGDITDLSRFKDSTFDAVLCLGGPISLVYGKSNRRKAMSELVRVAKPGAPIFISVMNRYGYALLAPRGWPKEIATTNFVNALTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME1</accession>
    <name>A0A218NME1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819802.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME1"/>
    <dbReference type="GeneID" id="33313869"/>
    <dbReference type="KEGG" id="marh:Mia14_0311"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="74" mass="8952" checksum="D1734D903F8BCBBB" modified="2017-09-27" version="1">MFSKLKHDSKDKPLDNEELYFEYKSSDGTIRKYRIISERDENKIIQKGIKMLKRQSREEIEKGEDDNTLRKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME3</accession>
    <name>A0A218NME3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819804.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME3"/>
    <dbReference type="GeneID" id="33313871"/>
    <dbReference type="KEGG" id="marh:Mia14_0313"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="244" mass="28236" checksum="7741A96FFCEE5410" modified="2017-09-27" version="1">MDEEQMLTELGFTNAESKVYTVLLRFGDSKTGLIMERSGLYSSVVYNSLKHLMEEGFVTFYTKGRIKYFSAVDPSRIVDAEKEKLELAEAMAERLSLIKKATEKRSSVFIFEGRKAARTIFNDILGTLRKGDEQLVIGVSDTGSGMGDFIRRWEEKRVKRGIRKRVLVSNRSSEWVSYYSIQRLVEIRTIPNSIYINMSINVYGNKVVLILWAREPTYILIEGEEVSKNFKSYFEMLWKKSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMG6</accession>
    <name>A0A218NMG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMG6"/>
    <dbReference type="KEGG" id="marh:Mia14_0328"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="465" mass="50935" checksum="25D31FFEB1B754DE" modified="2017-09-27" version="1">MLCKSNILDRMYKMQYQPGGGDSTGPNYNPYTPVDQNGGGGAYSPENIYGQTNPSGQGQNNNQNSPYGGIQPKRHTRRSPLTIPFVIIAIVILIIVAYRFIPSHPISVSNALPPATNPVISSVYHKSNIELFSVLGTSINRTDSLQDVNVTYSGKFSEDYSYSNKTFNVSVPFTLIYEKLDSNSKLYVRTSGNSEYGDIGLMMIKLNSSNYSCFEFLSNKYSCEKTSNTIGPSDLNSVSPNSNSSVFESILKLSGTRNSTYTGQKCYYLYGSGNVPLDSGSTKVNYTSGSCLPFYNSSLPLNLTLNYDILNQSEDSNTKVSFSINEVAYNSKPSYSFISGFPANVTSPSKVVVNSTPPRKNSTGIHIYNCSNLTITTSITSANITRECTFDGGFMNFTYGGGNSGYAELNVSSLNGYLYYSGYTTNTCPRYVRSVFMPEGLHYYLINFFTGNESGNCGNATLYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH0</accession>
    <name>A0A218NMH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH0"/>
    <dbReference type="KEGG" id="marh:Mia14_0344"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047627">
        <property type="term" value="F:adenylylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009150">
        <property type="term" value="P:purine ribonucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47670">
        <property type="entry name" value="ADENYLYLSULFATASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47670:SF1">
        <property type="entry name" value="ADENYLYLSULFATASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="158" mass="18413" checksum="401AF04CCF428BE1" modified="2017-09-27" version="1">MVYADFRYWSGKLISNWEKDGCVFCKIVSKELTADMVYEDDDVIAFLDKNPVFPGHTLVIPKEHYKTLLDIPDPIIAKLFSDVKFISRAVIKATKSEGIVILNNTIVSQSIPHAHVHLIPRNYKDGFYKYLPRRRYHYKEGEQPIEITIKEEIERLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK2</accession>
    <name>A0A218NMK2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891429.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK2"/>
    <dbReference type="GeneID" id="33313928"/>
    <dbReference type="KEGG" id="marh:Mia14_0371"/>
    <dbReference type="OrthoDB" id="371863at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06091">
        <property type="entry name" value="KOW_NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="NCBIfam" id="TIGR00405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="149" mass="16311" checksum="3166B6EEFEAE9405" modified="2017-09-27" version="1">MYFVVKVTSGQEKIVASVLQNKALKSDLPIYSIAIIEGMRGYIIMEAEDELSARSFISRERNVKGILPKALSSEELNKMIAANNTAAEIYVGDIVEFSTGPFKGYKAKVIKADTVKSEITVELMDVVVPIPITTKMNTAKVVQHVSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK3</accession>
    <name>A0A218NMK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819873.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK3"/>
    <dbReference type="GeneID" id="33313943"/>
    <dbReference type="KEGG" id="marh:Mia14_0387"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="272" mass="31491" checksum="922006FB715398E4" modified="2017-09-27" version="1">MGFVKAVQKGMAEKRIEKESGEFYSKLLHDGEKVLDVFKDAKYDFSYTDTNSPKSGDVIITDQRIIFTGKRVDLDNLKKGDVYSEISLNLDAAKESVREVSRHNKIALKEVENGNLKSFIKGRGYMENYTAFKDRVGVFGSVDKKGIFGGKIKITFYLLQDMYSIEIKNHLQNLKSWEEELSKTNSKDLDKYQSLIRKTEKVYSDPKYFDKFLKWMNPARVNVLIEKLDGNSDEIFNVLSRIDSSQLKEFIYDKGAVEKTYMESRMPVELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK4</accession>
    <name>A0A218NMK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819869.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK4"/>
    <dbReference type="GeneID" id="33313939"/>
    <dbReference type="KEGG" id="marh:Mia14_0382"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="301" mass="34972" checksum="E107A118DCD16AF6" modified="2017-09-27" version="1">MDKRVERNYESEYSKSISIDAYMKVINLEYVRDSDSIDNRVSHSGRNMDLLVKMLNRVNKKPKPQNQNQNGNKNLLRGNFSSNPYVNLSLARTGVIKSMGVYDDYYSRDDPEKYFYLHSDIADGIIYKVLNREELSAKEAKKVESISKYILDEGIISLSGKKYLVLKYNYDDSIQLIGLTKNEKVPVDKIETDDGKLLDASPLHIITIDFSDRHTLFMSSDDLIYANKNNLPKNLYYMDEHDDFEGNSIDYDFISELGNRRTAMFDVNFSREMHYGGRMNPEIAEKVANFIKSHDKFIYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML5</accession>
    <name>A0A218NML5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819883.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML5"/>
    <dbReference type="GeneID" id="33313954"/>
    <dbReference type="KEGG" id="marh:Mia14_0398"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="286" mass="32806" checksum="98BBA1E167E4EED6" modified="2017-09-27" version="1">MMAYKSKAGFKEILKATDAIILDINNKNQSDFVKKFVDATVRFAYENFPFLTLDNSYNVEVHMKKEDTLLGGSFTNEKGYLRKLNDNKDVVNYTLGVPGKENGNLTIYLGDEKNDVIDLKNKNQRTKFGFDLFLTALHEILHAKINELNKGKEAPYPIGYDESYLINEAMVYFISYLIAKKLTSNQDLLKCSGPAHKLPDFSRIIKYEDFKKELAFSYRKVSVLSSQSDHEDLMFGEELADIIKTEKLVYNIYDRFNGGLDDFLNTVSGIMSLDQLFDISDKYMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM3</accession>
    <name>A0A218NMM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819862.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM3"/>
    <dbReference type="GeneID" id="33313932"/>
    <dbReference type="KEGG" id="marh:Mia14_0375"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="473" mass="52570" checksum="0B7F82E9367090BB" modified="2017-09-27" version="1">MSITKKMIKNEKEFKDFKDEMKSTITNYPSIINEISNFVKDLKYNSGNIASYKPGSSFGSLTQQEYEKAMNMLEKMQSSAISKSKEGVAEGIKDLQDSIKGYNTNDPSEFKRFLKSSIRGIYDEINNLPNSKSGFNEIVDMLGNVNEVNLLVKKSNPAGVGSVLASAISARNRRIRKVNSRIEEGLKKMDQVKVDSLTDMISKYYKLYSEVEILRNTYNVLAQTGSSAKASLYLNNIKKSDADQLIPQDMAMGNKKDSPKESQAPAKGPKSKSTPSTNTDTSKVNANSSGTTTGNDSEWYDGTIKYIKLNGGALDRINEISKKDNVDYIKGLKDKSLTSGQKFDVWKALFQNWYDTQYPSEKKKFDAAANSGLTKIDGLQHIKIEQSDIEAVSKGGGRSKALELMKKAVAITVIERQAANGSFDRNLLTAVENAVKSGDYSENKDKDLWENIFRNYLYSITNGKQTNNTPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM5</accession>
    <name>A0A218NMM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPA3 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819877.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM5"/>
    <dbReference type="GeneID" id="33313947"/>
    <dbReference type="KEGG" id="marh:Mia14_0391"/>
    <dbReference type="OrthoDB" id="8914at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="22"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="621" mass="68477" checksum="42F1F5FDA82AD4AC" modified="2017-09-27" version="1">MEKSEASKFKSYEGALSNVKVFSKSLPGTRTLLIISIIYSLLIGIISSSIAGHSIFLSNLGSVMASGVLVGIVALIVPFTMTIIAFKAMKRYVTLKYILFSSMISLLSYGVFVMLSVSIASLTGIAALGVLVILLGDAAIYAWWFFVSKILLNERKASALTSLIQPTLNLLFLIPVFKILLIPVLPLKILLVKLYFGIFVFLLIAYVIIYFIDSPIKKSLGYSGFDVFTQMLQDWLFNVNIMIPQPIMSNSPSYNVNTDTIVFKDPSGKVKGIFFVPNLHYGPMGTIGSSNFPYLLEKYSVGNYKATTIIMHPTVSDDYNAVSSSEYGKVKSALSQGVKSSIRLNFSDNSEFYEGGYKTAKVTLIKFGSFGIATFTRAPRVTEDIAPETATLFKSALQAYVKHPIMIDAHNARYESAPKKELESVKINSGIANDYIKAISSLHRISKGKLKAGFYSVNPASKINCGVDIAPGNMNISVLSFGKFKYCMIYFNANNVKPQFRESLVNHIRKKYGMYGEVYSTDTHFVNSFKLTASNVLGLHTKYSKELEKMVDQGIESAVEDMSECTIGHSSIKMKNFKIWGANGRDKIVTTLNSMIAIAKLAVPLVIIGGFFLAAWIIYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMN3</accession>
    <name>A0A218NMN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMN3"/>
    <dbReference type="KEGG" id="marh:Mia14_0403"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="79" mass="9141" checksum="8393857162CADA86" modified="2017-09-27" version="1">MNRLEFNVCKNCGHSVVNFNSKWLHHISRSKLLGFPHWPAGHVITLDCKWNGCKCNIPEPDHTKPSKTKLVYLGKRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR3</accession>
    <name>A0A218NMR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819970.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR3"/>
    <dbReference type="GeneID" id="33314008"/>
    <dbReference type="KEGG" id="marh:Mia14_0452"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="97" mass="11229" checksum="C669D7B493321ED1" modified="2017-09-27" version="1">MNGLKERTQEIIFNKDGIIVTETVDDLVNKTNGIRLTRYDSLTELYTKFQGPIVLKSIKIEMSADVLMSLTLVVYNEDDCYDENPKMVLYFERADKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMS2</accession>
    <name>A0A218NMS2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMS2"/>
    <dbReference type="KEGG" id="marh:Mia14_0462"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="61"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="306"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="638" mass="71833" checksum="726E3E9B371CD713" modified="2017-09-27" version="1">MFSMKSQYIISEGALNPNIVGGKGYSLLKLKKEGIRVPEFFILNANAFDSYIKANQRSKTNIELPKEIINEVMESYSKYIKKGKVAVRSSATVEDSSKYSYAGKFKTDLFVTKGNLPKSVKDVYASLYRIKDFGYSSEHPKMAVVIQKQIDSEKSGVLFVTKDAVIINAIIGQGERFVSGKEVGDLYKIDLTKKKSTPGITVNFQLYANVKGHDRKLPMEVSYSRKLLSSEIHKLVKEAIKIYRIFNSPQDVEWCIKGNDIFILQSRPITSDLPKLKFEDNMGDIPVSAGIGKGIPWEDIRNIPESPVIIIKEEVELGDIKYLDNKNVAGIISRYDGMLSHVSILARELKIPYITGVNDFGKLLNSKEVYMDGSTGVIKVKGNDGRLAQIMNTAPRTFKWIHKGIKNIEYLNEANGLIRRSGRFAILYLDDDRSIEEAFNKGLPNLIKLSGPSDVYTSYWLLFRSINAKVDGIKRFKEAFVKALDERNSAKFRSAYNEAKSNMAKHYESAKASYSNYKRSKDLSELINTYIDSVKAYIFFNAIRNSAFDYAEYIFGREMSARSGLISDAELYNGFSDTGKGKLIGLRKELISMLDDISNAADENADYSMMDLEEQAASELKKKIGNKKYGEITKSNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU1</accession>
    <name>A0A218NMU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III restriction-modification enzyme subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819965.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU1"/>
    <dbReference type="REBASE" id="210408">
        <property type="entry name" value="Mar14ORF449P"/>
    </dbReference>
    <dbReference type="GeneID" id="33314003"/>
    <dbReference type="KEGG" id="marh:Mia14_0448"/>
    <dbReference type="OrthoDB" id="75806at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="364"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="850" mass="99327" checksum="3C39F1C293E58BB6" modified="2017-09-27" version="1">MNPSDILLPQDRDESKAYLVNKLRPAIKVWRDSGYPNVTNTTKRLLNFWFNEDHIINNEKFEFWYAQRESIETLIYIYEVMKIRKFLDLMANFGDKPQVFDPSTDIYPLYGFKMATGSGKTYVMALSIVWQYFNHKFESNDDYTSKFLLIAGEKNVIYDRLKRDYENGKIFHEIPLIPPEWIDEFNIKVILKEDPINDIPDSVLFLTNVQQLQDKANRKKEADEFIDKVLDLKEVNRTNIAQDNRIKEVLEKIPNIMILKDEAHHIYNYEKKWKQILIDLHRALKSEYGKGFNMELDFSATPRAENGVLFPWLIVDFTLKEAIEMNIVKRPLKGIVQNATEVTSTNVVERYKAWIDAGIRRWQEYNEALAKLNKKPILFFQCPDNKQADQLKEYLETLPQFSKKVLLIHTDSTGEVAKSDIEEARKSAQSIDSDNNNYRVIVSTMMLNEGWDVRNVNVIVGLRSYTSERNVLPEQVIGRGLRKMFPDENASIKDFINILEVIGSPGLMQIIEELEKDENIKFGTTKLENPINIVAISVDLDKKNLDIEIPILTPSIIVREFEINEGILDKIPSLSIKLENKIFKTNYKAFDMVTGAVQVERSWDLPVPQDVKSVIAYYTGKILNEIKLTNMFADLYPIVKEYIEKKLFDQEVNINDPRVLFQISQPEVEEKIIKAFGESMKNLAFINREVDKSDRILISETSPFPWTKDVYQANKCIFNYVPCDNNLEVNFSRFLDSTEDVIAFSKIVQKIGFSIEYRDSEGNLRHYIPDFIIKMQNKYVIAETKGEEDIDVKFKDKRAILWCEDAERVTGDKWVYVRINENGFDKYHFDNFENMIQFFTSKYAKDLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMU3</accession>
    <name>A0A218NMU3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RelE toxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819985.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMU3"/>
    <dbReference type="GeneID" id="33314016"/>
    <dbReference type="KEGG" id="marh:Mia14_0460"/>
    <dbReference type="OrthoDB" id="136544at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13745" checksum="0D43D0C50464A56A" modified="2017-09-27" version="1">MKPIKVILSPEAEAAYKELNKLAKNSKIDKSILNSIKKKIDLIKINPHYGDPIAKKLIPKEYAIKYDITNLFRIELSNFWRMLYTLTDDQTEVIVIAFILDIIDHDEYDKKFGYNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW6</accession>
    <name>A0A218NMW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820060.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW6"/>
    <dbReference type="GeneID" id="33314060"/>
    <dbReference type="KEGG" id="marh:Mia14_0502"/>
    <dbReference type="OrthoDB" id="371869at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="215" mass="24958" checksum="31CFC7DE6EED1D0D" modified="2017-09-27" version="1">MDLPILNILKRRSELETARLEDEVMSLLTGITDKMALHGGTAVWRCYNGKRFSTDIDVYIWAEDFKDKFIHAASGIGIDVTKFREKGVTFINVRKDNSEIKIEPRNVEKSALLMPYERVDGSKINILVLSPEDLILEKIDAYNDRRAYKDLYDITVLLNSVKQRNEIDRALQEFIKNIQTPNENVQSYSEFKAVIYAGVVPTYQKMVEFIKRWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX2</accession>
    <name>A0A218NMX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820048.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX2"/>
    <dbReference type="GeneID" id="33314051"/>
    <dbReference type="KEGG" id="marh:Mia14_0493"/>
    <dbReference type="OrthoDB" id="33550at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="379" mass="42058" checksum="A01978F8101682C5" modified="2017-09-27" version="1">MDVASQEKKLLFPDYEKGNLYNLAASIAEDLGINREDAIPSESINLDKGKVLLILIDGFGYNIMKAAGIPTEGAEKFSTVFPSTTSTALTSLNTVSTPAEHGVLGYTTYTKEYGIIQTLNYTLPEVSDPNLIKRISGLDMSSMFGVKSIGRELRDKGRRTEAIVPESISSSSMTKMLYGISKPSEFKTFWDSVYLAKEALEKDCTFVSLYLPFVDSLAHKYGPYAEPTMEAARYIYNTVVSTFSSYSSKYDIVITADHGFIEVSKAVFLDQQKDVIGMLDSPPYGDARAVFMKSHEDLKGKLVNKFNDFRIFDEDEIISKGLLGLKGEKPSSNSSEFIGVPLDNSVYVYRYKGNYSGHKGHHGALLQDEMEIPVINLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX3</accession>
    <name>A0A218NMX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820073.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX3"/>
    <dbReference type="GeneID" id="33314069"/>
    <dbReference type="KEGG" id="marh:Mia14_0512"/>
    <dbReference type="OrthoDB" id="211338at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04688">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="143" mass="16892" checksum="2D3F715E47005DC2" modified="2017-09-27" version="1">MVKNANGKFVLKALLLTENNGKILVQFVRNGKKGRLYRPLGGHVEFGEKSEGTIKREIREEVDSSIKDLKFVGFIENIYRSETRLHHEIDFIYEGKLSNEKLFENEIFDRDEDGRKEKAYWIEKSLFKEEKIKIVPRNILKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX4</accession>
    <name>A0A218NMX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="10" type="ORF">Mia14_0498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820055.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX4"/>
    <dbReference type="GeneID" id="33314056"/>
    <dbReference type="KEGG" id="marh:Mia14_0498"/>
    <dbReference type="OrthoDB" id="33250at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="314" mass="34965" checksum="99F37C0822F37A91" modified="2017-09-27" version="1">MAGINQVKQSKYSNLSRKKSGKGKDVDIRLGFHMSVAGSVSNAPLSAGKMGYGDFQFFPSSPRTWKHSPIKDEDISLFKEYTKKFDLMAFAHLPYLFNLASKSREQRSKSIGMLNDNLERCDVLGVRYLVVHLGSHMGSGFKEGRKRISDSLNEGLEKHNAMILFENTAGYRNGMGSSMPEIADISDNVNDRNIGLCLDTCHAFAAGYDLRSEKGVSRLADEIGDFGKRRLKLVHLNDAKYDLGSGLDRHWHLGKGKIGEKGFVNLFENPLFQKGCFVMETPVSSEGDEEYNYNEAVKIIEIAGKNSGKELSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX6</accession>
    <name>A0A218NMX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820080.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX6"/>
    <dbReference type="GeneID" id="33314073"/>
    <dbReference type="KEGG" id="marh:Mia14_0516"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="145" mass="17224" checksum="18D9519B88DDBD39" modified="2017-09-27" version="1">MYLDNYLEKGKKDFAINENYKKIDHLSWAVFRIMSDDPEFAENLERSFNGGSKSRKILADELRKVFDNEAMAYLSDLYRIMKDMARKDEVNRLSDIKKADEINIPSERIIMFANDNLTDEDMIRIYKQGKFLLMFYNGLARNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY2</accession>
    <name>A0A218NMY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216886.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY2"/>
    <dbReference type="GeneID" id="33314050"/>
    <dbReference type="KEGG" id="marh:Mia14_0492"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="138" mass="14896" checksum="4B8DFA031AA70FF7" modified="2017-09-27" version="1">MVSKKTSSLKMNHNGFKVRGDLFALEFIGSLFYLYLIYLIGANVMPVSTLLSTGSASFWLAVLPAVAVVAGVALFFHSFTYLFGGYNKISTLKLATVAGFAFFALTIGVAGGYFVVALIGFILTEVAAYMVHVEKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY4</accession>
    <name>A0A218NMY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820062.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY4"/>
    <dbReference type="GeneID" id="33314061"/>
    <dbReference type="KEGG" id="marh:Mia14_0503"/>
    <dbReference type="OrthoDB" id="350054at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="195" mass="23074" checksum="6A6BC24BD4D8B55C" modified="2017-09-27" version="1">MRYVKPFLEYFKSFPTFTVNDVKLFLHKNGAGGNYYKIFMHNMVKSGNVFSVSRGRYTLHDDPVIAGFAFSPFYYGMEMALTYYKLWDYMTPISIVTTKRIRNGQIEILGRNASLRRIQKDKFFGYSMVYYKDNLYIPMADIEKTFIDSVYFHSRFNKEVYAAMARKIDKKKLTRYLKLYNNSIEKQVEGLLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY5</accession>
    <name>A0A218NMY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY5"/>
    <dbReference type="KEGG" id="marh:Mia14_0508"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053177">
        <property type="entry name" value="ADP-glucose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42763">
        <property type="entry name" value="ADP-GLUCOSE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42763:SF2">
        <property type="entry name" value="ADP-GLUCOSE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="241"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="373" mass="43520" checksum="667C46D0E83E33C8" modified="2017-09-27" version="1">MTNLLNRSIPEMVMHLYKKVFKFSLHILLMYMDSKKERKDPDEKEAIPENLFGNGEIRTDYRTGLRAVFALSRKDRPIDYLAKEVIDDKGKEYCPFEPERYDLNRTFFEIGRPWRVRVIYNKYPLFECNAPYAREKWDIFERSTNYGFSFVIIDSREHKLRFENSSDLQTNDLAKAVLNTEKKIYGHNGIDFVYLNKNFGRKSGGTLSHSHWQTLGYMSMPDTVRARVDRVLEFEDTHGSCLMEYAANRESERKLLENRTLIAFAPFAQLYTGESIVMPKRHVSMLSELSTEEMAELLKACKKIIAANNRYFGVHSYNILGYSLKKEKEFHSYMEIVPRVSDIGPMQMAGNYGSNIIPEEYSKGIRSILGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ2</accession>
    <name>A0A218NMZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820131.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ2"/>
    <dbReference type="GeneID" id="33314102"/>
    <dbReference type="KEGG" id="marh:Mia14_0545"/>
    <dbReference type="OrthoDB" id="33550at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="396" mass="45054" checksum="4A7765A2D9A7B6CD" modified="2017-09-27" version="1">MHSIKSDLIDNGFIFPDYKNSSMELAKEVADGHGKMIGGKRKRRFLLFIDGFGYDLLKSAISNSRQLKRLPSEMQMGKISTVFPSFTPTVFTSIDSGKTPAEHGIIGSPIPIREYGMMKDILTLPWSPSVEEVSGKSEAEPLFPNLDTLLRMGSRGDFIYMQFERVTNKNSQTYLYSKINYTDYISFDDLLYQSIDIAESDQYNLAYTYIPDIDHAQHEYTKDSRRVLSITTFIMEMIMEKLLPKLKDNGWELLISSDHGQVSSRHEDINRFDAKTNILKYLRSPPWGTDRSIFFDAAEGMGEKFEKGFEKEFGKNFILYDSSEAIKSGLFGSTKVSDSLRYRFGTHMAIPKGKNIFYYKYPGGREYPGGKEWVSGSSGHHGGLSKEEMEIPLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN03</accession>
    <name>A0A218NN03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN03"/>
    <dbReference type="KEGG" id="marh:Mia14_0524"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="143" mass="16810" checksum="6E484C673F8F5922" modified="2017-09-27" version="1">MVRKYIRDLMVSKTRNSYRNTLDITSFNDHDSKLLKDIYRISNSTSMLRLEDVEIKALIEVKGKNSIGLVTNLNYKESGRPITIFINNFNWQSNNLNEIERRIKTSHSCTISINARIYPRYKSNDFFYPFSLYIDSAEAQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN09</accession>
    <name>A0A218NN09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heavy-metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820127.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN09"/>
    <dbReference type="GeneID" id="33314099"/>
    <dbReference type="KEGG" id="marh:Mia14_0542"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="135" mass="14658" checksum="F668EAA834B26D52" modified="2017-09-27" version="1">MAFTSDLSTSDFWLLRKQGYMPLGLVVGNSVYSMGVVGGMMTGIKGMGKGEIPQITELLYNARMMALNRMLDEANKLGADGVIAVKLNINYMHNGEWMEVTAIGTAVKHVDNGFGSRGDDPQVMIPMHSSDVKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN12</accession>
    <name>A0A218NN12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820133.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN12"/>
    <dbReference type="GeneID" id="33314104"/>
    <dbReference type="KEGG" id="marh:Mia14_0547"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="101" mass="11001" checksum="3FAF75665B694802" modified="2017-09-27" version="1">MDSKKRAEGSGKMGFMAASIIILLGSVIGYYILYAPAIAFGLIYLGIAIGIILFLISLGMLKSVRTLNTFAYIFFAVCCIFLPFIGGVIGYAFMRKNKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN28</accession>
    <name>A0A218NN28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820151.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN28"/>
    <dbReference type="GeneID" id="33314123"/>
    <dbReference type="KEGG" id="marh:Mia14_0567"/>
    <dbReference type="OrthoDB" id="381922at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="147" mass="17336" checksum="001AEE2B9839B17B" modified="2017-09-27" version="1">MPKRYNLTKFDVLSNAIHKLSVKDSSMESKRDTRNADAYKFSDEDNLLKAEAIIIASFSSGHSWKTYNALTNRSIELNSDEVKSDYKEAEKEKWKSISESDIKEILNLRISDNLFMQWLFFNVDKDEREIYKKAWGKIKEEFEEMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN60</accession>
    <name>A0A218NN60_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="15">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rtcB</name>
        <name evidence="16" type="ORF">Mia14_0602</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14 15">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN60"/>
    <dbReference type="KEGG" id="marh:Mia14_0602"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 15 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="12">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="397"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="474" mass="52262" checksum="760E2A1A6DE2AB77" modified="2017-09-27" version="1">MEKIDEFTWQIKGDENSKPVKIFASEEIIGYMKRDRTLMQAKNAASMPSLVNSMLVMPDGHEGYGFPVGGVAAFDADNGIISPGAIGFDINCGVRLIKTDLTEEDIKPKIKPLMDTLFKNVPSGVGSVIRLGFTPQDLEKVAVEGARYIIDKGYGFKDDVDRIEENGSMEGADPDKVSALAKKRGLHELGTLGAGNHFLEVQKVEKVLDQRLADAFGIKEGQVVVMVHSGSRGYGHQVCSDYLRVLSDYQKSHNITLADPELSYAYIGSKEANDYLAAMKSAVNFAFVNRQIMTNSIRKSFEEVFGKSADALGMDLVYDVAHNIAKEEEHIVDGKRKKVYVHRKGATRAFGPGRIEIPKIYRDYGQPVIIPGSMGTASYILAGREEAMLESFGSSCHGSGRKMSRHEAIREIPESKTFNTMKDKHIEIRVRNRKLVSEESEWAYKDVDEVVKSIAGAKISNIVARMTPLGVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN61</accession>
    <name>A0A218NN61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA 3'-5' helicase Hel308</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hel308</name>
        <name evidence="13" type="ORF">Mia14_0600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_198539371.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN61"/>
    <dbReference type="GeneID" id="33314154"/>
    <dbReference type="KEGG" id="marh:Mia14_0600"/>
    <dbReference type="OrthoDB" id="371946at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18028">
        <property type="entry name" value="DEXHc_archSki2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048772">
