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<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A7RLV8</accession>
    <name>A7RLV8_NEMVE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NEMVEDRAFT_v1g199029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CH2 X CH6</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS469519">
        <property type="protein sequence ID" value="EDO47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7RLV8"/>
    <dbReference type="HOGENOM" id="CLU_1002209_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDO47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <sequence length="278" mass="30203" checksum="44DE443F0CD25F69" modified="2007-10-02" version="1">MAAKKDVNKPNVCQEESDTTTSKQASFDASSTGYVPLDMKEGESTDKKPDLVEYTNSETDDDVILEKKFNTSESAASLTSEDKNNTLPGQPGNDGDSITTTEANPLSVSTAEVSKNTTPSLPMESESQGTTTATSASSSSVSAPDPVAGPSTDPEQAEDKSYLNSAEYAYTKRAEFTSEIFKIEINNLPKYSTTHSVQESIQAIFTCNHKLPQEKSRDQMLAKALKDPVVVKQKAAEGKERKRMIQEAAERNPDAKRAKTGGDKNQVDFFARLALLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A7RPQ3</accession>
    <name>A7RPQ3_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NEMVEDRAFT_v1g161329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CH2 X CH6</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS469526">
        <property type="protein sequence ID" value="EDO46549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7RPQ3"/>
    <dbReference type="HOGENOM" id="CLU_1280549_0_0_1"/>
    <dbReference type="OMA" id="TKEALMH"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDO46549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24214" checksum="D79D754CB99C9B59" modified="2007-10-02" version="1" fragment="single">MAATTNLPAIQHPLSRMGNPANLNVRGTSRDGPRVASRQSLNLGESKLRPITADQMPWRLTKSSNGHNQRSPRDDLNLGNIPEGIEVRRAEDPSKPTIPIFGSRADMASRVESRMSRLSSAAASSRGPDKASVDEFEYLLREKMKTGYFTIKNLFKQRDPENKGIVSRESLSQILTTFVGKPISLSQFNKLMVRLNLDHKKMIAYDEFYAAFRPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A7RUK6</accession>
    <name>A7RUK6_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NEMVEDRAFT_v1g182128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CH2 X CH6</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="7"/>
    <dbReference type="EMBL" id="DS469540">
        <property type="protein sequence ID" value="EDO44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7RUK6"/>
    <dbReference type="MEROPS" id="C26.001"/>
    <dbReference type="OMA" id="IHYHQWC"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000024">
        <property type="entry name" value="Folate gamma-glutamyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002711546" description="folate gamma-glutamyl hydrolase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDO44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <sequence length="302" mass="33789" checksum="12FEFF891D07FFB5" modified="2007-10-02" version="1">MLGYLLTILVPLVLCLRSNAKEAPFFRGNRDVFTNRPIIGVLSQDSSGFKNLGKHGKSYIASSYIKYLEAAGARVVPIRNDLTKSELTKLFYSINGVLFPGGDSDLWKSGYARTGAAIFDLAMEANDNGDVFPLWGTCLGFQLLHVRAAKGKDVLTKCSGENVSLPLNFTDGYKDSRMFRNAHNDVTQDMAKLGVTLNMHVNCVTVETYEKESSLSSFFKKLSTNMDKDDKVKFVSTVEGLKYPFYGTQWHPEKNQFEWTYEENINHSSEAVKVAQYVANFFVDQGRNQEIHTLAYAHIGAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A7SCE5-2</accession>
    <name>NA241_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 7</fullName>
            <shortName evidence="2">Nv1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.41.1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">v1g113105</name>
    </gene>
    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NOMENCLATURE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>A7SCE5-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>A7SCE5-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039751"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="23" mass="2422" checksum="A2EC00C9E0D9E768" modified="2010-10-05" version="2" precursor="true">MTSFKIVIVCLALLVAVASARSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A7SCM4</accession>
    <name>A7SCM4_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NEMVEDRAFT_v1g237112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CH2 X CH6</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="DS469624">
        <property type="protein sequence ID" value="EDO38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7SCM4"/>
    <dbReference type="KEGG" id="nve:5510112"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000074">
        <property type="entry name" value="Solute carrier family 25 member 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDO38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34216" checksum="DF274F82CCBA43A2" modified="2007-10-02" version="1">MIVDLVAGGLGGSTGVILTCPLDVIQTRLQSSAFRLQRISQLGLNMAGIEATSSVSKPTNFYGVFSYGRYIARTEGARSLFKGLCPNLLAVTPSRAIYFTTYQKLKEWLNNGGILAANSSMVYLVSGASAQIVNSTITNPLWFLKTRLQLDFKCGREVKLARVVRQAYATEGIRAFYKGLSASYLGSIEVGLHFAIYENLKQQLLRSQNKTNDHQFTLAECTLAAGSAKVVSTGLCYPYEVVRTRLRQQESDVLGKQRYRTCLQTLRTVFVEEGWFGLYGGLGTNLMKQVPFTTVMFCVYEGVIYMMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A7SGX1</accession>
    <name>A7SGX1_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NEMVEDRAFT_v1g170524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CH2 X CH6</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS469655">
        <property type="protein sequence ID" value="EDO37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7SGX1"/>
    <dbReference type="MEROPS" id="S01.414"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDO37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <sequence length="255" mass="27059" checksum="3DBB849BCBB5D9CD" modified="2007-10-02" version="1">MSLSPLNSGFSLVIGGVNAQSGAWPWQIALERSGSFICGGSLVSPTWVVTAAHCIAGSSHTPSYKVVTGEHIRNSPEGTEQTHDVKRIITHPTYNSPQLSNDIALIELSSPVPLSDRVNPVCLPPQGHQVSVGSKCFITGWGKIRHPGGSHHILQQAMMPPLSQDACKKKVQQAGFGIQITDSMVCAGVPGSLDQGGIDTCQGDSGGPMVCESRGRFYIHGATSWGYGCAQPGKFGVYAHVKNLVAWVRSEMARN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A7SRR3-2</accession>
    <name>SHKL2_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isoform 2 of Neuropeptide ShK-like2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ShK-like2a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ShK-like2b</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2)</scope>
        <source>
            <strain evidence="5">CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2018" name="Development" volume="145" first="0" last="0">
            <title>NvERTx: a gene expression database to compare embryogenesis and regeneration in the sea anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Warner J.F."/>
                <person name="Guerlais V."/>
                <person name="Amiel A.R."/>
                <person name="Johnston H."/>
                <person name="Nedoncelle K."/>
                <person name="Roettinger E."/>
            </authorList>
            <dbReference type="PubMed" id="29739837"/>
            <dbReference type="DOI" id="10.1242/dev.162867"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2020" name="Proc. Natl. Acad. Sci. U.S.A." volume="117" first="27481" last="27492">
            <title>Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Landau M."/>
                <person name="Surm J.M."/>
                <person name="Macrander J."/>
                <person name="Singer S.A."/>
                <person name="Reitzel A.M."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="33060291"/>
            <dbReference type="DOI" id="10.1073/pnas.2011120117"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PROTEIN SEQUENCE OF 77-86</scope>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>RECOMBINANT EXPRESSION</scope>
        <scope>ALTERNATIVE PROMOTER USAGE (ISOFORMS 1 AND 2)</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>A7SRR3-2</id>
            <name>2</name>
            <name>ShK-like2b</name>
            <sequence type="described" ref="VSP_061205"/>
        </isoform>
        <isoform>
            <id>A7SRR3-1</id>
            <name>1</name>
            <name>ShK-like2a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <comment type="tissue specificity">
        <text evidence="2">Transcripts are predominantly expressed in ectodermal sensory neurons in early and late planulae. They are expressed in endodermal ganglion cells in the body column and tentacles in primary polyps, as well as in a small number of ectodermal neurons in pharynx. They are not expressed in nematocytes.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="1 2">Is moderately detected in planulae and a little more detected in primary polyps (9d), as well as in both adult females and males (at protein level) (PubMed:33060291). Transcripts are expressed early in the life cycle and their expression is maintained through the adult stage (PubMed:29739837).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="29739837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="33060291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="33060291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="EDO33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <sequence length="92" mass="10216" checksum="4FE24EDD2CB47BA3" modified="2021-09-29" version="2" precursor="true">MDVKLVAILFACTLFSLSFANGYRLESLRNLPNDALEEESEVAEKSPLKKRGCSDAFPVVCRSPSVKAACYNPNHRSHAFITDVCKHTCHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A7SYF7</accession>
    <name>A7SYF7_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD finger protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NEMVEDRAFT_v1g194978</name>
        <name evidence="10" type="ORF">NEMVEDRAFT_v1g4240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CH2 x CH6</strain>
            <strain evidence="11">CH2 X CH6</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS469973">
        <property type="protein sequence ID" value="EDO30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DS469920">
        <property type="protein sequence ID" value="EDO31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7SYF7"/>
    <dbReference type="eggNOG" id="KOG1084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922362_0_0_1"/>
    <dbReference type="InParanoid" id="A7SYF7"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15508">
        <property type="entry name" value="PHD3_KMT2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDO30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDO31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14942" checksum="2DE9485681421002" modified="2007-10-02" version="1" fragment="single">LLMCDKCQRGYHVDCLGPSYPVVPEGSEDTWICGRCAQCKLCGSKSAGEDPEAVWMHEFTHCYDCGTAWDNGNYCPICEKCYSDNDFDSKMMHCNDCQHWVHASCQNINPDEYECLSDLPDSIPFVCKLCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-10-02" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A7T0R8</accession>
    <name>A7T0R8_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NEMVEDRAFT_v1g248390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CH2 X CH6</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DS470047">
        <property type="protein sequence ID" value="EDO30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A7T0R8"/>
    <dbReference type="KEGG" id="nve:116601119"/>
    <dbReference type="HOGENOM" id="CLU_016785_9_3_1"/>
    <dbReference type="OMA" id="DHNIHCM"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF53">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="94"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDO30444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001593"/>
        </source>
    </evidence>
    <sequence length="360" mass="41839" checksum="CDD8EAE2B2BBDDD0" modified="2007-10-02" version="1" fragment="single">GHLRPFGYQKPPNGPVIEYDYVLRPQEFWEKHVHENLPLVFRHGVAESPAIANWKDEYLKEKYGDLDVLIEGKRENRTHGKTQRMLLGDFIDRYRKDDLYVVTVMPDPMLAEVQVPPAIMCGTFAKFLHETNLWIGSGGTRSVIHYDADHNIHCMMAGRKDFIMIHQKFKQQLKLGKFPQFGSGFSMVNPDEINLDLYPNISDVEWTYATINDGDCIFLPSGYIHQVRSYGRSISATMLFTASVDNTFEADGCENETFEYKPLSEMRVHWTYKKGDKVVPMGYQNVENFRHNIIRQMGEVGVTQLTADLFQRFIDETFELEEDDERKLKRDPVKLFAKYLDKEKKGFVTVEDIKNVPFDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B1NWR6-2</accession>
    <name>NA228_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 3</fullName>
            <shortName evidence="2">Nv1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Delta-edwarditoxin-Nvc1c</fullName>
            <shortName evidence="3">Delta-EWTX-Nvc1c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Delta-edwarditoxin-Nvc1d</fullName>