        <property type="entry name" value="Hel308-like_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF10">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HEL308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21280">
        <property type="entry name" value="Helicase_dom4_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="701" mass="78735" checksum="3959841087FDB90D" modified="2017-09-27" version="1">MKIDFISDLVPSAMMESLRSRGIKEFTPPQAEAIEKGLLKGSNIMVASPTASGKTLIGELAAVYSILAKGKKAIYIGPMKALVSEKFNEFTKAYPYIKAAISMGDLDSGDPWLAEYDMIFVSTEKFDSLLRHKIDWLPSVGCVVFDEIHMVDDYSRGPVLEVIITKLSMYKEIQLVGLSATIGNPEELAKWIGAELVTSDYRPVKLLKGIVFSNSIYYYDGYSQEVYEMDGSSKVPEARVLEDTLHKGKQMLSFFYSKRNAESSAVKLSSVTKAVLTEDEKAKLAEIADKVENVLDSPTTQCRKEASLIRNGIAFHHSGLMSAQKAYVEDAFKSNLIKAICATTTLGLGVNLPAHTVLVRDLHKHSEEGNAYVGVNEVMQLFGRAGRPAYDTEGRALVIAKEKYNLMPLYERYIAADPEPIESKLGVMPVLRMHILSFIAEDFLNSKPEISKFLSNTFYGYQYGSTNMDTFIDQVISSLTDWNFVEEHSSSYVATKLGKRISELYIDPLSAKWIMDSVGKATDSIGLLYILCNTIEMRPYVYVTEEAESKFVYYKSLNPELYSMEASYSYYDPVAAFSTAMMLSDWISEEDEDAIMKGYHTTPGAMYAKISNIDWLIYAAAEISRILKMPTHLLVETRVRLRYGIKDELLDLVRLEQIGRVRARKLFNNGIKTIEDIRKNPEKVSILLGREIAKKVYSQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN87</accession>
    <name>A0A218NN87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="8">AdoMetDC</shortName>
            <shortName evidence="8">SAMDC</shortName>
            <ecNumber evidence="8">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">speH</name>
        <name evidence="9" type="ORF">Mia14_0637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="8">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820205.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN87"/>
    <dbReference type="GeneID" id="33314191"/>
    <dbReference type="KEGG" id="marh:Mia14_0637"/>
    <dbReference type="OrthoDB" id="114016at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866:SF2">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023522834" description="S-adenosylmethionine decarboxylase beta chain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023522835" description="S-adenosylmethionine decarboxylase alpha chain" evidence="8">
        <location>
            <begin position="81"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="8">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="136" mass="15207" checksum="C477ED25F29BABFE" modified="2017-09-27" version="1">MAKMQIKEISLEMPEVIGKHVYGNLDMVDPKLISNLNALIKIVVESTKIGNLHIIEMITKKFNPYNGFDGGVSIIALIEESHIALHTWPESMYATLDIYSCGEESNPDAAFNYIVSKLKPKKIVSNFVDRGKLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN94</accession>
    <name>A0A218NN94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN94"/>
    <dbReference type="KEGG" id="marh:Mia14_0636"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="96" mass="10881" checksum="93A95EF3AAE383A8" modified="2017-09-27" version="1">MQLILSKSGIMKSEKAKKADHINISLNPDIYNALMIASIEKDISISKVIETILMDSEEFKKFINKAKEYAELESKLNPSAANPRSVNKEDKDKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN98</accession>
    <name>A0A218NN98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820211.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN98"/>
    <dbReference type="GeneID" id="33314197"/>
    <dbReference type="KEGG" id="marh:Mia14_0644"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635:SF2">
        <property type="entry name" value="LAMG-LIKE JELLYROLL FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="288" mass="31570" checksum="2161F55BC0F84E87" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILVIAVVLAALYSLGIFNPNSFAPKASAGSCEVVRPFGPTTSTDIHSTGTCTNMLPKYVASFNGNGQISVLMPTLSHSITYTAWVNFASLAQSNYGDTGQIIGWEPGYGPSLLFLQPSIYQFEFSVWYANTQQEAVLSGTTPKLNTWYFMAGTYNESSGLIQVYVNNKVYNQTISKETLETGNVLTIGAWPSQLSYFKGELANVQIYNNSISSNQISALYQEGIGGDPIDLTNLVGWWPLNGNANDYSGNNYNGKETNVAYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC9</accession>
    <name>A0A218NNC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820239.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC9"/>
    <dbReference type="GeneID" id="33314225"/>
    <dbReference type="KEGG" id="marh:Mia14_0672"/>
    <dbReference type="OrthoDB" id="371772at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="230" mass="25966" checksum="D7B994DD1D62DC94" modified="2017-09-27" version="1">MNSLEEKIAGEITLSDSPGSVMKKWRELFGITQVELSKALKISTSTISDYESNRRLSPGVGVIRRFVEMLLYIDENKGGEVRKSLNMLNNEGGESNLPYLIHDFIAPVNGIDFNRIIDGKIVASQNYLDNLRLFGYTKLDSLRVILEMSPSDYPKLFGSTNERIFIFENVSTGRSPMVVIRIAPIKPRIVLIPSLQNVDKLAIRIAQIEKIPLITTRLSISEIEERLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE3</accession>
    <name>A0A218NNE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820260.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE3"/>
    <dbReference type="GeneID" id="33314250"/>
    <dbReference type="KEGG" id="marh:Mia14_0698"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="248" mass="28073" checksum="891943B60D1B1A1B" modified="2017-09-27" version="1">MNYGSLNESLIYIVLLVLNFILVLIAALAFNPTLIALALIFLLLSFFIIRFWDYINALIINHSNFIELFGGYELDLASSIAVSSSNGIYNAVSLGYFKFDGSDEFDQDKIESIIRSNPVPFRFVINIEKVNQKKILGDLRTKKHIKEIELANLSREKDFAKSSIIRRKIDVISQDIADISSGTSFKLVYYLIAYGSSENKFRAETMARENLEKISASFSSAFKCTMENLHGSDLVSFLKFESMISHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE7</accession>
    <name>A0A218NNE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE7"/>
    <dbReference type="KEGG" id="marh:Mia14_0671"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="283" mass="30795" checksum="47FCCA7681F6DBC8" modified="2017-09-27" version="1">MLNDWMKKKFLYVGIALILISIIIFGYIIHVVSSISSPSVQSKLGITNYTISKGGFESYNFTSNGNTSAFIAIMEEKVDFLIFNSSGYNLWIGNATLANAKNLEGRGTMLITLNSTNFTIPLPSSENVYYLSKSLNVTNLKKGLLPIGNYTSVFYNGPGSYSSNSSTNVVLTYLPSSKLSYLTGFFGNFAILGVVAIIAFIAGIILIIYSFFSKEKVLGSADIQGNVKSNGKGKGQNSQEDKYIDDLYKYVDNGNANKKPKSAKAAASKRSKKSSRPKQQEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF2</accession>
    <name>A0A218NNF2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820269.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF2"/>
    <dbReference type="GeneID" id="33314259"/>
    <dbReference type="KEGG" id="marh:Mia14_0707"/>
    <dbReference type="OrthoDB" id="6818at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="323" mass="34788" checksum="8FB5A1BCA8775961" modified="2017-09-27" version="1">MILGIESSAHTLGVGIVDNGKILANSKKMYDIKNSGMIPAKVADFHAENVYEVIESALESAGININQLDGIGYTKGPGIGPCLHVGQLAALYLAYKLKLPIYPVNHAIGHIEVTKHLAGFKDPLALYVSGGNSQVLGIVGKPRKHYHVYGETLDIGVGNMLDNFARAAKLVPAWGSTVAKAAENGKYIKMPYNVKGMDFTFTGLLTNAVKLLSSNRVSDIAFSLQETAFSMLTEATERALMLTGKKELVLSGGVAQSQRLRGMLGEMAESHGVKFYDADNQFNADNGAMIALVAEEMHNSGAKFENSQLGINQKYRIDKVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNF3</accession>
    <name>A0A218NNF3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820270.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNF3"/>
    <dbReference type="GeneID" id="33314260"/>
    <dbReference type="KEGG" id="marh:Mia14_0708"/>
    <dbReference type="OrthoDB" id="31344at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI14008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="202" mass="23463" checksum="F86B79C4D1381EF0" modified="2017-09-27" version="1">MIKLLKLSEGSEADIYIQKILGVEMIIKYRRKKPYLITDIDEDLRKHRTKKEAKMMSLAHSNGVNCPIPMVISNYSIYMNYIKGSSLNKVLDKIKDSEFFEVGKLLFLLHKAGIVHNDFTPANVILEGEQFWLIDFGLAELSSNAEERAIDLLLMKRSVNKKQYLYFAKGYSESNPFSEEVNNRLALMERRGRYQDRSLNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG4</accession>
    <name>A0A218NNG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">mRNA surveillance factor aPelota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820279.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG4"/>
    <dbReference type="GeneID" id="33314269"/>
    <dbReference type="KEGG" id="marh:Mia14_0717"/>
    <dbReference type="OrthoDB" id="31300at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="345" mass="39063" checksum="6607F85E74C53CAC" modified="2017-09-27" version="1">MSLQILKYYKDESKVSVLVETLEDLWALERIIFPGDLVKTKTVRKYKASETDVGELKDVVIEVKVEKVELDRSASRLRVLGRITYGKPLEYVSLNSHHTLNIASGDKVEITKAKWEDYILDLLYKEAKESRRPKLGIVLVDDEKAFYAKILGYGIEFGSEVYNNLSKNMSQKEYAELQTKFFNKVIEVINNMDVSTVILAGPGFTKNDIKSYIDNVPTSSKLNKNILIMDTSNTEKSGVYELIKSDSVKKLMENELIKSEFELMEKFLKGLSLGYSKYGTKNVEEALDNYEAGEIIVNDSKLDDNDIKKLLAKAESYGVKIDIINSLDEVGQQLQAFGDIASIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI2</accession>
    <name>A0A218NNI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820275.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI2"/>
    <dbReference type="GeneID" id="33314265"/>
    <dbReference type="KEGG" id="marh:Mia14_0713"/>
    <dbReference type="OrthoDB" id="14922at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="129"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="304" mass="35469" checksum="C6927AA60F5574A7" modified="2017-09-27" version="1">MKNESELTVNEKPIYARLFNIKYTFESAQPLTFYGDYYANESKLNYVEGDSLIKLRFKELKGNNTKIMIDNPNSWKLGKVYTKFRLDDDVSMLYKKISTDENMERAISAYKGMRVTLNDPWETTVCFITSQFNNVKRIRLIIKNLVNMFGEEHIDESTGIKFKSFPNPEKLSRVSKEDLLRSGMGFRAKYIMDAARVCSENIDLSKLNPKNYDELKGTLMDIEGVGPKVADCIILMGYGNFNAFPIDVWMKRTLERLYFNSKPQKIKDLYKFSEEKWGEYRGFAQQYLFFYGMKNLGRGNKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI6</accession>
    <name>A0A218NNI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820276.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI6"/>
    <dbReference type="GeneID" id="33314266"/>
    <dbReference type="KEGG" id="marh:Mia14_0714"/>
    <dbReference type="OrthoDB" id="6113at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000005">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI14014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="499" mass="57077" checksum="EE919BC85A409582" modified="2017-09-27" version="1">MEKENVDQLMNLCSRRGIIIPSFKIYGELAGFYDYGPIGLSIKSNLKSIWRKTFVKGLGSLEIESTIVGSDKVYQASGHINTFTDPILKCTKCGSTYRADKLLEEFFEKQKNYDLAKKVGHMTSDELQELVSKYNISCPKCKGEFSKITAFNLMMKTEIGPTGGTIGYLRPETAQGIFVDFKELYKSYNFKLPIGIAQEGKVFRNEISPRQILIRMREFSQMELEYFFNPEKADELPLIENQKVNDEFLNKKIYLLTREDQEKGEEAKKVSLSEALELKLIPNKIFSYMIYKESLILDLFGINEDLTRFRILMADELPHYSKGNIDLEIKINGKYEEVAGNAYRSDFDLSNHSRMSNTDMAVLDGGKSVLPHVIEVSFGLDRLFWAVLSNNLYKDEKRGWEVLMLNKSIQPFQYAVYPLQKDDSLIQKSIEAQRILQEKGYNVFYKETGSIGKRYAKADEIGIGKCVTIDYNTLEDGTVTIRDISDASQVRVKLNDIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ2</accession>
    <name>A0A218NNJ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820312.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ2"/>
    <dbReference type="GeneID" id="33314304"/>
    <dbReference type="KEGG" id="marh:Mia14_0752"/>
    <dbReference type="OrthoDB" id="10382at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="210" mass="23032" checksum="8CBDEFCCB649D2CA" modified="2017-09-27" version="1">MEKDMKDKIATLLEENKGKRKFTQSVEAAVNFRNVDFTKNVNRLNIEIKLRNGTGKVNKVAVFADDPSIADKAKELGATIISKSELTSVAGDKSRMNELLSYNLLAQPNLMPDIAKALGQFLGPKNKMPRPLIGLDVAEVIKGSGNSIFIRSKGKYLPTINCLIGNEKMSADQIAENVDSVVDALAKKVGKQNIKSIYVKLTMSKPVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK7</accession>
    <name>A0A218NNK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820298.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK7"/>
    <dbReference type="GeneID" id="33314290"/>
    <dbReference type="KEGG" id="marh:Mia14_0738"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="5">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="505" mass="57150" checksum="096B58753C4317D7" modified="2017-09-27" version="1">MSIVKMQHVMSNEVSKRSFLSRPPEPPANILLNDPMNSIYIGNTKIFKIPFAWNFDNVTNPHIAVVGITGAGKSYFVKTFLIRANYIWDTNAVIIDWASEYKAWVQQSGGTILSLGKGDYINIMDLAGMKPLDRVKQIMGAFEILTDIASYPEQRRLTEEALEQAYANLGFNLAERPPEGKDAPTLKDGIALLEEQLQSGGYQYPAELENAIYRLRQFARPGEDFFSRKSTLDIEKMANSGLVDIDLSGLSDDTFRALAALFILQTLKEKMRFEGFAETKGIKTFVVLDEAWKVASDDRSDAITIVREGRKYQFGLIVASQNPTDINEAIYSNVGTNFILRIKFERFLDYIQGSLNFSPYIRSEISNFGVGQAAVDMSFTTSMRFPNIFVLDRIKGEEPLYIYTINLTDVLTQAEVSANLLPRDYQFEEDELKNKMINYNVSGDIINQLFKKLDSQGRTINMLDFVRTLYSYHLRVADIIALLKSMSIEDLLITRIISSSGVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK9</accession>
    <name>A0A218NNK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5'-deoxyribose-phosphate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">AP lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Mia14_0773</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820329.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK9"/>
    <dbReference type="GeneID" id="33314325"/>
    <dbReference type="KEGG" id="marh:Mia14_0773"/>
    <dbReference type="OrthoDB" id="8999at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07436">
        <property type="entry name" value="PHP_PolX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050243">
        <property type="entry name" value="PHP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="PolX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047967">
        <property type="entry name" value="PolX_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006375">
        <property type="entry name" value="PRK08609.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36928">
        <property type="entry name" value="PHOSPHATASE YCDX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36928:SF1">
        <property type="entry name" value="PHOSPHATASE YCDX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="24">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase/histidinol phosphatase N-terminal" evidence="23">
        <location>
            <begin position="343"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ASI14067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="580" mass="64788" checksum="B3E161FBF935A750" modified="2017-09-27" version="1">MENKRISEIFEEMSNIIGIEKTSTSNFESRAYKRAALTIGTLQQDISDIYKQGGIKALMELPGIGKGLAEKISEYLTTGHIKEYDELKKKYPIDFTSLLSIEGIGPKKAIELYEKLGVTDIPTLKDALEKHKLKDLQGFGEKSESEIAKGVTLAESNKGRILLSEGLPEAEKIISILKGSNLVKEAVIAGSTRRMRETLGDLDILALSDNKTEVMDLFSKMADVTSIIVKGPTKTTVALNIGTTCDLRVIDPDSFGAALQYFTGSRDHNIKVRTIAVRKGYKLNEYGLFGRSDQLISKLNEKDIYEKLGMSYIPPEMRENRGEIELAEKGQIPDLLELKDIKGDLHTHTKETDGINTMEQMADYAMRKGYEYIATTNHTKSLKVAHGMDDKQFEEYFSKVDELNDRLKGKLTILKGAEVDILKDGSLDLLDKTLESMDCVVAAVHSSTNMTEEQMTSRIVKAIGSNQVNVLAHPTGRLINEREPYPVNLPKVAEACADMRTMLEINASPQRLDLNDTNILLTSKYPVIYSVNTDAHSTIHMDFMRYGVGTARRGWLTKERVANSLPLNKLREILKKQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM5</accession>
    <name>A0A218NNM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM5"/>
    <dbReference type="KEGG" id="marh:Mia14_0786"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="174" mass="20559" checksum="4415D67E05F10867" modified="2017-09-27" version="1">MNSSHQMRIIKYINRDRYNCDNMVGIFKSKNEKLNEETADLLTYHLPKEYKKDQENKITDLLNKRDKLVESYEGQKEYYSVKHLTDSIYNKFRQAYKETEKLSVQSNDMQSLGIKGVDNKIKEFNDKISKSNSEINENITKQLDEIISDYNKVFNTLSDKSKMKDFLNQMKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN9</accession>
    <name>A0A218NNN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820346.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN9"/>
    <dbReference type="GeneID" id="33314342"/>
    <dbReference type="KEGG" id="marh:Mia14_0791"/>
    <dbReference type="OrthoDB" id="30538at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="173" mass="19687" checksum="7FD5237A9AD3315D" modified="2017-09-27" version="1">MARLRPARTVRDISSQPWARYSQKKPKKNYIRALPHTSLLVFNMGVDKENYDLKVTLNTTYPIQLRSNALEAARQIINKYLEIKIPGGYYFKVLVYPHNVIREHKMATGAGADRISQGMSHAFGKPIGLAARLIRGQPVFMIKTTKQNMPIIREAFDRARSKLSGQYKVVIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR8</accession>
    <name>A0A218NNR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820387.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR8"/>
    <dbReference type="GeneID" id="33314374"/>
    <dbReference type="KEGG" id="marh:Mia14_0825"/>
    <dbReference type="OrthoDB" id="35908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF3">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="254" mass="28651" checksum="87352AF96B0AB5E8" modified="2017-09-27" version="1">MIDIKLLDKKADFQGYSFIEGFPGIGLVGPMAINYMIDKLDMDYCGYLDSDKFPPLIAIHDSIPMPPIRIYCSKKYKLVTIFAEFQIPMDLIYELSAKLNEFIKENKISRIFSVNGMPYKDDSQDATALKDPNVAFGMVSKKNLISELKKYNISPVNEGVATGISAMMMTKALNDNIDDITLLIPVNPNLIDPKYAESAIKYINQLVGLDINTDELEKESKEVEAKIKDLLKKNKDTHQTYKNSYNDSGLSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS2</accession>
    <name>A0A218NNS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820407.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS2"/>
    <dbReference type="GeneID" id="33314387"/>
    <dbReference type="KEGG" id="marh:Mia14_0839"/>
    <dbReference type="OrthoDB" id="9143at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="492"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="238"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="353"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="675"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="774"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="892"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125274" checksum="94A3CCA79A932F5F" modified="2017-09-27" version="1">MLYIDKIHIRNFKSFKNSSTQFTNGFNCIVGANGAGKSNICDSLLFALGETSLKRMRVSKTKDLLNSLSLENSKSKKTASVSITFSGSSSFEIYRSVDSDGKIEYRLDGKKATRQEIVDMLARNGAVVNETNTITQGEINKIMGLSVKERRYLIDIAAGIKEFDDKREDSLKELGKVDEKISAAKALLGERLGFLNELKKEKDDAEAYQHFASQIKKINYTVLKRRFEEIDSRMSKINEEIKAKNELLSKEKDSLDSLNGKISDLSSKHNEISKEINLKSSKLGSINAAVENANKNIAVYLANISNLNESVKELELSLESHKSDISKISSLIEAESAELAAISKDIESKSNYYKDLESANDAGMQEYKTLQKEYEEQSAKLNSLNSDYTDKKVRLEQLKSEYSSIQSKIATAGESVQSIKEDLSRLDLEKARLSSEISKEGKSISQLKSERIEIGGALDKANIRSINLREQLSSFGGARDSMEETLKSVIKEGFYGRAYELCRYDEKYSEAVNTASGSRMNYFVVDNISTANNAIKVLKRAMMGRASFIPIEEISYYPMQENKMDPLLRHIEYDSKFEKAFAYIFSNTYIIDNIEQAKKLGIGKYRFVTLDGELVEPSGIVTGGRSKSSNVFPGKLRMELEETETTRKGLSSRQAELDELINETFRQISQNQVRLENIDNEIQTKKKLLEQYNSASTVQEKESELKSNLSSLSKEVEMLDSEKSMIDLKIKKLKESMEEKESSMPAKSGVQNLPKLRSEIESLKVDHASKSKEVALNKTKLQELSEELKKVESKIALQKSQIKDFESKLEDEKAVKAENEAIMKAQDKDSVELYNKLSGIEKTIEDLGFEKGRISSHIDQMNREINDLKSGSIESNVRLSDIKAELSTYEGIEEMQGSIEELERKLSEFKSSLSKLGEVNLKAPEMYLEKSKGVEEAALKLNTLDSEKNSIMSMIKEVERKKLEVFNETFSKVNENFSTLHKVTIGTEGRLVLQNPKDPFNSGLNIIVKKESGREANSETLSGGEKSLNLLILLFAILMRDPKSFYIFDEIDSALDKDNSKKLSLLLKKMSERSQFIVVSHNDTLITSADAVIGFVNQNDESRSVAVKLSNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT3</accession>
    <name>A0A218NNT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820382.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT3"/>
    <dbReference type="GeneID" id="33314371"/>
    <dbReference type="KEGG" id="marh:Mia14_0822"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="75" mass="8673" checksum="8AC6AFB9D965AE32" modified="2017-09-27" version="1">MEQVGKEQINREDGYLYYLGSDGYVWQTPMKSNPSGKKKKVGSERVNREQGYLYFINKKGYVARSKMNRGGRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNT7</accession>
    <name>A0A218NNT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820372.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNT7"/>
    <dbReference type="GeneID" id="33314361"/>
    <dbReference type="KEGG" id="marh:Mia14_0812"/>
    <dbReference type="OrthoDB" id="372018at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051926">
        <property type="entry name" value="Ala_Aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488:SF2">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="35"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="412" mass="46687" checksum="308808915790A2CD" modified="2017-09-27" version="1">MVTVNEDLAKRSKFAYNDIEEDDAIASKIEKTGKEVIKLNRGDPPQYIKTPDYIIDAYVDALRSYKTGYVDMTGIKELREAVSDRYARSYKAKVSPENVIVTQGVSEALAFLNNVLINDRDQAILFAPYYPQYMPLLQMYGGSPIIEKYSEKLNWNLDIDSLGRSLKRMAKPQLRKVKYMMITNPNNPTGTVLKRDYLEDIVDLANEYGLFLVSDEIYDEIVYNGAKFTSVSEVANGVPHMILNGASKVYDSTGFRIGFMIIPGTDKFSSKVSAKLKDYATVRLSVNTPAQYAIAAAITNKKEHEKAIKNMVKEISDRVNYAYNLLKKNEYLDIVKPNGSFYIFPKIKLDLLKIKDDNDFVVKLLKDKNLQVTRGSGFGGDGHFRIVSLPTKSILKESVDRINDFCEENKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU0</accession>
    <name>A0A218NNU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU0"/>
    <dbReference type="KEGG" id="marh:Mia14_0854"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="59" mass="7217" checksum="4726C8EEF7BCB3DD" modified="2017-09-27" version="1">MWINKAWVKPYKRRDGTYVRGYTKNVDRKTRQRKFELNEIDVGTPSWFVPNVNVKFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU2</accession>
    <name>A0A218NNU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU2"/>
    <dbReference type="KEGG" id="marh:Mia14_0815"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="21068" checksum="B7A9BDD5A1F410F8" modified="2017-09-27" version="1">MFDMTEENNKQPVEAKERKESQKSSLTAEPKPATAMQKSKEKDNVSEYKSKLRRSIKNAIKINSLSHIDSRDAMKSAYLNNYQQIMKLAKTSENKTILNEISRIVVRGYRTLAVPTPKVTAEVSYNKMKETYDRYEALYKALSSNKIFMDEHTNEEKRIAKARHRSKTKMSRYEKKAKSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW4</accession>
    <name>A0A218NNW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHOCT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW4"/>
    <dbReference type="KEGG" id="marh:Mia14_0881"/>
    <dbReference type="OrthoDB" id="53394at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="63" mass="6969" checksum="7F94799A8F8DC1D3" modified="2017-09-27" version="1">MSCGCMKNAGNDMGKQHMHSHGGEENLPADDTKSALGILNERYARGEIAKEEYLSMKNEILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY2</accession>
    <name>A0A218NNY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF424 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820477.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY2"/>
    <dbReference type="GeneID" id="33314444"/>
    <dbReference type="KEGG" id="marh:Mia14_0906"/>
    <dbReference type="OrthoDB" id="18015at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1860.10">
        <property type="entry name" value="uncharacterized conserved protein from methanopyrus kandleri domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="106" mass="12057" checksum="C1B4CBC69AD5A3D8" modified="2017-09-27" version="1">MIYIKIHQAEEGDIIAACDESLIDKVLEEGEIYIDLKGYPEFYKGDLVDPKKYNLSTPLKELNSANIIGKESVDYMIEKGLIVAENVKYINGIPYAHSYVIKDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ0</accession>
    <name>A0A218NNZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2130 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820470.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ0"/>
    <dbReference type="GeneID" id="33314436"/>
    <dbReference type="KEGG" id="marh:Mia14_0896"/>
    <dbReference type="OrthoDB" id="372246at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019219">
        <property type="entry name" value="DUF2130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09903">
        <property type="entry name" value="DUF2130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="410" mass="47034" checksum="8C67C751517ABF58" modified="2017-09-27" version="1">MVKSSTKKRIGGNEALLVVCPKCGQEFSLTDTLKHELDDELENRLKIETERITKETTEKVRDEERKKISNEFKENEGKVKDLESKLEAANKKEVEILKKSRDIELKEKELPLKIEQEVETRRKEWEKNIEEIAKKSYENEISQLKLTIERQKKEVQEMQTKLTQGSQEAQGEIQELVLEETLRLLFPHDLIEPVPRGIKGADVTQTVRNSAGEAVGTIVWESKKTKNWSEKWIDKLIGDRDSVRGDIGVLMSETLPKDIKSFDLRKGIIIANFQLIDPIAHLLRGNLLKLFELKRANIDRTEKEGILYNFVLSNEFRSFMEGAALPVFNTLGDIQREKATMERIWKKRETQLTNSLRNLVKLYGNISGIANLPEIPVFSADNDSRKAIPDDLGMGHDPKKVKSNDDSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP05</accession>
    <name>A0A218NP05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor aIF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820503.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP05"/>
    <dbReference type="GeneID" id="33314472"/>
    <dbReference type="KEGG" id="marh:Mia14_0935"/>