            <shortName evidence="3">Delta-EWTX-Nvc1d</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.28.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Neurotoxin Nv1-13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Neurotoxin Nv1-15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 11">Neurotoxin Nv1-17</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 12">Neurotoxin Nv1-18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 13">Neurotoxin Nv1-19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Neurotoxin Nv1-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Neurotoxin Nv1-4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Neurotoxin Nv1-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Neurotoxin Nv1-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">v1g113139</name>
    </gene>
    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Toxicon" volume="60" first="539" last="550">
            <title>Development of a rational nomenclature for naming peptide and protein toxins from sea anemones.</title>
            <authorList>
                <person name="Oliveira J.S."/>
                <person name="Fuentes-Silva D."/>
                <person name="King G.F."/>
            </authorList>
            <dbReference type="PubMed" id="22683676"/>
            <dbReference type="DOI" id="10.1016/j.toxicon.2012.05.020"/>
        </citation>
        <scope>NOMENCLATURE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1NWR6-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039745"/>
        </isoform>
        <isoform>
            <id>B1NWR6-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="22683676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABW97332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABW97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="ABW97335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="ABW97338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="ABW97343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="EMBL" id="ABW97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="ACB71118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="EMBL" id="ACB71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="13">
        <source>
            <dbReference type="EMBL" id="ACB71120.1"/>
        </source>
    </evidence>
    <sequence length="23" mass="2476" checksum="AACDB0C9FBC2E6D8" modified="2010-10-05" version="2" precursor="true">MASFKIVIVCLALLVAVACARRK</sequence>
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    <accession>B1NWR7-2</accession>
    <name>NA245_NEMVE</name>
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        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 8</fullName>
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        <alternativeName>
            <fullName evidence="4">Neurotoxin 1-3</fullName>
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        <alternativeName>
            <fullName evidence="5">Neurotoxin 1-6</fullName>
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        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.45.1</fullName>
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    <gene>
        <name type="ORF">v1g113209</name>
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    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
            <strain>Rhode River</strain>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1NWR7-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B1NWR7-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039752"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABW97333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABW97336.1"/>
        </source>
    </evidence>
    <sequence length="23" mass="2476" checksum="AACDB0C9FBC2E6D8" modified="2008-04-29" version="1" precursor="true">MASFKIVIVCLALLVAVACARRK</sequence>
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<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>B1NWS1-2</accession>
    <name>NA227_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 2</fullName>
            <shortName evidence="2">Nv1</shortName>
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        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.27.1</fullName>
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        <alternativeName>
            <fullName evidence="5">Neurotoxin Nv1-12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Neurotoxin Nv1-7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">v1g113065</name>
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    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
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    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1NWS1-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B1NWS1-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039748"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABW97337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABW97342.1"/>
        </source>
    </evidence>
    <sequence length="23" mass="2460" checksum="AACDB0C9E0C2E6D8" modified="2010-10-05" version="2" precursor="true">MASFKIVIVCLALLVAVASARRK</sequence>
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    <accession>B1NWS4-2</accession>
    <name>NA225_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 1</fullName>
            <shortName evidence="2">Nv1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Delta-edwarditoxin-Nvc1b</fullName>
            <shortName evidence="3">Delta-EWTX-Nvc1b</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1 5">Neurotoxin Nv1-10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.25.1</fullName>
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        <alternativeName>
            <fullName evidence="1 6">Neurotoxin Nv3-2</fullName>
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    <gene>
        <name type="ORF">v1g113108</name>
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    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2012" name="Toxicon" volume="60" first="539" last="550">
            <title>Development of a rational nomenclature for naming peptide and protein toxins from sea anemones.</title>
            <authorList>
                <person name="Oliveira J.S."/>
                <person name="Fuentes-Silva D."/>
                <person name="King G.F."/>
            </authorList>
            <dbReference type="PubMed" id="22683676"/>
            <dbReference type="DOI" id="10.1016/j.toxicon.2012.05.020"/>
        </citation>
        <scope>NOMENCLATURE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1NWS4-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039746"/>
        </isoform>
        <isoform>
            <id>B1NWS4-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="22683676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABW97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABW97348.1"/>
        </source>
    </evidence>
    <sequence length="23" mass="2476" checksum="AACDB0C9FBC2E6D8" modified="2010-10-05" version="2" precursor="true">MASFKIVIVCLALLVAVACARRK</sequence>
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    <accession>B1NWS8-2</accession>
    <name>NA240_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoform 2 of N.vectensis toxin 1 6</fullName>
            <shortName evidence="2">Nv1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Neurotoxin Nv1-116.40.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Neurotoxin Nv1-14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Neurotoxin Nv1-9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">v1g113221</name>
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    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
            </authorList>
            <dbReference type="PubMed" id="17615350"/>
            <dbReference type="DOI" id="10.1126/science.1139158"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>CH2 X CH6</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18538344"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
            <strain>Rhode River</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
            </authorList>
            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
            <authorList>
                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>B1NWS8-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>B1NWS8-2</id>
            <name>2</name>
            <name>truncated</name>
            <sequence type="described" ref="VSP_039750"/>
        </isoform>
        <text>Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Due to an intron retention observed only in early life stages (embryo and planula).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000001593">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000303" key="1">
        <source>
            <dbReference type="PubMed" id="18222944"/>
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    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="18538344"/>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="ABW97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="ABW97344.1"/>
        </source>
    </evidence>
    <sequence length="23" mass="2476" checksum="AACDB0C9FBC2E6D8" modified="2008-04-29" version="1" precursor="true">MASFKIVIVCLALLVAVACARRK</sequence>
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<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>P0CH45-2</accession>
    <name>NA291_NEMVE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform 2 of Putative N.vectensis toxin 1 9</fullName>
            <shortName evidence="1">Nv1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Neurotoxin Nv1-3391.7.1</fullName>
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        <alternativeName>
            <fullName evidence="2">Putative delta-edwarditoxin-Nvc1a</fullName>
            <shortName evidence="2">Delta-EWTX-Nvc1a</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">v1g150294</name>
    </gene>
    <organism>
        <name type="scientific">Nematostella vectensis</name>
        <name type="common">Starlet sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="45351"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Edwardsiidae</taxon>
            <taxon>Nematostella</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="DOI" id="10.1126/science.1139158"/>
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    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
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                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
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        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
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    <reference key="3">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
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            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Toxicon" volume="60" first="539" last="550">
            <title>Development of a rational nomenclature for naming peptide and protein toxins from sea anemones.</title>
            <authorList>
                <person name="Oliveira J.S."/>
                <person name="Fuentes-Silva D."/>
                <person name="King G.F."/>
            </authorList>
            <dbReference type="PubMed" id="22683676"/>
            <dbReference type="DOI" id="10.1016/j.toxicon.2012.05.020"/>
        </citation>
        <scope>NOMENCLATURE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
            </authorList>
            <dbReference type="PubMed" id="29424690"/>
            <dbReference type="DOI" id="10.7554/elife.35014"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
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                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
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            <dbReference type="PubMed" id="31134275"/>
            <dbReference type="DOI" id=".1093/molbev/msz132"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
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    <reference key="1">
        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
            <authorList>
                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="DOI" id="10.1126/science.1139158"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
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            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
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        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
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    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
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            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
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        <scope>NOMENCLATURE</scope>
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    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
                <person name="Gurevitz M."/>