    <dbReference type="OrthoDB" id="33582at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="23942" checksum="1EBD3393B5FB053D" modified="2017-09-27" version="1">MPAIKYSIVGSDYIGAFVVSTDKYAFIGGDVPDKKVSEVEEVLRVKAIRTSIMGSDLIGIFAKANSKGIIFPATTSDIEIEAIKSMGLGINIGVLDTDMNALGNNILVNDKIAFINPDYNISNARIIEDVFDVETARITTGSFKTLGANNLLTNRGLVVNNNITDEEKDMIDSMTGFKSVRSTANFGSLSVGLAATANSNGVISGESTTGYELERIRQGLDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP26</accession>
    <name>A0A218NP26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820533.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP26"/>
    <dbReference type="GeneID" id="33314503"/>
    <dbReference type="KEGG" id="marh:Mia14_0967"/>
    <dbReference type="OrthoDB" id="10737at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="264" mass="29338" checksum="75DF64766808507E" modified="2017-09-27" version="1">MQVPVLDKDGKEEKEIDVPETFSIKLKPWLIKRAVISEQTYTLQPQGHSVLAGIQTTAAYYGAYSSYRTGRHMGRAIRPREKLGDGVQGKVRRIPSSVKGRRAHPHKIEKKIVELINKNEYQNAIYSAISGILREKEIKSIVIDDAVVKLEKTKDVVEFLSKLGLSEKFSALRPTRRKGLRRLSTQKKYKHVALLVVSDKSPILTAARNIPGLDISSVSKLTANKLAPGGDLIKVAIFSESAIKDLPNAIAKFDVGRQMAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP53</accession>
    <name>A0A218NP53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820556.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP53"/>
    <dbReference type="GeneID" id="33314530"/>
    <dbReference type="KEGG" id="marh:Mia14_0994"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="199" mass="22801" checksum="BB20B72B9628A157" modified="2017-09-27" version="1">MKNYYKEGEEKFGFLSSELYLLAEKVPSMSRFYRFVERDLSNKKFQSLLDVGFGVGSVIYQLSKSRKFNIYGVDPSKYMVKIANNRFKGNPNVNLAVGSSTYVPFDKKFDIIISSLSMHHWNDKKGSLKYLSKFLAEGGEIDIYEFLLSKGKSLSEHFEYCVAKSHMVSKQQLEQYGEEAGLKAQIKVNGNFIKATYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP61</accession>
    <name>A0A218NP61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U62 family protease subunit TldD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_1002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820563.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP61"/>
    <dbReference type="GeneID" id="33314538"/>
    <dbReference type="KEGG" id="marh:Mia14_1002"/>
    <dbReference type="OrthoDB" id="98233at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="entry name" value="PmbA/TldD superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051463">
        <property type="entry name" value="Peptidase_U62_metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30624">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN TLDD AND PMBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30624:SF11">
        <property type="entry name" value="ZINC-DEPENDENT PROTEASE, TLDD_PMBA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="Putative modulator of DNA gyrase, PmbA/TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloprotease TldD/E N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloprotease TldD/E C-terminal" evidence="6">
        <location>
            <begin position="237"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="470" mass="52027" checksum="93B53308F1B76C1A" modified="2017-09-27" version="1">MDLKSKSLYEGESPDFLLDLISKKTAKYDFSEVYLSSGISSAFDIHNGIFDGNFSSSSKGARIRIMENGLFYNMSTNDLSKSSLMSAISKIKGMPKGSTKLSSEKTVKGKYRVTPKILDEREASKLAYDLDYYLKGYKEVIYREVSLGYGEEETLFENSEGSSIMSYYPSAGLSIYLLIKGKKSTRERILEFGGVGGLEVLDYERITKRISEEIKGLKAVADNGASLSDAKIKSIKNVVISPEISGIAVHESIGHPNESDRVFGRELAQAGSSYINKDNLGMRIGSDSVNIFDYPSIKGTSGFYYYDDEGVKAAKKHIIKNGMQNELLLNREYAGMLKRKSNGSARSSSYDAEPLVRMSNTYLGAGDSSFEELITEAKDGIYVKSFNGWNIDDTRSFSMYQGNEAYLIKKGEISSPILNYRLEKGTLDLWKSVSLLSKKVELFNGECGKGEPLQGVPVTMGGPYALLQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP86</accession>
    <name>A0A218NP86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_1022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820581.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP86"/>
    <dbReference type="GeneID" id="33314557"/>
    <dbReference type="KEGG" id="marh:Mia14_1022"/>
    <dbReference type="OrthoDB" id="11638at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050535">
        <property type="entry name" value="DNA_Repair-Maintenance_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337">
        <property type="entry name" value="COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF0">
        <property type="entry name" value="NUCLEASE SBCCD SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="443" mass="49786" checksum="FE9CA5929CD53EAC" modified="2017-09-27" version="1">MKIGIVSDMHLGYSRFEEDAFRQAKFALSEAASMSDVIIMPGDIFDFRFPKPNIIAQAIKILRPLMEREWPAKIDSFSGANPIYTTLPILAIPGTHERTAVGKENPLNLLSLAGIVADISEGTAVISKGDEKVAVYGLGGISDDKVKERLKELDPKPTKGMFNIFVMHQSVYDFMPFSTDFLKLDDLPEGFDLYIDGHIHNKIESKVYGKPFLIPGSTVLTQLKESEQDSKGFLLYDTELDSYQFINIPSRPFMIKTLKFSKSNSDYVYKKCDETINSMLNAYLGRPNLPTEGKIPKPMKPIVRLVLEGTIEAGTSISSLNLRSLVGKYSDSAHLEIDSKLSSENLEEELSLIRKSQSDNNMSIKDLGMEMLKKNSEALDIKDLDVTELFEILDEEFPPNKKQELSEKVMELFTNKKPEAQAEPNNTYPDMAPEKGKDQKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA2</accession>
    <name>A0A218NPA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein insertase YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_1025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA2"/>
    <dbReference type="KEGG" id="marh:Mia14_1025"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="166" mass="19378" checksum="65FCC1F42DB2D65B" modified="2017-09-27" version="1">MIDLVVMPLYAELVVIAIGVLDVIVSIYLQRKVFIDEEKMYRSQMKMKKFQSDMKEMVKNKASQEELMNKQKEMMPLMSENMSFSIKSAIPSLILFFAIYDLILPYIYKAIAPNYIDATVYFIMPLNYHTLFWATILILGIVGAIYMAIRDRKNIKKLAEKVEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPA8</accession>
    <name>A0A218NPA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820569.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPA8"/>
    <dbReference type="GeneID" id="33314545"/>
    <dbReference type="KEGG" id="marh:Mia14_1010"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="19802" checksum="338EC0E0C74974BD" modified="2017-09-27" version="1">MDNWNSIDYERLNSMSAGLLPLMSKITGIIKGKDILDVAAGGGVFAAELSKHAKSVIAVDQSDSAIDTMKKVLSEYKNIKIIKSTAESIPLPEKSVGIVFTANALHDIGLQSLTKLIGLIKDGGYFIDLDWDKEDKEFAYGPPISIRLSASDVTASLKSKGLELSDRYDYRSHYLLVYKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPD0</accession>
    <name>A0A218NPD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_1030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820589.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPD0"/>
    <dbReference type="GeneID" id="33314565"/>
    <dbReference type="KEGG" id="marh:Mia14_1030"/>
    <dbReference type="OrthoDB" id="6262at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="3">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="133" mass="14311" checksum="EC5CC4FEFB8B5681" modified="2017-09-27" version="1">MKISDLRAGTGSVNITATVVNKEDPREVRTKYGKELKVANATLKDETGTISISLWENDIDAINVGDKVEISNGYVNEFKGNLQLSTGRNGKITVIGKGDETAESDESTEDMDDSSPAETDDLNPDLGSDETDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLJ4</accession>
    <name>A0A218NLJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819523.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLJ4"/>
    <dbReference type="GeneID" id="33313567"/>
    <dbReference type="KEGG" id="marh:Mia14_0005"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050833">
        <property type="entry name" value="Poly_Biosynth_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250:SF28">
        <property type="entry name" value="POLYSACCHARIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30250">
        <property type="entry name" value="PST FAMILY PREDICTED COLANIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="523" mass="56817" checksum="88C4253C2776EE1B" modified="2017-09-27" version="1">MSSESSDMSAADLGSSAAGMASIIMLSKVLSVAVLGVSFIFISRMLGSSVYGIYVLATAIIGLFDAIGNFGIGSAFNKFISQYKRNPEKVSAILSSGFLILISVGIALSLLTFIFSGPISYYALHTAEYNYIVKFIAIAILASMLFGASYPILIGIGDRREAAISVLTEALVQGVLSVGLIVLGFGVLGPIIGLIAGYLSSFFVTIFFLKLKMVYKLVIPSKADLRQIFHFSLPIAVSNIFNTLAGNLSTVVLGILTTTIVLGNFGIASKINYIFDIILGSISLSLLSAFAIASSTKKNKSRLGVMYSYSLFIAVVFISPVIFYMALFSTPLVNLLFGFTYKVAPLYISLISIGVLINFSASLASTMLMSINKVKQIMKNNIIISIIEIAIMPFAIYKLGGEGLIILLFLVAPVVNNFLFLRSAHRYIKFNINIWKISRVVISALVSAGMAFAVLQFLQFGSLFRVIAGIVIIAFVYPLFITVFRGAEDQDLENIKKFTKDIPVVRQFMSLIILYNESIIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLK8</accession>
    <name>A0A218NLK8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit Rpo10</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpo10</name>
        <name evidence="5" type="synonym">rpoN</name>
        <name evidence="6" type="ORF">Mia14_0018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819534.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLK8"/>
    <dbReference type="GeneID" id="33313580"/>
    <dbReference type="KEGG" id="marh:Mia14_0018"/>
    <dbReference type="OrthoDB" id="371754at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="66" mass="7837" checksum="AF5785D65C041FBC" modified="2017-09-27" version="1">MLMPIRCFTCGAVVADKWEEYDKRVNKENENPGKVLDELGVKRYCCRRMFLSNNDLLEEFMESSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL3</accession>
    <name>A0A218NLL3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">30S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819535.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL3"/>
    <dbReference type="GeneID" id="33313581"/>
    <dbReference type="KEGG" id="marh:Mia14_0019"/>
    <dbReference type="OrthoDB" id="371797at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000030">
        <property type="entry name" value="30S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="217" mass="24523" checksum="509B1F17F7F22444" modified="2017-09-27" version="1">MSEEEFSIASQNDYLESGIHIATKVKTPGTKKFIYKVREDGLYLFDLKTIDERIKVAASMLSKYDPKKIVVTASRIYAVAAAQKFSEIINANFIKGRVTPGIFTNPYRDNFMEPAVLFASDTRNEKQAVREASEIGVPIIALCDTDNMTRDVDLVIPCNNRGRKSLAFVYMLLAREFLKNKGIIKTNEEFKYTINDFELKVEANPADSEINISSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM2</accession>
    <name>A0A218NLM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819533.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM2"/>
    <dbReference type="GeneID" id="33313579"/>
    <dbReference type="KEGG" id="marh:Mia14_0017"/>
    <dbReference type="OrthoDB" id="52677at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="157" mass="17341" checksum="34719C1496824EB0" modified="2017-09-27" version="1">MPEAVKKTSKRKSSSAKSSKKEVKVAISKSKRKRSIARASVKNGPGTIRINGRLIDTIEPTFIKDEVLTPINFSDMTKDICNKLSISVNVHGGGVSSQAQACASAIAKAIVEYSGSAEIKREYLNYNRNLLIDDPRRVEPKKFLGPKARARFQTSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM7</accession>
    <name>A0A218NLM7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="10">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Mia14_0023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819539.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM7"/>
    <dbReference type="GeneID" id="33313585"/>
    <dbReference type="KEGG" id="marh:Mia14_0023"/>
    <dbReference type="OrthoDB" id="52849at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="93"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="94"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ASI13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="432" mass="47479" checksum="78D191C23B8162A4" modified="2017-09-27" version="1">MDFGDSLRKALAKLTHSTIIDAKVIREFNKELQKTLIMGDVDVELVLDLTKRIEEKALKSKPPAGIPSNDYITDIVYNELVSLVGDRYEPELKRQRILLLGLYGSGKTTTAAKLARFYQNKGLASGIICCDTTRPAAFEQLKTLAEQANVGFFGIRGEKDARKIVAEGLKELKDKPVIICDTGGRSALDPNLIDELSGITKSFNPDKKVLVISSDIGQVAGKQASEFNNSVGIDGVVVTKMDGSSKGGGALSATNAAKVHVMFIGTGEKLNDLEPFNPDDYIGSLLGIPNIKKLIDNVNEAVKEANLNPDEVNAEKLNFNTFYSQLKTLNKMGPLKNVLKMMGAVDAPKELIDQSEEKLKKYRVIIASMTNDERNDEKLLHNPSRVHRIALGSGTAESDVRSMIADFNKMKKSFNMLKNSRDIRKIFPGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLN9</accession>
    <name>A0A218NLN9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819548.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLN9"/>
    <dbReference type="GeneID" id="33313594"/>
    <dbReference type="KEGG" id="marh:Mia14_0033"/>
    <dbReference type="OrthoDB" id="6290at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01514">
        <property type="entry name" value="Elongation_Factor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="730" mass="80565" checksum="FEA4A3A246ED24F3" modified="2017-09-27" version="1">MVRKEYIVEEIVKIMKNTDQIRNVAIIAHVHHGKTTLTDSLLARAGLISKAAAGDALYTNYEAIEKDRKMTIKSANISLGFPYNGKDYIINLIDTPGHVDFGGGVTKAMRAIDGVILVVDPVEGIMPQTETVLKQALKEKAKPVLFINKVDRLLTELKLSPEDTFARISALIGSINRLIDKNVPEEFKGQWKVSVEDGSVAMGSAYKKWAISKLIMEKYHTTFKDIFALTAAGDEKKLQEVGPIDEAVLAMIIDHLPSPKTAQSYRIPHIWKGDMNSEIGKSMSLVDDNGKAVGVVFNLTYDQHSGEVVVARIFSGTIKKGTEVHISGQASTQRVQMVGIYMGPDRIIVDEIPAGNIAAIIGLKDLSIGDTLSEEEIEPFDQITHYSKPVVTKAIEAKDSRDTSKLIEALRELSKEDPTIQVEINQETGEHLVSGMGELHLEIIETKLRDNFKIQIISSPPIVIYRETIAQKAGPVESKTPNRHSRFYMTAEPLPDSVQKAIDDGIIREGKPKGQSAIEDLVSAGLDRAIAKNTVDVYNKCILADMTHGVQYMNEVMELLIDGFEEAIKDGPLAREKCAGVLISIVDATIHEDPVHRGPAQVIPASRNGVYASMLEAGVFLLEPMQIYTIESPQDYMSGLITFVQSRRGQVQEITQVGEDVKLVSKMPVADTLKGFSNDMRSLTQGRATWYTEFAGFEKLPTNIQPQIVREIRSRKGQPPEPPKASDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLP8</accession>
    <name>A0A218NLP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="6" type="ORF">Mia14_0057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLP8"/>
    <dbReference type="KEGG" id="marh:Mia14_0057"/>
    <dbReference type="OrthoDB" id="12054at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="161" mass="16879" checksum="769AA01692C99F75" modified="2017-09-27" version="1">MAKGKKLKTDEGKKNKGEESYEAKAMEALTVKERPQRLAVAHVYSSKNDTIITLTDMSGAETIAVGSGGMIVNADSQEGSPYAAMQAAYKVAADAKEKGITNITIEIRAPGGHNSKTPGPGAQAVVRVLARSGLTINGISDVTPIPTDTTRRAGGKRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ2</accession>
    <name>A0A218NLQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosome complex RNA-binding protein Rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819564.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ2"/>
    <dbReference type="GeneID" id="33313610"/>
    <dbReference type="KEGG" id="marh:Mia14_0050"/>
    <dbReference type="OrthoDB" id="35160at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="203" mass="22918" checksum="C9D5342E1EBD171F" modified="2017-09-27" version="1">MRRFVFPGEMILNSPTELSCSYIDNDKTYSKVLGLFDESSKSLIPLKSVWVPHIDDKVIGVISDIGRNGSYSVEINPLVKGVLLTDRRERQRFYVGDIVEATVKEIEHKTTVVLERAMLLKDGILMHINTAKIPRLMGKENTMINELTSFTKTKIAVGKNGYVWIKGENANKAIDAVLRIESEAHVPGLTDRIKDMLENENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ3</accession>
    <name>A0A218NLQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819560.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ3"/>
    <dbReference type="GeneID" id="33313606"/>
    <dbReference type="KEGG" id="marh:Mia14_0046"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="172" mass="19828" checksum="8F8B697D507307E2" modified="2017-09-27" version="1">MYYDLANFDYAPLGISPRDLGFNQIFRAGIDVKLLDVSSNNGDFSGSIVYNSDFKRLMSRMREGASGVLLNDYVLEKKFIQFLSQNDNFLILSINKLLADSGFSRQRDLLFMRKMVRYLESSRIKFSIVTFAENPVLQYSRMQLLYISQLVFSNPDHAKEHITNLKDIIVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ9</accession>
    <name>A0A218NLQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S8p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819585.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ9"/>
    <dbReference type="GeneID" id="33313632"/>
    <dbReference type="KEGG" id="marh:Mia14_0072"/>
    <dbReference type="OrthoDB" id="5670at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="127" mass="14449" checksum="495CA3F535284527" modified="2017-09-27" version="1">MVDKVADAINTIKTNERIGRVECDVPSNKLIKSILEILKSNNYIEGFEEFSVRYKKFLKIKLSNKINGIGVIKPRFTVSKSNMTKYEEMYIPSKDFGMLVISTTEGLLTNKEARAKNIGGSLIMYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLR0</accession>
    <name>A0A218NLR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">30S ribosomal protein S4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819571.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLR0"/>
    <dbReference type="GeneID" id="33313618"/>
    <dbReference type="KEGG" id="marh:Mia14_0058"/>
    <dbReference type="OrthoDB" id="10429at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="193" mass="21803" checksum="2AAE4F7C0FCE49BC" modified="2017-09-27" version="1">MGAPKRNRRKYDKPRDMWSTARIEVDSKFIKEFGLKNEKELWKIQTELSKLRGNVRLLLSAPESENINKISDSILSKLVKYGIAAPGVSLEKALDLDETAFLERRLQSLVFRKGLAKSMAQSRQLITHGFIAISGRKIDKPGYRVSVSEEDKLGYYRPINLEAAPKHEESRSDLNNEAKEAVASEESPAVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLS5</accession>
    <name>A0A218NLS5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">Mia14_0082</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780220.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLS5"/>
    <dbReference type="GeneID" id="33313642"/>
    <dbReference type="KEGG" id="marh:Mia14_0082"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04467">
        <property type="entry name" value="S1_aIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003076">
        <property type="entry name" value="PRK03999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="12">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="132" mass="14182" checksum="96857D30D28D26E8" modified="2017-09-27" version="1">MADGEIMKMTMKDIHVGRYIIIDGVPCKVVDIETSSPGKHGSAKMRVTAMGIFDGSKKTLLKPSDADADVPVIKKKKAQVVSISGNSAQIMDSETYEVYDLPIPEELDGKVVAGSEVEILEAMGKRAISKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV4</accession>
    <name>A0A218NLV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosortase EpsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819617.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV4"/>
    <dbReference type="GeneID" id="33313667"/>
    <dbReference type="KEGG" id="marh:Mia14_0107"/>
    <dbReference type="OrthoDB" id="387259at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="522" mass="58048" checksum="C384F9E2B502E36F" modified="2017-09-27" version="1">MKSDIDYKTNKLFGIIVLLISFLIIELSSIISTSFVISDTNQASYIIVVMLMLPLTILFSIKEDIHISRKWYDYAIGIAVFILYLTVFAYARAAMSFGFMSYRIDALLLPLVIISLTSIIFGSKNIKKFKFVIIYSLFASPVLLLPLLKENLAFTYLNASLIFSGIKLFDPNLVRVGLVITSPLGYQISIASTCADIGAFVSIMMFMLPLGYLYNGKLSHRALWIVVSVVFLLLLNFFRMFLISLIWIYYGLSAAILTLHLFFGELIFDIVIIVMILVASKFGMSIPKLNNNKSKTNFQNLKNSLIRSGYMVIVIALISIIGIFLSYPITSSVQHNPISFASAVPNMSEVQFMQPLEASNMTILYVGQVNGSAGSEPLEIFTMTNKTFSNNSLINALSYDEAGLSVPTILKLGNTKTIKSSSVILNNGITLHYAKEVSNGTVFYSNLLSIPYKISEENQSRYVTINYLLATTKNFTSCNIDLPIQNRFDSLIYNTINGNSNKGRYICAAYKIIDGAGNGTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLV5</accession>
    <name>A0A218NLV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WHTH transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLV5"/>
    <dbReference type="KEGG" id="marh:Mia14_0111"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="121" mass="13938" checksum="CB1D5ABF1463C4D3" modified="2017-09-27" version="1">MRRMVSSLEFDKEVLVVQPSKLPEKEQLTIIEIGLDDIDSASSFVSYLSEMYGFPKSSMWYDLRRLKEKGLVDFAAKGEKGKALRLTEKGIQIYKGFSAEKMKIINKFASKFIDEDSYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX3</accession>
    <name>A0A218NLX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1641 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819620.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX3"/>
    <dbReference type="GeneID" id="33313670"/>
    <dbReference type="KEGG" id="marh:Mia14_0110"/>
    <dbReference type="OrthoDB" id="56850at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38433:SF1">
        <property type="entry name" value="DUF1641 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="216" mass="23278" checksum="E7DFB49ACC7DB9E0" modified="2017-09-27" version="1">MLKNNPVNSENSFDPEYAPSITKALKMIKKLDDLGMLDYMSEVLDTEDTMESISTLIKSDEAVALRAKADQLRPLVGIIADKDTMSAIANLATILSALQKVGLLDPVIGMLKDDEVINAVMGLISNDFTMNLIANAKPILNSLSKLDLSAIPKYLDVLSSALTYMENGTIPPVKGLTGMLHELGDKDTQKGLGIVFYLLKSLGSANSTTQKADDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLY3</accession>
    <name>A0A218NLY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Preprotein translocase subunit SecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819627.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLY3"/>
    <dbReference type="GeneID" id="33313680"/>
    <dbReference type="KEGG" id="marh:Mia14_0121"/>
    <dbReference type="OrthoDB" id="146638at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048634">
        <property type="entry name" value="SecD_SecF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081:SF1">
        <property type="entry name" value="PROTEIN TRANSLOCASE SUBUNIT SECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PROTEIN-EXPORT MEMBRANE PROTEIN SEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Protein export membrane protein SecD/SecF C-terminal" evidence="10">
        <location>
            <begin position="361"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="525" mass="55506" checksum="C9D51D891F6D3E9E" modified="2017-09-27" version="1">MAKINGYLTDKRILVLVVIAIALLALDIHYGLHFGISFEGGVQIPVQLAHPVNSTTMSELISVLDQRASTFGLSEVTVEGVGDSEIYVTVPKADNSTINKTISILDSQGRFDGVVNGRLAVSGSDIIRDTIGQVPPAISGKNVTWAVTFSTTQSSATSFAKIVYGDANYPLYMFLDRPLNATILINSSILGNATDAISSSTALSAMKTALTLGNSTIPVIAVSNSNASIAGAESFYKSNIGRYKVVYASYNLNKSLISYIRSLNYTVNLESKKNMTPAYSIINASTTVLETWPLVGLLSAPLLNPEITDGNVTEDYEISGEAPTTLPLTAKTAYATNESKTIASILSGGALPVSIIVGTPTTVPQTLGADSFEISFVALGLAIISLSAFIAIRYRRIFLVGPILLTTFMELFIILSIIGLIGTIDLAAFAGIIAVVGTGVDAQIIITDEMLSNSGQTSNGKLLLSHAFYIVWMDAALLVIAMLPLFFSTSLVTIVGFSEAAIIGVIMGIAVTRPAYGAIISRHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLZ3</accession>
    <name>A0A218NLZ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiI</name>
        <name evidence="6" type="ORF">Mia14_0133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + ATP + H(+) = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + 2 oxidized [2Fe-2S]-[ferredoxin] + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[ThiS sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [ThiS sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="Rhea" id="RHEA-COMP:19908"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819639.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLZ3"/>
    <dbReference type="GeneID" id="33313692"/>
    <dbReference type="KEGG" id="marh:Mia14_0133"/>
    <dbReference type="OrthoDB" id="372227at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA-uracil-4 sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002937">
        <property type="term" value="P:tRNA 4-thiouridine biosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11716">
        <property type="entry name" value="THUMP_ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054173">
        <property type="entry name" value="ThiI_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049962">
        <property type="entry name" value="THUMP_ThiI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050102">
        <property type="entry name" value="tRNA_sulfurtransferase_ThiI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43209:SF1">
        <property type="entry name" value="TRNA SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22025">
        <property type="entry name" value="ThiI_fer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiI ferredoxin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Thil AANH" evidence="4">
        <location>
            <begin position="168"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="391" mass="43814" checksum="C9968E06DE328E99" modified="2017-09-27" version="1">MQEVIVVYFGELWLKGKNRPNFIKMLKDNVLDSISGLKYSRFVPLRDRFLIYIDGSSDTGSILEKLGYVFGISRFIKGVITDNSIDSVLKAALKLCSNEIGPFKISAHRTDKSLEFTSKDIVSAFINQDSIEVSRDSDKILFINPTNIGTFEYLNKEVFKGLGGLPVGMSGKAVILLSGGIDSPVASYYAMKRGLVPIYLHVHAFNDNGKAENSKMGLILETLSKYYSRFRVYYVPAYIFQLSILDVKHSFEIILFKRMLYQMAKKIAKKEGAKVIVTGESLSQVSSQTVSNLISTSHDVNDLLVMRPLIGLDKQDIISKAKEIGTYDQSIIKYKDVCSMHSRDAVTTTRLSYIDELSNSVGMDDISDRSLLKADALDYPIVKLKRSDRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM04</accession>
    <name>A0A218NM04_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM04"/>
    <dbReference type="KEGG" id="marh:Mia14_0166"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="750"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="812" mass="92203" checksum="DEA30E146DBF91E6" modified="2017-09-27" version="1">MTYMLELLVIVPLVFSFNAVLPLIPLIIIIILIAAAAGMTRGFSIFAFFGLDALMGVTQGTGGGRAGKGVRSVNYNRSAGPRSNASKRVPRGLVTNKLKKRKLTKQDTKIRAMKEAMGKNYDPKWRTKRGSVREGNKELKKTTKEYNEFLSNLKKTPSKMAQTGSSTKYPNTTGAMKFATSVLGSSFILSQNNSNKTQAALAKDYVKNKSKEYYKEVKEQERQQRPLAVLKRRKEARMRDLKLYKERLEELYKAQNQKIPPSTKLKSNGLTQDQIDEVNKRMGKATFFAKHSFLGTGAEFYRTAANTILNTQDKMLTQLYGKDYDSKAKGLINMVATGNVVKSSLSQKDQELYDLYKTYDLDKGGTSANVINHMYVGGNYNPDTKTLSQQVREDIKHNMFHPFKQAAMEIGYKDKRGSVDYKNYYKATYGQDLPSGIMTSNKYYFDLVKTIKADHTPPPLPIINTNKPPNVIRVMNTDDNGNPMYRKNGNRVETFLVENHTEDGGVSYGFANKEQIESLRKYELEHGNKYLEEKYKNDKRSWHDIVYGIGEKNSNVSSEAEYDKEGSRKLKTGNYNDRRERDIDNGTTFNYNKATYENAGRMDMYNIKENLLKKNEDDENILKSHTVLSINKDKNNDLITTDNDSSTPPTPNAMQKYKPTYPSNDTKGATDNNTGISQYSQEPNAQTTQVMLYTNIIPFSNSAGSESDSYYSNNGYSHDYHSHTYYSNNYSSSSSSSSNSTSQSINTSQDPYSILGIERDSSYEEIRRAYHKLALKYHPDVHSGRREEAEEKFKKIANAYEEAIYKNEHKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM12</accession>
    <name>A0A218NM12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SMR2 family DMT superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819665.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM12"/>
    <dbReference type="GeneID" id="33313720"/>
    <dbReference type="KEGG" id="marh:Mia14_0161"/>
    <dbReference type="OrthoDB" id="384841at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561:SF9">
        <property type="entry name" value="4-AMINO-4-DEOXY-L-ARABINOSE-PHOSPHOUNDECAPRENOL FLIPPASE SUBUNIT ARNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="113" mass="12521" checksum="C9A65132CF1A8120" modified="2017-09-27" version="1">MNKKLLYLLVLSSSALLGSFGQLFFKYSLTLLGTAFDYGSLMMVLGLAAYGLSTVIYFYVLSRVHLSWAYSVSGISYIVAVILSRLVLLENVTYLRWAGVILIFIGVVLVSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM13</accession>
    <name>A0A218NM13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system membrane protein GspF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819675.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM13"/>
    <dbReference type="GeneID" id="33313731"/>
    <dbReference type="KEGG" id="marh:Mia14_0173"/>
    <dbReference type="OrthoDB" id="380199at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35007">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35007:SF2">
        <property type="entry name" value="PILUS ASSEMBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Type II secretion system protein GspF" evidence="7">
        <location>
            <begin position="101"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="328" mass="36104" checksum="7BFC64E568330B04" modified="2017-09-27" version="1">MEFRFERLVSRNISYKLSHLLDLAGLKMTVNKLLSYMVIGSILLMVIVPFVLYFMKINIILAILSVVIAPAVYLVVIYFILNYLIDKRKSIMENFLPDYLQITAANLRSGVSLDRAMLMAARPEFGQLSLDVKEMNKKIYGGETLDAALTELANSYDSTTLKHSVRMVLEAYRYGGAMSDLISQMSKDLKNQQLTMKEISGQLLMYSIFIVFAGLIAAPAMYGLTSQMIVVTDTVWKGILAANPGGLPTTGVSFLKPSPPKISPQTYHTFSLISIIFITGFAAIIMSTIQSGSAIKGIKFVPVFIIVGIILYYIVGTVISGIFTGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM18</accession>
    <name>A0A218NM18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system ATPase GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM18"/>
    <dbReference type="KEGG" id="marh:Mia14_0170"/>
    <dbReference type="OrthoDB" id="33500at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01130">
        <property type="entry name" value="VirB11-like_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050921">
        <property type="entry name" value="T4SS_GSP_E_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486">
        <property type="entry name" value="TWITCHING MOTILITY PROTEIN PILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486:SF15">
        <property type="entry name" value="TYPE II_IV SECRETION SYSTEM ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="3">
        <location>
            <begin position="257"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="558" mass="62335" checksum="62A60F3913630771" modified="2017-09-27" version="1">MSDLEPKSIIDAGDLRGIDSSGADNIEPTAEPNPSPSVNENPKNEDNNAKVSENKGNEGSTPTQQTIQEYDLVANGLEAHITIYKTVEEFVPIYGVSFKGVSMATRLLLLSMRRPLLTSVPVDLSKINDKDYVSDLNKRYLAAAEVLIDRYLPRIEEGIKKVLLSYILNMMLGLGELEVPLSDDSLEEITVNGANYNIWVFHKKLGWLKTSLKPTSEDSIYNQAEQIGRRVGREINNLTPLMDAELEDGSRVNGTLFPISQSGNTLTIRKFSKNPWTMPALIKNGSLDANLASLVWLCIQNEISVLISGGTASGKTSFLNAMSIFFPSNRRVISVEDTRELALPNFLQWVPMITREPNPEGKGAVSMYDLMINSLRQRPDIIVVGEIRAAEDAQTLFEAIHTGHSVYGTLHADNVQDTIIRMTNPPINTPKISMNALGVIITVFRHRAKGIRRVLEFGELLRTGDANVLYRWNIRTDTFTKVSEMTRLQETLNLYTGMTKSEIDSDVKEKSDVLSWMAANNITNVDDAGFVIANYYNNRERVLDIVKENAKFSRDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM29</accession>
    <name>A0A218NM29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR subfamily 2 transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819696.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM29"/>
    <dbReference type="GeneID" id="33313754"/>
    <dbReference type="KEGG" id="marh:Mia14_0196"/>
    <dbReference type="OrthoDB" id="56053at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052509">
        <property type="entry name" value="Metal_resp_DNA-bind_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33169">
        <property type="entry name" value="PADR-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33169:SF14">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR RV3488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="118" mass="13747" checksum="9425AF71A8F0958A" modified="2017-09-27" version="1">MGEKETKKYKYREFHNILLKLFILKKIDQDKKAYPYDIIKKIKKSPLLSNLTEEGSIKNDVYNIISVLEKAGYIESEAIKSDGKIKKYYHITPDGKKALNVIKKDFHKLVKTVTSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM30</accession>
    <name>A0A218NM30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819678.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM30"/>
    <dbReference type="GeneID" id="33313734"/>
    <dbReference type="KEGG" id="marh:Mia14_0176"/>
    <dbReference type="OrthoDB" id="382693at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="179" mass="19740" checksum="CDAD96DD0B30C312" modified="2017-09-27" version="1">MKNAKAQFWSIDVIFSIVIFTVALTLLAYTWYNINNQLALSYSDGSTVMSIQAFTMSGTLMTPGYPINWQDDVNLSDNANWNEISIGLLKNGSDQISNSKLYTFIAMANSNYQATKTSLGASYNYYIVIRGSGINIKIGRNPALYNATSVVRQTSSAMLNNMQVSVIVETWTNGNLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM34</accession>
    <name>A0A218NM34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891416.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM34"/>
    <dbReference type="GeneID" id="33313761"/>
    <dbReference type="KEGG" id="marh:Mia14_0203"/>
    <dbReference type="OrthoDB" id="147253at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04179">
        <property type="entry name" value="DPM_DPG-synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050256">
        <property type="entry name" value="Glycosyltransferase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090:SF7">
        <property type="entry name" value="RFBJ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="224" mass="25098" checksum="852EFC5FDA43D13A" modified="2017-09-27" version="1">MDYSDTTIILPVKNEPYAKEVLGEVISSLPHSKIIIAYSGNVNDLKKYGSKKPNVIFLKQNGNGKGNACIYAFKSIRTKFVGLIDTDGTYDVKDLRKAINLIRKGGDMIIGRRIASEHGAMPSYIKFGNWVITQTANLIYGMHLKDSQTGLRVIKVSSLKTLNLYEQGFGIESEINIKMHKKGYVTKEIPISYHKRKGGHSNQLKLLDGLKLLAIDFKFMSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM47</accession>
    <name>A0A218NM47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819704.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM47"/>
    <dbReference type="GeneID" id="33313763"/>
    <dbReference type="KEGG" id="marh:Mia14_0205"/>
    <dbReference type="OrthoDB" id="372083at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="23549" checksum="DEBC67A2D5D0FF72" modified="2017-09-27" version="1">MVSYKVIENKKGLPKKLDNYVMSAIAYALPSYIKFLLPMPLKDGSIIESDNKDVYIDGKKVGNVLLYKSGLDVSISHEFDIKYAGGYSLDGKTIYISANMPPEIMIGNTKVSLLESIGRHHELPEKWLLDDDYEYPYAHEIATNIEREYAESLGINWDSYNLEVDKLLRENYKCKLKKSPPNLDLSPYIYSHDDETIKEIRSSTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM50</accession>
    <name>A0A218NM50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM50"/>
    <dbReference type="KEGG" id="marh:Mia14_0207"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="9">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="320" mass="35547" checksum="41E30FE49CD52E36" modified="2017-09-27" version="1">MLWLIVLKVIVMDKSNLDNTIEEDENLAEEVCKISYEALLKARDMIKPGVKLLDVAEATESYVIGKGYEVAFPLNLSIDNEAAHYTPSYMDDKVFGEKDLVKVDFGAAKNGYLGDCALTVDLSGEYGKLVDATKEALENAVSIVRAGRKVKEIGKEINSTFERLGFRPIENLGGHGVNLHELHAEPFIPNYDNGDDAELEEGRRIAIEPFATLKQSRGLVTETDVAEIYSFSDNISPRLPAARHVLSSIMEKYPSEPFAARWLSEGMKSKFELYSGIRELEKIGALDSYPVLAEVSRGMVAQTEFELLVEKDSCKVLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM66</accession>
    <name>A0A218NM66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CPA2 family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819717.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM66"/>
    <dbReference type="GeneID" id="33313776"/>
    <dbReference type="KEGG" id="marh:Mia14_0218"/>
    <dbReference type="OrthoDB" id="12029at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="13"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="390" mass="42426" checksum="0583F28A743FC22E" modified="2017-09-27" version="1">MEILIALLLLLAVSISLGKLLERFGITDIVGQIIAGMILGPSLLNIIQPSSLLSGIAEVAIFFILLFIGIEITTETLTNHIKSSIRFTLSSFIIPVILMCIVSIYLLNIPISESIIASVAIGVPSISIISVLIYRYSLIHTEGGLKILSAVIFTDIIAFVILAAVMQSSHLLLTVAGVMIFLLILLYIDRELRYHGRTIRPFFKKLLDNRKEDTIFALVLIMSLLVSAILQVIGITYVLGAVFAGMLIHKTTVGTRTTQMLKDTFRRLNDSFFIPIFFSIAGLEFRIPSSKYIILLVILVGISLLVGGVMNYFNAKRHIRNIPPSEVTGILGSRGAVGIVIASLAFQSSIINSQIYAIILVGTIVMSLIMPLLLSSGRAKRQVAGSSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM81</accession>
    <name>A0A218NM81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRC-barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819728.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM81"/>
    <dbReference type="GeneID" id="33313787"/>
    <dbReference type="KEGG" id="marh:Mia14_0229"/>
    <dbReference type="OrthoDB" id="378671at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.240">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="93" mass="10198" checksum="7E4801D2973910F3" modified="2017-09-27" version="1">MKLSDVYDMDVYSDGGQFLGNVKDAIVDLEHGEVGRLLMIGWSNVSEDNIQAILKDKSVLFKNIKNIGDVVLVSTSKKDSEEASAESSDLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM88</accession>
    <name>A0A218NM88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP family protease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891420.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM88"/>
    <dbReference type="GeneID" id="33313803"/>
    <dbReference type="KEGG" id="marh:Mia14_0245"/>
    <dbReference type="OrthoDB" id="28720at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL/LppC-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00481">
        <property type="entry name" value="YbhB/YbcL family Raf kinase inhibitor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="150" mass="17327" checksum="51DBE536544137FC" modified="2017-09-27" version="1">MEKITIKSFKNGEYIPKVYSCEGNDISPEITIDEASESKYYMLIMNDPDAPMGLFTHWVIYNMQLKQGQLHENIEKAPITKEGFYQGHNDFGKIGYGGPCPPKGDKPHRYNFNLYMQDSKIDEEAITVKKAYDLAYKFLKVASYLGMYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM90</accession>
    <name>A0A218NM90_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819745.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM90"/>
    <dbReference type="GeneID" id="33313809"/>
    <dbReference type="KEGG" id="marh:Mia14_0251"/>
    <dbReference type="OrthoDB" id="374354at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12271" checksum="061877E0E900F47C" modified="2017-09-27" version="1">MAKIDKNQDNIWALRKVLSRPNYAVMELLLQKSPRTTKELYSVLEKKFTRKTLIITLRELSLDLNVIQPTHIRTANGYGLGYKLNPKVKNIIRSVQKFSKTIDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMA7</accession>
    <name>A0A218NMA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819760.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMA7"/>
    <dbReference type="GeneID" id="33313825"/>
    <dbReference type="KEGG" id="marh:Mia14_0268"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="82" mass="9945" checksum="E2BF2C2863360009" modified="2017-09-27" version="1">MEAKYVKDKSFREELLPRFNANKKHELTSEEIKLKELHRKISEDKKISWDLSTKEINRLRKEGKYKEAERIEDTRQLLSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMC4</accession>
    <name>A0A218NMC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819787.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMC4"/>
    <dbReference type="GeneID" id="33313852"/>
    <dbReference type="KEGG" id="marh:Mia14_0295"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="85" mass="9804" checksum="88BFA3AD55D197B8" modified="2017-09-27" version="1">MGKYYCHWFSPEELVHEFKIASKKAKFLELSALEGLATPSIEEINNISKDRKAWKNWLSVHYKLCTKSEVVGVSIHILLIGRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD2</accession>
    <name>A0A218NMD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819791.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD2"/>
    <dbReference type="GeneID" id="33313856"/>
    <dbReference type="KEGG" id="marh:Mia14_0299"/>
    <dbReference type="OrthoDB" id="33636at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="296" mass="33122" checksum="14ABFA28C1790D76" modified="2017-09-27" version="1">MLYQHRKYGMVTPTVTLLRQGSIDLDAVKSLMQFLKKSGAKGAFIAGSTGNAPMLSLNEHKEVIKQYIKYAKEEHLATFVGIGRDSIDETVAMGEYSIELGADKLVAVTPYYMKEDQKQMHAYYSELLSKLDSEVLIYNIPSLTGNNIEAETVAKLAEENSNLIGIKSTNADFDQFQKLIYYTDNDFLVFQGYDHLLLPSLELGASGGVCGTTNLTDIAEKLYESYNRKEPAKSIKLHKQLSSIYHMLEPYEFPAVYNAMFYKTIMGTEIAKEPELFGNLSKKEASLLSKKLSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD4</accession>
    <name>A0A218NMD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mandelate racemase subfamily of enolase superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819790.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD4"/>
    <dbReference type="GeneID" id="33313855"/>
    <dbReference type="KEGG" id="marh:Mia14_0298"/>
    <dbReference type="OrthoDB" id="42605at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03316">
        <property type="entry name" value="MR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="396" mass="44013" checksum="11CF2505D8A542FB" modified="2017-09-27" version="1">MSKIKDIDIMEVGDIEEGEKSSPWSSTIVVLRMTTSDGIVGYGEAPTTLMTKPVIEEAREMARVLKGKDPTEIEKNSLEVYKHSFYMPESMETTSAFSAIEIASWDIIGKTYGVPVYKMLGGRLNEKIKAYANGWYSDCVSADSFAKKAKEVSKAGFKAMKFDPFGDAYDEIDKEHLEHAVDVIGAVKDAAKGSDVLIECHGRFNANSAIRMARAIEGLEPAFVEEPVHSDNIMGLKRLRTTTNVPIALGERVMNKNLFLPYLTDDLVDIVQPDITNCRGILEGKKIASMAESFGVEVAFHNAFGPIQTAASLNVDITIPNFFMQESFEHFWPEWKKKLVKGGYKLEDGMFTISGKPGLGIDVNERILEEYKVDGMEPFNPNEPSWAVKGTWKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NME8</accession>
    <name>A0A218NME8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819795.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NME8"/>
    <dbReference type="GeneID" id="33313860"/>
    <dbReference type="KEGG" id="marh:Mia14_0303"/>
    <dbReference type="OrthoDB" id="26806at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="151" mass="17137" checksum="498AAFE064450F47" modified="2017-09-27" version="1">MEDCTFCKIVSGKIPSFKIYDDGRYMAILDKYPNIKGQALVITKEHVDSYIFDMDDSALSDFMITVKKVAKLLEKGLGVERVHLVFEGTEINHLHAKLYPAIGISKHEKAIANNTINFDKYEGYLSTLRGVEASDDELEEEMKSIIENNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF0</accession>
    <name>A0A218NMF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819812.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF0"/>
    <dbReference type="GeneID" id="33313879"/>
    <dbReference type="KEGG" id="marh:Mia14_0321"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="21649" checksum="6BBC97DC5FC34A55" modified="2017-09-27" version="1">MAEKNTLEDLIGKLSDFMDKGTEETPYKPMTEFLKKKIANANFKKKSDREYILGLCKVENAAYKYQVKGESTGFYGSYVFLHPEEYGPYRKEFFEILKELSYQDYLKVVTMELFDPSQYGPGKQWEPFKLEDFNENDQAFIKRNLARWHAQERYKERQKKAEKKTEFDKLRKWWIDNGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF5</accession>
    <name>A0A218NMF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12 13">Pyruvate kinase</fullName>
            <ecNumber evidence="3 12 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 12 13"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819816.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF5"/>
    <dbReference type="GeneID" id="33313884"/>
    <dbReference type="KEGG" id="marh:Mia14_0326"/>
    <dbReference type="OrthoDB" id="56298at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="2"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="344"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="454" mass="50452" checksum="32AFB4D081A4ADCC" modified="2017-09-27" version="1">MKTKILATFGPAIEEKSKLAKIIKYTDIIRINFSHTNEEQAEQYIAHIKAAEKLAGKEISLLADLPGPKIRLGKIKDPIIVKKGDLLKLFYEGNKLEKGVIPVSYRYISDDCRNGMHLSIGDGYLKMKVEGIKDGIVFAKAINDGIISSRKGLNLIGADITEQTPTEEDIKFAKFAKDKFDFIALSFVKSDEDIKRLREKVGNDIFVISKIERRHALDNIKAIAEESDGIMVARGDLAFDIPVESIPIAQKKIIKASREAGKPVIVATQMLMSMVNNPMPTRAEVNDVANSVFEDADCVMLSDETAVGSYPIESIETMSRVIHNAEKEAQQSYPRSVDGIYSYIAHAAKDLSEKHDIKCIFVPTESGASAIRLSQFRPSSDIIALSENPNVRSKLALFKGVRAMDIKNYSSTDEMLENIKELALKLKIYEYLVVYGSPRKKGSTDSLKYVSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH3</accession>
    <name>A0A218NMH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOSE family ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819829.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH3"/>
    <dbReference type="GeneID" id="33313898"/>
    <dbReference type="KEGG" id="marh:Mia14_0341"/>
    <dbReference type="OrthoDB" id="44250at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42798:SF6">
        <property type="entry name" value="CELL DIVISION ATP-BINDING PROTEIN FTSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42798">
        <property type="entry name" value="LIPOPROTEIN-RELEASING SYSTEM ATP-BINDING PROTEIN LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="240" mass="26654" checksum="A5EAEAC21C18AA59" modified="2017-09-27" version="1">MNFTKQVKSVIEVKNLVKMYSYGNSEFAALDSISFDVKLGEFVSIIGPSGSGKTTLLNMLSAMDRPTSGDVIINGNNINELSNSELATLRNREIGFIFQSFNLINTMTALENVELPLMLQDVDRKERDVRAMELLKMLGIDNRAHNLPLMMSGGQQQRVAIARAIITKPKIILGDEPTGNLNTEDTEVVMGILEDIHKNFGNTLVIVTHNPEVANRAERIIRIKDGKIEGIDSKLKLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK5</accession>
    <name>A0A218NMK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DrsE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819874.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK5"/>
    <dbReference type="GeneID" id="33313944"/>
    <dbReference type="KEGG" id="marh:Mia14_0388"/>
    <dbReference type="OrthoDB" id="41780at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="DsrEFH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="106" mass="11731" checksum="7914EFA0E8C184B0" modified="2017-09-27" version="1">MAKILSIVMSGEKAKIKMALNFTSEMLKQGKDVKLMFWGPSEGVIAEDAELQEGLKKVSEVLHPLACINFARNNNLEEKLKGKVDLQPIGKYIAESVDDGYSILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMK7</accession>
    <name>A0A218NMK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH family RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819857.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMK7"/>
    <dbReference type="GeneID" id="33313927"/>
    <dbReference type="KEGG" id="marh:Mia14_0370"/>
    <dbReference type="OrthoDB" id="84806at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06555">
        <property type="entry name" value="ASCH_PF0470_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016645">
        <property type="entry name" value="UCP016134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016134">
        <property type="entry name" value="UCP016134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="115" mass="13496" checksum="F1E2B4BBE25A7DA4" modified="2017-09-27" version="1">MIHEMSLYEDPFEKIKGGRKSIEVRLYDEKRRKVNVGDAIVFRKLPDKSESLRVVVVGYSVFGSFRDLFMNFDKSKFGHPENISIDDQIKLSRQYYTEDKEKEYGVMGIHIKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML2</accession>
    <name>A0A218NML2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DHA2 family major facilitator superfamily permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819882.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML2"/>
    <dbReference type="GeneID" id="33313953"/>
    <dbReference type="KEGG" id="marh:Mia14_0397"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="484" mass="53046" checksum="70D985879C1A2C22" modified="2017-09-27" version="1">MQDKPINDKNKVEYLSKKNIYLIIAIMAFAGILISYVETTIVLEIPILVKFFNVSYDSVSWILIAYIISSTISAALSGKIADNYGKRKVFLALALFYALAVSMGGFARTLDELIIIRAIQGIGTGMFPLAFAVINDFVDKDKLPLAQGIMGATLTIGAGLGLVLGTLITQSYRWQWSYYSTIPAAFVLVILTYAFLKDKIYPGNLALKQKGKVDYIGASALGISLFSIIFYISEGGIVGYTKLYMLFTLAISFISLIYFVRYEMNFTNPFINIKLLKTRNVLLSNIVGLFVMALMYILFFTVPTFLQDPSPSGLGKTIFESGIIELPLALLNIIFAPIAATVIKRKSAEESILIGFGIALVSFILLIDYRYTVTGIIIGSAVFGSSMSFMLVGVINKLLNSVPKENAGEASGVNDVFRNIGMAIAPAIGGVIETIYFISVKVAPTVIRHFPSATAFNYIYYIGLVFSIIGIILTLFMKPNKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMM6</accession>
    <name>A0A218NMM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U-APC2 family APC superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMM6"/>
    <dbReference type="KEGG" id="marh:Mia14_0393"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="108"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="514" mass="54919" checksum="6F17E51F443D5323" modified="2017-09-27" version="1">MIIYLGPMAENNPSNNTADNNGNLGINPVSASDSPSQANTVETSSQGGEIFNGNINKISKELDKDKKSNDKAAASAANGAASSQAKGDKEEEDDKEKKKLGFKETFFLAFGGQAPFISLLTFGTVMISMVGVAGAFAMIIATFVVLINGLVVYVMSSKFKRGGGYYIYAFYSLTSKLGLETGWSYFLYSLAYGGALLVGGAYVLFTFTGINQTFLALVVAVIASAFVLKGIKISAKYAMVMSIIEITVIIALSIFFLNTSHWHFYDPISFPALLFTAVIFGLGIPTGYGSIAPLSSDIKDSTRTIGKASISVLLVGGFIAAFFFYSLGALSFTGNVIELMAVKFGIIGAILIGFIALNDGTLGGMAYMIANSRTFSAMSSDKKFPTIFSININDKPILSEIFIVMVFVIVIVSVTQFIGLYAAFIALGALAGLTNLVVHISAGISLARISIKKLHKRIVEFGIGFLASLLSFIVLVFSLPGIDKYTVYLFFGWIILGFLYSEALDMANDVTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP4</accession>
    <name>A0A218NMP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819938.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP4"/>
    <dbReference type="GeneID" id="33313986"/>
    <dbReference type="KEGG" id="marh:Mia14_0431"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="257" mass="29291" checksum="E6D92976FB4F934A" modified="2017-09-27" version="1">MRMISLNLWGGRAFEGLKAFLNKEKGRTDIFCFQETLQYSLGRPDNDSLKAKTMHQPKEFSERENLYADLEGILDGYKGFLTDPYSSGKERLSMFIKDGISASEDANRVVNDVGVTVDNLPYKVGCIMQHASVTFENKTYDICNTHGLWQHSSKEDTPERLQQSENIIKLMSKMGPRRVLAGDFNLLPDTRSIKMLEDSGMRNLIKEYNITDTRGKLYTKKIRHADYTFVSNAVDVKGFRVLPVEASDHLPMALEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP7</accession>
    <name>A0A218NMP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819953.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP7"/>