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            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
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        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
            <title>Dynamics of venom composition across a complex life cycle.</title>
            <authorList>
                <person name="Columbus-Shenkar Y.Y."/>
                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
                <person name="Moran Y."/>
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            <dbReference type="DOI" id="10.7554/elife.35014"/>
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        <scope>FUNCTION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2019" name="Mol. Biol. Evol." volume="36" first="2001" last="2012">
            <title>The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.</title>
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                <person name="Sachkova M.Y."/>
                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
                <person name="Moran Y."/>
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            <dbReference type="DOI" id=".1093/molbev/msz132"/>
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        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
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        <citation type="journal article" date="2007" name="Science" volume="317" first="86" last="94">
            <title>Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.</title>
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                <person name="Putnam N.H."/>
                <person name="Srivastava M."/>
                <person name="Hellsten U."/>
                <person name="Dirks B."/>
                <person name="Chapman J."/>
                <person name="Salamov A."/>
                <person name="Terry A."/>
                <person name="Shapiro H."/>
                <person name="Lindquist E."/>
                <person name="Kapitonov V.V."/>
                <person name="Jurka J."/>
                <person name="Genikhovich G."/>
                <person name="Grigoriev I.V."/>
                <person name="Lucas S.M."/>
                <person name="Steele R.E."/>
                <person name="Finnerty J.R."/>
                <person name="Technau U."/>
                <person name="Martindale M.Q."/>
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            <strain>CH2 X CH6</strain>
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    <reference key="2">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="380" first="437" last="443">
            <title>Intron retention as a posttranscriptional regulatory mechanism of neurotoxin expression at early life stages of the starlet anemone Nematostella vectensis.</title>
            <authorList>
                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Reitzel A.M."/>
                <person name="Sullivan J.C."/>
                <person name="Kahn R."/>
                <person name="Gordon D."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
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            <dbReference type="DOI" id="10.1016/j.jmb.2008.05.011"/>
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        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>TOXIC DOSE</scope>
        <source>
            <strain>Sippewissett Marsh</strain>
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    <reference key="3">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="25" first="737" last="747">
            <title>Concerted evolution of sea anemone neurotoxin genes is revealed through analysis of the Nematostella vectensis genome.</title>
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                <person name="Moran Y."/>
                <person name="Weinberger H."/>
                <person name="Sullivan J.C."/>
                <person name="Reitzel A.M."/>
                <person name="Finnerty J.R."/>
                <person name="Gurevitz M."/>
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            <dbReference type="PubMed" id="18222944"/>
            <dbReference type="DOI" id="10.1093/molbev/msn021"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Crane Marsh</strain>
            <strain>Neponset River Marsh</strain>
            <strain>Rhode River</strain>
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    <reference key="4">
        <citation type="journal article" date="2012" name="Proc. R. Soc. B" volume="279" first="1351" last="1358">
            <title>Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.</title>
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                <person name="Moran Y."/>
                <person name="Genikhovich G."/>
                <person name="Gordon D."/>
                <person name="Wienkoop S."/>
                <person name="Zenkert C."/>
                <person name="Ozbek S."/>
                <person name="Technau U."/>
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            <dbReference type="PubMed" id="22048953"/>
            <dbReference type="DOI" id="10.1098/rspb.2011.1731"/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="0" last="0">
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                <person name="Sachkova M.Y."/>
                <person name="Macrander J."/>
                <person name="Fridrich A."/>
                <person name="Modepalli V."/>
                <person name="Reitzel A.M."/>
                <person name="Sunagar K."/>
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            <dbReference type="DOI" id="10.7554/elife.35014"/>
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        <scope>FUNCTION</scope>
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                <person name="Singer S.A."/>
                <person name="Macrander J."/>
                <person name="Reitzel A.M."/>
                <person name="Peigneur S."/>
                <person name="Tytgat J."/>
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        </source>
    </evidence>
    <sequence length="23" mass="2460" checksum="AACDB0C9E0C2E6D8" modified="2010-10-05" version="1" precursor="true">MASFKIVIVCLALLVAVASARRK</sequence>
</entry>
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</uniprot>