    <dbReference type="REBASE" id="210407">
        <property type="entry name" value="M.Mar14ORF442P"/>
    </dbReference>
    <dbReference type="GeneID" id="33313997"/>
    <dbReference type="KEGG" id="marh:Mia14_0442"/>
    <dbReference type="OrthoDB" id="372040at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="entry name" value="Adenine-specific Methyltransferase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="DNA ADENINE METHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481:SF2">
        <property type="entry name" value="SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="294" mass="34838" checksum="D831D19AC24D68A1" modified="2017-09-27" version="1">MKNLTPLRFPGNKRWLVNYVENFITYHKLDRSIAEPYGGSASISISLLEMGIVNKAYINDKDFMIYAFWYSVFNLNQEFIEKIEEMSTNITIEKYYEFKKFYKIFMNSKVKYGDKDMLKYASTFLFLNRTSYSGIIKGGPLGGRNQESKYKIYCRFRDSNIVNKIKYLYKFKKQVVLSNLDGLRFIKNFSNKHSNSLLYIDPPYFKAGKDLYSFYFNREDHKKLATLLSNKIISPWLVSYDNNEFIKNLYSNKGVFNDKVLSNQNIYLPKQYLISSHKRVVYEILFSNKKIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR0</accession>
    <name>A0A218NMR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819968.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR0"/>
    <dbReference type="GeneID" id="33314007"/>
    <dbReference type="KEGG" id="marh:Mia14_0451"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="153" mass="17829" checksum="6193AB1737ABAC69" modified="2017-09-27" version="1">MEDCIPNRYSELYKSLNNEINNIIEYSLKTQDQELDCINKEIQNAENMEDLNLVFDNLKLFRLKLIKDVERKLRQEKAKEIDYEMHYEMFSYRKISALLLSLIETNVDKAIESLFKIDTNVIGSVEKIAKKLGAKGFSITLGLPLNLTVTLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR5</accession>
    <name>A0A218NMR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819990.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR5"/>
    <dbReference type="GeneID" id="33314019"/>
    <dbReference type="KEGG" id="marh:Mia14_0463"/>
    <dbReference type="OrthoDB" id="97369at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="159" mass="17949" checksum="8A138E4310BF06F3" modified="2017-09-27" version="1">MGKLNASENIDYIKPLNSYAEPNEVGGKAYNLMKLSHAHYNTVVGFAITTEVYRYWKKNGKLPKEFFDKLNEYLKWFSYGMKFPVIVRSSATVEDAKKASFAGLFASYPNANSILDRVLFTDSNTATIYIVLYISPLSLLQQTADSLPCLFLMAVLHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT2</accession>
    <name>A0A218NMT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CYTH-like superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819959.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT2"/>
    <dbReference type="GeneID" id="33314000"/>
    <dbReference type="KEGG" id="marh:Mia14_0445"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="200" mass="23929" checksum="B7FB624358B90022" modified="2017-09-27" version="1">MLHEIEISVTNINLEEAKERLQELEANYVGTYNYKILNIEIENRGNIESEEYYTKWARVRSDGKKTTLTLKEQYGTDINKRLEYEVETSDFITTAKIILKMLPDAKYSYIEKSRIDYRYKENNLDIVIDKWPKLPYKMEVEGPSEESIKEFYKRLNLKSGTLAPSIAVSNEEYYKMFNIDYKEMINEYNEKFEKMLEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV0</accession>
    <name>A0A218NMV0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">Mia14_0466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819996.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV0"/>
    <dbReference type="GeneID" id="33314022"/>
    <dbReference type="KEGG" id="marh:Mia14_0466"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="138" mass="15415" checksum="E70FBC2B68CDB2B0" modified="2017-09-27" version="1">MMVLDASAIVKLIINESESDFVRKKVVSEAKKSEPIYTPDIALAESLNVIWKYSSLKSQNNINQYKLLSDLMLLWNTLTVVNTATLASLAMKIAVDNKITIYDALYAALSKLENAPLLTFDKYLKSKATDIEIKVVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV4</accession>
    <name>A0A218NMV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome-binding GTPase RsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820068.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV4"/>
    <dbReference type="GeneID" id="33314065"/>
    <dbReference type="KEGG" id="marh:Mia14_0507"/>
    <dbReference type="OrthoDB" id="69796at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.50">
        <property type="entry name" value="Probable gtpase engc, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00157">
        <property type="entry name" value="ribosome small subunit-dependent GTPase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT BIOGENESIS GTPASE RSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120:SF11">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT BIOGENESIS GTPASE RSGA 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="126"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EngC GTPase" evidence="4">
        <location>
            <begin position="135"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="347" mass="38566" checksum="FA5610A2B2FC9AF2" modified="2017-09-27" version="1">MMDEYDYAESRKSKGKGSNRSRSDHHEKRQGDLNEINVYSPGDAQKLGKIGIVAEMSPTNYRILYNNKFIEGIAEDDSQKGIVSQLVVGDNVIFELNESNPIIKGRTERHSKLARLRTDSSKKSQAGAEEHVIVANIDVAVIVASAIQPAFNPNMVDRYLVISQYGNVAPILCITKTDLAKPPDLSMYKSADLPIVKVSNKTMDGISDLLPYLKGKRCVMIGSSGVGKSSLINSILHKEVLFTDEVSEKSGKGRHTTSSSSLHLLDESTMLIDTPGIRSLGLWELDPESLRLYYPEFAEFAPNCKFSDCTHSHEPGCAVKKAVEEGFISRERYDSYIRLLAKLEYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV8</accession>
    <name>A0A218NMV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819997.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV8"/>
    <dbReference type="GeneID" id="33314023"/>
    <dbReference type="KEGG" id="marh:Mia14_0468"/>
    <dbReference type="OrthoDB" id="359531at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="262" mass="30720" checksum="175F8B483E1DE9F4" modified="2017-09-27" version="1">MIDETKEWRAYADRLGFPKTQDAEKDYLQELMLYQIFNRSTNIIFRGGTAISKLYGSGRFSEDLDFILQNPTEVEVIKKLINRAIKGINLQYNANFKVEKYKNMLKYTIKIKGPLYAISNNPQSVQTLGLDMNLFERPMMDVKHMPRMPIYSDIPSYIINSLDVNELLADKIKALMERTEPVARDMYDSWILCRKYDTKPNLELVGKKMQLYGRTDNEEFSLERLKEKIEIVGKVWDSEMSRLVRNPPDYNEVKSYLLALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMV9</accession>
    <name>A0A218NMV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mercuric reductase</fullName>
            <ecNumber evidence="4">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Mia14_0477</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Hg + NADP(+) + H(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820013.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMV9"/>
    <dbReference type="GeneID" id="33314032"/>
    <dbReference type="KEGG" id="marh:Mia14_0477"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF4">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE RCLA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0475">Mercuric resistance</keyword>
    <keyword evidence="11" id="KW-0476">Mercury</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="362"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ASI13793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="486" mass="52187" checksum="6694B3268C436188" modified="2017-09-27" version="1">MTTNHNHLGSPHCLQVGGCHDYIIIGQGAAAFSAAIEANSLGARTLMIGKNETEGSLLGGTCVNVGCVPSKRLITVGEFIDDVRKSRYYGVDADAIVDYSKVVAEKDKLVSGMRSKKYKEVLDKLANVDFVDGFGSLGDSHTVIANGKEYHSNHILIATGARAYIPSIKGLESINPLTNEEALSLKDLPRSLIIIGGRAMGLEFAQMFSHFGSKVTVLQRSGTIIPGWEPVLISKLANYLKDDGISVNTNTAINEVGKDGGEEFVKASVNGKEAIFKAERIMFATGRQPNVEKLNLGAIGLKTDEKGFIQINSKMETNVPGIYAAGDVTGEPMLETLAGKEGKIATDNMFTRNTKEIDLNEVPQAIFTMPEAAMVGLTDDQAHGKGIKCSCNSIPFSMIPKASIIGDERGVIKVVIDYATKRILGVSILSRNAADLIAEATLAVKFKLTIDDIIDTVHVFPTLSEAFKLASQNFYQDISNMSCCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW0</accession>
    <name>A0A218NMW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820001.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW0"/>
    <dbReference type="GeneID" id="33314025"/>
    <dbReference type="KEGG" id="marh:Mia14_0470"/>
    <dbReference type="OrthoDB" id="381347at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="344" mass="39208" checksum="C91470F8CE44F472" modified="2017-09-27" version="1">MVSKEKRIEFKKGAFREELNKDAEKIMNVAEYVSINNKALLDFAKNNAFSKVSLPKWDLPVFPEKANKATISFIILGNTQNFAFTDFITKQKYVAEYKGSDYVGAMGMWASIKKAIERGVPLLDGEFLSTISYKELEEIYNSKSKIPMLQERLDILNEVGNVLCKKYDGKFYNILKGYELGKEMMFDNGKGFVELLVSDFPSFRDESDYKEIKIKFDKRAQLTAAMTFEKFLGLGKNIFKQGEEEKLSVFADYELPKVLNSIGILNYNESLSNDINNGVLLKSGSKEEVELRAATILAADRIEEEIKRFNKSSKINQLGIDYLLWSAGRQIKTANHHLTITTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW3</accession>
    <name>A0A218NMW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820039.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW3"/>
    <dbReference type="GeneID" id="33314046"/>
    <dbReference type="KEGG" id="marh:Mia14_0488"/>
    <dbReference type="OrthoDB" id="111898at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE AHPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33930:SF2">
        <property type="entry name" value="BLR3452 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="115" mass="12545" checksum="B6FF67EA174F2DB1" modified="2017-09-27" version="1">MDANEKLKEVNRVVKELGADQPNVQAGFMKLLTSSESDGKLPTKVKELISLALAINVKCEWCIAYHMNNYLKAGATKDEIMETASVAILMGGAPSLMYLNPVLDAFEQLGGDQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY9</accession>
    <name>A0A218NMY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-K factor-processing regulatory protein bofA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820097.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY9"/>
    <dbReference type="GeneID" id="33314083"/>
    <dbReference type="KEGG" id="marh:Mia14_0526"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="86" mass="9165" checksum="65C1572D7BE27C2D" modified="2017-09-27" version="1">MLIEMIVLYGIIVFAIIFGLYLLFKLGGIILGLIANTIMGLASIFIVNFFFGLGIAINLLTIVLVAIFGLPAAAIIIILKIIGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMZ8</accession>
    <name>A0A218NMZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phosphoglycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820116.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMZ8"/>
    <dbReference type="GeneID" id="33314093"/>
    <dbReference type="KEGG" id="marh:Mia14_0536"/>
    <dbReference type="OrthoDB" id="31230at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF3">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="206" mass="23493" checksum="A9F2B45C933241CA" modified="2017-09-27" version="1">MADYKIIFIGGVPGVGKTSISGALSRKYNIDIMLSGDYLREFARPIISSKGEGNNLMTSVYEAWKEFGEKTNENIIKGYLEQSKPICSGINAVIERADKNGENVIVESLYLNQELLDTLKKYNACSAYLYISDWDLHSKRLNERELYTHKKSPGSRLSAQLDVYRSIMDYSIDLLKKNSMRIFDNTDYAKTRDDVIKFVGEYYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN08</accession>
    <name>A0A218NN08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820120.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN08"/>
    <dbReference type="GeneID" id="33314095"/>
    <dbReference type="KEGG" id="marh:Mia14_0538"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="277" mass="32232" checksum="966F7AF4FEE48D4D" modified="2017-09-27" version="1">MYVYVRNIELPRAEIIGCSRKLDDEGKGASIEFHLDDYSIAKEFTSSDKSVKIEREEKEKDPGRQNSASGYSYFISYEHEGRRHRIGLYPRSMDEKAVLDYLSSHQGHFKTDAYFRDIFGNNVKVDFASRYSSTLRISSRVKRLKVESDLYFDENENCQTLSIPYIPNKLAKKLETAENLVVEKVKYLYPSVPGIFNNAGKDYDYAISFKYHGIRDEIYLEPVKEETEKMLEYLSSNGKLLRYGNIRTGDGTSSMDIDFSLKYEMVDLYLDGKKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN23</accession>
    <name>A0A218NN23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoacid dehydrogenase multienzyme complex, 2-oxoacid decarboxylase (E1) component subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_420835677.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN23"/>
    <dbReference type="GeneID" id="33314107"/>
    <dbReference type="KEGG" id="marh:Mia14_0550"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43257:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="321" mass="34941" checksum="8BFD1DB6B58C90A7" modified="2017-09-27" version="1">MMANMISALNNALDLCLAENEDIVIMGEDVAKDGGVFRVTDGLLDKYGPTRVMNTPLAENSIIGTAVGMALGGMHPFPEIQFGGFSYQAFSQIMHHAARFRTRTRSKMPIPMVIRFPASGGVGGPEIHSESPEALFSHIGSLVVIEASTPYDAKGLLISASHLNDPVVFIEPTKLYRMFKQEVPEDSYEVPIGKANVVNHGDDITIITYGTMSPVVQNAVKDKKVSADVIDLRTINPLDEKTILDSVKRTGRALIVHEDQKSFSVGAEVSAVIAEKAMFELKAPILRVAGFHTPIPFAGYENYWIPNEKRVSQAIDSLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN29</accession>
    <name>A0A218NN29_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820149.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN29"/>
    <dbReference type="GeneID" id="33314121"/>
    <dbReference type="KEGG" id="marh:Mia14_0564"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.20">
        <property type="entry name" value="Class I aminoacyl-tRNA synthetases (RS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.720">
        <property type="entry name" value="leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="10"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="696"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="944" mass="107080" checksum="F0D9780DF5888CB8" modified="2017-09-27" version="1">MIDHNSIQSKWLSEWEKAKLFESDVNDKEGILVTAAFPYVDMPLHIGHLRTYGTADFYARYKRMRGFNVLYPMAFHKTGTPILAISKRIASNEPEIIGVLKKLGVEDAEVIKKMSDPYFLADYFEKITEEGMRHAGFSVDWRRKFDSINPFFSKMVEWQFSKLNEKKLLVTGEHPVGWCPNEGNAVGQHDTKGDVQPEISKLVAIKFKDSSSDAYFACATYRPETIYGVTNLFVNPKVQYVIADMKGTKVYMSKEAFGILKYQFDMDAVSEISGEELLARKAINPMDGKEVPVLPGSFVKPDFATGVVMSVPSHAPFDYNELEKLKDSNYDTGVKYEDYIRCLETPDESKSSETPALQYLNGKKKEDGSYDVDAATKDIYRDELRKGTMLIGDYKGKGVNEARELISKDLTSSGKAFDVSIISNEEPVYCRCGARVVVHTVKNQWFINYGEKSWKEETKSYVPEMLIYPEKTRNAFMAAVDWIDLRAAERAQGLGTKFPLDNGHIIESLSDSTIYPMFYTISNTVLSSVAKPEQLNGDFFDYVVYGKLDANEVSKSTGIDYEVLKKCRDSFSYWYKFTSRHSASDLVFNHLTMYIYNHLAVFPEEYWPKQIVVNGLVNYEGVKMSKSLGNVIPIMKGIELYGADTLRFIEIVNSDLDQVAEFNTESVNSVNQKIDYLYSAVEKLKGMGSGELKAIDFWLYSKLNRKIRDATEMVEKFNLRDAYISIFYGSINELRYYLERGGDNSIVVSDFLSKVILMLSPVMPYNAEELWHLMGNDTFVSKQQWPEPEASLIDDSVEQLEGLLNSTIEDIANTMKLTSKMDANNGKSVKSAEIIVADDWKFKAYAKLKEYKSMSKVINLPEFSATSKESLSKYLSSLIKSVNSLSDLQYGSEDEYNTLNSSKDYIKSKLNNMFEVSVKKEAESDSGRAFRASPTSPAIILEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN32</accession>
    <name>A0A218NN32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN32"/>
    <dbReference type="KEGG" id="marh:Mia14_0560"/>
    <dbReference type="OrthoDB" id="56710at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="317" mass="34895" checksum="241AAEC2ABC3C696" modified="2017-09-27" version="1">MVAINLWNPTDVGFYTAIIIALLLGFVHGITPDEHTWPITFSYAVGSYSTKGGMKAGFIFSSGFTLQRSILSEIAYFALAGIFMTATAFGITYVFVGLAMLAAGIYIKNKKIYPHWHWIEEKLSYMVGIHKKGSKSHLLEEEHVLNPLNTTDSSPQLKAVPSKLAFLHGLIAGFGFGAFALIIYTVLSPAMPSPWVGWVPGFMFGIGTMIMQILFGAGFGRWLTSAKKLTQKGIAFVARTISSDVLLYGGLAFMVSGSLILEFPWLLTYDIVTPLKIHNLHDLGIGFFLVIFAVIIIGFLSYIRAVKIAERSKDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN36</accession>
    <name>A0A218NN36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820146.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN36"/>
    <dbReference type="GeneID" id="33314118"/>
    <dbReference type="KEGG" id="marh:Mia14_0561"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="242" mass="28481" checksum="FAC26FFD0AA47C18" modified="2017-09-27" version="1">MVQKEKRVYYASSVVKDLDSVMDDLRYNVFRSISAAEEKLAKKYSLEIDDFKDDVLHFPNSDINRDFFIEEDETDDKEGNLVWLENINNSVSREKKYRFIHDVTFKSLMDYKIEHSYNVTSTALIDLDYSLEDKLKDLDESEHVYINNDIERLLNKFIGLQELEANNLNEKLKSIDFGNNRAEDEFHSAFDHYLYKISRYTHCLDRVSKALDDPDAGLREIHNSIASEVTFMESLMKIRSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN37</accession>
    <name>A0A218NN37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820161.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN37"/>
    <dbReference type="GeneID" id="33314134"/>
    <dbReference type="KEGG" id="marh:Mia14_0579"/>
    <dbReference type="OrthoDB" id="378732at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="448" mass="51957" checksum="899DDBD9D7CCF7BF" modified="2017-09-27" version="1">MVEVPEKVQEAFNELKGIYGQSLELKIIDNEFYVFLTNSNEESSESDSYIGRITSNGIVILADSKQASLVYKKISNKEKKERKSKNITGNNISDEDIKLLKALSMNSRLSLKRLSEITGISIHALEYRIERLERLLGIKYTLELNMNNLGFSEYMILAKFTRSKPNFEKIGDFLEKNPRVQLALATKGIYDLVIFCVAENNNVVAEVLDNIRTSEALNDIEAEWYITPISGDYGFIPLRQEFFDALKEKVWQRKKKGERPSLSSLMYREYALLHELNENSKKSLSAIDKKYNLPAGSAKKAYKDLKNEEGKNVISRPTLRVKKINKKYDIALIAVLINYTEFMKFRDNHHKYIINEPNRFINRFSYICDMETPNGIFYLFPALKEGDIEKTENELSEIIKGVKFDSLIVEKAIVGDIDYRKFDNLYSMQYINLVKRKSIRPQQRIQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN45</accession>
    <name>A0A218NN45_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Archaeal Lon protease</fullName>
            <ecNumber evidence="14">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent protease La homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Mia14_0574</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13 14">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN45"/>
    <dbReference type="KEGG" id="marh:Mia14_0574"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046843">
        <property type="entry name" value="LonB_AAA-LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20436">
        <property type="entry name" value="LonB_AAA-LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="461"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASI13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="660" mass="72155" checksum="90E83053E3101078" modified="2017-09-27" version="1">MLYTAIILWRYEEITMKELKFKTTDDIAIPKKLIDQVIGQKNAIEIVKKAAKQRRNVLLIGEPGTGKTMLAQAMAELLPVSNLEDVLVYKNTNDENMPLIKEVKTYPDPEAMKKGLDGQGRQIVMKSRMNSRINLNSGGSSIITTIVFVLVLILVGLSFSGYIKGYDLIVISALILGIMIFGAVFMFTAGLTKRPGIMTLGENSEPKLIVDNTGRQTAPFIDATGSRAGALFGDVKHDPLQTGGLGTPAHLRVESGAIHKANEGVLFIDEISSMDLHSQEELLTAMQEKKYPITGQSELSSGALVRTEPVPSDFILVAAGNVQDIKRMHPALRSRIRGYGYEVYMQTTMPDTVENRNQLIQFIAQEVKKDKKIPPFEMDAVYQTIEEAKRRAGKKDSLTLELRDLGGLIRAAGDIAIERKEKLVTKKDVLDARKLASPVESQMVDQMLKDREEYKVFEASGYKIGRVNGLAVLGATATSAGIIVPIVSEVTPAGSKAEGKFIPTGKLGKIASEAVKNVSAIIKKHIGADISKYDVHVQFLQTYEGIEGDSASVSVALSILSALEDLPIDQSFAMTGSLSVRGNVLPVGGVTGKVEAAIQSHMKAVILPKSNLQDVYLDKDKAKLIKLIPVSTFAEVIKYAIKPSKKRDEIVKSLEKYERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN58</accession>
    <name>A0A218NN58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lrp-AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820160.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN58"/>
    <dbReference type="GeneID" id="33314133"/>
    <dbReference type="KEGG" id="marh:Mia14_0578"/>
    <dbReference type="OrthoDB" id="378732at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="457" mass="53056" checksum="293511CDF7740771" modified="2017-09-27" version="1">MVKFPKKVLKAFQELKDAYGRDAELKFLNGKFRIFEVTYKEDSQSNEPIRVTNYIGYITKDGFIVPARPKRKNLKFGNGEKLKINNNVEENKSPNKKLTLKNNDIKLLKALSMNSRLSLKGLSEITGISIHALEYRIERLERLLGIKYTLELNMNNLGFSEYMILAKFTRDKLNFEKIKEGISKNPMVQLALATKGIYDLVIFCVAENNNVVAEVLDNIRTSEALNDIEAEWYITPIAGSYGFIPLRQEFFDALKEKVWQRKKKGEKHNLSSLTYREYALLRELNENSRKSLSSIDKKYNLPAGSAKKAYNDLKNEEGKNVISRPTLMVKNINKKYDMALIAVLINYTEFMRFRDNHRKYIIDEPEYLINRFSYICDMEIPNAILYLFPILNEKDIGKIKSELSEIIKGVKFDSLIVEKAIVGDIDYRKFDNLYSMQYINLVKRKSISPKKRVSYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN63</accession>
    <name>A0A218NN63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820183.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN63"/>
    <dbReference type="GeneID" id="33314161"/>
    <dbReference type="KEGG" id="marh:Mia14_0607"/>
    <dbReference type="OrthoDB" id="358785at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731:SF4">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731">
        <property type="entry name" value="SLL1084 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="246"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="560" mass="62598" checksum="3A112915A01F87DD" modified="2017-09-27" version="1">MAKFVLVADSTLIYTYHDFPLLDFLPSAPKKTVPSGVYNFLKGEHPKYMDNGELLVAPYSIRKLEAKLLEKYPRKDVAVVDGNNAAKFIDANTEVIGVSTMDPFGIGPLTMSYAVLFGGDFYAWVRRDFEILINKLNAARKGKKAKLVVGGPGVWDFTVLKEEFEKMNIDYAVQGETDDVLIDLFEQLTAGQIDKSMFNTGYLTFNDKFQMSSVSDERFISRKSYGHYPPLEKIPAIVRPSIKGMVEVMRGCGVGCDFCEVTLRPLRYQPLDFIKKEIEVNIKSGTTNKAWLHSDEFFGYKHGKFFEPNQEALVDLFTQIKQMPGVKYMNPTHGRIAIPAGFPDLIKRLSEIAQAGPSNWIGLQVGLETGSEELAKKHMPAKTLPLKVGSDGSWHEIVWRGVQTFTKYYWRPAFTVQVGQDGETDDDNWETVALINKLSNSYVDGRPFEFTVTPMVNVPMGRIKSHSLNEDVLKPSMFAVYYAAYRHLRKMALRDARAESKGNPLTRIGTTAAMDIGSGILLNYIGKLAKKSGVDLEKASTYGLSGNKGKMIESVSQIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN70</accession>
    <name>A0A218NN70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tricorn interacting prolyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820182.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN70"/>
    <dbReference type="GeneID" id="33314160"/>
    <dbReference type="KEGG" id="marh:Mia14_0606"/>
    <dbReference type="OrthoDB" id="7531at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="193" mass="21570" checksum="9A6538C0E596B4FC" modified="2017-09-27" version="1">MEKEKFIFDDKEILYFHSGAEGNDAILLMHGYNFSTQVWIDVGLVEKLKGIGYEVFSLDVPGFPKSENKAKLSQDDIERLLEKFIKDKMHSNAVLLGASASGRIALEFAEKHAHLLRKLILVDPVYESVDFGKLNGIDILGIWGGNDPISKPFRSVASNVKLAILKGAGHACYLDKPDEFNSIVANFLKEQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN95</accession>
    <name>A0A218NN95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820206.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN95"/>
    <dbReference type="GeneID" id="33314192"/>
    <dbReference type="KEGG" id="marh:Mia14_0638"/>
    <dbReference type="OrthoDB" id="385733at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="309" mass="35892" checksum="2A41DDB241943FF5" modified="2017-09-27" version="1">MSIVIVICVFIALFYTFYYIIDISRSIGIYEGILTISEHYNITLSQSLKLGLSTLPTLGIALDIVYIMIPISVMMFAIAILWMFSRLYSKWSVSAIIILSAIYVMLVHLLESNFNFNGFAESFMVPYIINLLILALSVYSLIAILYGSDSDFEIEINPLTPYSNMAIISNKLMRHLKGDLRILDSHFDNTSFDNLSRLILRNMNKYTSIYILTYLEENSRGFGRGYTDFKNELQNKNIKFELRIMGREDFSRQHERIMMDSNTAYKIPPINIINRKSEHIVSLNHDEAFRRFNEIWNRSKSYENFSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA4</accession>
    <name>A0A218NNA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase IV</fullName>
            <shortName evidence="15">Pol IV</shortName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dbh</name>
        <name evidence="17" type="ORF">Mia14_0648</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820215.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA4"/>
    <dbReference type="GeneID" id="33314201"/>
    <dbReference type="KEGG" id="marh:Mia14_0648"/>
    <dbReference type="OrthoDB" id="372207at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 15" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="16">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="15">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ASI13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="354" mass="39658" checksum="34E073C4C4D8D4B2" modified="2017-09-27" version="1">MDSKAGYVVYLDMDSFFASCEQLRHPELIGKPFAVVTDSLDKFRGVVQTASYSARKFGIHSGMPTMKALQLYPNLHCIKEDYDYYEKISNEVMEIIKSYGFKMEAVSVDEAAIDTTELNESQVLEVAKGIKTKISNELKLKCTIGIAKGKTFAKMACDSAKPNGFLFIKDYETIEFIKYKKVSDIPGVGAKTEGKLAGLNIHYIGDIQNSNVQVLVGLLGEYGSELYKLSKGIDEEKIVSDYTALSISREKNLYEDTNDIPTIMAQLKELSEDAANAVRSTQKLYKSITVKVRYYDFTTKIKTKTLSYYSDSSDVLYSEASELIKPLIKDNILVRRVGVKVSSLTDSAHQHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB6</accession>
    <name>A0A218NNB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB6"/>
    <dbReference type="KEGG" id="marh:Mia14_0631"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="290" mass="31846" checksum="5F5D5F6138DD5EC5" modified="2017-09-27" version="1">MEYLMTYGWAILVIAVVLAALYSLGIFNPSSFAPKASAGSCEVVRPFGPTTSTDVHLEGTCTNMLPKYVASLNGNDGYVYSNISSLPEGKQPRTVIVWFYLTAEPSTSNGQSAIFAYGTANTCDETFWVSATTPSSTCDNSELFIDNWCTCQSFPDVPTISLDRWYFVADEYNGTYQIGYLSDNGSIISINSQQLGVNTGESPFYIGYWTVRGYFPGMIANLQIYNKSLSSNQISALYDEGIGGDPIDLTHLVAWYPLNGNAQDYSGNNYNGKAFNVSYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC6</accession>
    <name>A0A218NNC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC6"/>
    <dbReference type="KEGG" id="marh:Mia14_0657"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="11">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="9">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="10">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI13960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="406" mass="46504" checksum="F70AD04810D82421" modified="2017-09-27" version="1">MFCMKTAYKYRAYPSKEQKGTLNRQMYLSKELYNLLLEKSKSYYKETGKTLTEFRMNGWITKLKKEKPEFAEIHSQVLQNISKRVSDAYKHFFLRCKEKKQGKKVKAGFPRYKKFVSSLTYPQTNGFKIEKKKVELSKIGRINFVNHRNIEGGIKTLNIKKTKSQEWYITIAVEKEDKPFISNGKPRIGIDLGIMQYAALSDNTILQNAKITKHERKHSRALQQNISRKEKGSSNRRKAVTRFARYSEHISRIRLDCINNLSNELVNSYSFIAYEDLEINNMVKNHRYAKSINESSWGNFTQLLQYKAESAGCVAMKVNPQYTSMTCSKCGNVQSISISQRTFVCEKCGMSMDRDVNAAQNILKRALDSISPTTEGHSGSQARGDDIRPSAGEAVAYEAGTTWVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNC8</accession>
    <name>A0A218NNC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1 8"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820227.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNC8"/>
    <dbReference type="GeneID" id="33314213"/>
    <dbReference type="KEGG" id="marh:Mia14_0660"/>
    <dbReference type="OrthoDB" id="30823at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="13"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="683"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="1049" mass="120421" checksum="365FA079D6128C25" modified="2017-09-27" version="1">MIDLGEIENFTKEYWSKEDPIKKIKKESVDKKKYYFLDGPPYATGELGVHHVWVGVVKDVMLRYKRFRGFYVHDRAGFDVHGLPIENKVEHKLGLKTKEDIDSYGIDNFIEACKSFADEQVSGMIDIYRKYGSSLDFEDAYIPYKKNYMDAGWRMFKGIYDKGLVYSGKKALAYCPHCETVLSAQGPEIEYSDDTDPSIFVRFKVDPERSKDSRINIESNLYLVIWTTTPWTLPSNMAVAVNPEGLYVKAQFGDNIYIVAKDRLDAFAKSIDQSFTVLGEFYGSELQGIYYKGPFEDEIPKQREFAKFHRVLMEKGLVSMGDGTGLVHVAPGHGPEDFNVGFKNGIPIYSPVSDQAEYTDEAGGLKGIKIPDEANKFVLEKLKKDGSLLYRGSITHSYPHCWRCNSKLIYRSTDQWFIDIQKIKDKTIKANSKIKWHPKNTKEWQDDTLRNSPDWCISRQRYWGAPIPIWKCNDCDNTIAIGSAAELKEKAGLSKEPEDLHIPYIDNITFKCDKCEGTMHRVKDVFDVWWDSGIAHTASLSEEEWKRLFPSDWITESRDQLRGWFSMLIRTSVALYGKTPFKEVTIGGMVYDEHGMEMHRHLGNLILAKDLPKYVSADGYRLWCLGKPRWEDLKVKVSELKESDNIIVTYYNIMKLAREFSNLSGSDSKRVKKPNLALADKDDRWILSRINTIVKNSTELFDSYGIDQAINQMADFLVNDFSRTYLKIAKQKSEDMSTKKLRYLSNLINYVLYKFTVISSVALPFTSEYIYQKLFSIDGGSVFYEPWPKADIKYIDDNIEKEFDIAKELSSEILNLREKNSVRLRQPLSNAKVITRYNEVADAVAKLSNIIESLTNVKTISAEISDNLNLRIIPVFAKIGPEFKENSNVVSDALRKADPKELSEAVEKEGYYTLHTEKGNFTIKPEMYTISEDLIKENEEESKYGLIYLDTEITDDLKGELLVREIIRRIQMLRKEKGFSKSDRINVYLSADVALSALVKENIERIKKVTNSRSIDERLSDANGLEEVSFEISPGNSIKIAIEKNERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NND9</accession>
    <name>A0A218NND9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216893.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NND9"/>
    <dbReference type="GeneID" id="33314222"/>
    <dbReference type="KEGG" id="marh:Mia14_0669"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="354" mass="39133" checksum="1B017508E887B600" modified="2017-09-27" version="1">MIKNMDKVSNSGSNNSKTKAGANAPDTDSKKKNASADGNKNNVKIVLKQKEKYFIIIILLALLIIVTLLFSSLASRANPNTVKGCESKLLNQDQCLENLAASEANASICRLLPNSSVQGCYLNIANKTKNISYCGLVNTSSTAYQNCVYSFTNASNSNICLSNSNATLRSECASKLELISNQTDDKYCSYLLGDANKSLCYNEYYFKSAIYDNVPEYCSYLPDNTSVPLSNLLEMLPLNKSADYNLEGDSLYLDQNHIVNDRSLCYVSLFELTNNRSLCSDIPSSLSYLCSYNVTTPTLINSTEINETCADVPSLLHSVCISEEYYNLANETKNYSYCRYVTNATLKSKCNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNE0</accession>
    <name>A0A218NNE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecA-superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNE0"/>
    <dbReference type="KEGG" id="marh:Mia14_0670"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637:SF1">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="249" mass="27657" checksum="E24A4E58DC612771" modified="2017-09-27" version="1">MSEMKDKIIKLKTGIKGLDYMLYGGIPSKNQIMIGGVPGAGKTLMSFEVAYKMAQSGIPSTFISFEEPPESIIRNAKEVFTEFDDIEKLQEQHMLQIGGSSVAMKITEKTDSSSYSFSSIVSDIDDMIIANESKFVVIDSISLLHLMIPDNTNYRIALLSLISKLRSLGVTSIFTVEVSSSERKGILFEPEFFTFDGIIMMYELGEQDKRQLTLEVVKMRGSDHSWFLAPYSITSSGINILTPESQGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNG7</accession>
    <name>A0A218NNG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820273.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNG7"/>
    <dbReference type="GeneID" id="33314263"/>
    <dbReference type="KEGG" id="marh:Mia14_0711"/>
    <dbReference type="OrthoDB" id="26806at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40730:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40730">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="112" mass="12588" checksum="1ABBBDB8119FA970" modified="2017-09-27" version="1">MKLGCNDEIKNLLPSIKGAICEDLIYKMNYSQEKAAALLGITQPMVSKYIHRRYSANLKITISRIKNNKMYIRAIDGFIKGGGNADVDSLINALLFDKEFVDELRTSESSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI4</accession>
    <name>A0A218NNI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216899.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI4"/>
    <dbReference type="GeneID" id="33314285"/>
    <dbReference type="KEGG" id="marh:Mia14_0733"/>
    <dbReference type="OrthoDB" id="387635at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="370" mass="39131" checksum="3004C628CE1AF8F8" modified="2017-09-27" version="1">MTRLRFAAVGISLFLVLFMELGTGFAPAATTSYLPANLCGSMYNVAGNPTGFVKYESLTGLLAISLILLTIMLLITGVLWAFGGLLEMPKLKESARSEIGEVLLTGLIVVIILGSFSLTNFSAGDALPLSNGLFSSRIYYDDCNVIFTGVQKGISEDIGLLAYDDVVKLISSLTLTIEPGYFGYSFSPYAGMGYGSNVIGVTMSIVGGVVMLSFAGILVLNYVFIIMPIFLFIGIVLRTIPWTRPAGGAFIGMFIGFFILFPLLLHFMIVGSIQTINLATVSSSTPTSLPGLSGLTNVLNIMGDIEGYVSDFSGGIAAVNSVITDIIGPLLYIILSLLITLIIAFDFTDTMGDLLGSPSLSSSGGLKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ9</accession>
    <name>A0A218NNJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820319.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ9"/>
    <dbReference type="GeneID" id="33314312"/>
    <dbReference type="KEGG" id="marh:Mia14_0760"/>
    <dbReference type="OrthoDB" id="12267at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="259" mass="27455" checksum="FE0C8F622D99FCF7" modified="2017-09-27" version="1">MIVTLLQSILSIISGLLVGFSLGLIGGGGSILAIPLFIYFVGIDEPHKAIGTTALAVGVNAFINFYQHARDKNVNLKVGVLFAFIGLIGVFIGSEVGLYLPGKSLLALFSVLMVIIGVYMYLSKCKTLPDENCKSLDGIKKKKLTFYSSLVGFASGFFGIGGGFLIVPGIMSSTKIKINQAVGTSLFVVGTFGIGTAIRYAFAGDVLPELSVLFIIGGILGGYFGTRVSVKMNKNLLRKIFAAIVIVFGIYIFLESAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNK6</accession>
    <name>A0A218NNK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820322.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNK6"/>
    <dbReference type="GeneID" id="33314317"/>
    <dbReference type="KEGG" id="marh:Mia14_0765"/>
    <dbReference type="OrthoDB" id="120490at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="9">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="7">
        <location>
            <begin position="183"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="8">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="418" mass="49050" checksum="5384A4FAE0EA25AE" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQNEIDERLILAQQFYNKILEKSIESYKNGKAKASMAQFNRFVKEIIQDDKKYLKLYSQTRCEIEYRLLKAYQNFFRRIKEGNRKAGFPRFRSRDRYKSITYPQYNGSFSIKRGRLRVSRIGTMRIELHRKIEGTIKTLAIKREGKDYYAIFTTANEIKIPQLKDTNPVGIDMGLHSFIGMSSRMKIEKPRFVRKRAKHLARWQRRIAKREKGSKRRENAKNHLQKEWEHVTEQSDDFSHKLSNKLVNSGYTSFAVEDLHIQNMAKNHNFAQAIYNASWNRFIQMLSYKAESAGMKVIRVDARNTTQECSNYHCIKEGGERLALKDRVYNCNRCGMQLDRDINASINILHRATTLGQRGSHAQGDMASAVQQELKSRIAELRTDKTHPLRDAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL8</accession>
    <name>A0A218NNL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL8"/>
    <dbReference type="KEGG" id="marh:Mia14_0746"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="595" mass="66299" checksum="052C4A06C1FD108A" modified="2017-09-27" version="1">MINMATLTDAKLNSKVEITGISFSLGSYSISSRDKVSSIVDSSRLKDETDKVVLGLGINRTSVAAKGEDVITNAALAIIKLIVSYNVDTSKVSNVVIATETPHDISQSMANPVLKLTNKLIDKLNNNGYNIKHLNPEIGMHVQSACTSAGSAISSYAINGLSGYAIIVATDNAEYKLGTAADETGGFGSVAVLLEPYEKGKKGIVLLDKIGHYSDEVPDFIKVIFDDNYSSSGLSLVARYPIVFGKFSEEAYSLAIFEALKRISENTGIPINNRKMLESYDLISHLPYPKIPEKLLAYLIRHLSRTDSSLKEDLSVDLGILNSSGTMLKESFLPGFDSLEDEFKFIIKFESLYNNAVGLSSEIKGRMSERKNEMDSFLNAGNTKDEVKSIIWEIENISSEFESNTDILELLGNCKESFLMLLESDKIGEKDIENAFKPIMDVINEFEKEDNVYNKSIRSSKIFKQIKEELHIEEAVKLSKEIGNIYTGSILIGLVSYLTNVKKPKNNLLLTFYGSGFESYVIEAIPNIDENFISLLDRNVENEFARQRIIDGETYIKIRKNAYDDAKIPLSRDNIFRVDFINEGEFLDEIKKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN0</accession>
    <name>A0A218NNN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN0"/>
    <dbReference type="KEGG" id="marh:Mia14_0781"/>
    <dbReference type="OrthoDB" id="386592at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="213" mass="23997" checksum="7565802708A15419" modified="2017-09-27" version="1">MDIILKVMVMAIILIAVIAIIFIVHSYFVKVKPNYITENEALSIVTKDIKLENPNSNITIMNITKSKLANDSWDITLRLINYSNSVCPTLEIESYNYPAVTLVPTVISVYSSDCSIYGNQTCETPYSDITMGPVALTCAYIENTSDLNSYITDYGLKNITASAKFYSNLNLTQPKAYYRNIWLLNYSSNLSNYNLIVVMNKSGYIINSFKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP8</accession>
    <name>A0A218NNP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="11">IPP isomerase</shortName>
            <ecNumber evidence="11">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="11">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fni</name>
        <name evidence="13" type="ORF">Mia14_0809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="11"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820366.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP8"/>
    <dbReference type="GeneID" id="33314358"/>
    <dbReference type="KEGG" id="marh:Mia14_0809"/>
    <dbReference type="OrthoDB" id="371955at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="12">
        <location>
            <begin position="189"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="365" mass="39583" checksum="464BE1B0E1C4AC55" modified="2017-09-27" version="1">MHDSDSAKEEKIKDIMQRKEDHINICIDKPVQAKKISTLFECVHLINNSLPEINFDDIDTSVNFLGHKFSAPLMVGAMTGGADLAYKINENIGTAVEELNLGMAVGSQRAALYDKRLEETYSIARKSAPSAFIGANIGGAQISKGFSIDDARELVRMLEADALYTHLNPAQELVQPEGEPHYSSVLGGIKELVDKVGVPVVPKEVGFGISGDVASNLEKANVSAIEVAGMGGTSYSAVEYYRAKQMNMQRKELLGSLLWDWGIPTAASLCSVVNKVKMPVVSSGGLRTGLDIAKSIALGASMTAMAWPALRPATESSDAVKKFLEQRIYELKSIMFLLGVKDIEGLKKAKYVMTEPLQSWINADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNR1</accession>
    <name>A0A218NNR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U-APC2 family APC superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780209.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNR1"/>
    <dbReference type="GeneID" id="33314363"/>
    <dbReference type="KEGG" id="marh:Mia14_0814"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="47"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI14105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="523" mass="56092" checksum="80D44F2E21F831F1" modified="2017-09-27" version="1">MEPEGKAVARLKKNQVGTLGAIAEEISAMAPGCDAIAFVVASATFAFFLTPLAFLIATLTMFLEVNTLYHLSKRHASAGGYYGYIANAFGSIPAISSGLLYVMYQIVSTAAIPVFVAGVVLPGVINYFLAISLPGWIWIPSILIFIVLPIVIAMIGIRPQMRYIRVAAFFEVAFLALLSAIIILKAPDNTLNVFNPFVWPQYSSWFASEGGPLSGVGLGMIFGLTSFIGYGGSAPLGEEAKNSRTITKSLIFGLLITGIVLVEVSYSQIVGWGIPMMQSFAKSGIPGIIVATIYTGAIGGVMLSLVAFNSAFSDSVAMQSNAGRVYFAMARDGVLPKFFATLHKKFVTPINALSFIAISASVIAIGSTFLVSAGMGVSPISLITESANNPNIITALTDSFEFLTTMALAGLIVTHVLLNTSVMTMFRRLKEKHVGYRKITHPIQHYLLPAIATIIFIFVLYESVVPPVYPITEAIIIIAVYVVLSTAYGFYLKKKRPDIAANAGKSVNIVAEEELEEKAKQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS0</accession>
    <name>A0A218NNS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Mia14_0801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891459.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS0"/>
    <dbReference type="GeneID" id="33314350"/>
    <dbReference type="KEGG" id="marh:Mia14_0801"/>
    <dbReference type="OrthoDB" id="27736at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="235" mass="26463" checksum="F150692A64E2B472" modified="2017-09-27" version="1">MATNKTKKEIKLAVFDIDGTIVRSKNGSSIFRLLDSRKGLGKEAQELREKYKDNLDEARLLEWSIKSFELYQKHGVTQDDILELAISHLKPALGLKKMINYLHKNGIKIAVVSGSIKNAFDIFAEANNIKIDYEFISNHYIFDKNGRLVDKEIHNYNFSGKVKAISEICKNEGISLDNVLFIGDGVNDKDALREVGLGIAFNTDDVEVIESANVHVKGKSFSSILKLLEEMIEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNS1</accession>
    <name>A0A218NNS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820412.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNS1"/>
    <dbReference type="GeneID" id="33314390"/>
    <dbReference type="KEGG" id="marh:Mia14_0842"/>
    <dbReference type="OrthoDB" id="10567at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="58" mass="6617" checksum="E941E4CFFF5C411E" modified="2017-09-27" version="1">MEKEYTRFEKSRIVGARALQLAYGAPPLIRVPEGMINSLDLAQLEFEKDVIPITVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNU3</accession>
    <name>A0A218NNU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF763 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNU3"/>
    <dbReference type="KEGG" id="marh:Mia14_0835"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597:SF1">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="365" mass="41009" checksum="EB6C29EA010E5CA2" modified="2017-09-27" version="1">MNRMQNYSFLPLHGGNAPKWLFGRMVKLSSLIANEIIDEYGADEFVKRVADPYWFQALACAVGYDWHSSGTTTVTMAALKQALDGYSDIYIAGGKGKTGLKTPDDILKGADLLSTNNAEQLVKYSRITAKIDSSLIYDNFGIYHHTFVFSKDKWSVVQQGMFNKGNTAVRFQIFCDNIDKNDISCETNSAVASDLSNNTVDLTFKDNSEIKAKSLDMVNDNLNEIVNFGKTYNLPGRHEIIPSCDLSKQAIKLLEYANDMKPENYNDLLSIKGIGRKTLKSVALISSLIYKNEIYERDPVLYSYNLGGKDGIPYRINLKDYDNVISSMKEIIDNAKIGPQDRGKVLSRLSKDLEEKYLRLNKFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW1</accession>
    <name>A0A218NNW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820466.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW1"/>
    <dbReference type="GeneID" id="33314432"/>
    <dbReference type="KEGG" id="marh:Mia14_0890"/>
    <dbReference type="OrthoDB" id="359457at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="429" mass="49569" checksum="0978D16CF6C6653F" modified="2017-09-27" version="1">MTMQPKYQQLLLDDDVRRWFENLRAKSVLTATVALRNLGHYCELTETTPKEILIRARTNEKDFRYEFTDFVRKMEKEGKAGSYIARFKKVILSWLKFNDIRLQLTVNISGENETPTIANERVPSKEELARVLRKATSRGRVAIAIMAFSGLRPESLGDYEGSDGLRLGDFKELKLSNEIQFDNIPAMVMVKSRLSKTRHQYFSFIGEEGVTYIREYLEERRKQGEELTYESPLLQFDSRGTKKNAFLRTTLVTRDIREAIEQAGLKMRPYVLRAYFSTALDIAESKGLISHPWRQFIMGHKGDIEARYSTNKRLPPDIIDEMRESYRKCLKFLETRISEVSEDNAKLFLQQQLLSAVGYKQEEIDKIDLASVSNEDFQQLLRDKVAGAMSDNGAKQKVIPVSDIEQYISDGYDFEAVLPNGKAVMRVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNW2</accession>
    <name>A0A218NNW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820464.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNW2"/>
    <dbReference type="GeneID" id="33314430"/>
    <dbReference type="KEGG" id="marh:Mia14_0887"/>
    <dbReference type="OrthoDB" id="387129at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="357" mass="39954" checksum="0C9A98EF1E6DEED6" modified="2017-09-27" version="1">MQNFFKRLLALFLVFVSSFVLSYIYSEDLYLKLGSGTLDVFYAEFSIGTIPLIFYLFIWWRKHKYQEGDKFIHFLRISFGYLWILDALLQMQPGMNEYFAAMIIAPNISAGGITGYVSTFALSLWNMHPVVFDVASSLIQLYIGGVLLTQNRGKIYSLTQMIAILWGFSIWIFGEGFGGTFGSGATILTGFPGSVLIYVYASLILLLSSKNRGGMIRKSSYFFGGLIFIPSLIVQLMPSNGYLGNMSVIFMPMPSPSGILNFANEFQYYFTQSPVWPDIVTLFLILASAAGWILGKSYGYVFSGILASFSWIVFQGLGILGILSTDPNTGLPMLIISIFFYLWTKEYFTSSNGLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX0</accession>
    <name>A0A218NNX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase, DNA invertase Pin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820472.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX0"/>
    <dbReference type="GeneID" id="33314438"/>
    <dbReference type="KEGG" id="marh:Mia14_0898"/>
    <dbReference type="OrthoDB" id="24728at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03768">
        <property type="entry name" value="SR_ResInv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="entry name" value="Resolvase, N-terminal catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050639">
        <property type="entry name" value="SSR_resolvase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461">
        <property type="entry name" value="DNA-INVERTASE FROM LAMBDOID PROPHAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461:SF2">
        <property type="entry name" value="SERINE RECOMBINASE PINE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="Resolvase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="3">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="204" mass="22927" checksum="936B4C7030EA950F" modified="2017-09-27" version="1">MTLVFGYVRASTLEEVKQGSNERQKAEILKYAKAKGYDVEFFEDKAKSGKNTQRPEFERMLKSLGKRPKVIIVSKIDRFARSLSDLLKTLEFLEQNGIGFVSVNDSGIDTTTPNGRLLLQILGAFAEFERNMINYRTKAGREQAISKGIKFGRPSLKTKNGYFIDRRRVLELRNRGLSARAIAKALGCSITPVLKIIKEESGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNX1</accession>
    <name>A0A218NNX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820457.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNX1"/>
    <dbReference type="GeneID" id="33314423"/>
    <dbReference type="KEGG" id="marh:Mia14_0880"/>
    <dbReference type="OrthoDB" id="56524at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="137" mass="14988" checksum="E1190B417FF920C6" modified="2017-09-27" version="1">MNGKRDSPTGRGSLFDRSENDQTGRNSNISELISVGKGNVELGNGVVKIAEGKYLVLELSEEKGPCPDNMCQLKAEINIRILGSINDPSSYEIIRTDKFTLAISKAVWHAIDKGRQGISIRKGRFGNLSVKGFSLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNY3</accession>
    <name>A0A218NNY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF302 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891469.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNY3"/>
    <dbReference type="GeneID" id="33314425"/>
    <dbReference type="KEGG" id="marh:Mia14_0882"/>
    <dbReference type="OrthoDB" id="2559at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38342:SF1">
        <property type="entry name" value="SLR5037 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="132" mass="15104" checksum="15A5F74644278EC2" modified="2017-09-27" version="1">MATEYRVKSKHSFDEVCDKIREIVPPNGFSILSEIRTSDILRSKGFEYPNLRTFDICNAGYANRALSLDTRVETIIPCHLIVKEAENHTEVSVQLPREMFDSLHTEESEEMESFMSEVEAKLKGIVDSFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ5</accession>
    <name>A0A218NNZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S ribosomal protein L30p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820487.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ5"/>
    <dbReference type="GeneID" id="33314456"/>
    <dbReference type="KEGG" id="marh:Mia14_0919"/>
    <dbReference type="OrthoDB" id="6379at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="139" mass="15650" checksum="18D5AD076C6F73CD" modified="2017-09-27" version="1">MKDKELNNKLIAAVRIRGRVNVRGDITETLDRLRLKRVNNCVVIKVNDSYMGMINKCSSYIAYGEVNEEVLSKLLEKGGIEMKPSDLEKAEDSDKLKESLPIRLHPPRHGFKSTKLGFKQGGSLGYMGEEINGLISRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ7</accession>
    <name>A0A218NNZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ7"/>
    <dbReference type="KEGG" id="marh:Mia14_0885"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="192" mass="21091" checksum="4A6343FE7DD172CC" modified="2017-09-27" version="1">MSQQQDRHFRPGIMLFPIRKYMSRPQHDFINTNVKRGMTALDLGSGPGFFTTMLSEAVGINGTVHAVDGDKAAVTRLQNRAGALGMVNIKAYASSAASIPYIQSKSIDVLFSNGLLCCMLDHRGAVDEMMRVMKTGSRGFISVTKLFRKDGLGVPKDEWKEITRSFDVVDSGSSVVMDWVVVSKPGDDKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP08</accession>
    <name>A0A218NP08_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">Mia14_0947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820514.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP08"/>
    <dbReference type="GeneID" id="33314483"/>
    <dbReference type="KEGG" id="marh:Mia14_0947"/>
    <dbReference type="OrthoDB" id="371908at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="215"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ASI14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="365" mass="39187" checksum="39002A677508271E" modified="2017-09-27" version="1">MGEFTSVDDEDILKFIESSKPKIYIVGTGGSGSNTIDRLYDLGVEGATLMAMNTDAPHLIKVRAERKLLLGKKVTKGLGAGSDFTVGEEAAKESKEEIKHMLADANMVFVTCGLGGGTGTGSIDTIAREAKELGALTIAIVTLPFSSEGKTRMKNALEGLAKLKKTADTTIIIHNDKLLSIAPDLPLNMAFKVSDEVLANAAKGIVEMITKPGMVNIDFADLKMVLKSSGYAVISSGESSQQTDRKKNRALVALENAVKSPLLDVDLGTAKKALINVVGGESLTLREAESIFQEVSSMINTDALIKWGARIDKDMAKESLKVMVVISGVEFTEYSDENIEKKVDELSNLDLDEVFEGDKKKPINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP13</accession>
    <name>A0A218NP13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820490.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP13"/>
    <dbReference type="GeneID" id="33314459"/>
    <dbReference type="KEGG" id="marh:Mia14_0922"/>
    <dbReference type="OrthoDB" id="17730at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000010">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002294">
        <property type="entry name" value="PRK01221.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="338" mass="38282" checksum="18F7CB10BD3C9EB2" modified="2017-09-27" version="1">MKGVNKKNLSEDAVKYEVNKKDRSKIAKQLLEIEVKDIRLKKDMKVSELISQMDYIGGFSAQHMVNGIHILSNMFNDKKCYKFLSFPADLVSTGLRGVLVSMVKHFDAIITTGGTLDHDLARAYGGRYSLGTFNTDDAMMHELGIYREGNVFIKNEEYGQRVEDAFNEIMNDIYTSKDYKKEYSPSELIYEFGKRMKDEKSIMRQAYLHNVKIFNPGIVDGAFGTQLTLFSQDHDFKLNVLKDELELSNIAFDNSVTGALMIGGGISKHHVIWWNQFKDGLDYAVYITTATQFDGSLSGARLSEAVSWGKIREKAQYMTIDGDATILLPFMMSALNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP18</accession>
    <name>A0A218NP18_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_157891475.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP18"/>
    <dbReference type="GeneID" id="33314493"/>
    <dbReference type="KEGG" id="marh:Mia14_0957"/>
    <dbReference type="OrthoDB" id="371943at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000001">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000002">
        <property type="entry name" value="DNA gyrase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="entry name" value="DNA gyrase/topoisomerase IV, subunit A, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050220">
        <property type="entry name" value="Type_II_DNA_Topoisomerases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01063">
        <property type="entry name" value="gyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004043">
        <property type="entry name" value="PRK05560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004044">
        <property type="entry name" value="PRK05561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF5">
        <property type="entry name" value="DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493">
        <property type="entry name" value="DNA GYRASE/TOPOISOMERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="GyrA/ParC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI14229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="813" mass="90625" checksum="0F7AFCD39DD2885F" modified="2017-09-27" version="1">MSENIEVPIENEMQKSYIDYAMSVIVGRALPDARDGLKPAQRRILYAMYQINNLHDQPTKKSARIVGEVIGKYHPHGDAAAYETLVRMAQNFSMNYMLVEGQGNMGSIDGDPPAAQRYTEVRLRRIAEDMLEDLDKDAVPFVPNFDNTEREPVVLPSKLPNLLINGSSGIAVGVATNILPHNLGEVSDAIIEYINNKDATSEDLLKFIKGPDFPTGGIVFDTEDLRRSYLTGRGTVTIRARYHIENIGKRNVIIVTEIPYTVNKATLIQKIGELVKDKIITSISALRDESDKKGIRIYIEVKNDVDPEFVMNLLYKHTQLQISLPVMNIAVMGNRLLTLNIRNFIKIFVEHRISVVRNRTAHDLKVAEDRLHIVKGLLIAISDIDSIINTIKSSSDTKAAREAIMSNFNLSEKQSNAILDMKLSKLTNLEKTSLEAEDKTLTGNIEYYNKVLSDENEVYSIIKEETESVKSRYSKERATSIEPNVNYANITNEDLIKDEENLVLLTKQGYLKRVSASEYRTQRRGGKGVRSIDLKEGDFVKRSINCMSKDYLLFITSLGKVHWLKAYGIPETGRYSSGKAAVNLVNLGENEQIVEIINTRTFEGKFIIFITEKGIIKKTKSELFSHPRSKGIRALALRDGDSLVDVVLSTGDSNILIITKKGLAVRFKESGFRPLGRNASGVIGIRLREGDSVRNVITASDSDLVFTFTEHGYGKATVISEYRLQRRGGVGVRNLKVTQKTGDVVIALCTSLDSQFMLTSMKGVAIQVEAKGIRKTGRNASGVRVMKIEKDDSLATAMAIEGKEDTGEIQPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP39</accession>
    <name>A0A218NP39_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820536.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP39"/>
    <dbReference type="GeneID" id="33314506"/>
    <dbReference type="KEGG" id="marh:Mia14_0970"/>
    <dbReference type="OrthoDB" id="8183at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="169" mass="19446" checksum="F4D1335524619506" modified="2017-09-27" version="1">MGAYKYIRNTFINEYKVRSDEYKNRLAIWGKENSIMRVDKPTNLPRARELGYKDKQGLIVVRVKVKKGRKKRAMVGGGRKPSKNGRFFSRATSMQSIAEVRATKRYSNCEVLNSYYVGDTGPYKFYEVMLLDSGHPVITKDPIFKDIAKQKGRAERSLTSSGKRHRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP51</accession>
    <name>A0A218NP51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfpI family non-peptidase-like protein stress response protein YhbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820544.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP51"/>
    <dbReference type="GeneID" id="33314517"/>
    <dbReference type="KEGG" id="marh:Mia14_0981"/>
    <dbReference type="OrthoDB" id="82036at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="174" mass="20030" checksum="FE457F87C7A86761" modified="2017-09-27" version="1">MKFLVFIEPKDFKDETLKSIKMFFERWDVNYKISSYTKDSCVGMHGDVVDIDFNTNLVNPDNFDGLILVDGKGIDEYKLYEFRPLLDLVMLFNNSNKWIIAFGNAVGLVARANVINNRKIATIESDSEVTRFVKLFHGTPSRKELEFDGNLITIKDSSKSNELFDTILEKLNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP69</accession>
    <name>A0A218NP69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH superfamily phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820555.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP69"/>
    <dbReference type="GeneID" id="33314529"/>
    <dbReference type="KEGG" id="marh:Mia14_0993"/>
    <dbReference type="OrthoDB" id="18016at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052968">
        <property type="entry name" value="Nucleotide_metab_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146:SF1">
        <property type="entry name" value="OLIGORIBONUCLEASE NRNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="346" mass="39012" checksum="30C4E71907196DDB" modified="2017-09-27" version="1">MELKFAKDNFNMDKAVKEMLDRKDHIISITHREDFDGIGSAAIIKHYFNIPDSNLMFGDYKSSTINAITEKIKAMNLSKMFVIITDLGLDEPLIPAYQSLISYLKDKDSYVIWLDHHNWSNETVEKVAKMCDFAVVGDNDKFCGAELTFRELIKGRFDEGFGEKIAAFTHKTDFNLPNLEDFLLNIIKYITYSNYHGSDNALVELVNFVSEEDFNNEKINETAQLYNKEESENLEKLKSMVFDYSINEDYKIGIGFGGNINSTKACLIVSDLTNSDISIFVNVPMAKISIRGKGKLDCIKLANKMGGNGHFNAAGAPLTESIELSDREKIKAEADKMAAMAKEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP80</accession>
    <name>A0A218NP80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_1026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820585.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP80"/>
    <dbReference type="GeneID" id="33314561"/>
    <dbReference type="KEGG" id="marh:Mia14_1026"/>
    <dbReference type="OrthoDB" id="26198at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="194" mass="22906" checksum="398DB48AE1B06B5F" modified="2017-09-27" version="1">MENKSVILVLGIPGSGKTTILDGVEGYKDYKYVNVGTIMKKTTEEIYKEGIDRDKIRYLKESEIDHIRDRTFEKIIEMEGKILVDTHSSIEREGKFITGLPYETELMKHIKSVIYIDAAPEEILYRRSLDKSRKREDDDEYMLNMQRDFNISTLSFYMSYLNIPVYMLNNKHDKVSESIRRMKKILDMIDLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP85</accession>
    <name>A0A218NP85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase or thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP85"/>
    <dbReference type="KEGG" id="marh:Mia14_1033"/>
    <dbReference type="OrthoDB" id="5970at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="287" mass="31537" checksum="31BA18D69A8542A7" modified="2017-09-27" version="1">MVSKNQKSRLKAPTLAAIILVVIIILIAVVYFYSSNQNKAPSSSYLLSKLNTSLSNSTLLQLKAIADNTTLANDVGVYVKNFPAETHLQTSNITIINGKPVVIFYGAQFCPYCAVSRWGMVLALMRFGNFSKLTYMLSSPTDVYPNTPTFTFYKSSYESNDITFESVGTETRLDAPLQTPNKLENATFSEFDLDNSAIPQDSRGGIPFIDFGNYSYEVGALILPSIIDNLSWSEVISSLSNPNTAQSKNIIGIANIYTAQICEITNFTEPVCKSSYVSSILKLENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP93</accession>
    <name>A0A218NP93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820574.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP93"/>
    <dbReference type="GeneID" id="33314550"/>
    <dbReference type="KEGG" id="marh:Mia14_1015"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="205" mass="21721" checksum="D0EAAFECBF262AB7" modified="2017-09-27" version="1">MDLIGDFKAGINAAMHPSSNTQNMSLGQAIGFYYRASVLPGIIALIIDGIIGFVLSPSEGVLALATIVGSLWIALPLGIIIDAAIYQFFDKMLFGIFNEDISKTATATMFAEMPVLALAFLYFLPSVGALTYLKDVFGIIIGIWGIIVLTISFREQQKISTGKAILAWLLPGIILGVIFAIIILVMAFALGAVSPVGIPGTSILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NPC1</accession>
    <name>A0A218NPC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stomatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_1020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820579.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NPC1"/>
    <dbReference type="GeneID" id="33314555"/>
    <dbReference type="KEGG" id="marh:Mia14_1020"/>
    <dbReference type="OrthoDB" id="10752at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="76"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="354" mass="38351" checksum="8B237A2572377056" modified="2017-09-27" version="1">MVQNSDKPSVNASTNAAPGYYYIYKSSKSMTANSALAIIIGIIISVIFFFIAYAATSSTTSGIIAFAIVLIIYLLMSIKVLQEWKRAPILSLGKYKGTYGPGLFFIIPLIQKMPYKFDLRTFSATFSAEKTLTQDNVGVDVDAIMFTRIENPEKTALQVNDMQQSVSLAAQTALRDVIGKVELSKMIVGRSEIAAQVKSLIDQRVSPWGVDVISVEIRDVKIPDDLQDAMAKVAIASRERDARVILAESEKLAAVNMVAAAQTYNSNIYAMQLRALNMLYEIGISGRNHLIFIPTESRGLGIPTPVGVLGIDKLAGIGDVGDPNSSKSSDNKDNANDDKSGGSSIPKPQKKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLL2</accession>
    <name>A0A218NLL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819522.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLL2"/>
    <dbReference type="GeneID" id="33313566"/>
    <dbReference type="KEGG" id="marh:Mia14_0004"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="148" mass="17257" checksum="93404CB5CDC66840" modified="2017-09-27" version="1">MVTLIKNVKVLEDKDMRSEIKFSKVLVIRDNEVKEYYVGFENLTYSKLFGDRNLYSESLVFLTPNEKIDGKVFTAKVMDKENSSKYEFLMTASYVLNDRQKESEKQARIYEMLRGDDSIGISKETAKMMDAYENSVVLLKESLFRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLM9</accession>
    <name>A0A218NLM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLM9"/>
    <dbReference type="KEGG" id="marh:Mia14_0039"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="343" mass="37438" checksum="3D864ED596372682" modified="2017-09-27" version="1">MALNSKKRLSTNYKSQSAMEYLMTYGWAILVIAIILAALYTLGIFNPLTFEPRLQPGGCYVERPYGPGQASGLSLVGECGYLLPKFVGGFNGKDSNVSASLTTLEYLNTGKFSVSAWIYVNGPTSMGEQMPISIGDDVCSSTYGPEDNGTILLAAPAYPASINLFYSPSTGTPVVFDSGNPDYFKAAACVYNKTYGGAQWAYTNYPFGHYKAWYFVAETYNGTYLDLYINGRLVNKTYAPGYTNLPTNYISLGNMDSPLMSGRFWFNGSISNVQIYNASLGSAVISDMYDENIAGAPVDLINLVSWIPLNGNENDYSGNTAGGKFYSGNFNGGWVDNYNYFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLQ8</accession>
    <name>A0A218NLQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ORF">Mia14_0067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819580.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLQ8"/>
    <dbReference type="GeneID" id="33313627"/>
    <dbReference type="KEGG" id="marh:Mia14_0067"/>
    <dbReference type="OrthoDB" id="23569at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="132" mass="14012" checksum="7BC86FCD5CB39093" modified="2017-09-27" version="1">MAGIIGKVSKTLIPGSILTCADNSGAKTLMIINKIGKSGRRGGLANSGIGDIVMASVKTGTPAYRKKKVRAIIIRQKHPLRRKNGIHVRFEDNAAILITESDLPVGTEVKGAMAREVIEKNIKLAGIASRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLT5</accession>
    <name>A0A218NLT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819591.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLT5"/>
    <dbReference type="GeneID" id="33313638"/>
    <dbReference type="KEGG" id="marh:Mia14_0078"/>
    <dbReference type="OrthoDB" id="5583at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="120" mass="13156" checksum="DDEE1D38849963F4" modified="2017-09-27" version="1">MEVWVNKPKCTGCQHCKDVCPVGVFELMNRNDKDKINGGDPAPENEKWEGKSDPAVVEKWKDVDDGHRHFADDNDGTSGGMSVAVNGEACILCQACLIECEGECITIKDDTGTEYKSIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW0</accession>
    <name>A0A218NLW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS pair superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819623.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW0"/>
    <dbReference type="GeneID" id="33313676"/>
    <dbReference type="KEGG" id="marh:Mia14_0117"/>
    <dbReference type="OrthoDB" id="8919at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="377" mass="42687" checksum="862ED99A1CDAECD8" modified="2017-09-27" version="1">MMDSINDEIKIPEELAKEVPVSDYTDKMSDLIPKISKFGAVIINKDDEVMGIIDKKAIEKIDLEIPRSLSAERFVVRTPKVNDQTALSDIIMYFYKSHSIALPYMVKGKVSKIIDRITLFKILLSRSDIKDVLVKDIMSTPMAVIDSKTDIAKAKKVMEDENMSTLGVLDDGKFYGIITSEDIINNVVIKERSPAIENNKYSPSNIPVKDYVNTNPVMIKESGSVQDSVRLMVENENKPIVVTSGSQPIGIVTSTDILEYLTSNKKEVSPSILISGLDESTYIYEDEILSEIKNFSYKISKIKDIGIRYISATIKRIGKSQYEVRMKLLSEKYGSLQVNYSDYRLERTLSEALEKLNDQILKAKEKSENVKDYFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW1</accession>
    <name>A0A218NLW1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="14">BCAT</shortName>
            <ecNumber evidence="14">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvE</name>
        <name evidence="15" type="ORF">Mia14_0113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="14"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_232780222.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW1"/>
    <dbReference type="GeneID" id="33313673"/>
    <dbReference type="KEGG" id="marh:Mia14_0113"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005146">
        <property type="entry name" value="PRK06606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 14 15" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 15" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ASI13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="303" mass="33690" checksum="7E799AA5BBB3E013" modified="2017-09-27" version="1">MEKNLKVWLDGEIRDYEDCKVPILTHSLQYGTGIFEGIRAYLSEDKGSYIFRLDDHVKRFLNSMMIYSIKQPYGAKELTEAIISTVRANNPSTDMYVRPFAFYNDDSIGISVKGKKVSVFVAAIPFGAYFKGVSEGIRCKVSSWERINSSILPVQAKASGNYINSTLASTEADSVGFDEAIMLSKGYVAEGPGENIFLVKGNRLITPAVSESILLGITRDSILHFAGDLGYEVEERRISREELYSADEIFFAGTAAEITPIIQVDSIKIGSGKVGDVTTSISKYYQDITRGRNKEYLKWLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLW6</accession>
    <name>A0A218NLW6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819622.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLW6"/>
    <dbReference type="GeneID" id="33313674"/>
    <dbReference type="KEGG" id="marh:Mia14_0114"/>
    <dbReference type="OrthoDB" id="6075at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="120" mass="13448" checksum="5C1A56205FB3A2F3" modified="2017-09-27" version="1">MNGNEIKQVIIIRSDFNMSKGKIAAQAAHASLMSYFEAVRQDDKIAKEWLDEGEKKIVLKVNDETSLIKLYEAFKFKRIPCALVHDAGLTEVPPNSKTALGIGPWYSKDLDVITGRLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NLX7</accession>
    <name>A0A218NLX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Preprotein translocase subunit SecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819641.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NLX7"/>
    <dbReference type="GeneID" id="33313694"/>
    <dbReference type="KEGG" id="marh:Mia14_0135"/>
    <dbReference type="OrthoDB" id="52835at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="65" mass="7287" checksum="F264CBA6F2629527" modified="2017-09-27" version="1">MNVYEKFKSFLSNSRHIIDISYKPESREYDRSAKIIILGILLLGVVGFIIAVIISLLVTGTLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NM36</accession>
    <name>A0A218NM36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ML/Adaptin/NPCBM-associated NEW3 domain-containing cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NM36"/>
    <dbReference type="KEGG" id="marh:Mia14_0199"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902:SF3">
        <property type="entry name" value="NPCBM-ASSOCIATED, NEW3 DOMAIN OF ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902">
        <property type="entry name" value="S-LAYER DOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-galactosidase NEW3" evidence="3">
        <location>
            <begin position="402"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="535" mass="58233" checksum="63C7DDC2AB69E302" modified="2017-09-27" version="1">MSDKMYKISLISLCIIVLGLAGISSAQGLSQVSGALSITNLQISPSPLVAGENATISFNLYNSYSHSLYDINLQLLSQNPMLNFSPVYSNIIYNIGEGTDNDGVFYFTFRVPKNIPAGEYEIDAVATYRSKFAETPTFTTSEPGESEMPIYIYIYGKPVLSASIQQANPIVPESDANLEIDLTNLGNGVADNVTVILHNSTYLKFIGQSKFSISDLPNSQSTDLSAQAYVSRGITSGVQDINATLVYENMFGNKTVENETLPINVLINSPEISVSTSSSVPETLYSGGNQTITLLISNSGLGTAKNLTLSLLPNQNITYGSMDKFFIPTLEPGSSNTEPIYIKLGREFEGNSTKLPIELTYSNANLKNSTSRNFSINISVQKSAIINIENLSDTLLPGATDVPVTLQIKNTGNEEAQEMTLSFESVYPITPVDSNSYVNALQPGQSVNVTFYVNVDSKATAGSYPITIYEEWLQPNGGPTQEFSGTNNYYVEVYSSSKKSSADSFINYIYALIIIIVVIYIIFRILKRSSSKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMB3</accession>
    <name>A0A218NMB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR subfamily 1 transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819766.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMB3"/>
    <dbReference type="GeneID" id="33313831"/>
    <dbReference type="KEGG" id="marh:Mia14_0274"/>
    <dbReference type="OrthoDB" id="56053at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="199" mass="22456" checksum="E0443E3C6604817E" modified="2017-09-27" version="1">MEEKDENEDREDIEEDSHQGMGKGSKGMMGGKHRGMCGHGPHGMMGHSCHLGFRGLKYLILKVAKEKEISGSQIISIVNEITEGRMKPSPGNVYPALKELESLGYLKKREEDNTKYYSITDKGIDLLKDSELPIWYKLKGNMDSQTSEYLNKYAISSELDKLQYEATYLQESSAVIKADEELSKKVKDIIKRLSSITES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMD3</accession>
    <name>A0A218NMD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819789.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMD3"/>
    <dbReference type="GeneID" id="33313854"/>
    <dbReference type="KEGG" id="marh:Mia14_0297"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053507">
        <property type="entry name" value="NADP-Glyceraldehyde_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040792">
        <property type="entry name" value="glyc_ald_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="475" mass="52170" checksum="2527DB89D79D4EB7" modified="2017-09-27" version="1">MKLFINGSWCSSSSGNTIEKLSPVTGKKMYNFPAATKDDVDNAIDAAYNSWEKWYSLGSVSRSKIIYKAKDLIEKNRKQLEDILVKENGKIRPEAVGEVDGVIDQLQYYAEFARKITGDIVEGEKANRKILQYKVPYGVVVAITPWNFPAAMVARKIAPALMTGNSVVLKPSSDTPGSAEFLVKMFLKAGIPKGVLNLVTGKGSEIGDYIIAHKKVSLVSMTGSTFTGQRIMEKASSNMAKLILELGGKAPFMVWEDADLNTALKVFMWAKYSNSGQSCIAAERLYVHERVFDKFMKMIAEASRKLTVGDPEKAKMGPLINKAALANMSKYVDEAKAEGGKVITGGGKPKLSKELKEGYFYEPTIVTGVSQESKLFQEEVFGPVIGAAKVSSFDEMLEKANDSKYGLASYLFTKDFKLANKAAEAVRFGELYINMPGPEASQGYHTGFRLTGQAGEGSKYGIAEYLKLKNVYIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMF8</accession>
    <name>A0A218NMF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator with C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819811.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMF8"/>
    <dbReference type="GeneID" id="33313878"/>
    <dbReference type="KEGG" id="marh:Mia14_0320"/>
    <dbReference type="OrthoDB" id="9280at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="181" mass="20169" checksum="5A934092D3FF417F" modified="2017-09-27" version="1">MLTIPELKEITYEIRTARQKHKIKSSELARASKISPSAMSKLENDRLKPSYNMVYGVLDALNKLIVAKGTPKSVSLKMIRNVISVSPVDTISRAREIMKKNDISQLPIVDRDGRITGLVTEKSILDNPDAVTCDEAIEFSYAIVGPDEDLEKARQVVRNVQAILVVKDGRLFGILTKSDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMH5</accession>
    <name>A0A218NMH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMH5"/>
    <dbReference type="KEGG" id="marh:Mia14_0340"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="499" mass="56210" checksum="291FD7D81986D50F" modified="2017-09-27" version="1">MLILNLNLKDNKHLFLVLLIVLYVFSLVALFSIYNLRGVSWDFVAHYLNAKSMISSNFLNYIKPLGQSTIVINSHIYFETDRAPLDSVIMGLIMLSGAKEIIPIYITILATLLFISIYLFSKYFKVNPLISASVIITPYILKFSFLLNSSGALSIAMLLISLALIKKGSIYAGAFMALAGLAKYISIIFFPLLLLLGSNRKRAESIALLFIVSLPWLLFNLIALGNPFYSYLASFSVYSNSTPGGLPILGAIGEVLGNLVFPIIVLLILAGYLFYRRSRMSRKDNDKNIMHYLRSNIADLKSIIMNKGGTAQILASLFLLSVIQYLIVVPRMMEFDQIRLSYFVYIAIALMIITALNGYLRKLPKNKNIRLIPTLVIMIIFSVSLLNVAYLSYSVRQPSSNWMISATNNSTLKDTVAELQLYNLSNCNVVSNSWIYLRYYGIKAYSPFYYNNTILKYPVVLIEYQGVNETYVKDKGASLLFKEDMVDIYLPSGFECVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMI8</accession>
    <name>A0A218NMI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">A-type Na(+),H(+)-transporting-ATP synthase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Mia14_0355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819842.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMI8"/>
    <dbReference type="GeneID" id="33313912"/>
    <dbReference type="KEGG" id="marh:Mia14_0355"/>
    <dbReference type="OrthoDB" id="50539at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18181">
        <property type="entry name" value="ATP-synt_Vo_Ao_c_TtATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ASI13677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="73" mass="7563" checksum="0C99784E4680225C" modified="2017-09-27" version="1">MVASALVEIAASIAFAGGLIGTGMAQQGIGASGMGIIAEKPEKFGQVLFFFVIPETLWIIGFVLGLILLLQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMJ1</accession>
    <name>A0A218NMJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">IS200/IS605 family transposase OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819835.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMJ1"/>
    <dbReference type="GeneID" id="33313904"/>
    <dbReference type="KEGG" id="marh:Mia14_0347"/>
    <dbReference type="OrthoDB" id="33505at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF11">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE RV2885C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="415" mass="48566" checksum="9A56D9287154515A" modified="2017-09-27" version="1">MNGYTNNMDSTRAYKFRIYPDTKRQNEIDERLILAQQFYNKILEKSIESYKNGKAKASMAQFNRFVKEIIQDDKKYLKLYSQTRCEIEYRLLKAYQNFFRRIKEENRKAGFPRFKSRNRYKSITYPQYNGSFSIKRGRLRVSRIGTMRIELHRKIEGTIKTLAIKREGRNYYAVLTTINEIKTPQVEDTNPIGIDMGLNSFVAMSDGTKIEKPKFMQQERKRIAHWQRIVARRNKGSKRREKAKTHLQKTYEYSTNQSDDYLHKLSDRLVDSGYTSFAVEDLHIQNMVKNHRLAGSIQNASWNRFIQMLSYKAESAGMKVIKVDSRDTTQECSNCHHIKEGSERLTLGDRSYRCNVCGLEIDRDINASINILNRATTLGQRESHAQGESVRPQREAVLAELRTDKTHPLRDAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NML7</accession>
    <name>A0A218NML7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819881.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NML7"/>
    <dbReference type="GeneID" id="33313952"/>
    <dbReference type="KEGG" id="marh:Mia14_0396"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="204" mass="23052" checksum="09674D6042AAD8B6" modified="2017-09-27" version="1">MINDSLLDKEILNIDKFFHSLINVELPLPKARISNEIDDAEVSSNDGSTGYVTINPSYLKGRNRISYRALLAHGYFHQVQYFLIGFYKSYLKEIKKGLGSGLNSERLSDLLDNLIESSAMFFAISYITKDLRGSARKYKIIKYLKSKQYMPLNGKFYNGNGVMLLAYSNSHYSIKDTVSKVLSPKEAVGIMKIYLDSVTASDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMP3</accession>
    <name>A0A218NMP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chorismate mutase / prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819936.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMP3"/>
    <dbReference type="GeneID" id="33313985"/>
    <dbReference type="KEGG" id="marh:Mia14_0430"/>
    <dbReference type="OrthoDB" id="34329at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046826">
        <property type="entry name" value="PDH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI13748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="339" mass="37830" checksum="746AF18A4E614D1C" modified="2017-09-27" version="1">MDDLNSYRKQIDEADEGIIKLIKKRFDIVKAVGEFKRAQGMPLKDNSREDALKIKWKQMAEENGVDGNLGLSVITDILRFSKEQEMPKNENRLLVIGYGGMGLSIASYFHKHNFSNVYVTGRHVDKMESGIADAGCIPIKDPSAKDFDTIIMATPPESVNSDIVEGILQDAEGKLVMDIFSVKTDAYKKLLDYSKKLNFKYVSVHPLFGPNQLEDIKKIAVITDGVDEKLLADAEGIWSYAGFTTIRTTLDEHEKAMAIVQVLRMLDFVALKNSIGDLKGSLNVDYSKLATVSFEKVEELIDNLSDDNDLIHEIVSSNRYSKQAIEALAKGIESIKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMQ1</accession>
    <name>A0A218NMQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VapC toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819950.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMQ1"/>
    <dbReference type="GeneID" id="33313995"/>
    <dbReference type="KEGG" id="marh:Mia14_0440"/>
    <dbReference type="OrthoDB" id="147588at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051749">
        <property type="entry name" value="PINc/VapC_TA_RNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42740">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42740:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="125" mass="14382" checksum="97C40F6A0E982581" modified="2017-09-27" version="1">MVILDTSIIIDLLYGVESIEKKIKQYEEDHEEMNITSIKAYELLRHPKEIKRTTANSILKVFSVYSFDKRASEKAADVYRELMAKGEQINENDVLIIGIAISKGEKLLTRDNKFAFIDDSKIEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMR8</accession>
    <name>A0A218NMR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819963.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMR8"/>
    <dbReference type="GeneID" id="33314002"/>
    <dbReference type="KEGG" id="marh:Mia14_0447"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="272" mass="31556" checksum="13152B8791A2F37F" modified="2017-09-27" version="1">MGKYVNKDNLINLEIIIMPILIIFIAVAVWIKLFNNSIISILISLVAILLGFYSFIISIKNDKINLESYYFYSPCKNFDIEGATTPYLMVFSIKNYSKKENVTNCQIIIDKIEFFGDKIQKFTKNLRESPDYNYTNPRCSILGNGISFDSVSSDILQDNGILRFDAFVIAKVRTIKENNIFYPVKNLSYQITNYFKFDNDYNNDPNKVTKIYYKIISNNFKQIDFDIYISLKEINDMEKGIKENNGKMPTLKGNINNKSVEFKFSKSALQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMT3</accession>
    <name>A0A218NMT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088819999.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMT3"/>
    <dbReference type="GeneID" id="33314024"/>
    <dbReference type="KEGG" id="marh:Mia14_0469"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="205" mass="23568" checksum="0E8B074C73DFE312" modified="2017-09-27" version="1">MNQLQFIKEIKSLNIPVFSTKEASMIVNKDIKYTSLYLSRLLNRGEISRIEKGKYYLKDANPYAVASNIIYPSYVSMMSAFKYYGITTQNLSAIDILTDARHSNGISIGGYNIIFTKIPRRLMFGFYRSKEDGTFVAYVEKAIIDAILIGNLPIPYIEEAYENAKESRILEKGRLSSYIKRIGSKDLKEKINKIEKEVKEIKFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMW5</accession>
    <name>A0A218NMW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Mia14_0517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820082.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMW5"/>
    <dbReference type="GeneID" id="33314074"/>
    <dbReference type="KEGG" id="marh:Mia14_0517"/>
    <dbReference type="OrthoDB" id="142306at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ASI13830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="198" mass="22964" checksum="7484B68117A18AD7" modified="2017-09-27" version="1">MADVEKKKNSDSKINDRNKSLLRTHYTVDDNKRSADLANSIYKLYLNGDFGIAEAISSYMLKLDYLDRKRDFGYLFEKSIKSVGDEEFSKFIEKVKRKRRGEALVEDSVLSIRYNKSSEGVNLSVFLGNLPIMERVDKETWNVHSHSAENFWYQVKFKDGRAVCPCDDFKYRSSKFGGKCKHIYEVEAAIRMLVLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMX1</accession>
    <name>A0A218NMX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multipass membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820015.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMX1"/>
    <dbReference type="GeneID" id="33314033"/>
    <dbReference type="KEGG" id="marh:Mia14_0478"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="176" mass="18813" checksum="C40522F61D5B7F04" modified="2017-09-27" version="1">MIGSALKFVYSEKRYLLSTIAIAILMGALYYYLVHIGGLFYPIIFGSIALGEITDIAGFALISVLMGISISMQIYSYKLTRLDDSKGETAIAVITGVFAQGLCCTPIVGSLLAMLGLSTSALLTLSGAISHTFAVLEPILIIASILLLLYSIRSTAKSLLYCSKRELKISQKTKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NMY3</accession>
    <name>A0A218NMY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mevalonate pyrophosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NMY3"/>
    <dbReference type="KEGG" id="marh:Mia14_0535"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="1">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="371" mass="41330" checksum="680D9443F10CDDDF" modified="2017-09-27" version="1">MTNSEMQELKAMGSAIQKIAQKNGKFLSTKRYTADPHDGEISYGEGNPIIGMEKFLGYYDPSMNIAYSPSISMNTDFSVAKAFCRYSKSGKDSIMVDGTTNEKYLGRMEKALDLFRKENSIEGSFQFFLKRERRYKEAKGLGESAAVASATARALLGCVFGKEAVGDTAFVSRYARLVSGSGSRSAAGGISLWMSFPGIANEECYAERMEADYKGIKFFTIPEKSLIETISAHSAAVQSDFYKNWIFGKYNRIKALLENPFSAEDLLSMAEKDMFRLDGILMSSGFFVHNNSSMSNLGKFFDFKKSNDGVYVTADTGPSLVFFSKDERQLKELEAYLNPPNVLYGNAAVDFHMNPNQKDKEQADNYFSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN47</accession>
    <name>A0A218NN47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U-APC2 family APC superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820170.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN47"/>
    <dbReference type="GeneID" id="33314145"/>
    <dbReference type="KEGG" id="marh:Mia14_0591"/>
    <dbReference type="OrthoDB" id="44220at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="441" mass="46901" checksum="F39C8BCCB569778D" modified="2017-09-27" version="1">MAKNNKQISLWVATAVGLGAIIGAGIFVLSGTAIALAGAYSLIAFILVGVLAVIIAMEFGELGSIMPHAKGASFSYAYEAFGSELGFIVGILMYFSFATAISAIALGFGSYATSLLGVASHSYSVMFAILLIFILSIVNIIGIKKAAKADSFLVMIKLGILTLFIVAAMALAYSSHIFAASNFSVTKSTGTIAAIFAASIAVFFAYSGFQSISTMTSDVKGGSKAAGKAIVLSVVISMIFYVLVVIAMMMMVPASKFTISADPLSFALQYAHAPYALFVIVGIGALIATTSATLAMILTSSRVLYQISDNKLLPKALRKYDKKKDVAINGVIISSVIGVVMLFSGNIYIIAAISNFGLLLSYLISSFALIHFRRNNKEGIFRTPLYPYSTIAGIILLGLFIAGMPREALDIGVLLILGLLMAYYFLVEFKRKKVIREEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NN84</accession>
    <name>A0A218NN84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LamG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820195.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NN84"/>
    <dbReference type="GeneID" id="33314173"/>
    <dbReference type="KEGG" id="marh:Mia14_0619"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47635:SF2">
        <property type="entry name" value="LAMG-LIKE JELLYROLL FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI13922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="286" mass="30864" checksum="1B19BB29FEA6450D" modified="2017-09-27" version="1">MKSQSAMEYLMTYGWAILVIAIVLAALYSLGIFNPSTFAPKASAGSCEVVRPFGPTTSTDVHLEGTCTNMLPKYVASFNGADSGITISSPSEFPASSEPGISIFVWIKTTRSSEGVFEYYSPSNNICEGSVRLEVSPKLQADFSCDAISNGPVLDNNTWNFVGWTLKSGTSKVILYVNGIPYGPYQITPINVPTTGLEGLIGAPYPGWPYYYGSMSNVQLYNTALSSNQITALYDEGIGGDPIDLQNLVGWWPLNGNSNDYSGNNNNGKATNIAYSSTWYRTYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNA7</accession>
    <name>A0A218NNA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Mia14_0646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820213.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNA7"/>
    <dbReference type="GeneID" id="33314199"/>
    <dbReference type="KEGG" id="marh:Mia14_0646"/>
    <dbReference type="OrthoDB" id="145578at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="11">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="151" mass="17155" checksum="CD1674F73D606A01" modified="2017-09-27" version="1">MLLENTKAPDFELDGSDGKKHSLDEFKGKYLVLYFYPKDNTPGCTIEARQFNEKIEEIEKLNATVVGVSKDDLKSHDKFKSKFDLKFLLLSDPTSEMIKKYESYGKSMIGFGTLRSTYIIGKDGTILKAYPKVKPAIHADEVIDYLKSVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNB4</accession>
    <name>A0A218NNB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DrugE1 family ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Mia14_0656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI13959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820223.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNB4"/>
    <dbReference type="GeneID" id="33314209"/>
    <dbReference type="KEGG" id="marh:Mia14_0656"/>
    <dbReference type="OrthoDB" id="147058at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF2">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ASI13959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="256" mass="27799" checksum="325CAF18A968BEC9" modified="2017-09-27" version="1">MNRDISVIYVLWLRAMKRFIRSPSQIIGSIAMPVLFLLFLDAGFGSLAAFLHLPPGVSYIDFLVPGIVGMSMLFAATTSGISLLWDKQFGFLKEVMVAPVRRVSIVLGRVLGGLSTAIIQSTLLIIIALFIGFKLPSVLGILITYGFMVLIGIVFICLGLIIASFMKDMQGFGLILNLLIFPLFFLSGAIYPITVLPTFVKYITYFNPLTYGVDGMRFALIGISVFPGYVDAIVLGIIAIAMLILGAIAFAKGKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNH2</accession>
    <name>A0A218NNH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C/D box methylation guide ribonucleoprotein complex subunit aNOP56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Mia14_0715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820277.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNH2"/>
    <dbReference type="GeneID" id="33314267"/>
    <dbReference type="KEGG" id="marh:Mia14_0715"/>
    <dbReference type="OrthoDB" id="11877at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Nop" evidence="4">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="335" mass="38629" checksum="D1C57954BEA9BB8B" modified="2017-09-27" version="1">MADDNFDEIRKNMLSEVKNEIKSGYSSEEYTLIQAVNAYDEVLRSYNLFSERLTEWYLLYYPNIRVQSPNLLADLIKVIDNKDELTLENINSVVNDVNKSKTIYEKATAENIGKEISPEEAYIVERYAELIKKSNETLEELQKYIDTTANKLMPNTVYLTNSLTASELLNKAGSMEKLSIMPSSTIQLLGAENALFKHIKFGSKPPKYGLLFKLPEINTARRDTKGRIARVYANKISIALKADYYTKNFIAKELKESLDSSISRISKSPVKAKSSTQTNRSYSSKRHNQGDGERHRNDFHRDNNRDSSRNNNRFRRKDRKNHFTGKADKKPNFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI1</accession>
    <name>A0A218NNI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WHTH transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820278.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI1"/>
    <dbReference type="GeneID" id="33314268"/>
    <dbReference type="KEGG" id="marh:Mia14_0716"/>
    <dbReference type="OrthoDB" id="382882at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="182" mass="21073" checksum="B4F0B6B271DE1F3D" modified="2017-09-27" version="1">MHSKKELEKEIANIKNQLKMINATNLNDYKPSQESDEDFVSLFKYMLEENKKTTLVLDSILKRIEKLESDVSEVYDDDEEEEEESSKVEKTESFVDQPKKEILLASTDVKIVQILQLSENSMASAEEVSRKMNYKGKNAASARLNRLYKMGLIDRYQLGHKVYYKYDPGKTTSTLIISPPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNI5</accession>
    <name>A0A218NNI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820274.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNI5"/>
    <dbReference type="GeneID" id="33314264"/>
    <dbReference type="KEGG" id="marh:Mia14_0712"/>
    <dbReference type="OrthoDB" id="26985at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="193" mass="22558" checksum="93A3B7A5F5F47995" modified="2017-09-27" version="1">MANKEGSPIDKEIEKYERQLEDKEKLYDEISLESRDIIRGSGIAITLLHNGNKKESKDKINLLSKSVKSLLGKDSGFRYYTLQAYQEYAEAQIFYNLLINDRFVVLDEIKIPTESYILGMLDVVGELKREIISLLMSRNVKRSEQLFHYMEEIYDKTRTIRFPEVILPGFRKKQDVARIQIESAGNEIVLFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ3</accession>
    <name>A0A218NNJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit Sec61beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Mia14_0726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820286.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ3"/>
    <dbReference type="GeneID" id="33314278"/>
    <dbReference type="KEGG" id="marh:Mia14_0726"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ASI14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="52" mass="5458" checksum="45EFD6110636CC4C" modified="2017-09-27" version="1">MASLASPQSSAGVLSFYDAPTNGPKINPKFVLVTIIVVAVIILAVNHFVIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNJ4</accession>
    <name>A0A218NNJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820302.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNJ4"/>
    <dbReference type="GeneID" id="33314294"/>
    <dbReference type="KEGG" id="marh:Mia14_0743"/>
    <dbReference type="OrthoDB" id="384283at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="796" mass="89177" checksum="FAE8F38019A1F427" modified="2017-09-27" version="1">MKKKIAILILVVVMAIIFAGIFAYLSSLFAQLKPPAPPVLKYIAPSENVYLTGQNLLFYNYSYDIMPYTLLDYAASNVTGLYINESILQKSPPSYNEIYILNYTNDCLSCSNPTAEVSYITNDLIKYRIISNYSQVQVVSASQVASLPNNSILIIMNGRLPISMMGNYSLSDNNPQLARQYNESNTSVIGYALMKGISIIYIGNDFSSLVGPGDIVVPDSRMPSYLSTSGVSPLPKENGFYFTNRTFVFNNGRTYGPVSYTYVYNGTIIAFSNYLSSWPSLNDSAYDIAKSISQLYWIPTYISGTATVNVGLNNVVSGSEGVFLNSSTLGYSYPLIKKLNSGIIRIVAYTNSTYGFGNGSIYNYLTYKPDYKVYGKLGIQNNIVAGSTDPVDMDIFTNSSTNVNIVPHLAIYYTNMTKFEDIYLTSFEASGNFSLIQYKTFTLPPGQYIAILRNDLDFDYASALFTVPPISVTLSPYFTKNVFTFTVYSQGKPISGIPYSINVDGKYTQNGTVENGVINYTLPKTAPKLTTKSTFNLNMLSTDFVNTATPPTFHINSEYIEAGIVFLVAFIVIVFVHPAPRDEFYIDVSNLPVAKKQDIRLKDIDLIGAFDKLNTYYHWRYMPLTVHEFRTAVSNYIRSNNIPVNLTLNNINTILTQMVEKNELVSVRDLYAPKSWITLSKHDIAYLAIFKELRMFMISHAITFTDLDSNDKADMVIAMKDQKANIIIYSKTSKFKEVSITPGLKTFIVFLSEEELNKFKETVYSVSSYDMDLFRIYLSSGLVKLVSLDNLNDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNL6</accession>
    <name>A0A218NNL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNL6"/>
    <dbReference type="KEGG" id="marh:Mia14_0748"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="117" mass="13055" checksum="CEF495DCCF54E522" modified="2017-09-27" version="1">MQHYQRFGFARNAKPGTRQEQRSAGSADLNTLGQREKILELKSDIMAELSNIEQLIVDVMQSMGATKETSIKTADDIAKKCSRPKGLVTNSLITLTQKGLIKRVAREKVAGYYIVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNM1</accession>
    <name>A0A218NNM1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fen</name>
        <name evidence="13" type="ORF">Mia14_0777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820332.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNM1"/>
    <dbReference type="GeneID" id="33314328"/>
    <dbReference type="KEGG" id="marh:Mia14_0777"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="11">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ASI14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="349" mass="39335" checksum="5F3146C0EEF74466" modified="2017-09-27" version="1">MSVDLSKLIVKKVINLDDLKDRTVAIDAYNTIYQFLSIIRQPDGTPLADSNGNVTSHLSGLFYRTIELIQHGIKPIYVYDGIPSMLKQKTIEARIQKRNEAYKAWQEAVEKGNVEEAHSYAERSTRINKEIVASSKELLSLMGIGYINAPSEGEAEASYLSMKGLVFSAVSQDYDTLLFGARNIVRNIAISGKRKLPKKNIYINVNTELVNLDETLSSIGISRRQLIWVGIMLGTDFNKGIKGIGPKTAVKIVKQCESLDQVIEYIKSKYKLEFEFDVNEVENLFLNPEVKELSDLDISNLNSLKPDVGGIVDFMCRKHEFSEDRIRRYAELLSKAKGSLNQKGISNWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNN2</accession>
    <name>A0A218NNN2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo11</name>
        <name evidence="3" type="synonym">rpoL</name>
        <name evidence="5" type="ORF">Mia14_0756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820316.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNN2"/>
    <dbReference type="GeneID" id="33314308"/>
    <dbReference type="KEGG" id="marh:Mia14_0756"/>
    <dbReference type="OrthoDB" id="24205at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ASI14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="87" mass="9696" checksum="2722164A6C7F9D89" modified="2017-09-27" version="1">MDYKILKDDENELMVEFNSPDLTIPDLVANTALEDSKVTFAGVYKEHPDVGNPQLVIKTKGEKAAEAFKGALNKIESSIKDMKKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP2</accession>
    <name>A0A218NNP2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 10">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Mia14_0794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Mia14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 10"/>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820349.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP2"/>
    <dbReference type="GeneID" id="33314344"/>
    <dbReference type="KEGG" id="marh:Mia14_0794"/>
    <dbReference type="OrthoDB" id="314at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ASI14088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="321" mass="35996" checksum="FEAC52CBC369DAD4" modified="2017-09-27" version="1">MKILIQFPEGLKDKVFDYAKKLEEEGNEVYIDAHPTFGACDLAIEEAKTLKVDKLIHFGHAEYGHDRLPKDLGFEVEYNEYKIEAPLNLLPESLDYLKDYGVIGLVTTVQHQHQLSEIKEFYEKNGKSIMIGKPYGLARKEGQVLGCDVGSATTIDKSVDAFVYFGGGVFHPLGAVIATTKPFLIIDPFNGEVKFIDYMREQYSKRRKGLIMSSINAKKFGLLVSTKNGQYNKALADLLKKKIESSGLQAEILITNTFDFGSIDNMIDIDAFVNTACPRIAIDDVDRIRKPLLDANELMEVLKIKEDSEKLKEIAESGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNP9</accession>
    <name>A0A218NNP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_0788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820343.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNP9"/>
    <dbReference type="GeneID" id="33314339"/>
    <dbReference type="KEGG" id="marh:Mia14_0788"/>
    <dbReference type="OrthoDB" id="25344at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114:SF2">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="479"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="765" mass="87601" checksum="8EF0C93C15C88133" modified="2017-09-27" version="1">MIKSIDLKNWKVHSDTHLDFDKGVNILIGIMGAGKSSIVDAISFGLFGTFPALNSGRVKLDNLISNSANVNEASVKLEFDIDNNSYTVTRKIKREKGADALLEKNGKFLQTQPKRVNEEIESLLKLNYDTFIKAIYAEQNKLDYFLDIRKGERKKSIDEMLGLDRFTNVDENATSVIGMINRIIKEDEQLIGNIDVRSIKQQIEDLSVKKQDILGEIGSYKSEFGKLSLEVEKYANSLKEMKEKRLKKLKLKEEMASISSKINTLKAEMEKISVPMQKEELENNYLIAKNKFESLSADLEKSRKQQMDLARDIATAKSDFEANSKKLKENEEILLKVKEFEKLDLDKAIAEAEDRINKENLEIASDEGSVKELSKWVAELSKDISKCPVCDREIGTDLRLKLLEEKNSSIADYKSKILLHKNELNALKEKFNAFNEDKRKLDILRGKLEDIDKIKQIIDLLSSKSQNLKSQYELVAKTVEGYNSNREQAREDVNKIEKYIEDLKRQETLKKSIDTENKALKEKNGEFQSIDISEDRIENLQNEYNNLYSKRNEIKIRYETGKKRYDDILLQIADKINQVNRVEESEERVSSRKRLVSSLEKFRTALKETESGLRNRLVSSVNDVMADLWPKIYPYGDYEYIMLNTYKDDYLLEGIVNINGKKEKVSIDSFASGGERSTASLALRIALGMVIVPNLKWIILDEPTHNLDAAGISRLVSVFSETLPDIVEQIFIITHDDSLKQVHPAKIYMVERDKEARAPAAISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV2</accession>
    <name>A0A218NNV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper/silver-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Mia14_0877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Mia14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820453.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV2"/>
    <dbReference type="GeneID" id="33314420"/>
    <dbReference type="KEGG" id="marh:Mia14_0877"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01512">
        <property type="entry name" value="ATPase-IB2_Cd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="11">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ASI14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="691" mass="74271" checksum="665554A6FE7843D9" modified="2017-09-27" version="1">MPTDPVCGMFVPEDTDLKSVVDGQTYYFCSKTCQQKYSSPETEARKLKRRLIVGWSLSIPVIVITYGFSHSIFYLNYLLLILTLPVQFYSGYGFYEGSYHALKSRSANMDLLVSLGTLTAFVFSAYVTIARPSSIPPSEVYFDASSFIVTLILTGNFIENLTKVKANRAASKLIGMIPNVVHYIASLGDITDKKTDEIRPGDKILVKPGEVISVDGIIYEGKSEVDESMLTGEQEPVLKSAGQVVASGTKNLNGVIRINVTRTGKDSTVSQIYELIQRASSGRVKVQRIADVFSSVFVPIVISSALVASLFWYFYLSSVGYPLALEIGILAFVSVVVVACPCAIGLAGPITLLISSNVSSENGIIVKNVSALDRLSKSTRAVFDKTGTLTEPDPVVTGISVSPADSEENVIALAASVESASNHPIARAIVALAENKKIPLFEATEIKEIPGVGITGRVNDKEIRVSRAKKEGGSTVSVNVDNEERGFISLSYVIRKEAVSAIKGLRSMGIRSSMITGDSMEEARRVGNQLGIDDIHAEVLPADKSEIIKKYQAAGDHVIFTGDGINDTVALETADVGIAMGSGTDIARESGDIILLKNDLNDVVYAKIIGKKTIGKVKQNIGWAFGYNTALIPVAGGLLVPLFGLSIYSFLPILSALAMGMSSTSVVLNSLLLRRNVSKLIQKYEKGVVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNV3</accession>
    <name>A0A218NNV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type III restriction-modification enzyme subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Mia14_0869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820444.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNV3"/>
    <dbReference type="REBASE" id="210406">
        <property type="entry name" value="M.Mar14ORF869P"/>
    </dbReference>
    <dbReference type="GeneID" id="33314414"/>
    <dbReference type="KEGG" id="marh:Mia14_0869"/>
    <dbReference type="OrthoDB" id="57527at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="560"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ASI14151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="620" mass="72371" checksum="53A02A4F38464362" modified="2017-09-27" version="1">MRDFGIYWKNKREEVERVELPFQKIETINLPRSNIGTLAQFKKDSENGEWKNKLIWGDNKYVMASLLSEFRGKIKLIYADPPFFTGTNMNITLEVGDEGAVKEPSAIEEIAYRNMWKEGPSSFFQYMYDRFVLMKDLLAEDGAIWVRFDYHYSHYIKTILDEIFGYDNFRNEIIINRTRKNVMASRTQTVFPTATDSLFLYAKSENMLLTETKIKTEEERKGYWRHMDDSAGQGSAKTFFGKSMEPPPGKHWKFSQENIDKMIEEGRLRLNPKTSRPEYWVEPSDEYLLDTNWTDIPGYSFSTGYPTENAEQLLERVILSSSVREDLVADFFSGSGTTAAVAEKLGRKWIAADIGRFSVHTIRKRSLDIPHCKPFEVLNLGKYERKHWMDQNLGSVYRNYIDFILQLYKAKPVYDYKCIHGIISGKAVHVGPIDYPVTKSEVEECLKEAKDNGFDSLDVLGWDFEMEFNDRILRELRGSYDFGISLRIIPNEVMDKRAVEAGDVDFYEHAFLEAKLATSGRKVKVNLENFIIPNPESIPEELRDKILKWSDFIDYWSVDWNYRDDTFHNEWQEFRTKKKKSLQLQSIEHHYDAPGTYKVMVKVIDVFGNDTTTMKEVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ2</accession>
    <name>A0A218NNZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216923.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ2"/>
    <dbReference type="GeneID" id="33314463"/>
    <dbReference type="KEGG" id="marh:Mia14_0926"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="154" mass="17842" checksum="51E8E4ED9F753F2C" modified="2017-09-27" version="1">MMSIDSDSDFRKYLHTSKNTKKEATILRINTYMKEDLEKFYNSSEELVGLNEKLIHITGVDDPLELVKSEIIKKSEDSIYNSYGTITNKLRFDNDYGKSELVKDLKNARRNTSEVISKLDLSINEGNSKLLSVHPKVMRKKPKEKTKDYSIWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NNZ8</accession>
    <name>A0A218NNZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_124216915.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NNZ8"/>
    <dbReference type="GeneID" id="33314426"/>
    <dbReference type="KEGG" id="marh:Mia14_0883"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="257" mass="28822" checksum="48522A619F88753D" modified="2017-09-27" version="1">MNDNDWISTVLSSPFMKIMADSLNRSSNEMDPRATPLYKAVIGHVGPERTVIDIGAGVGRFAIPLAQDGIKVTAVEPSDEMRRHLKEAIASSGLSSGINVVPSSWPVDKALTAEVVFASFVIQFSKNPMEFIHAMERSARNQCILSVHVDQPLEFLRNIWQVFRPTEPVPVMLTFSDLYPMLLNMGIIANVAIIEEKRMSRPVMEPAKIITLLSDLLSIRDKPADMQRLKEILEGMRSRIQEPPSMRTAIVSWQPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP10</accession>
    <name>A0A218NP10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Mia14_0930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Mia14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820498.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP10"/>
    <dbReference type="GeneID" id="33314467"/>
    <dbReference type="KEGG" id="marh:Mia14_0930"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ASI14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="62" mass="7049" checksum="052AE0D5325EB50F" modified="2017-09-27" version="1">MVGLASRGYYHFLYLMNYMHGSGVLAKSKIKKTGPDGTEINLLPYHCKRSTNKNKKMENSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP52</accession>
    <name>A0A218NP52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N6-threonylcarbamoyl-adenosine(37)-tRNA synthase dimerization module Pcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Mia14_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820535.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP52"/>
    <dbReference type="GeneID" id="33314505"/>
    <dbReference type="KEGG" id="marh:Mia14_0969"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011470">
        <property type="entry name" value="PRK14887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ASI14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="90" mass="10236" checksum="290F78FBF20DF339" modified="2017-09-27" version="1">MVFKNSNKNKFRYYARITIPYDKFITESRVEGNLESYDRAKVNISKSENLLQINISATDISALRASFNSITRDLSVIEGTNKVLQSKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-09-27" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A218NP62</accession>
    <name>A0A218NP62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Mia14_1000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Mancarchaeum acidiphilum</name>
        <dbReference type="NCBI Taxonomy" id="1920749"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Candidatus Micrarchaeota</taxon>
            <taxon>Candidatus Mancarchaeum</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="60" last="60">
            <title>'ARMAN' archaea depend on association with euryarchaeal host in culture and in situ.</title>
            <authorList>
                <person name="Golyshina O."/>
                <person name="Toshchakov S."/>
                <person name="Makarova K."/>
                <person name="Gavrilov S."/>
                <person name="Korzhenkov A."/>
                <person name="La Cono V."/>
                <person name="Arcadi E."/>
                <person name="Nechitaylo T."/>
                <person name="Ferrer M."/>
                <person name="Kublanov I."/>
                <person name="Wolf Y."/>
                <person name="Yakimov M."/>
                <person name="Golyshin P."/>
                <person name="Slesarev A."/>
                <person name="Kozyavkin S."/>
            </authorList>
            <dbReference type="PubMed" id="28680072"/>
            <dbReference type="DOI" id="10.1038/s41467-017-00104-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Mia14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP019964">
        <property type="protein sequence ID" value="ASI14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_088820562.1">
        <property type="nucleotide sequence ID" value="NZ_CP019964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A218NP62"/>
    <dbReference type="GeneID" id="33314536"/>
    <dbReference type="KEGG" id="marh:Mia14_1000"/>
    <dbReference type="OrthoDB" id="26738at2157"/>
    <dbReference type="Proteomes" id="UP000197679">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ASI14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000197679"/>
        </source>
    </evidence>
    <sequence length="358" mass="40389" checksum="004D8C27F8DC05CB" modified="2017-09-27" version="1">MAEDNFVSYMKEQGSRVNKLLEEVLSDKNVDQNIEKLLGRGGYDYDTDAIEKSVMDPAWYLISQGGKRLRPVFTSLVISLFKKNPDDYIEFSIIPEVLHTATLIHDDIEDRSVKRRNVDCVHIKYGLDIALNLGDFMFYFPMKALIDSSKLENEQKIKIMQLYIEDMLKLGIGQGVDLAWHNFLINPNNISEENYMRMAFDKTGALLGFAAELGAVIGGATDRQIKLLGKFGATVGVVFQIKDDLLNIEKSNVSESKGGVGDDITEGKITLLVTHAIKEADEKDRSRLLEILKSHSSDPKLKEEASNILIKYNSDGYVEKIADSLINDVWNEVDKEFPDSHGKELIKQMVGFVLNRNF</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>